JP2020172535A5 - - Google Patents
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- JP2020172535A5 JP2020172535A5 JP2020116636A JP2020116636A JP2020172535A5 JP 2020172535 A5 JP2020172535 A5 JP 2020172535A5 JP 2020116636 A JP2020116636 A JP 2020116636A JP 2020116636 A JP2020116636 A JP 2020116636A JP 2020172535 A5 JP2020172535 A5 JP 2020172535A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- lymphoma
- substituted
- fibrosis
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 COc1ccccc1C(NCC(C=C1)=CCC1c1n[n](C2CC2)c(*N)c1C(N)=O)=O Chemical compound COc1ccccc1C(NCC(C=C1)=CCC1c1n[n](C2CC2)c(*N)c1C(N)=O)=O 0.000 description 12
- FURWRYDMHKIPCD-UHFFFAOYSA-N CC(C)(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1 Chemical compound CC(C)(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1 FURWRYDMHKIPCD-UHFFFAOYSA-N 0.000 description 1
- WAMIWWRAQHHIFM-UHFFFAOYSA-N CC(C)N(CC1[n](c(N)c2C(N)=O)nc2-c2ccc(CNC(c3cc(F)ccc3OC)=O)cc2)CC1(F)F Chemical compound CC(C)N(CC1[n](c(N)c2C(N)=O)nc2-c2ccc(CNC(c3cc(F)ccc3OC)=O)cc2)CC1(F)F WAMIWWRAQHHIFM-UHFFFAOYSA-N 0.000 description 1
- OGZZPXMMRMETQL-UHFFFAOYSA-N CC(CC1)(CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)O Chemical compound CC(CC1)(CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)O OGZZPXMMRMETQL-UHFFFAOYSA-N 0.000 description 1
- RDQGZEZFBQBVIO-UHFFFAOYSA-N CC1(C=CC=CC1OC)C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1cc(C)ccc1)=O Chemical compound CC1(C=CC=CC1OC)C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1cc(C)ccc1)=O RDQGZEZFBQBVIO-UHFFFAOYSA-N 0.000 description 1
- JZQDGEJAEPKVGK-UHFFFAOYSA-N CC[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1 Chemical compound CC[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1 JZQDGEJAEPKVGK-UHFFFAOYSA-N 0.000 description 1
- UZONARPHOQPNEY-UHFFFAOYSA-N CN(C)C(C(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)=O Chemical compound CN(C)C(C(CC1)CCC1[n](c(N)c1C(N)=O)nc1-c1ccc(CNC(c(cccc2)c2OC)=O)cc1)=O UZONARPHOQPNEY-UHFFFAOYSA-N 0.000 description 1
- MEBBGZAFWHMPNM-UHFFFAOYSA-N COc(c(C(NCc(cc1)ccc1-c1n[n](C(COC2)C2(F)F)c(N)c1CN)=O)c1)ccc1F Chemical compound COc(c(C(NCc(cc1)ccc1-c1n[n](C(COC2)C2(F)F)c(N)c1CN)=O)c1)ccc1F MEBBGZAFWHMPNM-UHFFFAOYSA-N 0.000 description 1
- WLRCPRUFXLOORH-UHFFFAOYSA-N COc(c(C(NCc(cc1)ccc1C(C1C(N)=O)=NN(C(C2CCCC2)C(F)(F)F)C1N)=O)c1)ccc1F Chemical compound COc(c(C(NCc(cc1)ccc1C(C1C(N)=O)=NN(C(C2CCCC2)C(F)(F)F)C1N)=O)c1)ccc1F WLRCPRUFXLOORH-UHFFFAOYSA-N 0.000 description 1
- LAXXDERKUSIJDS-MSUUIHNZSA-N COc(cccc1)c1C(N/C=C1/C=CC(c2n[n](C(CC3)c4c3cccc4)c(N)c2C(N)=O)=CC1)=O Chemical compound COc(cccc1)c1C(N/C=C1/C=CC(c2n[n](C(CC3)c4c3cccc4)c(N)c2C(N)=O)=CC1)=O LAXXDERKUSIJDS-MSUUIHNZSA-N 0.000 description 1
- VRWALNOIQXJOQE-UHFFFAOYSA-N COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(C2)Cc3c2cccc3)c(N)c1C(N)=O)=O Chemical compound COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(C2)Cc3c2cccc3)c(N)c1C(N)=O)=O VRWALNOIQXJOQE-UHFFFAOYSA-N 0.000 description 1
- NOPTVQQJNWYPKJ-UHFFFAOYSA-N COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2OCc2ccccc2)c(N)c1C(N)O)=O Chemical compound COc(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2OCc2ccccc2)c(N)c1C(N)O)=O NOPTVQQJNWYPKJ-UHFFFAOYSA-N 0.000 description 1
- RXOAFCGAWUXBRJ-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)O)c1N)n[n]1-c1cccc(F)c1)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)O)c1N)n[n]1-c1cccc(F)c1)=O RXOAFCGAWUXBRJ-UHFFFAOYSA-N 0.000 description 1
- ZEMFIILRYIPVGZ-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2O)c(N)c1C(N)=O)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c1n[n](C(CC2)CCC2O)c(N)c1C(N)=O)=O ZEMFIILRYIPVGZ-UHFFFAOYSA-N 0.000 description 1
- QCRCLFBYNOGRAQ-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c1n[n](CCc2nnn[nH]2)c(N)c1C(N)=O)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c1n[n](CCc2nnn[nH]2)c(N)c1C(N)=O)=O QCRCLFBYNOGRAQ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022092275A JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1522245.8A GB201522245D0 (en) | 2015-12-16 | 2015-12-16 | Compounds useful as kinase inhibitors |
| GB1522245.8 | 2015-12-16 | ||
| GB1613945.3 | 2016-08-15 | ||
| GBGB1613945.3A GB201613945D0 (en) | 2016-08-15 | 2016-08-15 | Compounds useful as kinase inhibitors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Division JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092275A Division JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020172535A JP2020172535A (ja) | 2020-10-22 |
