JP2020143104A5 - - Google Patents

Download PDF

Info

Publication number
JP2020143104A5
JP2020143104A5 JP2020084303A JP2020084303A JP2020143104A5 JP 2020143104 A5 JP2020143104 A5 JP 2020143104A5 JP 2020084303 A JP2020084303 A JP 2020084303A JP 2020084303 A JP2020084303 A JP 2020084303A JP 2020143104 A5 JP2020143104 A5 JP 2020143104A5
Authority
JP
Japan
Prior art keywords
sirpα
polypeptide variant
high affinity
use according
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020084303A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020143104A (ja
JP6918179B2 (ja
Filing date
Publication date
Priority claimed from JP2017134728A external-priority patent/JP6742279B2/ja
Application filed filed Critical
Publication of JP2020143104A publication Critical patent/JP2020143104A/ja
Priority to JP2021119529A priority Critical patent/JP2021176873A/ja
Publication of JP2020143104A5 publication Critical patent/JP2020143104A5/ja
Application granted granted Critical
Publication of JP6918179B2 publication Critical patent/JP6918179B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020084303A 2012-01-17 2020-05-13 高親和性sirp−アルファ試薬 Active JP6918179B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021119529A JP2021176873A (ja) 2012-01-17 2021-07-20 高親和性sirp−アルファ試薬

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261587247P 2012-01-17 2012-01-17
US61/587,247 2012-01-17
JP2017134728A JP6742279B2 (ja) 2012-01-17 2017-07-10 高親和性sirp−アルファ試薬

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017134728A Division JP6742279B2 (ja) 2012-01-17 2017-07-10 高親和性sirp−アルファ試薬

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021119529A Division JP2021176873A (ja) 2012-01-17 2021-07-20 高親和性sirp−アルファ試薬

Publications (3)

Publication Number Publication Date
JP2020143104A JP2020143104A (ja) 2020-09-10
JP2020143104A5 true JP2020143104A5 (https=) 2021-07-26
JP6918179B2 JP6918179B2 (ja) 2021-08-11

Family

ID=48799653

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2014552401A Active JP6460796B2 (ja) 2012-01-17 2013-01-17 高親和性sirp−アルファ試薬
JP2017134728A Active JP6742279B2 (ja) 2012-01-17 2017-07-10 高親和性sirp−アルファ試薬
JP2019151758A Active JP6783361B2 (ja) 2012-01-17 2019-08-22 高親和性sirp−アルファ試薬
JP2020084303A Active JP6918179B2 (ja) 2012-01-17 2020-05-13 高親和性sirp−アルファ試薬
JP2021119529A Withdrawn JP2021176873A (ja) 2012-01-17 2021-07-20 高親和性sirp−アルファ試薬

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2014552401A Active JP6460796B2 (ja) 2012-01-17 2013-01-17 高親和性sirp−アルファ試薬
JP2017134728A Active JP6742279B2 (ja) 2012-01-17 2017-07-10 高親和性sirp−アルファ試薬
JP2019151758A Active JP6783361B2 (ja) 2012-01-17 2019-08-22 高親和性sirp−アルファ試薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021119529A Withdrawn JP2021176873A (ja) 2012-01-17 2021-07-20 高親和性sirp−アルファ試薬

Country Status (19)

