ES2919345T3 - Variante de la acetohidroxiácido sintasa, microorganismo que comprende la misma, y método para producir L-aminoácidos de cadena ramificada mediante el uso del mismo - Google Patents

Variante de la acetohidroxiácido sintasa, microorganismo que comprende la misma, y método para producir L-aminoácidos de cadena ramificada mediante el uso del mismo Download PDF

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ES2919345T3
ES2919345T3 ES18832634T ES18832634T ES2919345T3 ES 2919345 T3 ES2919345 T3 ES 2919345T3 ES 18832634 T ES18832634 T ES 18832634T ES 18832634 T ES18832634 T ES 18832634T ES 2919345 T3 ES2919345 T3 ES 2919345T3
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amino acid
seq
chain
branched
microorganism
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Ae Ji Jeon
Byeong Cheol Song
Ji Hye Lee
Jong Hyun Kim
Hye Won Kim
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CJ CheilJedang Corp
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1022Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine
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    • C12YENZYMES
    • C12Y202/00Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01Transketolases and transaldolases (2.2.1)
    • C12Y202/01006Acetolactate synthase (2.2.1.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/03Oxo-acid-lyases (4.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
ES18832634T 2017-07-11 2018-07-10 Variante de la acetohidroxiácido sintasa, microorganismo que comprende la misma, y método para producir L-aminoácidos de cadena ramificada mediante el uso del mismo Active ES2919345T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170087978A KR101996129B1 (ko) 2017-07-11 2017-07-11 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
PCT/KR2018/007821 WO2019013532A2 (ko) 2017-07-11 2018-07-10 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법

Publications (1)

Publication Number Publication Date
ES2919345T3 true ES2919345T3 (es) 2022-07-26

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ES18832634T Active ES2919345T3 (es) 2017-07-11 2018-07-10 Variante de la acetohidroxiácido sintasa, microorganismo que comprende la misma, y método para producir L-aminoácidos de cadena ramificada mediante el uso del mismo

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US (3) US10844359B2 (https=)
EP (1) EP3553171B1 (https=)
JP (1) JP6794555B2 (https=)
KR (1) KR101996129B1 (https=)
CN (2) CN110724679B (https=)
AU (1) AU2018301879B2 (https=)
BR (1) BR112019020183B1 (https=)
CA (1) CA3064569C (https=)
ES (1) ES2919345T3 (https=)
MX (1) MX2019015056A (https=)
RU (1) RU2743964C1 (https=)
WO (1) WO2019013532A2 (https=)
ZA (1) ZA201908353B (https=)

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KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물
KR102311391B1 (ko) * 2020-05-21 2021-10-12 씨제이제일제당 주식회사 L- 분지쇄 아미노산 생산능이 강화된 미생물 및 이를 이용하여 l-분지쇄 아미노산을 생산하는 방법
CN112195204B (zh) * 2020-10-21 2022-04-15 通辽梅花生物科技有限公司 一种混菌发酵生产支链氨基酸的方法
KR102619598B1 (ko) * 2021-08-23 2023-12-29 씨제이제일제당 주식회사 신규한 아세토하이드록시산 신타아제 소단위체 변이체 및 이를 이용한 l-발린 생산 방법
KR102935702B1 (ko) * 2022-12-28 2026-03-09 씨제이제일제당 주식회사 신규한 아세토락테이트 합성효소 활성을 갖는 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법
CN121532502A (zh) * 2023-05-19 2026-02-13 Cj第一制糖株式会社 变体多肽和使用其生产l-缬氨酸的方法

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KR100815041B1 (ko) 1999-08-02 2008-03-18 아처 다니엘 미드랜드 캄파니 아미노산 생산의 대사 공학
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
EP1491634A1 (en) 2003-06-26 2004-12-29 Degussa AG Feedback resistant acetohydroxy acid synthetase mutants
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WO2007149069A2 (en) 2006-06-15 2007-12-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Resistance to acetolactate synthase-inhibiting herbicides
RU2355763C2 (ru) * 2006-09-13 2009-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Мутантная ацетолактатсинтаза и способ продукции разветвленных l-аминокислот
BRPI0716980A2 (pt) 2006-09-15 2013-10-22 Cj Cheiljedang Corp Corynebacteria com produtividade de l-lisina aumentada e método de produção da l-lisina usando a mesma
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EP2582815B1 (en) * 2010-06-15 2016-08-10 Daesang Corp. Production process for amino acids of the aspartate family using microorganisms
CN102286505B (zh) * 2011-05-26 2013-04-03 江南大学 用于发酵生产l-缬氨酸的重组dna、菌株及方法
KR101117022B1 (ko) 2011-08-16 2012-03-16 씨제이제일제당 (주) L-발린 생산능이 향상된 미생물 및 이를 이용한 l-발린 제조방법
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KR101796830B1 (ko) 2015-08-25 2017-11-13 씨제이제일제당 (주) L-류신 생산능을 가지는 미생물 및 이를 이용한 l-류신의 제조방법
CN106754807B (zh) * 2016-12-29 2020-10-30 廊坊梅花生物技术开发有限公司 生产l-亮氨酸菌株和生产l-亮氨酸的方法

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CN110724679B (zh) 2022-01-11
EP3553171A2 (en) 2019-10-16
BR112019020183A2 (pt) 2020-06-02
US20200263149A1 (en) 2020-08-20
CN110506112B (zh) 2021-06-08
JP2020505023A (ja) 2020-02-20
WO2019013532A2 (ko) 2019-01-17
CN110506112A (zh) 2019-11-26
ZA201908353B (en) 2021-04-28
CA3064569A1 (en) 2019-01-17
RU2743964C1 (ru) 2021-03-01
EP3553171B1 (en) 2022-05-04
WO2019013532A3 (ko) 2019-04-04
AU2018301879B2 (en) 2022-02-17
US11085029B2 (en) 2021-08-10
BR112019020183B1 (pt) 2023-03-21
EP3553171A4 (en) 2020-05-13
CN110724679A (zh) 2020-01-24
US20210040457A1 (en) 2021-02-11
KR101996129B1 (ko) 2019-07-04
JP6794555B2 (ja) 2020-12-02
MX2019015056A (es) 2020-08-03
US10844359B2 (en) 2020-11-24
US11345901B2 (en) 2022-05-31
AU2018301879A1 (en) 2020-01-16
KR20190007142A (ko) 2019-01-22
US20210324349A1 (en) 2021-10-21
CA3064569C (en) 2023-03-14

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