JP2020172535A5 - - Google Patents
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- JP2020172535A5 JP2020172535A5 JP2020116636A JP2020116636A JP2020172535A5 JP 2020172535 A5 JP2020172535 A5 JP 2020172535A5 JP 2020116636 A JP2020116636 A JP 2020116636A JP 2020116636 A JP2020116636 A JP 2020116636A JP 2020172535 A5 JP2020172535 A5 JP 2020172535A5
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- Prior art keywords
- alkyl
- lymphoma
- substituted
- fibrosis
- disease
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- 0 COc1ccccc1C(NCC(C=C1)=CCC1c1n[n](C2CC2)c(*N)c1C(N)=O)=O Chemical compound COc1ccccc1C(NCC(C=C1)=CCC1c1n[n](C2CC2)c(*N)c1C(N)=O)=O 0.000 description 12
- FURWRYDMHKIPCD-UHFFFAOYSA-N CC(C)(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1 Chemical compound CC(C)(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1 FURWRYDMHKIPCD-UHFFFAOYSA-N 0.000 description 1
- WAMIWWRAQHHIFM-UHFFFAOYSA-N CC(C)N(CC1[n](c(N)c2C(N)=O)nc2-c2ccc(CNC(c3cc(F)ccc3OC)=O)cc2)CC1(F)F Chemical compound CC(C)N(CC1[n](c(N)c2C(N)=O)nc2-c2ccc(CNC(c3cc(F)ccc3OC)=O)cc2)CC1(F)F WAMIWWRAQHHIFM-UHFFFAOYSA-N 0.000 description 1
- OGZZPXMMRMETQL-UHFFFAOYSA-N CC(CC1)(CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)O Chemical compound CC(CC1)(CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)O OGZZPXMMRMETQL-UHFFFAOYSA-N 0.000 description 1
- RDQGZEZFBQBVIO-UHFFFAOYSA-N CC1(C=CC=CC1OC)C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1cc(C)ccc1)=O Chemical compound CC1(C=CC=CC1OC)C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1cc(C)ccc1)=O RDQGZEZFBQBVIO-UHFFFAOYSA-N 0.000 description 1
- JZQDGEJAEPKVGK-UHFFFAOYSA-N CC[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1 Chemical compound CC[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1 JZQDGEJAEPKVGK-UHFFFAOYSA-N 0.000 description 1
- UZONARPHOQPNEY-UHFFFAOYSA-N CN(C)C(C(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)=O Chemical compound CN(C)C(C(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)=O UZONARPHOQPNEY-UHFFFAOYSA-N 0.000 description 1
- MEBBGZAFWHMPNM-UHFFFAOYSA-N COc(c(C(NCc(cc1)ccc1-c1n[n](C(COC2)C2(F)F)c(N)c1CN)=O)c1)ccc1F Chemical compound COc(c(C(NCc(cc1)ccc1-c1n[n](C(COC2)C2(F)F)c(N)c1CN)=O)c1)ccc1F MEBBGZAFWHMPNM-UHFFFAOYSA-N 0.000 description 1
- WLRCPRUFXLOORH-UHFFFAOYSA-N COc(c(C(NCc(cc1)ccc1C(C1C(N)=O)=NN(C(C2CCCC2)C(F)(F)F)C1N)=O)c1)ccc1F Chemical compound COc(c(C(NCc(cc1)ccc1C(C1C(N)=O)=NN(C(C2CCCC2)C(F)(F)F)C1N)=O)c1)ccc1F WLRCPRUFXLOORH-UHFFFAOYSA-N 0.000 description 1
- LAXXDERKUSIJDS-MSUUIHNZSA-N COc(cccc1)c1C(N/C=C1/C=CC(c2n[n](C(CC3)c4c3cccc4)c(N)c2C(N)=O)=CC1)=O Chemical compound COc(cccc1)c1C(N/C=C1/C=CC(c2n[n](C(CC3)c4c3cccc4)c(N)c2C(N)=O)=CC1)=O LAXXDERKUSIJDS-MSUUIHNZSA-N 0.000 description 1
- VRWALNOIQXJOQE-UHFFFAOYSA-N COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(C2)Cc3c2cccc3)c(N)c1C(N)=O)=O Chemical compound COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(C2)Cc3c2cccc3)c(N)c1C(N)=O)=O VRWALNOIQXJOQE-UHFFFAOYSA-N 0.000 description 1
- NOPTVQQJNWYPKJ-UHFFFAOYSA-N COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2OCc2ccccc2)c(N)c1C(N)O)=O Chemical compound COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2OCc2ccccc2)c(N)c1C(N)O)=O NOPTVQQJNWYPKJ-UHFFFAOYSA-N 0.000 description 1
- RXOAFCGAWUXBRJ-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)O)c1N)n[n]1-c1cccc(F)c1)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)O)c1N)n[n]1-c1cccc(F)c1)=O RXOAFCGAWUXBRJ-UHFFFAOYSA-N 0.000 description 1
- ZEMFIILRYIPVGZ-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2O)c(N)c1C(N)=O)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2O)c(N)c1C(N)=O)=O ZEMFIILRYIPVGZ-UHFFFAOYSA-N 0.000 description 1