Country Link
US (4) US9944911B2 (https=)
EP (2) EP3766511A1 (https=)
JP (5) JP6460796B2 (https=)
CN (2) CN104136037B (https=)
AU (1) AU2013209736C1 (https=)
CA (1) CA2861307C (https=)
CY (1) CY1123419T1 (https=)
DK (1) DK2804617T3 (https=)
ES (1) ES2816647T3 (https=)
HK (1) HK1253217A1 (https=)
HR (1) HRP20201285T1 (https=)
HU (1) HUE050875T2 (https=)
LT (1) LT2804617T (https=)
PL (1) PL2804617T3 (https=)
PT (1) PT2804617T (https=)
RS (1) RS60606B1 (https=)
SI (1) SI2804617T1 (https=)
SM (1) SMT202000689T1 (https=)
WO (1) WO2013109752A1 (https=)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2804617T1 (sl) * 2012-01-17 2020-10-30 The Board Of Trustees Of The Leland Stanford Junior University Visokoafinitetni SIRP-alfa reagenti
KR102338833B1 (ko) 2012-02-06 2021-12-13 인히브릭스, 인크. Cd47 항체 및 그 사용 방법
ES2914814T3 (es) * 2012-12-17 2022-06-16 Pf Argentum Ip Holdings Llc Tratamiento de células enfermas CD47+ con fusiones SIRP Alfa-Fc
PT2970493T (pt) * 2013-03-15 2019-06-27 Univ Leland Stanford Junior Métodos para obter doses terapeuticamente eficazes de agentes anti-cd47
ES2898627T3 (es) 2013-04-29 2022-03-08 Univ Leland Stanford Junior Uso de agentes anti-CD47 para mejorar la inmunización
ES2765483T3 (es) * 2013-09-18 2020-06-09 Univ Leland Stanford Junior Modulación de las vías de eferocitosis para el tratamiento de una enfermedad aterosclerótica
EP3131917B1 (en) 2014-04-18 2020-06-17 The Board of Trustees of the Leland Stanford Junior University Humanized and chimeric monoclonal antibodies to cd99
TWI759810B (zh) * 2014-08-08 2022-04-01 美商Alx腫瘤技術股份有限公司 信號調節蛋白α(signal-regulatory proteinα, SIRP-α)變體構築物及其用途
US10087257B2 (en) 2014-08-08 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University SIRP alpha-antibody fusion proteins
WO2016023001A1 (en) * 2014-08-08 2016-02-11 The Board Of Trustees Of The Leland Stanford Junior University Multispecific high affinity pd-1 agents and methods of use
US9546206B2 (en) 2014-08-08 2017-01-17 The Board Of Trustees Of The Leland Stanford Junior University High affinity PD-1 agents and methods of use
HUE046661T2 (hu) 2014-08-15 2020-03-30 Merck Patent Gmbh SIRP-alfa immunglobulin fúziós proteinek
FI3656869T4 (fi) 2014-08-26 2025-06-04 Univ Leland Stanford Junior Kantasolujen siirrostaminen kantasoluihin kohdentuvan aineen ja immunoregulatorista signaalia moduloivan aineen yhdistelmän kanssa
EP3194024B1 (en) * 2014-09-15 2020-08-05 The Board of Trustees of the Leland Stanford Junior University Targeting aneurysm disease by modulating phagocytosis pathways
EP3209769B1 (en) 2014-10-24 2020-08-05 The Board of Trustees of the Leland Stanford Junior University Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
EP3012271A1 (en) 2014-10-24 2016-04-27 Effimune Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
CA2967379A1 (en) * 2014-11-18 2016-05-26 Janssen Pharmaceutica Nv Cd47 antibodies, methods, and uses
WO2016109415A1 (en) * 2014-12-30 2016-07-07 Celgene Corporation Anti-cd47 antibodies and uses thereof
US11253588B2 (en) 2015-02-27 2022-02-22 The Board Of Trustees Of The Leland Stanford Junior University Combination therapy for treatment of coronary artery disease
CN106146670B (zh) * 2015-04-24 2019-01-15 宜明昂科生物医药技术(上海)有限公司 一种新的重组双功能融合蛋白及其制备和应用
US10358472B2 (en) 2015-05-06 2019-07-23 The Board Of Trustees Of The Leland Stanford Junior University High affinity CD47 analogs
CA2994935A1 (en) 2015-05-18 2016-11-24 Ab Initio Biotherapeutics, Inc. Sirp polypeptide compositions and methods of use
