DK1751181T3 - BINDINGSDELE, DER ER BASERET PÅ HAJ IgNAR-DOMÆNER - Google Patents

BINDINGSDELE, DER ER BASERET PÅ HAJ IgNAR-DOMÆNER

Info

Publication number
DK1751181T3
DK1751181T3 DK05744734.4T DK05744734T DK1751181T3 DK 1751181 T3 DK1751181 T3 DK 1751181T3 DK 05744734 T DK05744734 T DK 05744734T DK 1751181 T3 DK1751181 T3 DK 1751181T3
Authority
DK
Denmark
Prior art keywords
haj
parts based
binding parts
ignar domains
ignar
Prior art date
Application number
DK05744734.4T
Other languages
English (en)
Inventor
Stewart Nuttal
Victor Streltsov
Katherine Merne Griffiths
Jennifer Ann Carmichael
Peter Hudson
Robert Alexander Irving
Joseph Noozhumutry Varghese
Miles Mackay Barraclough
David Peter Simmons
Kylie Anne Henderson
Original Assignee
Adalta Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adalta Pty Ltd filed Critical Adalta Pty Ltd
Application granted granted Critical
Publication of DK1751181T3 publication Critical patent/DK1751181T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464Igs containing CDR-residues from one specie grafted between FR-residues from another
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK05744734.4T 2004-06-02 2005-06-02 BINDINGSDELE, DER ER BASERET PÅ HAJ IgNAR-DOMÆNER DK1751181T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57584504P 2004-06-02 2004-06-02
PCT/AU2005/000789 WO2005118629A1 (en) 2004-06-02 2005-06-02 BINDING MOIETIES BASED ON SHARK IgNAR DOMAINS

Publications (1)

Publication Number Publication Date
DK1751181T3 true DK1751181T3 (da) 2012-11-26

Family

ID=35462883

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10179638.1T DK2330121T3 (da) 2004-06-02 2005-06-02 Bindingsdele baseret på haj-IgNar-domæner
DK05744734.4T DK1751181T3 (da) 2004-06-02 2005-06-02 BINDINGSDELE, DER ER BASERET PÅ HAJ IgNAR-DOMÆNER

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10179638.1T DK2330121T3 (da) 2004-06-02 2005-06-02 Bindingsdele baseret på haj-IgNar-domæner

Country Status (7)

