JP2019536765A5 - - Google Patents

Download PDF

Info

Publication number
JP2019536765A5
JP2019536765A5 JP2019523684A JP2019523684A JP2019536765A5 JP 2019536765 A5 JP2019536765 A5 JP 2019536765A5 JP 2019523684 A JP2019523684 A JP 2019523684A JP 2019523684 A JP2019523684 A JP 2019523684A JP 2019536765 A5 JP2019536765 A5 JP 2019536765A5
Authority
JP
Japan
Prior art keywords
compound according
alkyl
compound
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019523684A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019536765A (ja
JP7330101B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/060434 external-priority patent/WO2018089373A2/en
Publication of JP2019536765A publication Critical patent/JP2019536765A/ja
Publication of JP2019536765A5 publication Critical patent/JP2019536765A5/ja
Priority to JP2023129158A priority Critical patent/JP7872252B2/ja
Application granted granted Critical
Publication of JP7330101B2 publication Critical patent/JP7330101B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2019523684A 2016-11-08 2017-11-07 ステロイド及びそのタンパク質コンジュゲート Active JP7330101B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023129158A JP7872252B2 (ja) 2016-11-08 2023-08-08 ステロイド及びそのタンパク質コンジュゲート

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662419365P 2016-11-08 2016-11-08
US62/419,365 2016-11-08
US201762508317P 2017-05-18 2017-05-18
US62/508,317 2017-05-18
PCT/US2017/060434 WO2018089373A2 (en) 2016-11-08 2017-11-07 Steroids and protein-conjugates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023129158A Division JP7872252B2 (ja) 2016-11-08 2023-08-08 ステロイド及びそのタンパク質コンジュゲート

Publications (3)

Publication Number Publication Date
JP2019536765A JP2019536765A (ja) 2019-12-19
JP2019536765A5 true JP2019536765A5 (enExample) 2021-04-30
JP7330101B2 JP7330101B2 (ja) 2023-08-21

Family

ID=60409441

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019523684A Active JP7330101B2 (ja) 2016-11-08 2017-11-07 ステロイド及びそのタンパク質コンジュゲート
JP2023129158A Active JP7872252B2 (ja) 2016-11-08 2023-08-08 ステロイド及びそのタンパク質コンジュゲート

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023129158A Active JP7872252B2 (ja) 2016-11-08 2023-08-08 ステロイド及びそのタンパク質コンジュゲート

Country Status (17)