BR102016018074A2 (pt) 2015-08-07 2021-11-16 ALX Oncology Inc. Construção variante de sirp-alfa, seu método de preparação e seus usos, molécula de ácido nucleico, vetor, célula hospedeira, e composição farmacêutica
WO2017027422A1 (en) 2015-08-07 2017-02-16 Alexo Therapeutics Inc. Constructs having a sirp-alpha domain or variant thereof
EP3341015B2 (en) 2015-08-26 2023-12-27 The Board of Trustees of the Leland Stanford Junior University Enhanced depletion of targeted cells with cd47 blockade and an immune costimulatory agonist
AU2016365829B2 (en) 2015-12-11 2020-02-06 The Board Of Trustees Of The Leland Stanford Junior University Treatment of cancer with dual targeting of CD47 and EGFR
EP3747906A1 (en) 2016-01-11 2020-12-09 Forty Seven, Inc. Humanized, mouse or chimeric anti-cd47 monoclonal antibodies
RS66062B1 (sr) 2016-04-14 2024-11-29 Ose Immunotherapeutics Nova anti-sirpa antitela i njihove terapijske primene
AU2017250809B2 (en) 2016-04-15 2024-02-29 The Board Of Trustees Of The Leland Stanford Junior University Methods for determining and achieving therapeutically effective doses of anti-CD47 agents in treatment of cancer
US11649284B2 (en) 2016-04-18 2023-05-16 Baylor College Of Medicine Cancer gene therapy targeting CD47
WO2017190148A1 (en) 2016-04-29 2017-11-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for the prevention and treatment of surgical adhesions
US11560433B2 (en) 2016-05-27 2023-01-24 Albert Einstein College Of Medicine Methods of treatment by targeting VCAM1 and MAEA
US10148939B2 (en) 2016-07-19 2018-12-04 Gopro, Inc. Mapping of spherical image data into rectangular faces for transport and decoding across networks
EP3532497B1 (en) * 2016-10-26 2024-07-24 The Board of Trustees of the Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
CA3042581A1 (en) 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Enhancement of cd47 blockade therapy by proteasome inhibitors
WO2018081898A1 (en) 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by hdac inhibitors
EP3563835A4 (en) * 2016-12-29 2020-12-30 Korea Institute of Science and Technology NEW EXOSOME-BASED ANTI-CANCER AGENT
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
LT3565579T (lt) 2017-01-05 2023-09-11 Kahr Medical Ltd. Pd1-41bbl sulietas baltymas ir jo panaudojimo būdai
PT3565828T (pt) 2017-01-05 2022-02-08 Kahr Medical Ltd Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização
JP2020505016A (ja) 2017-01-06 2020-02-20 シンロジック オペレーティング カンパニー インコーポレイテッド 腫瘍細胞において免疫モジュレーターおよび抗がん治療剤を産生するようにプログラムされた微生物
JP7321934B2 (ja) 2017-01-30 2023-08-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 幹細胞移植のための非遺伝毒性移植前処置レジメン
EP3589368A4 (en) 2017-02-28 2021-03-24 The Board of Trustees of the Leland Stanford Junior University ANTIFIBROTIC ACTIVITY OF CD47 BLOCKING
US11078272B2 (en) 2017-03-09 2021-08-03 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of CD47 pathway
SI3642242T1 (sl) 2017-06-21 2024-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Parametri odmerjanja za terapije, ki ciljajo na CD47, za hematološke malignosti
CN111246865A (zh) 2017-07-12 2020-06-05 同生运营公司 程序化以在肿瘤细胞中产生免疫调节剂和抗癌治疗剂的微生物
JP7262440B2 (ja) 2017-08-02 2023-04-21 フェインズ セラピューティクス,インコーポレーテッド 抗cd47抗体及びその使用
CN111051350B (zh) * 2017-09-07 2022-11-01 苏州丁孚靶点生物技术有限公司 包含信号调节蛋白α的免疫缀合物
WO2019061012A1 (zh) * 2017-09-26 2019-04-04 南京凯地生物科技有限公司 靶向cd47的特异性嵌合抗原受体t细胞的制备及其应用
JP7395471B2 (ja) 2017-10-13 2023-12-11 オーセ イミュノセラピューティクス 改変抗SIRPa抗体及びその使用