Country Link
US (3) US7977071B2 (da)
EP (3) EP2330121B1 (da)
JP (2) JP2008511286A (da)
AU (3) AU2005250055B2 (da)
CA (1) CA2567655C (da)
DK (2) DK2330121T3 (da)
WO (1) WO2005118629A1 (da)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
AU2005269527B2 (en) 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
JP5444553B2 (ja) 2007-04-27 2014-03-19 フェネックス インコーポレイテッド 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および/または質が改善されている特定の株を同定する方法
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CA2691940C (en) 2007-07-03 2018-03-06 Joost Alexander Kolkman Methods for providing improved immunoglobulin sequences
WO2009026638A1 (en) * 2007-08-31 2009-03-05 Melbourne Health Marine-animal derived therapeutic and diagnostic agents for hepatitis b
AU2009273749B2 (en) 2008-07-25 2016-04-21 QIAGEN Australia Holding Pty. Ltd. A diagnostic method
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
US20100092470A1 (en) * 2008-09-22 2010-04-15 Icb International, Inc. Antibodies, analogs and uses thereof
EP2344545A4 (en) 2008-10-06 2012-10-03 Commw Scient Ind Res Org CRYSTALLINE STRUCTURE OF BETA-AMYLOID PEPTIDE
US9403898B2 (en) 2009-05-07 2016-08-02 Novozymes Biopharma Dk A/S Method for purifying albumin
EP2448966B1 (en) 2009-07-03 2018-11-14 Avipep Pty Ltd Immuno-conjugates and methods for producing them
WO2011056056A2 (es) * 2009-11-04 2011-05-12 Laboratorios Silanes, S.A. De C.V. Dominios vhnar anti -citocinas
ES2735438T3 (es) 2009-12-23 2019-12-18 Cellestis Ltd Un ensayo para medir la capacidad de respuesta inmune mediada por células
US9315581B2 (en) 2009-12-23 2016-04-19 A Vipep Pty Limited Immuno-conjugates and methods for producing them
EP2686016B1 (en) 2011-03-14 2019-05-01 Cellmid Limited Antibody recognizing n-domain of midkine
US10551380B2 (en) 2011-04-29 2020-02-04 Cellestis Limited TLR agonist-enhanced in vitro assay of cell mediated immune responsiveness
CA2838246C (en) 2011-06-13 2018-07-10 Csl Limited Antibodies against g-csfr and uses thereof
KR102022513B1 (ko) 2011-06-29 2019-09-19 셀레스티스 리미티드 감도가 증진된 세포 매개 면역 반응 검정법
AU2012327878A1 (en) 2011-10-28 2014-05-29 Patrys Limited PAT-LM1 epitopes and methods for using same
US10112988B2 (en) * 2012-01-09 2018-10-30 Icb International, Inc. Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
US10112987B2 (en) * 2012-01-09 2018-10-30 Icb International, Inc. Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
MX347154B (es) 2012-02-24 2017-02-21 Centro De Investigación Científica Y De Educación Superior De Ensenada Baja California (Cicese) Prueba de diagnóstico para enfermedades infecciosas en ganado bovino.
AU2013257848A1 (en) 2012-05-07 2014-11-27 The University Court Of The University Of Aberdeen Single domain binding molecule
EP2939025B1 (en) 2012-12-28 2018-04-25 Cellestis Limited A cell mediated immune response assay
CN105073781A (zh) 2013-01-11 2015-11-18 加州生物医学研究所 牛融合抗体
EP2762496A1 (en) 2013-02-05 2014-08-06 EngMab AG Method for the selection of antibodies against BCMA
US9963513B2 (en) 2013-02-05 2018-05-08 Engmab Sàrl Method for the selection of antibodies against BCMA
CN117843785A (zh) 2013-02-07 2024-04-09 Csl有限公司 Il-11r结合蛋白及其应用
EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
WO2014173975A1 (en) * 2013-04-23 2014-10-30 The University Court Of The University Of Aberdeen Isolation of therapeutic target specific vnar domains to icosl
RU2718054C2 (ru) 2013-11-28 2020-03-30 СиЭсЭл ЛИМИТЕД Способ лечения нефропатии
KR20160096194A (ko) 2013-12-18 2016-08-12 씨에스엘 리미티드 상처 치료 방법
WO2015100246A1 (en) 2013-12-24 2015-07-02 Ossianix, Inc. Baff selective binding compounds and related methods
WO2015158937A1 (es) 2014-04-17 2015-10-22 Teraclón Idf, S.L. ANTICUERPOS MONOCLONALES RECOMBINANTES vNAR NEUTRALIZANTES DEL FACTOR DE CRECIMIENTO DEL ENDOTELIO VASCULAR VEGF
JP6454981B2 (ja) * 2014-04-24 2019-01-23 住友電気工業株式会社 半導体積層体および受光素子
JP6355020B2 (ja) * 2014-05-14 2018-07-11 パナソニックIpマネジメント株式会社 目元用美容装置
EP3160995A2 (en) 2014-06-26 2017-05-03 Ossianix Inc. Semi-synthetic nurse shark vnar libraries for making and using selective binding compounds
AU2015329965A1 (en) 2014-10-09 2017-04-27 Engmab Sàrl Bispecific antibodies against CD3epsilon and ROR1
AU2015336946A1 (en) 2014-10-23 2017-04-13 La Trobe University Fn14-binding proteins and uses thereof
WO2016065199A1 (en) 2014-10-23 2016-04-28 Qiagen Sciences, Llc Peptide composition and uses thereof
EP3218411B1 (en) 2014-11-14 2022-01-12 Ossianix, Inc. Variable new antigen receptors (vnars) directed against transferrin receptor (tfr) and their use