| JP2020172535A5 true JP2020172535A5 (enExample) | 2021-02-18 |
| JP7086140B2 JP7086140B2 (ja) | 2022-06-17 |
Family
ID=57590725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Country Status (37)
Families Citing this family (37)
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|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| EP4116303A1 (en) | 2015-09-16 | 2023-01-11 | Loxo Oncology, Inc. | Pyrazolopyrimidine derivatives as btk inhibitors for the treatment of cancer |
| EP3782994B1 (en) | 2015-12-16 | 2025-07-16 | Loxo Oncology, Inc. | Compounds useful as kinase inhibitors |
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| SG11202009570SA (en) | 2018-04-06 | 2020-10-29 | Black Belt Tx Ltd | Atf6 inhibitors and uses thereof |
| CN112119063B (zh) | 2018-05-18 | 2023-10-17 | 富士胶片株式会社 | 3-二氟甲基吡唑化合物的制造方法及3-二氟甲基吡唑-4-羧酸化合物的制造方法以及吡唑烷化合物 |
| KR102545594B1 (ko) | 2018-07-31 | 2023-06-21 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제 |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| US20220273593A1 (en) * | 2019-09-19 | 2022-09-01 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Compounds and compositions for treating kidney disease |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| MX2022006631A (es) | 2019-12-06 | 2022-09-07 | Loxo Oncology Inc | Dosificacion de un inhibidor de la tirosina cinasa de bruton. |
| CN120118089A (zh) | 2020-01-02 | 2025-06-10 | 迪哲(江苏)医药股份有限公司 | Btk抑制剂 |
| US20230145305A1 (en) * | 2020-03-12 | 2023-05-11 | Fochon Biosciences, Ltd. | Compounds useful as kinase inhibitors |
| TWI809489B (zh) * | 2020-09-10 | 2023-07-21 | 美商絡速藥業公司 | 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體 |
| CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2022228302A1 (en) * | 2021-04-25 | 2022-11-03 | Bionova Pharmaceuticals (Shanghai) Limited | Heteroaromatic carboxamide compounds and its use |
| CA3217452A1 (en) | 2021-05-14 | 2022-11-17 | David Andrew Coates | Cocrystalline forms of a bruton's tyrosine kinase inhibitor |
| AU2022303441A1 (en) * | 2021-07-01 | 2024-01-25 | Hangzhou Healzen Therapeutics Co., Ltd. | Bruton's tyrosine kinase and mutant degrader, composition and application thereof |
| CN115611810B (zh) * | 2021-07-16 | 2025-03-04 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑类化合物及包含该化合物的组合物及其用途 |
| EP4448523A1 (en) | 2021-12-14 | 2024-10-23 | Crossfire Oncology Holding B.V. | Macrocyclic btk inhibitors |
| WO2023143355A1 (en) * | 2022-01-28 | 2023-08-03 | Hansoh Bio Llc | Azacycle amide derivative, preparation methods and medicinal uses thereof |
| US20250179027A1 (en) * | 2022-03-03 | 2025-06-05 | Shenzhen Targetrx, Inc. | Cycloalkyl or heterocyclyl substituted heteroaryl compound, and composition and use thereof |
| WO2023174397A1 (en) * | 2022-03-18 | 2023-09-21 | Insilico Medicine Ip Limited | Pyrazole membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (pkmyt1) inhibitors and uses thereof |
| CN115894376B (zh) * | 2022-12-15 | 2025-05-16 | 南京雷正医药科技有限公司 | 一种芳香族酰胺类化合物、药物组合物及其用途 |
| IL322630A (en) | 2023-02-22 | 2025-10-01 | Assia Chem Ind Ltd | Solid forms of pirobrutinib |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| KR20250046558A (ko) | 2023-09-27 | 2025-04-03 | 임창섭 | 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템 |
| WO2025124496A1 (zh) * | 2023-12-13 | 2025-06-19 | 正大天晴药业集团股份有限公司 | 含有吡唑环和双环杂芳基的化合物、其药物组合物及用途 |
| WO2025137329A1 (en) * | 2023-12-22 | 2025-06-26 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| CN119059974B (zh) * | 2024-08-12 | 2025-10-28 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的制备方法 |
| CN119059973A (zh) * | 2024-08-12 | 2024-12-03 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的合成工艺 |
| CN120504661B (zh) * | 2025-07-14 | 2025-11-07 | 复旦大学 | Alkbh8小分子抑制剂及其制备方法和用途 |
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-
2016
- 2016-12-16 EP EP20194724.9A patent/EP3782994B1/en active Active
- 2016-12-16 CN CN202210312064.XA patent/CN114605327B/zh active Active
- 2016-12-16 DK DK16816363.2T patent/DK3390395T3/da active
- 2016-12-16 TN TNP/2018/000213A patent/TN2018000213A1/en unknown
- 2016-12-16 ES ES20194724T patent/ES3041897T3/es active Active
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