SI4177270T1 (sl) 2017-10-18 2024-10-30 Forty Seven, Inc. Terapija za raka jajčnikov na osnovi sredstva proti cd47
US11771764B2 (en) 2017-11-06 2023-10-03 Pfizer Inc. CD47 blockade with radiation therapy
KR20200091901A (ko) * 2017-12-01 2020-07-31 시애틀 지네틱스, 인크. 암을 치료하기 위한 cd47 항체 및 이의 용도
WO2019109357A1 (zh) * 2017-12-08 2019-06-13 杭州翰思生物医药有限公司 抗pd-1/cd47的双特异性抗体及其应用
CN109971716B (zh) * 2017-12-28 2023-08-01 上海细胞治疗研究院 自分泌cd47抗体的egfr特异性car-t细胞及其用途
AU2019218271B2 (en) 2018-02-12 2024-12-12 Forty Seven, LLC Anti-cancer regimen using anti-CD47 and anti-CD20 antibodies
CN108484774B (zh) * 2018-03-09 2021-11-05 上海高菲生物科技有限公司 一种SIRPα融合蛋白及其制备方法和用途
US20210040219A1 (en) * 2018-03-13 2021-02-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by egfr antibody
AU2019233577A1 (en) 2018-03-13 2020-09-03 Ose Immunotherapeutics Use of anti-human SIRPa v1 antibodies and method for producing anti-SIRPa v1 antibodies
CN108872569A (zh) * 2018-06-19 2018-11-23 浠思(上海)生物技术有限公司 利用HTRF一步法筛选CD47/SIRP alpha阻断剂的方法
KR20250079073A (ko) 2018-07-10 2025-06-04 고쿠리츠다이가쿠호진 고베다이가쿠 항 SIRPα 항체
US12134638B2 (en) 2018-07-11 2024-11-05 Kahr Medical Ltd. SIRPalpha-4-1BBL variant fusion protein and methods of use thereof
KR20210044221A (ko) 2018-07-11 2021-04-22 카 메디컬 리미티드 Pd1-4-1bbl 변이체 융합 단백질 및 이의 사용 방법
KR102129522B1 (ko) * 2018-07-26 2020-07-02 한국과학기술연구원 암세포 특이적 항암 단백질-형광 복합체 및 이를 포함하는 암의 진단 및 영상화용 조성물
WO2020047326A2 (en) 2018-08-31 2020-03-05 ALX Oncology Inc. Decoy polypeptides
JP7557920B2 (ja) 2018-09-04 2024-09-30 ファイザー・インク 疾患治療のためのparp阻害と組み合わせたcd47遮断
CN109306017B (zh) * 2018-10-12 2021-02-09 倍而达药业(苏州)有限公司 一种基于SIRP-αD1突变体制备的重组蛋白及应用
EP3878469A4 (en) * 2018-11-07 2022-08-03 Daiichi Sankyo Company, Limited METHOD OF IMPROVING THE BLOOD KINETICS OF A PEPTID
CN111303293B (zh) 2018-11-14 2022-08-30 杭州尚健生物技术有限公司 一种融合蛋白及其用途
US20220023348A1 (en) 2018-11-28 2022-01-27 Forty Seven, Inc. Genetically modified hspcs resistant to ablation regime
US20220289821A1 (en) * 2018-11-29 2022-09-15 Trillium Therapeutics Inc Biomarkers for cd47 blockade therapy
AU2019409805A1 (en) 2018-12-21 2021-07-22 Ose Immunotherapeutics Bifunctional anti-PD-1/SIRPA molecule
AU2020243431B2 (en) 2019-03-18 2025-12-18 Ludwig Institute For Cancer Research Ltd. A2/NY-ESO-1 specific T cell receptors and uses thereof
BR112021024003A2 (pt) 2019-05-31 2022-04-19 Alx Oncology Inc Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico
CN114206912B (zh) 2019-06-07 2025-02-11 Alx肿瘤生物技术公司 用于在血清学测定中减少结合cd47的药物的干扰的方法和试剂
WO2020257196A1 (en) * 2019-06-17 2020-12-24 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating infections by blocking pathogen mimics of cd47
CN114761041A (zh) 2019-07-16 2022-07-15 吉利德科学公司 Hiv疫苗及其制备和使用方法
CN114555123B (zh) 2019-10-18 2024-04-02 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
KR20220091576A (ko) 2019-10-31 2022-06-30 포티 세븐, 인코포레이티드 혈액암의 항-cd47 및 항-cd20 기반 치료
AU2020394204A1 (en) 2019-11-27 2022-06-02 ALX Oncology Inc. Combination therapies for treating cancer
LT4081305T (lt) 2019-12-24 2024-11-25 Carna Biosciences, Inc. Diacilglicerolio kinazę moduliuojantys junginiai
KR20260017503A (ko) 2020-02-14 2026-02-05 길리애드 사이언시즈, 인코포레이티드 Ccr8에 결합하는 항체 및 융합 단백질, 및 이의 용도
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
US20230220342A1 (en) * 2020-04-24 2023-07-13 Georgia State University Research Foundation, Inc. SIRPa Deficient Macrophages for Treating Cancer
US12343377B2 (en) 2020-06-01 2025-07-01 ALX Oncology Inc. Combination therapies comprising a hypomethylation agent for treating cancer
