JP2020189802A - サーチュイン1活性化剤及びサーチュイン1活性化用皮膚化粧料 - Google Patents
サーチュイン1活性化剤及びサーチュイン1活性化用皮膚化粧料 Download PDFInfo
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- JP2020189802A JP2020189802A JP2019095699A JP2019095699A JP2020189802A JP 2020189802 A JP2020189802 A JP 2020189802A JP 2019095699 A JP2019095699 A JP 2019095699A JP 2019095699 A JP2019095699 A JP 2019095699A JP 2020189802 A JP2020189802 A JP 2020189802A
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- sirtuin
- extract
- kiwi
- sennenboku
- activator
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
さらにキウイ及び/又はセンネンボクの抽出物を配合することにより、作用効果に優れ、かつ安全性の高いサーチュイン1活性化用皮膚用化粧料を提供することができる。
〔サーチュイン1活性化剤〕
本実施形態のサーチュイン1活性化剤は、キウイ(学名:Actinidia chinensis Planch. (Actinidiaceae))及び/又はセンネンボク(学名:Cordyline terminalis)の抽出物を有効成分とする。
ここで皮膚外用剤としては、その区分に制限はなく、後述する皮膚化粧料のほか、経皮的に使用される医薬部外品、医薬品等を幅広く含むものである。
上記実施形態にかかるキウイ及びセンネンボクの抽出物は優れたサーチュイン1活性化作用を有しているため、皮膚化粧料に配合するのに好適である。この場合、サーチュイン1活性化成分であるキウイ又はセンネンボクの抽出物をそのまま配合してもよいし、キウイ又はセンネンボクの抽出物から製剤化したサーチュイン1活性化剤を配合してもよい。
キウイ及びセンネンボクの抽出物は、サーチュイン1活性化作用を有しており、安全性に優れているため、飲食品に配合するのに好適である。この場合において、飲食品には、キウイ又はセンネンボクの抽出物をそのまま配合してもよいし、キウイ又はセンネンボクの抽出物から製剤化したサーチュイン1活性化剤を配合してもよい。キウイ又はセンネンボクの抽出物、又は当該キウイ又はセンネンボクの抽出物から製剤化したサーチュイン1活性化剤を配合することにより、飲食品にサーチュイン1活性化作用を付与することができる。
キウイ(Actinidia chinensis Planch. (Actinidiaceae),レインボーレッド種)の摘果果実(糖度:4.3%,長径:2cm)の粉砕物200gに抽出溶媒(精製水)400mLを加え、30℃にて1時間加温抽出し、熱時濾過した。残渣についてさらに同様の抽出処理をした。得られた抽出液に対し合わせて減圧下で濃縮し、さらに乾燥してキウイ摘果果実抽出物5.5gを得た。30%BG(ブチレングリコール)にて0.43%に調製した。
アオヒロバセンネンボク(東京都小笠原諸島産)の葉部の乾燥物20gに対し、50%BG(1,3ブチレングリコール,ハイシュガーケインBG,高級アルコール工業社製)4kgを混合し、7日間浸漬した。ADVANTEC定性濾紙(No.2,東洋濾紙社製)及びメンブラン(0.45μm)を用いて濾過し、濾液としてセンネンボク葉部抽出物(固形分:1.76質量%)を得た。
NMN(Nicotine amide mononucleotide)は東京化成工業社より購入し、リン酸緩衝液(PBS(−),シグマ アルドリッチ ジャパン社製)で0.43%に調製した。
実施例1のキウイ摘果果実抽出液、実施例2のセンネンボク葉部抽出液及び比較例1のNMN溶液について、以下のようにしてサーチュイン1遺伝子の発現試験を行った。
結果を表1に示す。
下記組成に従い、乳液を常法により製造した。
キウイ抽出物 0.01g
ホホバオイル 4.00g
1,3−ブチレングリコール 3.00g
アルブチン 3.00g
ポリオキシエチレンセチルエーテル(20E.O.) 2.50g
オリーブオイル 2.00g
スクワラン 2.00g
セタノール 2.00g
モノステアリン酸グリセリル 2.00g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 2.00g
パラオキシ安息香酸メチル 0.15g
グリチルレチン酸ステアリル 0.10g
黄杞エキス 0.10g
グリチルリチン酸ジカリウム 0.10g
イチョウ葉エキス 0.10g
コンキオリン 0.10g
オウバクエキス 0.10g
カミツレエキス 0.10g
香料 0.05g
精製水 残部(全量を100gとする)
下記組成のクリームを常法により製造した。
センネンボク抽出物 0.01g
クジンエキス 0.1g
オウゴンエキス 0.1g
流動パラフィン 5.0g
サラシミツロウ 4.0g
スクワラン 10.0g
セタノール 3.0g
ラノリン 2.0g
ステアリン酸 1.0g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 1.5g
モノステアリン酸グリセリル 3.0g
油溶性甘草エキス 0.1g
1,3−ブチレングリコール 6.0g
パラオキシ安息香酸メチル 1.5g
香料 0.1g
精製水 残部(全量を100gとする)
下記組成の美容液を常法により製造した。
キウイ抽出物 0.01g
センネンボク抽出物 0.01g
アスコルビン酸2−グルコシド 0.1g
カミツレエキス 0.1g
ニンジンエキス 0.1g
キサンタンガム 0.3g
ヒドロキシエチルセルロース 0.1g
カルボキシビニルポリマー 0.1g
1,3−ブチレングリコール 4.0g
グリチルリチン酸ジカリウム 0.1g
グリセリン 2.0g
水酸化カリウム 0.25g
香料 0.01g
防腐剤(パラオキシ安息香酸メチル) 0.15g
エタノール 2.0g
精製水 残部(全量を100gとする)
Claims (2)
- キウイ及び/又はセンネンボクの抽出物を有効成分とするサーチュイン1活性化剤。
- キウイ及び/又はセンネンボクの抽出物を配合したサーチュイン1活性化用皮膚化粧料。
Priority Applications (6)
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JP2019095699A JP7301347B2 (ja) | 2019-05-22 | 2019-05-22 | サーチュイン1活性化剤及びサーチュイン1活性化用皮膚化粧料 |
SG10202004623QA SG10202004623QA (en) | 2019-05-22 | 2020-05-18 | Sirtuin-1 activation agent and skin cosmetic for activating sirtuin 1 |
KR1020200059723A KR102573074B1 (ko) | 2019-05-22 | 2020-05-19 | 시르투인1 활성화제 및 시르투인1 활성화용 피부 화장료 |
TW109116600A TW202110424A (zh) | 2019-05-22 | 2020-05-19 | 沉默調節蛋白1 活化劑和用於活化沉默調節蛋白1 的皮膚化妝品 |
US16/880,676 US20200368143A1 (en) | 2019-05-22 | 2020-05-21 | Sirtuin-1 activation agent and skin cosmetic for activating sirtuin 1 |
CN202010441640.1A CN111973505A (zh) | 2019-05-22 | 2020-05-22 | 沉默调节蛋白1活化剂和用于活化沉默调节蛋白1的皮肤化妆品 |
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- 2020-05-19 KR KR1020200059723A patent/KR102573074B1/ko active IP Right Grant
- 2020-05-19 TW TW109116600A patent/TW202110424A/zh unknown
- 2020-05-21 US US16/880,676 patent/US20200368143A1/en not_active Abandoned
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CN111973505A (zh) | 2020-11-24 |
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