JP2002517245A5 - - Google Patents
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- Publication number
- JP2002517245A5 JP2002517245A5 JP2000553585A JP2000553585A JP2002517245A5 JP 2002517245 A5 JP2002517245 A5 JP 2002517245A5 JP 2000553585 A JP2000553585 A JP 2000553585A JP 2000553585 A JP2000553585 A JP 2000553585A JP 2002517245 A5 JP2002517245 A5 JP 2002517245A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- gpi
- conjugate
- antibody
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 description 45
- 102000004196 processed proteins & peptides Human genes 0.000 description 45
- 108090000765 processed proteins & peptides Proteins 0.000 description 45
- 230000001419 dependent effect Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 210000001744 T-lymphocyte Anatomy 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 239000012472 biological sample Substances 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000007820 coagulation assay Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8865698P | 1998-06-09 | 1998-06-09 | |
| US60/088,656 | 1998-06-09 | ||
| US10308898P | 1998-10-05 | 1998-10-05 | |
| US60/103,088 | 1998-10-05 | ||
| US09/328,199 | 1999-06-08 | ||
| US09/328,199 US6858210B1 (en) | 1998-06-09 | 1999-06-08 | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| PCT/US1999/013194 WO1999064595A1 (en) | 1998-06-09 | 1999-06-09 | THERAPEUTIC AND DIAGNOSTIC DOMAIN 1 β2GPI POLYPEPTIDES AND METHODS OF USING SAME |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002517245A JP2002517245A (ja) | 2002-06-18 |
| JP2002517245A5 true JP2002517245A5 (https=) | 2006-08-03 |
Family
ID=27376031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000553585A Pending JP2002517245A (ja) | 1998-06-09 | 1999-06-09 | 治療的および診断的ドメイン１β２ＧＰＩポリペプチドおよびその使用の方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6858210B1 (https=) |
| EP (1) | EP1092027B1 (https=) |
| JP (1) | JP2002517245A (https=) |
| KR (1) | KR20010052713A (https=) |
| CN (1) | CN1310759A (https=) |
| AT (1) | ATE346922T1 (https=) |
| AU (1) | AU772851B2 (https=) |
| CA (1) | CA2329942A1 (https=) |
| DE (1) | DE69934228T2 (https=) |
| ES (1) | ES2275348T3 (https=) |
| PT (1) | PT1092027E (https=) |
| WO (1) | WO1999064595A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| CN1762990A (zh) * | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
| IL147854A0 (en) | 1999-07-29 | 2002-08-14 | Epix Medical Inc | Multimeric compounds, contrast agents containing the same and diagnostic methods utilizing the same |
| MXPA02005236A (es) * | 1999-11-28 | 2004-03-19 | Jolla Pharma | Metodos de tratamiento de lupus con base en la afinidad de anticuerpos y metodos de separacion por exclusion y composiciones para el uso de los mismos. |
| WO2001093914A2 (en) * | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| ATE513854T1 (de) * | 2000-12-13 | 2011-07-15 | Bac Ip B V | Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| US20030114405A1 (en) * | 2001-08-13 | 2003-06-19 | Linnik Matthew D. | Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function |
| EP1534269B1 (en) * | 2002-07-19 | 2013-10-30 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| WO2004060320A2 (en) * | 2002-12-27 | 2004-07-22 | La Jolla Pharmaceutical Company | Methods of improving health-related quality of life in individuals with systemic lupus erythematosus |
| DE10310082A1 (de) * | 2003-03-07 | 2004-09-16 | Ktb Tumorforschungsgesellschaft Mbh | Protein-bindende Doxorubicin-Peptid-Derivate |
| US20040258683A1 (en) * | 2003-03-30 | 2004-12-23 | Linnik Matthew D. | Methods of treating and monitoring systemic lupus erythematosus in individuals |