Country Link
US (4) US10711032B2 (enExample)
EP (2) EP3538539B1 (enExample)
JP (2) JP7330101B2 (enExample)
KR (3) KR102835535B1 (enExample)
CN (2) CN110291097B (enExample)
AU (1) AU2017359043B2 (enExample)
CA (1) CA3042428A1 (enExample)
CL (1) CL2019001259A1 (enExample)
CO (1) CO2019005966A2 (enExample)
ES (1) ES3046537T3 (enExample)
IL (2) IL307357A (enExample)
MX (2) MX394528B (enExample)
MY (1) MY199937A (enExample)
PH (1) PH12019501021A1 (enExample)
SG (1) SG10202104259RA (enExample)
WO (1) WO2018089373A2 (enExample)
ZA (1) ZA201902871B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62040B1 (sr) 2016-06-02 2021-07-30 Abbvie Inc Agonist receptora glukokortikoida i njegovi imunokonjugati
CA3042428A1 (en) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
KR20250008984A (ko) 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
CA3247730A1 (en) 2017-11-07 2025-10-30 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
EP3658192B1 (en) 2017-12-01 2021-04-28 AbbVie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
MA50259A1 (fr) * 2018-01-08 2021-07-29 Regeneron Pharma Stéroïdes et leurs conjugués-anticorps
WO2019217591A1 (en) 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof
CA3120528A1 (en) * 2018-11-20 2020-05-28 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists
JP2022517767A (ja) * 2019-01-08 2022-03-10 レゲネロン ファーマシューティカルス,インコーポレーテッド 無痕跡型リンカー及びそのタンパク質-コンジュゲート
CA3166619A1 (en) 2020-02-28 2021-09-02 Julian Andreev Bispecific antigen binding molecules that bind her2, and methods of use thereof
US12605459B2 (en) * 2020-07-13 2026-04-21 Regeneron Pharmaceuticals, Inc. Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
US11866502B2 (en) 2020-10-22 2024-01-09 Regeneron Pharmaceuticals, Inc. Anti-FGFR2 antibodies and methods of use thereof
MX2023004935A (es) 2020-11-10 2023-07-07 Regeneron Pharma Conjugados de anticuerpos y selenio.
KR20230117182A (ko) * 2020-12-04 2023-08-07 다인 세라퓨틱스, 인크. 항체-올리고뉴클레오티드 복합체 및 그의 용도
WO2022135332A1 (zh) * 2020-12-21 2022-06-30 映恩生物制药(苏州)有限公司 一种甾体偶联物
TWI924779B (zh) * 2021-02-04 2026-05-11 大陸商上海森輝醫藥有限公司 糖皮質激素受體激動劑的藥物偶聯物及其在醫藥上的應用
WO2022171101A1 (zh) * 2021-02-10 2022-08-18 映恩生物制药(苏州)有限公司 一种甾体偶联物
TWI899455B (zh) 2021-03-23 2025-10-01 美商美國禮來大藥廠 糖皮質素受體激動劑
CN117043172A (zh) * 2021-03-23 2023-11-10 伊莱利利公司 糖皮质激素受体激动剂
AR125079A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas de receptores de glucocorticoides sustituidos con carboxi
AR125084A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas del receptor de glucocorticoides novedosos
CN113264983A (zh) * 2021-05-20 2021-08-17 联宁(苏州)生物制药有限公司 一种用于抗体偶联药物的连接子lnd1088的合成方法
KR20240016287A (ko) * 2021-06-01 2024-02-06 아지노모토 가부시키가이샤 항체 및 기능성 물질의 콘쥬게이트 또는 이의 염, 및 이의 제조에 사용되는 화합물 또는 이의 염
JP2024531480A (ja) * 2021-08-26 2024-08-29 デュアリティ バイオロジクス(スーチョウ)カンパニー,リミティド ステロイド化合物及びそのコンジュゲート
CN114394933B (zh) * 2022-01-07 2023-08-22 厦门沃克沃德医药科技有限公司 11,12-二氢-γ-氧代-二苯并[f]偶氮-5-(6h)-丁酸的合成方法
MX2024008640A (es) 2022-01-12 2024-07-24 Regeneron Pharma Analogos de camptotecina conjugados a un residuo de glutamina en una proteina y su uso.
JP2025513101A (ja) 2022-03-11 2025-04-23 ファイヤフライ バイオ,インコーポレイティド フェニルマレイミドリンカー剤
CN119744180A (zh) 2022-05-13 2025-04-01 伊莱利利公司 人肿瘤坏死因子α抗体糖皮质激素缀合物
IL317037A (en) * 2022-05-18 2025-01-01 Systimmune Inc Ligand-drug conjugate and its uses
WO2023235738A1 (en) 2022-06-02 2023-12-07 Eli Lilly And Company Human interleukin-4 receptor alpha antibody glucocorticoid conjugates
AU2023289376A1 (en) 2022-06-22 2025-01-16 Eli Lilly And Company Human cd33 antibodies and glucocorticoid conjugates
WO2024020164A2 (en) 2022-07-21 2024-01-25 Firefly Bio, Inc. Glucocorticoid receptor agonists and conjugates thereof
CN115212315A (zh) * 2022-08-03 2022-10-21 联宁(苏州)生物制药有限公司 一种抗体偶联药物中间体及含有其的抗体偶联药物
JP2025532110A (ja) * 2022-09-22 2025-09-29 イーライ リリー アンド カンパニー グルココルチコイド受容体アゴニスト
WO2024138000A1 (en) 2022-12-21 2024-06-27 Regeneron Pharmaceuticals, Inc. Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof
WO2024140838A1 (zh) * 2022-12-28 2024-07-04 映恩生物制药(苏州)有限公司 抗bdca2抗体-药物偶联物及其用途
WO2024153162A1 (en) * 2023-01-18 2024-07-25 Shanghai Micurx Pharmaceutical Co., Ltd. Peptide-drug conjugates for targeted therapy of renal diseases
IL325400A (en) * 2023-07-10 2026-02-01 Regeneron Pharma Anti-human CACNG1 antibody-drug conjugates and their uses

