|
EP3322732A2
(en)
|
2015-07-13 |
2018-05-23 |
Cytomx Therapeutics Inc. |
Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof
|
|
US12030942B2
(en)
|
2015-10-02 |
2024-07-09 |
Les Laboratoires Servier |
Anti-PD-1 antibodies and compositions
|
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗ｌａｇ３抗體及其用途
|
|
SG10201911035QA
(en)
|
2015-11-18 |
2020-01-30 |
Merck Sharp & Dohme |
Pd1 and/or lag3 binders
|
|
MA55697A
(fr)
|
2016-05-18 |
2022-02-23 |
Boehringer Ingelheim Int |
Molécules d'anticorps pour le traitement du cancer
|
|
CN109689694B
(zh)
|
2016-05-19 |
2022-11-22 |
通用医疗公司 |
与其受体IL-2Rβ结合的IL2作为用来增强自然杀伤细胞和调节性T细胞活性的平台
|
|
CA3037380A1
(en)
|
2016-10-11 |
2018-04-19 |
Agenus Inc. |
Anti-lag-3 antibodies and methods of use thereof
|
|
UA127050C2
(uk)
|
2016-10-13 |
2023-03-29 |
Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд. |
Ahtи-lag-3 антитіло i композиція, що містить його
|
|
ES2991086T3
(es)
|
2016-11-18 |
2024-12-02 |
Servier Lab |
Anticuerpos y composiciones anti-PD-1
|
|
EP3360898A1
(en)
|
2017-02-14 |
2018-08-15 |
Boehringer Ingelheim International GmbH |
Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
|
|
BR112019016336A2
(pt)
|
2017-02-10 |
2020-03-31 |
Regeneron Pharmaceuticals, Inc. |
Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto.
|
|
BR112019021032A2
(pt)
*
|
2017-04-05 |
2020-05-05 |
Boehringer Ingelheim Int |
terapia combinada anticâncer
|
|
CN110621698B
(zh)
|
2017-04-05 |
2024-04-12 |
法国施维雅药厂 |
靶向pd-1、tim-3及lag-3的组合疗法
|
|
JOP20190260A1
(ar)
|
2017-05-02 |
2019-10-31 |
Merck Sharp & Dohme |
صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
|
|
SG11201909955XA
(en)
|
2017-05-02 |
2019-11-28 |
Merck Sharp & Dohme |
Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
|
|
BR112019021847A2
(pt)
|
2017-05-30 |
2020-06-02 |
Bristol-Myers Squibb Company |
Composições compreendendo um anticorpo anti-lag-3 ou um anticorpo anti-lag-3 e um anticorpo anti-pd-1 ou anti-pd-l1
|
|
BR112019018759A2
(pt)
|
2017-05-30 |
2020-05-05 |
Bristol-Myers Squibb Company |
composições compreendendo uma combinação de um anticorpo anti-lag-3, um inibidor da via pd-1, e um agente imunoterápico
|
|
HUE065242T2
(hu)
|
2017-05-30 |
2024-05-28 |
Bristol Myers Squibb Co |
LAG-3-pozitív tumorok kezelése
|
|
EP3630822A1
(en)
*
|
2017-06-02 |
2020-04-08 |
Boehringer Ingelheim International GmbH |
Anti-cancer combination therapy
|
|
BR112020011664A2
(pt)
*
|
2017-12-22 |
2020-11-17 |
Jiangsu Hengrui Medicine Co., Ltd. |
composição farmacêutica do anticorpo lag-3 e seu uso
|
|
CN109970856B
(zh)
*
|
2017-12-27 |
2022-08-23 |
信达生物制药(苏州)有限公司 |
抗lag-3抗体及其用途
|
|
JP7366908B2
(ja)
|
2018-01-15 |
2023-10-23 |
ナンジン レジェンド バイオテック カンパニー，リミテッド |
Ｐｄ－１に対する単一ドメイン抗体及びその変異体