| CN101146826A (zh) * | 2005-01-24 | 2008-03-19 | 得克萨斯大学体系董事会 | 与磷脂酰丝氨酸结合的fc融合构建体及其治疗用途 |
| EP1872132B1 (en) * | 2005-04-18 | 2013-09-18 | Bio-Rad Laboratories, Inc. | Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment |
| WO2008036449A2 (en) * | 2006-06-29 | 2008-03-27 | The Regents Of The University Of California | Chemical antibodies for immunotherapy and imaging |
| US20080015145A1 (en) * | 2006-07-11 | 2008-01-17 | Maria Gyongyossy-Issa | Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions |
| WO2010075604A1 (en) * | 2009-01-02 | 2010-07-08 | Flysun Development Co. Ltd | Synthetic peptides, methods and kits for diagnosing autoimmune diseases |
| EP2585108A4 (en) * | 2010-06-24 | 2016-04-13 | Univ Kansas | CONJUGATES WITH AN N-OXIM BINDING AND ASSOCIATED METHODS |
| CN105273080A (zh) * | 2014-07-14 | 2016-01-27 | 于珮 | 一种还原型β2-糖蛋白Ⅰ的制备方法 |
| US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
| TWI572617B (zh) * | 2016-01-20 | 2017-03-01 | 國立陽明大學 | 重組β－醣蛋白胜肽及其於抗腫瘤之應用 |
| CN105801694A (zh) * | 2016-05-03 | 2016-07-27 | 上海科新生物技术股份有限公司 | 一种抗心磷脂/β2糖蛋白I复合物的嵌合抗体 |
| US11661447B2 (en) * | 2017-08-03 | 2023-05-30 | The Cleveland Clinic Foundation | Human β2-glycoprotein I expression |
| WO2022195051A1 (en) * | 2021-03-18 | 2022-09-22 | Université De Genève | Peptides and use thereof for diagnosing and treating antiphospholipid syndrome |
| CN115894270B (zh) * | 2022-10-10 | 2024-09-06 | 深圳市迪克曼生物科技有限公司 | 一种神经酰胺及其制备方法和应用 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191668A (en) | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
| US5126131A (en) | 1983-01-24 | 1992-06-30 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates. |
| US5370871A (en) | 1983-01-24 | 1994-12-06 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US6022544A (en) | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US4650675A (en) | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
| US4751181A (en) | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| JP2524586B2 (ja) | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| DE68925899T2 (de) | 1988-04-04 | 1996-10-02 | Byron E Anderson | Bindung von immunkomplexen durch modifizierte formen von c-reaktiven proteinen |
| WO1991006006A1 (en) | 1989-10-19 | 1991-05-02 | Yamasa Shoyu Kabushiki Kaisha | Carrier for binding antiphospholipid antibody, immunoassay using the same, and kit therefor |
| US5162515A (en) | 1990-01-16 | 1992-11-10 | La Jolla Pharmaceutical Company | Conjugates of biologically stable polymers and polynucleotides for treating systemic lupus erythematosus |
| US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| JPH04218000A (ja) | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5498538A (en) | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| ATE127925T1 (de) | 1990-04-06 | 1995-09-15 | Yamasa Shoyu Kk | Verfahren zur bestimmung von antiphospholipid antikörpern. |
| JPH06503833A (ja) | 1990-12-17 | 1994-04-28 | ザ ジョンズ ホプキンス ユニバーシティ | 制御された化学のオリゴマー形態の抗原での免疫応答抑制 |
| JP2899111B2 (ja) | 1991-07-15 | 1999-06-02 | ラ ホヤ ファーマシューティカル カンパニー | オリゴヌクレオチドの５’末端へ官能基を提供するための修飾された亜リン酸中間体 |
| AU666352B2 (en) | 1992-02-05 | 1996-02-08 | Takao Koike | Solid-phase reagent and assay method for measuring antibodies specific to antiphospholipid syndrome |
| FR2701263B1 (fr) | 1993-02-09 | 1995-04-21 | Elie Stefas | Procédé d'obtention d'une composition aqueuse protéinique, composition correspondante, glycoprotéine contenue et son utilisation pour la stabilisation de l'albumine et la détection ou le dosage d'anticorps. |