- QCRCLFBYNOGRAQ-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c1n[n](CCc2nnn[nH]2)c(N)c1C(N)=O)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c1n[n](CCc2nnn[nH]2)c(N)c1C(N)=O)=O QCRCLFBYNOGRAQ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022092275A JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522245.8 | 2015-12-16 | ||
| GBGB1522245.8A GB201522245D0 (en) | 2015-12-16 | 2015-12-16 | Compounds useful as kinase inhibitors |
| GB1613945.3 | 2016-08-15 | ||
| GBGB1613945.3A GB201613945D0 (en) | 2016-08-15 | 2016-08-15 | Compounds useful as kinase inhibitors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Division JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092275A Division JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020172535A JP2020172535A (ja) | 2020-10-22 |
| JP2020172535A5 true JP2020172535A5 (enExample) | 2021-02-18 |
| JP7086140B2 JP7086140B2 (ja) | 2022-06-17 |
Family
ID=57590725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Country Status (38)
Families Citing this family (37)
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| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN114685516A (zh) | 2015-09-16 | 2022-07-01 | 洛克索肿瘤学股份有限公司 | 用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物 |
| ES2828431T3 (es) | 2015-12-16 | 2021-05-26 | Loxo Oncology Inc | Compuestos útiles como inhibidores de cinasa |
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| EP3774782A2 (en) * | 2018-04-06 | 2021-02-17 | Black Belt TX Ltd | Atf6 inhibitors and uses thereof |
| WO2019220962A1 (ja) * | 2018-05-18 | 2019-11-21 | 富士フイルム株式会社 | ３－ジフルオロメチルピラゾール化合物の製造方法及び３－ジフルオロメチルピラゾール－４－カルボン酸化合物の製造方法、並びに、ピラゾリジン化合物 |
| CA3224985C (en) * | 2018-07-31 | 2025-11-18 | Loxo Oncology, Inc. | SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021053234A1 (en) * | 2019-09-19 | 2021-03-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Compounds and compositions for treating kidney disease |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| JP7142173B2 (ja) * | 2019-12-06 | 2022-09-26 | ロクソ オンコロジー， インコーポレイテッド | ブルトン型チロシンキナーゼ阻害剤の投薬 |
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| CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| CN116348453B (zh) * | 2021-04-25 | 2025-07-04 | 烨辉医药科技(上海)有限公司 | 杂芳族甲酰胺化合物及其用途 |
| CN117320712A (zh) | 2021-05-14 | 2023-12-29 | 罗索肿瘤学公司 | 布鲁顿酪氨酸激酶抑制剂的共晶型 |
| CA3223769A1 (en) * | 2021-07-01 | 2023-01-05 | Xinglu ZHOU | Bruton's tyrosine kinase and mutant degrader, composition and application thereof |
| WO2023284765A1 (zh) * | 2021-07-16 | 2023-01-19 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑类化合物及包含该化合物的组合物及其用途 |
| KR20240157639A (ko) | 2021-12-14 | 2024-11-01 | 크로스파이어 온콜로지 홀딩 비.브이. | 거대고리 btk 억제제 |
| WO2023143355A1 (en) * | 2022-01-28 | 2023-08-03 | Hansoh Bio Llc | Azacycle amide derivative, preparation methods and medicinal uses thereof |
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| CN115894376B (zh) * | 2022-12-15 | 2025-05-16 | 南京雷正医药科技有限公司 | 一种芳香族酰胺类化合物、药物组合物及其用途 |
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| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| KR20250046558A (ko) | 2023-09-27 | 2025-04-03 | 임창섭 | 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템 |
| TW202532067A (zh) * | 2023-12-13 | 2025-08-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有吡唑環及雙環雜芳基的化合物 |
| WO2025137329A1 (en) * | 2023-12-22 | 2025-06-26 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| CN119059974B (zh) * | 2024-08-12 | 2025-10-28 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的制备方法 |
| CN119059973A (zh) * | 2024-08-12 | 2024-12-03 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的合成工艺 |
| CN120504661B (zh) * | 2025-07-14 | 2025-11-07 | 复旦大学 | Alkbh8小分子抑制剂及其制备方法和用途 |
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2016
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