CN116133679A (zh) 2020-06-30 2023-05-16 门德斯有限公司 白血病衍生细胞在卵巢癌疫苗中的用途
WO2022010806A1 (en) 2020-07-06 2022-01-13 ALX Oncology Inc. Methods for reducing the interference of drugs that bind therapeutic targets expressed on blood cells in serological assays
CN114057888A (zh) * 2020-07-30 2022-02-18 三生国健药业(上海)股份有限公司 一种SIRPα-Fc融合蛋白
JP7446953B2 (ja) * 2020-08-27 2024-03-11 株式会社三共 遊技機
KR102557016B1 (ko) * 2020-09-22 2023-07-20 비피진 주식회사 암 치료를 위한 cd47 바인더 및 리포좀 복합체
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
AU2021370483A1 (en) * 2020-10-28 2023-06-08 The Board Of Trustees Of The Leland Stanford Junior University Cd47 blockade and combination therapies thereof for reduction of vascular inflammation
WO2022120286A1 (en) 2020-12-06 2022-06-09 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays
KR20230157388A (ko) 2021-03-12 2023-11-16 멘두스 비.브이. 백신접종의 방법 및 cd47 차단의 용도
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
WO2022229818A1 (en) 2021-04-27 2022-11-03 Pf Argentum Ip Holdings Llc Enhancement of cd47 blockade therapy with dhfr inhibitors
JP2024520902A (ja) 2021-05-13 2024-05-27 エーエルエックス オンコロジー インコーポレイテッド がんを治療するための併用療法
WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222277A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240005901A (ko) 2021-06-23 2024-01-12 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
KR20230016152A (ko) * 2021-07-19 2023-02-01 주식회사유한양행 Sirp-alpha 변이체 및 이의 용도
US20230183216A1 (en) 2021-10-28 2023-06-15 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
WO2023073580A1 (en) 2021-10-29 2023-05-04 Pfizer Inc. Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy
EP4422756A1 (en) 2021-10-29 2024-09-04 Gilead Sciences, Inc. Cd73 compounds
WO2023072279A1 (zh) * 2021-11-01 2023-05-04 江苏先声药业有限公司 SIRPa突变体及其应用
US20250367255A1 (en) 2021-11-08 2025-12-04 Pfizer Inc. Enhancement Of CD47 Blockade Therapy With Anti-VEGF Agents
US20230203202A1 (en) 2021-12-08 2023-06-29 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and 5t4
WO2023107954A1 (en) 2021-12-08 2023-06-15 Dragonfly Therapeutics, Inc. Antibodies targeting 5t4 and uses thereof
WO2023121887A2 (en) * 2021-12-21 2023-06-29 Fbd Biologics Limited ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF
CN118488946A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
EP4452415B1 (en) 2021-12-22 2026-02-25 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
US20250051441A1 (en) * 2021-12-23 2025-02-13 Fbd Biologics Limited Cd47/4-1bb-targeting protein complex and methods of use thereof
CN118401564A (zh) * 2022-01-18 2024-07-26 Fbd生物制品有限公司 靶向cd47/pd-l1的蛋白质复合物和其使用方法
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
WO2023154578A1 (en) 2022-02-14 2023-08-17 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
CA3253296A1 (en) 2022-03-17 2023-09-21 Gilead Sciences, Inc. Zinc Finger Degradation Agents of the Ikaros Family and Their Uses
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
IL315706A (en) 2022-03-24 2024-11-01 Bitterroot Bio Inc Sirp-alpha fusion polypeptides with modified fc domains
AU2023240346A1 (en) 2022-03-24 2024-09-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2023183890A1 (en) 2022-03-24 2023-09-28 Bitterroot Bio, Inc. Multivalent sirp-alpha fusion polypeptides
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
AU2023263628A1 (en) * 2022-05-06 2024-12-19 Biosion Inc. Recombinant fusion protein targeting cd40 and cd47
JP2025518578A (ja) 2022-05-25 2025-06-17 ファイザー・インク がんの処置のためのsirpアルファ融合タンパク質の投薬レジメン