| ES2282988T3 (es) | 1993-09-08 | 2007-10-16 | La Jolla Pharmaceutical Company | Moleculas plataforma de valencia no polimericas,. |
| CA2176007A1 (en) | 1993-11-16 | 1995-05-26 | Eiji Matsuura | Method of assaying antiphospholipid antibody and kit therefor |
| FR2722991B1 (fr) | 1994-08-01 | 1996-10-11 | Orstom | Utilisation de la beta2-glycoproteine i sous au moins une de ses formes comme agent anti-infectueux et composition pharmaceutique corrrespondante |
| JPH08333390A (ja) | 1995-04-07 | 1996-12-17 | Hoechst Japan Ltd | ペプチド及びそれからなる自己免疫疾患治療剤 |
| US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| US5780319A (en) | 1996-04-19 | 1998-07-14 | Pasteur Sanofi Diagnostics | Immunoassays to detect antiphospholipid antibodies |
| KR20000016414A (ko) | 1996-06-06 | 2000-03-25 | 와이즈먼 앤드루 | Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법 |
| DE19637770A1 (de) | 1996-09-16 | 1998-03-19 | Koenig & Bauer Albert Ag | Verfahren und Anlage zum automatischen Zu- und Abführen von Rollen |
| DE69728289T2 (de) | 1996-11-12 | 2005-02-24 | City Of Hope, Duarte | Immunreaktive ctl-peptidepitope von humanem cytomegalovirus |
| GB9805477D0 (en) | 1998-03-13 | 1998-05-13 | Oxford Glycosciences Limited | Methods and compositions for diagnosis of rheumatoid arthritis |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| IL125262A0 (en) | 1998-07-07 | 1999-03-12 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
| IL126447A (en) | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
| WO2001088088A2 (en) | 2000-05-18 | 2001-11-22 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| JP2002542819A (ja) | 1999-05-04 | 2002-12-17 | ゲネトール ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特異的免疫反応の低減方法 |
| CN1762990A (zh) | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
| AUPQ272699A0 (en) | 1999-09-09 | 1999-09-30 | Unisearch Limited | Use of beta2GPI in diagnostic tests for autoimmune diseases |
| MXPA02005236A (es) | 1999-11-28 | 2004-03-19 | Jolla Pharma | Metodos de tratamiento de lupus con base en la afinidad de anticuerpos y metodos de separacion por exclusion y composiciones para el uso de los mismos. |
| US20010051351A1 (en) | 2000-03-27 | 2001-12-13 | Racis Stanley Paul | Antigen-specific immune complex-based enzyme-linked immunosorbent assay |
| US20020150898A1 (en) | 2000-04-18 | 2002-10-17 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| WO2001093914A2 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| DE10048417A1 (de) | 2000-09-29 | 2002-04-11 | Roche Diagnostics Gmbh | Verbindungen mit verzweigtem Linker |
-
1999
- 1999-06-08 US US09/328,199 patent/US6858210B1/en not_active Expired - Lifetime
- 1999-06-09 AU AU43395/99A patent/AU772851B2/en not_active Ceased
- 1999-06-09 DE DE69934228T patent/DE69934228T2/de not_active Expired - Lifetime
- 1999-06-09 CN CN99808415A patent/CN1310759A/zh active Pending
- 1999-06-09 KR KR1020007013980A patent/KR20010052713A/ko not_active Ceased
- 1999-06-09 WO PCT/US1999/013194 patent/WO1999064595A1/en not_active Ceased
- 1999-06-09 CA CA002329942A patent/CA2329942A1/en not_active Abandoned
- 1999-06-09 ES ES99937843T patent/ES2275348T3/es not_active Expired - Lifetime
- 1999-06-09 AT AT99937843T patent/ATE346922T1/de active
- 1999-06-09 EP EP99937843A patent/EP1092027B1/en not_active Expired - Lifetime
- 1999-06-09 PT PT99937843T patent/PT1092027E/pt unknown
- 1999-06-09 JP JP2000553585A patent/JP2002517245A/ja active Pending
-
2004
- 2004-07-30 US US10/903,058 patent/US20050004351A1/en not_active Abandoned
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