KR101996129B1 - 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 - Google Patents

아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 Download PDF

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KR101996129B1
KR101996129B1 KR1020170087978A KR20170087978A KR101996129B1 KR 101996129 B1 KR101996129 B1 KR 101996129B1 KR 1020170087978 A KR1020170087978 A KR 1020170087978A KR 20170087978 A KR20170087978 A KR 20170087978A KR 101996129 B1 KR101996129 B1 KR 101996129B1
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KR20190007142A (ko
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전애지
송병철
이지혜
김종현
김혜원
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씨제이제일제당 (주)
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Priority to BR112019020183-1A priority patent/BR112019020183B1/pt
Priority to ES18832634T priority patent/ES2919345T3/es
Priority to PCT/KR2018/007821 priority patent/WO2019013532A2/ko
Priority to CA3064569A priority patent/CA3064569C/en
Priority to JP2019538131A priority patent/JP6794555B2/ja
Priority to AU2018301879A priority patent/AU2018301879B2/en
Priority to US16/479,813 priority patent/US10844359B2/en
Priority to MX2019015056A priority patent/MX2019015056A/es
Priority to RU2019138301A priority patent/RU2743964C1/ru
Priority to CN201911130496.3A priority patent/CN110724679B/zh
Priority to EP18832634.2A priority patent/EP3553171B1/en
Priority to CN201880015829.5A priority patent/CN110506112B/zh
Publication of KR20190007142A publication Critical patent/KR20190007142A/ko
Application granted granted Critical
Publication of KR101996129B1 publication Critical patent/KR101996129B1/ko
Priority to US16/692,558 priority patent/US11021697B2/en
Priority to ZA2019/08353A priority patent/ZA201908353B/en
Priority to US17/076,057 priority patent/US11085029B2/en
Priority to US17/225,756 priority patent/US11248220B2/en
Priority to US17/357,196 priority patent/US11345901B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01006—Acetolactate synthase (2.2.1.6)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020170087978A 2017-07-11 2017-07-11 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 Active KR101996129B1 (ko)

Priority Applications (18)

Application Number Priority Date Filing Date Title
KR1020170087978A KR101996129B1 (ko) 2017-07-11 2017-07-11 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
EP18832634.2A EP3553171B1 (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
PCT/KR2018/007821 WO2019013532A2 (ko) 2017-07-11 2018-07-10 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
CA3064569A CA3064569C (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
JP2019538131A JP6794555B2 (ja) 2017-07-11 2018-07-10 アセトヒドロキシ酸シンターゼ変異体、これを含む微生物、またはこれを用いるｌ−分岐鎖アミノ酸の生産方法
AU2018301879A AU2018301879B2 (en) 2017-07-11 2018-07-10 Acetohydroxy Acid Synthase Variant, Microorganism Comprising The Same, And Method Of Producing L-Branched-Chain Amino Acid Using The Same
US16/479,813 US10844359B2 (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
MX2019015056A MX2019015056A (es) 2017-07-11 2018-07-10 Variante de acetohidroxiacido sintasa, microorganismo que comprende la misma, y procedimiento de produccion de aminoacidos de cadena l-ramificada mediante el uso del mismo.
RU2019138301A RU2743964C1 (ru) 2017-07-11 2018-07-10 Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма
CN201880015829.5A CN110506112B (zh) 2017-07-11 2018-07-10 乙酰羟酸合酶变体、包含其的微生物和用其生产l-支链氨基酸的方法
BR112019020183-1A BR112019020183B1 (pt) 2017-07-11 2018-07-10 Variante de aceto-hidroxiácido sintase, micro-organismo que compreende a mesma e método de produção de aminoácido de cadeia ramificada l com o uso da mesma
ES18832634T ES2919345T3 (es) 2017-07-11 2018-07-10 Variante de la acetohidroxiácido sintasa, microorganismo que comprende la misma, y método para producir L-aminoácidos de cadena ramificada mediante el uso del mismo
CN201911130496.3A CN110724679B (zh) 2017-07-11 2018-07-10 乙酰羟酸合酶变体、包含其的微生物和用其生产l-支链氨基酸的方法
US16/692,558 US11021697B2 (en) 2017-07-11 2019-11-22 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
ZA2019/08353A ZA201908353B (en) 2017-07-11 2019-12-13 Acetohydroxy acid synthase mutant and method for producing microorganism comprising same or l-branched chain amino acid using same
US17/076,057 US11085029B2 (en) 2017-07-11 2020-10-21 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
US17/225,756 US11248220B2 (en) 2017-07-11 2021-04-08 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
US17/357,196 US11345901B2 (en) 2017-07-11 2021-06-24 Acetohydroxy acid synthase variant and a microorganism comprising the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020170087978A KR101996129B1 (ko) 2017-07-11 2017-07-11 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법

