RU2743964C1 - Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма - Google Patents

Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма Download PDF

Info

Publication number
RU2743964C1
RU2743964C1 RU2019138301A RU2019138301A RU2743964C1 RU 2743964 C1 RU2743964 C1 RU 2743964C1 RU 2019138301 A RU2019138301 A RU 2019138301A RU 2019138301 A RU2019138301 A RU 2019138301A RU 2743964 C1 RU2743964 C1 RU 2743964C1
Authority
RU
Russia
Prior art keywords
ala
gly
val
leu
pro
Prior art date
Application number
RU2019138301A
Other languages
English (en)
Russian (ru)
Inventor
Э Чжи ЧОН
Бён Чоль СОН
Джи Хе Ли
Чжон Хён КИМ
Хе Вон КИМ
Original Assignee
СиДжей ЧеилДжеданг Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by СиДжей ЧеилДжеданг Корпорейшн filed Critical СиДжей ЧеилДжеданг Корпорейшн
Application granted granted Critical
Publication of RU2743964C1 publication Critical patent/RU2743964C1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1022Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y202/00Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01Transketolases and transaldolases (2.2.1)
    • C12Y202/01006Acetolactate synthase (2.2.1.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/03Oxo-acid-lyases (4.1.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
RU2019138301A 2017-07-11 2018-07-10 Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма RU2743964C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020170087978A KR101996129B1 (ko) 2017-07-11 2017-07-11 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
KR10-2017-0087978 2017-07-11
PCT/KR2018/007821 WO2019013532A2 (ko) 2017-07-11 2018-07-10 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법

Publications (1)

Publication Number Publication Date
RU2743964C1 true RU2743964C1 (ru) 2021-03-01

Family

ID=65002267

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019138301A RU2743964C1 (ru) 2017-07-11 2018-07-10 Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма

Country Status (13)

Country Link
US (3) US10844359B2 (https=)
EP (1) EP3553171B1 (https=)
JP (1) JP6794555B2 (https=)
KR (1) KR101996129B1 (https=)
CN (2) CN110724679B (https=)
AU (1) AU2018301879B2 (https=)
BR (1) BR112019020183B1 (https=)
CA (1) CA3064569C (https=)
ES (1) ES2919345T3 (https=)
MX (1) MX2019015056A (https=)
RU (1) RU2743964C1 (https=)
WO (1) WO2019013532A2 (https=)
ZA (1) ZA201908353B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2853992C2 (ru) * 2024-05-17 2025-12-29 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Штамм Corynebacterium glutamicum - продуцент L-валина и способ получения L-валина с использованием этого штамма

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물
KR102311391B1 (ko) * 2020-05-21 2021-10-12 씨제이제일제당 주식회사 L- 분지쇄 아미노산 생산능이 강화된 미생물 및 이를 이용하여 l-분지쇄 아미노산을 생산하는 방법
CN112195204B (zh) * 2020-10-21 2022-04-15 通辽梅花生物科技有限公司 一种混菌发酵生产支链氨基酸的方法
KR102619598B1 (ko) * 2021-08-23 2023-12-29 씨제이제일제당 주식회사 신규한 아세토하이드록시산 신타아제 소단위체 변이체 및 이를 이용한 l-발린 생산 방법
KR102935702B1 (ko) * 2022-12-28 2026-03-09 씨제이제일제당 주식회사 신규한 아세토락테이트 합성효소 활성을 갖는 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법
CN121532502A (zh) * 2023-05-19 2026-02-13 Cj第一制糖株式会社 变体多肽和使用其生产l-缬氨酸的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014142463A1 (ko) * 2013-03-11 2014-09-18 씨제이제일제당(주) L-발린 생산능이 향상된 균주 및 이를 이용한 l-발린 생산방법
US20140335574A1 (en) * 2006-09-13 2014-11-13 Ajinomoto Co., Inc. Mutant Acetolactate Synthase and a Method for Producing Branched-Chain L-Amino Acids
RU2535973C2 (ru) * 2010-06-15 2014-12-20 Пайк Кванг Индастриал Ко., Лтд. Способ продуцирования аминокислот семейства аспартата с использованием микроорганизмов