AU2015367224B2 (en) 2014-12-19 2020-12-10 Monash University IL-21 antibodies
CN114478773A (zh) 2015-01-09 2022-05-13 阿达尔塔有限公司 Cxcr4结合分子
WO2016198470A2 (en) 2015-06-08 2016-12-15 Lophius Biosciences Gmbh Composition for determination of cell-mediated immune responsiveness
EP3670535A1 (en) 2015-08-03 2020-06-24 EngMab Sàrl Monoclonal antibodies against bcma
WO2017041143A1 (en) 2015-09-11 2017-03-16 Ctm@Crc Ltd. Chimeric antigen receptors and uses thereof
US10273196B2 (en) 2015-09-25 2019-04-30 Exxonmobil Chemical Patents Inc. Hydrocarbon dehydrocyclization
CN109311968A (zh) 2016-05-02 2019-02-05 埃博灵克斯股份有限公司 治疗rsv感染
CA3034105A1 (en) 2016-09-23 2018-03-29 Csl Limited Coagulation factor binding proteins and uses thereof
CN110167964B (zh) 2016-11-02 2023-12-01 百时美施贵宝公司 组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物
CN110325547B (zh) 2016-11-07 2023-12-26 德格克斯有限公司 新淀粉样蛋白β寡聚体特异性结合分子
US11155612B2 (en) 2017-04-21 2021-10-26 Centro De Investigación Científica Y De Educación Superior De Ensenada, Baja California vNAR antibody which binds VEGF for use in dogs or cats
SG10201913144TA (en) 2017-07-11 2020-03-30 Compass Therapeutics Llc Agonist antibodies that bind human cd137 and uses thereof
KR102657978B1 (ko) 2017-09-27 2024-04-16 엘라스모겐 리미티드 특이적 결합 분자
WO2019067015A1 (en) 2017-09-29 2019-04-04 City Of Hope RECEPTORS OF CHIMERIC ANTIGENS AND BISPECIFIC ANTIBODIES FOR THE TREATMENT OF COAT CELL LYMPHOMA
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
US11180544B2 (en) * 2017-11-07 2021-11-23 City University Of Hong Kong Method of producing antibody fragment
EP3713961A2 (en) 2017-11-20 2020-09-30 Compass Therapeutics LLC Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
WO2019104385A1 (en) 2017-11-29 2019-06-06 Csl Limited Method of treating or preventing ischemia-reperfusion injury
US20210221864A1 (en) 2018-08-24 2021-07-22 City Of Hope Masked cytokine conjugates
MX2021005594A (es) 2018-11-13 2021-10-22 Compass Therapeutics Llc Constructos multiespecificos de union contra moleculas de puntos de control y usos de los mismos.
US20230303654A1 (en) 2020-08-11 2023-09-28 City Of Hope Compositions and uses of sars-cov-2 targeted chimeric antigen receptor modified nk cells
GB202020152D0 (en) 2020-12-18 2021-02-03 Elasmogen Ltd Fast-track humanisation of specific binding molecules
WO2023092177A1 (en) * 2021-11-23 2023-06-01 Adalta Limited Rank-l binding molecules
WO2024008904A2 (en) 2022-07-08 2024-01-11 Novo Nordisk A/S Highly potent isvd compounds capable of substituting for fviii(a)
CN116284423B (zh) * 2022-12-29 2023-10-03 江苏百英生物科技有限公司 一种靶向条纹斑竹鲨IgNAR-CH1多克隆抗体、其制备方法及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
GB8927230D0 (en) 1989-12-01 1990-01-31 Unilever Plc Reagents
US5955363A (en) 1990-01-03 1999-09-21 Promega Corporation Vector for in vitro mutagenesis and use thereof
ES2162863T3 (es) 1993-04-29 2002-01-16 Unilever Nv Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
WO1997027213A1 (en) 1996-01-23 1997-07-31 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and rna molecules
AUPP221098A0 (en) * 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
AU747637B2 (en) * 1998-03-06 2002-05-16 Arana Therapeutics (Vic) Pty Ltd V-like domain binding molecules
AU1325102A (en) * 2000-10-16 2002-04-29 Phylos Inc Protein scaffolds for antibody mimics and other binding proteins
EP2277913A3 (en) * 2001-08-10 2012-08-08 Aberdeen University Antigen binding domains from fish
PL208712B1 (pl) * 2001-08-31 2011-05-31 Avidex Ltd Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd
WO2003050531A2 (en) 2001-12-11 2003-06-19 Algonomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
US20040266993A1 (en) * 2003-06-30 2004-12-30 Evans Glen A. Non-immunoglobulin binding polypeptides

Also Published As

Publication number Publication date
JP2008511286A (ja) 2008-04-17
AU2005250055A1 (en) 2005-12-15
AU2008229687B2 (en) 2009-01-29
JP2011244822A (ja) 2011-12-08
AU2009201692B2 (en) 2012-08-30
CA2567655C (en) 2015-06-30
CA2567655A1 (en) 2005-12-15
EP2330121B1 (en) 2014-09-03
US20160237169A1 (en) 2016-08-18
AU2009201692A1 (en) 2009-05-21
EP1751181A4 (en) 2008-03-12
US7977071B2 (en) 2011-07-12
EP1751181A1 (en) 2007-02-14
EP2330121A3 (en) 2011-11-16
EP2330120A3 (en) 2011-11-16
EP1751181B1 (en) 2012-08-15
US20120003214A1 (en) 2012-01-05
US20090148438A1 (en) 2009-06-11
WO2005118629A1 (en) 2005-12-15
DK2330121T3 (da) 2014-12-15
EP2330121A2 (en) 2011-06-08
AU2008229687A1 (en) 2008-10-30
AU2005250055B2 (en) 2008-09-11
JP5631812B2 (ja) 2014-11-26
EP2330120A2 (en) 2011-06-08

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