JP2020500181A5 - - Google Patents
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- JP2020500181A5 JP2020500181A5 JP2019523769A JP2019523769A JP2020500181A5 JP 2020500181 A5 JP2020500181 A5 JP 2020500181A5 JP 2019523769 A JP2019523769 A JP 2019523769A JP 2019523769 A JP2019523769 A JP 2019523769A JP 2020500181 A5 JP2020500181 A5 JP 2020500181A5
- Authority
- JP
- Japan
- Prior art keywords
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- seq
- cdr3l
- cdr3h
- cdr1h
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100035359 Cerebellar degeneration-related protein 2-like Human genes 0.000 claims 32
- 101000737792 Homo sapiens Cerebellar degeneration-related protein 2-like Proteins 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 16
- 239000002955 immunomodulating agent Substances 0.000 claims 12
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 7
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 7
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 7
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 102000046935 human TNFRSF17 Human genes 0.000 claims 7
- 229960003433 thalidomide Drugs 0.000 claims 7
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 6
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 6
- 230000001024 immunotherapeutic effect Effects 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- VVHQVXXPZDALDV-BOXHHOBZSA-N (3s)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1h-isoindol-2-yl]piperidine-2,6-dione;hydrochloride Chemical compound Cl.O=C1N([C@@H]2C(NC(=O)CC2)=O)CC2=C1C=CC=C2OCC(C=C1)=CC=C1CN1CCOCC1 VVHQVXXPZDALDV-BOXHHOBZSA-N 0.000 claims 2
- RSNPAKAFCAAMBH-UHFFFAOYSA-N 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione Chemical compound CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O RSNPAKAFCAAMBH-UHFFFAOYSA-N 0.000 claims 2
- 229960002204 daratumumab Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 229950007752 isatuximab Drugs 0.000 claims 2
- 229960004942 lenalidomide Drugs 0.000 claims 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229950010773 pidilizumab Drugs 0.000 claims 2
- 229960000688 pomalidomide Drugs 0.000 claims 2
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims 2
- 229950007213 spartalizumab Drugs 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 229950002916 avelumab Drugs 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000006037 cell lysis Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196874.8 | 2016-11-02 | ||
| EP16196874 | 2016-11-02 | ||
| PCT/EP2017/078109 WO2018083204A1 (en) | 2016-11-02 | 2017-11-02 | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500181A JP2020500181A (ja) | 2020-01-09 |
| JP2020500181A5 true JP2020500181A5 (enExample) | 2020-12-10 |
| JP7267914B2 JP7267914B2 (ja) | 2023-05-02 |
Family
ID=57226831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523769A Active JP7267914B2 (ja) | 2016-11-02 | 2017-11-02 | Ｂｃｍａ及びｃｄ３に対する二重特異性抗体、及び多発性骨髄腫を治療するために併用して使用される免疫療法薬 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11124577B2 (enExample) |
| EP (2) | EP3535295A1 (enExample) |
| JP (1) | JP7267914B2 (enExample) |
| KR (1) | KR102687833B1 (enExample) |
| CN (1) | CN110167964B (enExample) |
| AU (1) | AU2017353427A1 (enExample) |
| BR (1) | BR112019008426A2 (enExample) |
| CA (1) | CA3041183A1 (enExample) |
| CL (1) | CL2019001198A1 (enExample) |
| EA (1) | EA201990787A1 (enExample) |
| IL (1) | IL266424B2 (enExample) |
| MX (1) | MX2019004621A (enExample) |
| SG (1) | SG11201903359RA (enExample) |
| WO (1) | WO2018083204A1 (enExample) |
Families Citing this family (63)
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| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| EP3204415B1 (en) | 2014-10-09 | 2020-06-17 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and ror1 |
| CN111234027A (zh) | 2015-05-21 | 2020-06-05 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| PT3411402T (pt) | 2016-02-03 | 2022-02-01 | Amgen Inc | Construtos de anticorpos biespecíficos engajadores de células t contra bcma e cd3 |
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-
2017
- 2017-11-02 US US16/346,771 patent/US11124577B2/en active Active
- 2017-11-02 MX MX2019004621A patent/MX2019004621A/es unknown
- 2017-11-02 AU AU2017353427A patent/AU2017353427A1/en not_active Abandoned
- 2017-11-02 WO PCT/EP2017/078109 patent/WO2018083204A1/en not_active Ceased
- 2017-11-02 BR BR112019008426A patent/BR112019008426A2/pt unknown
- 2017-11-02 SG SG11201903359RA patent/SG11201903359RA/en unknown
- 2017-11-02 CN CN201780081998.4A patent/CN110167964B/zh active Active
- 2017-11-02 JP JP2019523769A patent/JP7267914B2/ja active Active
- 2017-11-02 KR KR1020197015708A patent/KR102687833B1/ko active Active
- 2017-11-02 CA CA3041183A patent/CA3041183A1/en active Pending
- 2017-11-02 EP EP17797905.1A patent/EP3535295A1/en not_active Withdrawn
- 2017-11-02 EA EA201990787A patent/EA201990787A1/ru unknown
- 2017-11-02 IL IL266424A patent/IL266424B2/en unknown
- 2017-11-02 EP EP23204427.1A patent/EP4295918A3/en not_active Withdrawn
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2019
- 2019-04-30 CL CL2019001198A patent/CL2019001198A1/es unknown
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2021
- 2021-06-24 US US17/304,702 patent/US20220002427A1/en not_active Abandoned
- 2021-06-24 US US17/304,683 patent/US20220017631A1/en not_active Abandoned
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