|
|
EP3746119A4
(en)
*
|
2018-02-01 |
2021-11-10 |
Merck Sharp & Dohme Corp. |
METHOD OF TREATMENT FOR CANCER OR INFECTION USING A COMBINATION OF ANTI-PD-1 ANTIBODY, ANTI-LAG3 ANTIBODY, AND ANTI-TIGITE ANTIBODY
|
|
US12090142B2
(en)
*
|
2018-02-22 |
2024-09-17 |
Board Of Regents, The University Of Texas System |
Combination therapy for the treatment of cancer
|
|
FR3078536A1
(fr)
*
|
2018-03-05 |
2019-09-06 |
Peptinov Sas |
Composition vaccinale anti-pd-1
|
|
TWI841554B
(zh)
|
2018-03-21 |
2024-05-11 |
丹麥商珍美寶股份有限公司 |
以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
|
|
US20210024873A1
(en)
|
2018-03-27 |
2021-01-28 |
Bristol-Myers Squibb Company |
Real-time monitoring of protein concentration using ultraviolet signal
|
|
UA130009C2
(uk)
|
2018-05-07 |
2025-10-15 |
Генмаб А/С |
Спосіб лікування раку за допомогою комбінації антитіла до pd-1 і кон'югата антитіла до тканинного фактора і лікарського засобу
|
|
SG11202009986QA
(en)
|
2018-05-07 |
2020-11-27 |
Genmab As |
Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
|
|
EP3569618A1
(en)
|
2018-05-19 |
2019-11-20 |
Boehringer Ingelheim International GmbH |
Antagonizing cd73 antibody
|
|
TWI848953B
(zh)
|
2018-06-09 |
2024-07-21 |
德商百靈佳殷格翰國際股份有限公司 |
針對癌症治療之多特異性結合蛋白
|
|
CN119185533A
(zh)
*
|
2018-06-11 |
2024-12-27 |
耶鲁大学 |
新型免疫检查点抑制剂
|
|
KR20210040080A
(ko)
*
|
2018-07-26 |
2021-04-12 |
브리스톨-마이어스 스큅 컴퍼니 |
암의 치료를 위한 lag-3 조합 요법
|
|
PL3866850T3
(pl)
|
2018-10-19 |
2024-10-14 |
Bristol-Myers Squibb Company |
Terapia skojarzona czerniaka
|
|
TWI844571B
(zh)
|
2018-10-30 |
2024-06-11 |
丹麥商珍美寶股份有限公司 |
使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
|
|
JP7553439B2
(ja)
*
|
2018-11-05 |
2024-09-18 |
メルク・シャープ・アンド・ドーム・エルエルシー |
がんを処置するための抗ｌａｇ３抗体の投薬レジメンおよび抗ｐｄ－１抗体との組み合わせ治療
|
|
US20210380694A1
(en)
|
2018-11-07 |
2021-12-09 |
Merck Sharp & Dohme Corp. |
Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
|
|
EP3876990A4
(en)
*
|
2018-11-07 |
2023-09-06 |
Merck Sharp & Dohme LLC |
CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES
|
|
TWI894135B
(zh)
|
2019-01-25 |
2025-08-21 |
德商百靈佳殷格翰國際股份有限公司 |
編碼ccl21之重組棒狀病毒
|
|
US20220135619A1
(en)
|
2019-02-24 |
2022-05-05 |
Bristol-Myers Squibb Company |
Methods of isolating a protein
|
|
TW202104258A
(zh)
*
|
2019-03-29 |
2021-02-01 |
德商百靈佳殷格翰國際股份有限公司 |
抗癌組合療法
|
|
BR112021016520A2
(pt)
*
|
2019-03-29 |
2021-10-26 |
Boehringer Ingelheim International Gmbh |
Terapia de combinação anticâncer
|
|
EP3947640A4
(en)
|
2019-04-02 |
2022-12-14 |
The Brigham & Women's Hospital, Inc. |
PROCEDURE FOR DETERMINING THE PROGRESSION OF PRIMARY MELANOMA
|
|
PH12021552675A1
(en)
*
|
2019-05-13 |
2022-07-04 |
Regeneron Pharma |
Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer
|
|
KR20220012292A
(ko)
|
2019-05-23 |
2022-02-03 |
브리스톨-마이어스 스큅 컴퍼니 |
세포 배양 배지를 모니터링하는 방법
|
|
US20220363760A1
(en)
|
2019-05-30 |
2022-11-17 |
Bristol-Myers Squibb Company |
Multi-tumor gene signature for suitability to immuno-oncology therapy
|
|
WO2020243570A1
(en)
|
2019-05-30 |
2020-12-03 |
Bristol-Myers Squibb Company |
Cell localization signature and combination therapy
|
|
JP2022534982A
(ja)
|
2019-05-30 |
2022-08-04 |
ブリストル－マイヤーズ スクイブ カンパニー |
細胞局在化シグネチャーおよびその使用
|
|
US20220220204A1
(en)
*
|
2019-06-12 |
2022-07-14 |
Nanjing GenScript Biotech Co., Ltd. |
Anti-pd-l1/anti-lag-3 multiple antigen binding proteins and methods of use thereof
|
|
CN112121169B
(zh)
*
|
2019-06-24 |
2023-10-24 |
广州再极医药科技有限公司 |
用于治疗具有高间质压力的肿瘤受试者的癌症的小分子抑制剂
|
|
TWI889320B
(zh)
|
2019-07-05 |
2025-07-01 |
日商小野藥品工業股份有限公司 |
以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療
|
|
US20220289846A1
(en)
*
|
2019-07-09 |
2022-09-15 |
Cadila Healthcare Limited |
Antibodies to human programmed death receptor pd-1
|
|
WO2021024020A1
(en)
|
2019-08-06 |
2021-02-11 |
Astellas Pharma Inc. |
Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
|
|
EP4011918A4
(en)
|
2019-08-08 |
2023-08-23 |
ONO Pharmaceutical Co., Ltd. |
DUAL SPECIFIC PROTEIN
|
|
TWI844666B
(zh)
*
|
2019-08-22 |
2024-06-11 |
俄羅斯聯邦商拜奧卡德聯合股份公司 |
抗ＰＤ－１抗體Ｐｒｏｌｇｏｌｉｍａｂ的水性藥物組合物及其用途
|
|
CA3148291A1
(en)
*
|
2019-09-11 |
2021-03-18 |
Boehringer Ingelheim Io Canada, Inc. |
Methods of treating cancer by the use of pd-1 axis inhibitors and anti-periostin antibodies
|
|
WO2021055994A1
(en)
|
2019-09-22 |
2021-03-25 |
Bristol-Myers Squibb Company |
Quantitative spatial profiling for lag-3 antagonist therapy
|
|
TWI878355B
(zh)
|
2019-10-02 |
2025-04-01 |
德商百靈佳殷格翰國際股份有限公司 |
用於癌症治療之多重專一性結合蛋白
|
|
WO2021092221A1
(en)
|
2019-11-06 |
2021-05-14 |
Bristol-Myers Squibb Company |
Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
|
|
WO2021092220A1
(en)
|
2019-11-06 |
2021-05-14 |
Bristol-Myers Squibb Company |
Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
|
|
US20220411499A1
(en)
|
2019-11-08 |
2022-12-29 |
Bristol-Myers Squibb Company |
LAG-3 Antagonist Therapy for Melanoma
|
|
CN110950966B
(zh)
*
|
2019-12-13 |
2020-12-11 |
启辰生生物科技(珠海)有限公司 |
融合蛋白、编码核酸和细胞及用途
|
|
US20230087600A1
(en)
|
2020-02-06 |
2023-03-23 |
Bristol-Myers Squibb Company |
Il-10 and uses thereof
|
|
WO2021245111A1
(en)
|
2020-06-03 |
2021-12-09 |
Boehringer Ingelheim International Gmbh |
Recombinant rhabdovirus encoding for a cd80 extracellular domain fc-fusion protein
|
|
CN111808192B
(zh)
*
|
2020-06-05 |
2022-02-15 |
北京天广实生物技术股份有限公司 |
结合lag3的抗体及其用途
|
|
MX2023000197A
(es)
|
2020-07-07 |
2023-02-22 |
BioNTech SE |
Arn terapeutico para el cancer positivo para vph.