JP2025523369A (ja) 2022-06-01 2025-07-23 エーエルエックス オンコロジー インコーポレイテッド 尿路上皮癌腫を治療するための併用療法
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
CN119677546A (zh) 2022-07-12 2025-03-21 吉利德科学公司 Hiv免疫原性多肽和疫苗及其用途
US20260103501A1 (en) * 2022-07-15 2026-04-16 Nutcracker Therapeutics, Inc. MRNA Therapies Including SIRP-ALPHA
WO2024040151A1 (en) 2022-08-18 2024-02-22 Pfizer Inc. Sirp alpha fusion protein and anti-cd38 antibody combination therapies
WO2024064668A1 (en) 2022-09-21 2024-03-28 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
CN120390653A (zh) 2022-12-09 2025-07-29 辉瑞大药厂 Cd47阻断剂及抗bcma/抗cd3双特异性抗体的组合疗法
WO2024124107A2 (en) 2022-12-09 2024-06-13 Pfizer Inc. Cd47 blocking agent and anti-cd20 / anti-cd3 bispecific antibody combination therapy
EP4638436A1 (en) 2022-12-22 2025-10-29 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024193635A1 (en) * 2023-03-22 2024-09-26 Wangzhi LI Sirp variants and uses thereof
CN120882725A (zh) 2023-04-11 2025-10-31 吉利德科学公司 Kras调节化合物
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024245380A1 (en) * 2023-05-31 2024-12-05 Fbd Biologics Limited Cd47/pd-l1-targeting protein complex and methods of use thereof
KR20260019369A (ko) 2023-05-31 2026-02-10 에프비디 바이올로직스 리미티드 Cd47/pd-l1-표적화 단백질 복합체 및 그의 사용 방법
US20250042922A1 (en) 2023-06-30 2025-02-06 Gilead Sciences, Inc. Kras modulating compounds
AU2024297978A1 (en) 2023-07-26 2026-02-05 Gilead Sciences, Inc. Parp7 inhibitors
US20250066328A1 (en) 2023-07-26 2025-02-27 Gilead Sciences, Inc. Parp7 inhibitors
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
WO2025054347A1 (en) 2023-09-08 2025-03-13 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
US20250376484A1 (en) 2024-05-21 2025-12-11 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025247303A1 (zh) * 2024-05-30 2025-12-04 上海艾乐晞生物科技有限公司 具有pH依赖结合活性的人信号调节蛋白α突变体及其应用
WO2026039365A1 (en) 2024-08-12 2026-02-19 Gilead Sciences, Inc. Kras modulating compounds
WO2026062544A1 (en) 2024-09-23 2026-03-26 Pfizer Inc. Sirp alpha fusion protein formulation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541615B1 (en) * 1996-11-15 2003-04-01 Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. SIRP proteins and uses thereof
JP2003502062A (ja) * 1999-06-11 2003-01-21 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 49個のヒト分泌タンパク質
US7691970B2 (en) * 2003-08-25 2010-04-06 Pieris Ag Muteins of a bilin-binding protein with affinity for a given target
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
US20100239578A1 (en) 2007-10-11 2010-09-23 University Health Network Modulation of sirp-alpha - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
US20110237498A1 (en) * 2008-12-19 2011-09-29 Novartis Ag Soluble polypeptides for use in treating autoimmune and inflammatory disorders
PL2995315T3 (pl) * 2009-05-15 2024-04-22 University Health Network Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47
SI2804617T1 (sl) * 2012-01-17 2020-10-30 The Board Of Trustees Of The Leland Stanford Junior University Visokoafinitetni SIRP-alfa reagenti
FI3656869T4 (fi) * 2014-08-26 2025-06-04 Univ Leland Stanford Junior Kantasolujen siirrostaminen kantasoluihin kohdentuvan aineen ja immunoregulatorista signaalia moduloivan aineen yhdistelmän kanssa
EP3341015B2 (en) * 2015-08-26 2023-12-27 The Board of Trustees of the Leland Stanford Junior University Enhanced depletion of targeted cells with cd47 blockade and an immune costimulatory agonist
KR102024554B1 (ko) * 2018-02-26 2019-09-24 엘지전자 주식회사 유도 가열 장치 및 유도 가열 장치의 제어 방법