Related Child Applications (1)

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KR1020190037330A Division KR102063909B1 (ko) 2019-03-29 2019-03-29 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법

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US (3) US10844359B2 (https=)
EP (1) EP3553171B1 (https=)
JP (1) JP6794555B2 (https=)
KR (1) KR101996129B1 (https=)
CN (2) CN110724679B (https=)
AU (1) AU2018301879B2 (https=)
BR (1) BR112019020183B1 (https=)
CA (1) CA3064569C (https=)
ES (1) ES2919345T3 (https=)
MX (1) MX2019015056A (https=)
RU (1) RU2743964C1 (https=)
WO (1) WO2019013532A2 (https=)
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KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물
KR102311391B1 (ko) * 2020-05-21 2021-10-12 씨제이제일제당 주식회사 L- 분지쇄 아미노산 생산능이 강화된 미생물 및 이를 이용하여 l-분지쇄 아미노산을 생산하는 방법
CN112195204B (zh) * 2020-10-21 2022-04-15 通辽梅花生物科技有限公司 一种混菌发酵生产支链氨基酸的方法
KR102619598B1 (ko) * 2021-08-23 2023-12-29 씨제이제일제당 주식회사 신규한 아세토하이드록시산 신타아제 소단위체 변이체 및 이를 이용한 l-발린 생산 방법
KR102935702B1 (ko) * 2022-12-28 2026-03-09 씨제이제일제당 주식회사 신규한 아세토락테이트 합성효소 활성을 갖는 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법
CN121532502A (zh) * 2023-05-19 2026-02-13 Cj第一制糖株式会社 变体多肽和使用其生产l-缬氨酸的方法

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CN110724679B (zh) 2022-01-11
EP3553171A2 (en) 2019-10-16
BR112019020183A2 (pt) 2020-06-02
US20200263149A1 (en) 2020-08-20
CN110506112B (zh) 2021-06-08
JP2020505023A (ja) 2020-02-20
WO2019013532A2 (ko) 2019-01-17
CN110506112A (zh) 2019-11-26
ZA201908353B (en) 2021-04-28
CA3064569A1 (en) 2019-01-17
RU2743964C1 (ru) 2021-03-01
EP3553171B1 (en) 2022-05-04
WO2019013532A3 (ko) 2019-04-04
AU2018301879B2 (en) 2022-02-17
US11085029B2 (en) 2021-08-10
BR112019020183B1 (pt) 2023-03-21
EP3553171A4 (en) 2020-05-13
CN110724679A (zh) 2020-01-24
US20210040457A1 (en) 2021-02-11
JP6794555B2 (ja) 2020-12-02
MX2019015056A (es) 2020-08-03
US10844359B2 (en) 2020-11-24
US11345901B2 (en) 2022-05-31
ES2919345T3 (es) 2022-07-26
AU2018301879A1 (en) 2020-01-16
KR20190007142A (ko) 2019-01-22
US20210324349A1 (en) 2021-10-21
CA3064569C (en) 2023-03-14

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