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2218526C (en) * 1995-04-20 2012-06-12 American Cyanamid Company Structure-based designed herbicide resistant products
KR100815041B1 (ko) 1999-08-02 2008-03-18 아처 다니엘 미드랜드 캄파니 아미노산 생산의 대사 공학
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
EP1491634A1 (en) 2003-06-26 2004-12-29 Degussa AG Feedback resistant acetohydroxy acid synthetase mutants
KR100671167B1 (ko) 2005-09-12 2007-01-19 이상익 개인용 긴급 구난 벨트
WO2007149069A2 (en) 2006-06-15 2007-12-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Resistance to acetolactate synthase-inhibiting herbicides
BRPI0716980A2 (pt) 2006-09-15 2013-10-22 Cj Cheiljedang Corp Corynebacteria com produtividade de l-lisina aumentada e método de produção da l-lisina usando a mesma
PL2203565T3 (pl) 2007-10-05 2016-02-29 Cibus Europe Bv Zmutowane geny syntazy kwasu acetohydroksy roślin kapustnych
CN102286505B (zh) * 2011-05-26 2013-04-03 江南大学 用于发酵生产l-缬氨酸的重组dna、菌株及方法
KR101117022B1 (ko) 2011-08-16 2012-03-16 씨제이제일제당 (주) L-발린 생산능이 향상된 미생물 및 이를 이용한 l-발린 제조방법
US9290770B2 (en) * 2011-08-22 2016-03-22 Research Institute Of Innovative Technology For The Earth Coryneform bacterium transformant and process for producing valine using the same
DK2811028T3 (en) 2013-06-03 2017-05-01 Evonik Degussa Gmbh Process for Preparation of L-Valine Using Recombinant Coryn Bacteria Containing the Propionate Inducible IlvBN Operon
KR20150119785A (ko) 2014-04-15 2015-10-26 삼성전자주식회사 라이프 로그 서비스 제공 시스템 및 그 서비스 방법
KR101720836B1 (ko) * 2014-08-05 2017-04-03 씨제이제일제당 (주) 피드백 저항성 아세토하이드록시산 신타아제 변이체 및 이를 이용한 l-발린의 생산방법
KR101796830B1 (ko) 2015-08-25 2017-11-13 씨제이제일제당 (주) L-류신 생산능을 가지는 미생물 및 이를 이용한 l-류신의 제조방법
CN106754807B (zh) * 2016-12-29 2020-10-30 廊坊梅花生物技术开发有限公司 生产l-亮氨酸菌株和生产l-亮氨酸的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140335574A1 (en) * 2006-09-13 2014-11-13 Ajinomoto Co., Inc. Mutant Acetolactate Synthase and a Method for Producing Branched-Chain L-Amino Acids
RU2535973C2 (ru) * 2010-06-15 2014-12-20 Пайк Кванг Индастриал Ко., Лтд. Способ продуцирования аминокислот семейства аспартата с использованием микроорганизмов
WO2014142463A1 (ko) * 2013-03-11 2014-09-18 씨제이제일제당(주) L-발린 생산능이 향상된 균주 및 이를 이용한 l-발린 생산방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2853992C2 (ru) * 2024-05-17 2025-12-29 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Штамм Corynebacterium glutamicum - продуцент L-валина и способ получения L-валина с использованием этого штамма

Also Published As

Publication number Publication date
CN110724679B (zh) 2022-01-11
EP3553171A2 (en) 2019-10-16
BR112019020183A2 (pt) 2020-06-02
US20200263149A1 (en) 2020-08-20
CN110506112B (zh) 2021-06-08
JP2020505023A (ja) 2020-02-20
WO2019013532A2 (ko) 2019-01-17
CN110506112A (zh) 2019-11-26
ZA201908353B (en) 2021-04-28
CA3064569A1 (en) 2019-01-17
EP3553171B1 (en) 2022-05-04
WO2019013532A3 (ko) 2019-04-04
AU2018301879B2 (en) 2022-02-17
US11085029B2 (en) 2021-08-10
BR112019020183B1 (pt) 2023-03-21
EP3553171A4 (en) 2020-05-13
CN110724679A (zh) 2020-01-24
US20210040457A1 (en) 2021-02-11
KR101996129B1 (ko) 2019-07-04
JP6794555B2 (ja) 2020-12-02
MX2019015056A (es) 2020-08-03
US10844359B2 (en) 2020-11-24
US11345901B2 (en) 2022-05-31
ES2919345T3 (es) 2022-07-26
AU2018301879A1 (en) 2020-01-16
KR20190007142A (ko) 2019-01-22
US20210324349A1 (en) 2021-10-21
CA3064569C (en) 2023-03-14

Similar Documents

Publication Publication Date Title
RU2770464C1 (ru) Новая аденилосукцинат-синтетаза и способ получения нуклеотидов пурина с ее использованием
RU2743964C1 (ru) Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма
AU2019221267B2 (en) Modified polypeptide with attenuated activity of citrate synthase and method for producing L-amino acids using same
KR101720836B1 (ko) 피드백 저항성 아세토하이드록시산 신타아제 변이체 및 이를 이용한 l-발린의 생산방법
US11180784B2 (en) Microorganism of the genus Corynebacterium producing L-amino acids and a method for producing L-amino acids using the same
KR102063909B1 (ko) 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
JP7286758B2 (ja) α-グルコシダーゼの活性が強化されたL-アミノ酸を生産する微生物及びそれを用いたL-アミノ酸生産方法
US11248220B2 (en) Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
JP7470187B2 (ja) アセトヒドロキシ酸シンターゼ新規変異体及びこれを含む微生物
RU2802274C1 (ru) Новый вариант аминотрансферазы аминокислот с разветвленной цепью и способ получения лейцина с его использованием
HK40035066A (en) Variant phosphoribosyl pyrophosphate amidotransferase and method of preparing purine nucleotide using the same
HK40035066B (en) Variant phosphoribosyl pyrophosphate amidotransferase and method of preparing purine nucleotide using the same