Similar Documents

Publication Publication Date Title
JP2020143104A5 (https=)
JP2020007329A5 (https=)
Leal et al. Peptides as surface coatings of nanoparticles that penetrate human cystic fibrosis sputum and uniformly distribute in vivo following pulmonary delivery
Soto et al. Virus hybrids as nanomaterials for biotechnology
Bonhivers et al. FhuA, a transporter of the Escherichia coli outer membrane, is converted into a channel upon binding of bacteriophage T5.
EP2308900B1 (en) Immunogenic compositions and methods of use
US20040018587A1 (en) Nanostructures containing antibody assembly units
US20030198956A1 (en) Staged assembly of nanostructures
CN113667657B (zh) 蛋白、跨膜核酸解旋纳米孔及其构建方法与应用
JPS62502378A (ja) 型特異的乳頭腫ウイルスdna配列およびペプチド
CN118272512A (zh) 突变体孔
WO2018106273A1 (en) Collagen targeting nanofibers and nanosheets
JP2002517245A5 (https=)
CN118949941A (zh) 纳米孔组件及其用途
JP2003522948A (ja) ウイルス融合インヒビターの検出のための分析
JP2000510454A (ja) カルシウム依存性結合タンパク質の改変されたリガンド
Lim et al. Tunable bacterial agglutination and motility inhibition by self‐assembled glyco‐nanoribbons
JP2023516312A (ja) タンパク質ナノ粒子の設計および適用
KR20180025509A (ko) Cd133을 타겟팅하는 펩타이드-금나노입자 복합체 프로브
Placido et al. Layer-by-layer films containing peptides of the Cry1Ab16 toxin from Bacillus thuringiensis for potential biotechnological applications
CN107635548B (zh) 利用突变型伴侣蛋白复合体的细胞内局部性药物递送系统用纳米胶囊
JP3972108B2 (ja) 細胞死誘導のためのペプチド
EP3574328A1 (en) Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
TWI642685B (zh) 新穎胜肽及其應用
Thanjavur Given Name Priyadharshini