|
|
CA3193421A1
(en)
|
2020-08-28 |
2022-03-03 |
Bristol-Myers Squibb Company |
Lag-3 antagonist therapy for hepatocellular carcinoma
|
|
EP4204453A1
(en)
|
2020-08-31 |
2023-07-05 |
Bristol-Myers Squibb Company |
Cell localization signature and immunotherapy
|
|
EP4217394A1
(en)
|
2020-09-24 |
2023-08-02 |
Merck Sharp & Dohme LLC |
Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof
|
|
CN116406369A
(zh)
|
2020-10-05 |
2023-07-07 |
百时美施贵宝公司 |
用于浓缩蛋白质的方法
|
|
EP4232019A1
(en)
|
2020-10-23 |
2023-08-30 |
Bristol-Myers Squibb Company |
Lag-3 antagonist therapy for lung cancer
|
|
MX2023005528A
(es)
|
2020-11-17 |
2023-06-23 |
Seagen Inc |
Metodos de tratamiento del cancer con una combinacion de tucatinib y un anticuerpo anti-pd-1/anti-pd-l1.
|
|
WO2022120179A1
(en)
|
2020-12-03 |
2022-06-09 |
Bristol-Myers Squibb Company |
Multi-tumor gene signatures and uses thereof
|
|
WO2022135666A1
(en)
|
2020-12-21 |
2022-06-30 |
BioNTech SE |
Treatment schedule for cytokine proteins
|
|
TW202245808A
(zh)
|
2020-12-21 |
2022-12-01 |
德商拜恩迪克公司 |
用於治療癌症之治療性ｒｎａ
|
|
WO2022135667A1
(en)
|
2020-12-21 |
2022-06-30 |
BioNTech SE |
Therapeutic rna for treating cancer
|
|
RS66849B1
(sr)
|
2020-12-28 |
2025-06-30 |
Bristol Myers Squibb Co |
Kompozicije antitela i postupci njihove upotrebe
|
|
US20220233689A1
(en)
|
2020-12-28 |
2022-07-28 |
Bristol-Myers Squibb Company |
Methods of treating tumors
|
|
US20240384350A1
(en)
|
2021-01-29 |
2024-11-21 |
Board Of Regents, The University Of Texas System |
Methods of treating cancer with kinase inhibitors
|
|
KR20240005700A
(ko)
|
2021-03-29 |
2024-01-12 |
주노 쎄러퓨티크스 인코퍼레이티드 |
체크포인트 억제제 요법 및 car t 세포 요법의 조합을 사용한 투여 및 치료 방법
|
|
WO2022216979A1
(en)
|
2021-04-08 |
2022-10-13 |
Board Of Regents, The University Of Texas System |
Compounds and methods for theranostic targeting of parp activity
|
|
US20240285740A1
(en)
|
2021-05-12 |
2024-08-29 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating cancer
|
|
US12275798B2
(en)
|
2021-06-17 |
2025-04-15 |
Boehringer Ingelheim International Gmbh |
Tri-specific binding molecules
|
|
CA3225254A1
(en)
|
2021-07-13 |
2023-01-19 |
BioNTech SE |
Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
|
|
WO2023057534A1
(en)
|
2021-10-06 |
2023-04-13 |
Genmab A/S |
Multispecific binding agents against pd-l1 and cd137 in combination
|
|
TW202333802A
(zh)
|
2021-10-11 |
2023-09-01 |
德商拜恩迪克公司 |
用於肺癌之治療性rna(二)
|
|
WO2023077090A1
(en)
|
2021-10-29 |
2023-05-04 |
Bristol-Myers Squibb Company |
Lag-3 antagonist therapy for hematological cancer
|
|
WO2023083439A1
(en)
|
2021-11-09 |
2023-05-19 |
BioNTech SE |
Tlr7 agonist and combinations for cancer treatment
|
|
JP2025503962A
(ja)
|
2022-01-26 |
2025-02-06 |
ブリストル－マイヤーズ スクイブ カンパニー |
肝細胞がんのための併用療法
|
|
JP2025507694A
(ja)
|
2022-02-25 |
2025-03-21 |
ブリストル－マイヤーズ スクイブ カンパニー |
結腸直腸癌に対する組み合わせ療法
|
|
WO2023168404A1
(en)
|
2022-03-04 |
2023-09-07 |
Bristol-Myers Squibb Company |
Methods of treating a tumor
|
|
AU2023230110A1
(en)
|
2022-03-08 |
2024-10-24 |
Alentis Therapeutics Ag |
Use of anti-claudin-1 antibodies to increase t cell availability
|
|
WO2023173011A1
(en)
|
2022-03-09 |
2023-09-14 |
Bristol-Myers Squibb Company |
Transient expression of therapeutic proteins
|
|
KR20240159621A
(ko)
|
2022-03-18 |
2024-11-05 |
브리스톨-마이어스 스큅 컴퍼니 |
폴리펩티드를 단리하는 방법
|
|
US20250270318A1
(en)
*
|
2022-03-21 |
2025-08-28 |
Ab Therapeutics, Inc. |
Multispecific antibodies and uses thereof
|
|
IL316628A
(en)
|
2022-05-12 |
2024-12-01 |
Genmab As |
Binding agents capable of binding to CD27 in combination therapy
|
|
AU2023281061A1
(en)
|
2022-06-02 |
2024-12-05 |
Bristol-Myers Squibb Company |
Antibody compositions and methods of use thereof
|
|
PE20250669A1
(es)
|
2022-07-15 |
2025-03-04 |
Boehringer Ingelheim Int |
Moleculas de union para el tratamiento del cancer
|
|
CN120390652A
(zh)
|
2022-12-01 |
2025-07-29 |
免疫医疗有限公司 |
用于治疗癌症的包含抗pd-l1抗体和抗cd73抗体的组合疗法
|
|
WO2024115725A1
(en)
|
2022-12-01 |
2024-06-06 |
BioNTech SE |
Multispecific antibody against cd40 and cd137 in combination therapy with anti-pd1 ab and chemotherapy
|
|
AU2023393653A1
(en)
|
2022-12-14 |
2025-05-22 |
Astellas Pharma Europe Bv |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
|
|
AU2023409221A1
(en)
|
2022-12-21 |
2025-06-12 |
Bristol-Myers Squibb Company |
Combination therapy for lung cancer
|
|
AU2024208858A1
(en)
|
2023-01-20 |
2025-06-19 |
Boehringer Ingelheim International Gmbh |
Il-12 fc fusion proteins
|
|
WO2024173876A1
(en)
|
2023-02-17 |
2024-08-22 |
Regeneron Pharmaceuticals, Inc. |
Radiolabeled anti-lag3 antibodies for immuno-pet imaging
|
|
CN115960834B
(zh)
*
|
2023-03-07 |
2023-06-09 |
浙江省肿瘤医院 |
一种pd-1/ptx联合pd-1耐药模型建立的方法
|
|
WO2024196952A1
(en)
|
2023-03-20 |
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|
|
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|
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|
|
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|
|
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|
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|
|
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|
|
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|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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