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2737518A (en) * 1955-01-19 1956-03-06 Schering Corp 1-hydroxycortisone, 1-hydroxyhydrocortisone and esters thereof
US2968655A (en) * 1956-11-23 1961-01-17 Upjohn Co 11-oxygenated-6-methyl progesterone and intermediates therefor
US2920999A (en) 1957-06-07 1960-01-12 Pfizer & Co C 21-nitrogen derivatives of corticosteroids
GB889766A (en) 1958-03-04 1962-02-21 Olin Mathieson Improvements in steroids and the synthesis thereof
DE1165595B (de) 1958-03-04 1964-03-19 Olin Mathieson Verfahren zur Herstellung von Triamcinolonacetonid-21-hemisuccinat und dessen Salzen
US3197469A (en) 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3007923A (en) * 1959-01-22 1961-11-07 Lab Francais Chimiotherapie Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids
GB898295A (en) 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3033874A (en) 1960-05-11 1962-05-08 Pfizer & Co C 17beta-propenoyl steroids and process for preparing same
US3033873A (en) 1960-05-11 1962-05-08 Pfizer & Co C 21-aminomethyl-pregnenes
US3020275A (en) 1960-06-07 1962-02-06 American Cyanamid Co 21-nitrogen substituted steroids of the pregnane series and methods of preparing the same
DE1169444B (de) * 1961-02-22 1964-05-06 Schering Ag Verfahren zur Herstellung von ?-16ª‡-Methylsteroiden
US3047468A (en) * 1961-06-06 1962-07-31 American Cyanamid Co Method of preparing delta1, 4-3-keto steroids of the pregnane series
US3383394A (en) * 1965-08-30 1968-05-14 Schering Corp Novel 17-acylating process and products thereof
US3798216A (en) 1969-03-07 1974-03-19 Fabrication Des Antibiotique S 9-fluoro-11beta,21-dihydroxy-16alpha,17-(2-propenylidenedioxy)-pregna-1,4-diene-3,20-dione and derivatives thereof
DE2047105C3 (de) 1970-09-18 1979-02-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen 17-Chlorsteroide und Verfahren zu ihrer Herstellung
IT1057859B (it) 1972-04-28 1982-03-30 Sigma Tao Ind Farmaceutiche Sp Perivato del triamoinolone
SE378110B (enExample) 1972-05-19 1975-08-18 Bofors Ab
SE378109B (enExample) 1972-05-19 1975-08-18 Bofors Ab
US4076737A (en) 1975-02-20 1978-02-28 Ciba-Geigy Corporation Aldehydes of the pregnane series and derivatives thereof
IL73337A (en) 1984-10-28 1988-09-30 Yissum Res Dev Co Antitumor steroid-platinum complexes and method for the preparation thereof
ES8605537A1 (es) 1985-07-03 1986-02-01 Elmu Sa Procedimiento de obtencion de cetales ciclicos de corticoi- des y sus 21-c esteres
SE8604059D0 (sv) 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5116829A (en) 1990-04-23 1992-05-26 Kao Corporation Steroid compounds
US5183815A (en) 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
CZ171095A3 (en) 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium
DE4311987A1 (de) 1993-04-07 1994-10-13 Schering Ag Neue Glucocorticoide
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
AU3703900A (en) 1999-02-24 2000-09-14 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20070258987A1 (en) 2000-11-28 2007-11-08 Seattle Genetics, Inc. Recombinant Anti-Cd30 Antibodies and Uses Thereof
SE0101220D0 (sv) 2001-04-04 2001-04-04 Astrazeneca Ab New use
US6908934B2 (en) 2001-06-11 2005-06-21 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
US20050009798A1 (en) 2002-02-20 2005-01-13 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists
US7190468B2 (en) 2002-07-17 2007-03-13 Hewlett-Packard Development Company, L.P. Background document rendering system and method
ES2369542T3 (es) 2002-07-31 2011-12-01 Seattle Genetics, Inc. Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
US7985422B2 (en) 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
EP1562627A4 (en) 2002-08-23 2006-11-02 Mclean Hospital Corp CORTICOSTEROID CONJUGATES AND ITS USES
KR20140070676A (ko) 2002-09-06 2014-06-10 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
CN1414008A (zh) * 2002-10-17 2003-04-30 南开大学 含氮甾体化合物及其制备方法
US7015349B2 (en) 2003-03-26 2006-03-21 The Gillette Company Reduction of hair growth
ES2605443T3 (es) 2003-11-06 2017-03-14 Seattle Genetics, Inc. Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
WO2005063777A1 (en) 2003-12-23 2005-07-14 Corus Pharma Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation
US8101714B2 (en) 2004-02-18 2012-01-24 The University Of Georgia Research Foundation, Inc. Teleost derived antimicrobial polypeptides
US20050192257A1 (en) 2004-02-26 2005-09-01 Peyman Gholam A. Predictors for patients at risk for glaucoma from steroid therapy
TW200539855A (en) 2004-03-15 2005-12-16 Wyeth Corp Calicheamicin conjugates
NZ551180A (en) 2004-06-01 2009-10-30 Genentech Inc Antibody drug conjugates and methods
EP1602931A1 (en) 2004-06-03 2005-12-07 Universiteit Leiden SR-A antagonists
US7541330B2 (en) 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
EP1625854B1 (en) 2004-08-09 2008-10-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Albumin conjugates containing a glucuronic linker
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
US20080305044A1 (en) 2004-11-29 2008-12-11 Seattle Genetics, Inc. Engineered Antibodies and Immunoconjugates
WO2006135371A1 (en) 2005-06-09 2006-12-21 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
AU2006259604A1 (en) 2005-06-14 2006-12-28 Gilead Sciences, Inc. Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction
WO2007056181A2 (en) 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide
PT1977252E (pt) 2005-12-22 2013-01-28 Baxter Int Teste de activação de monócitos melhorado mais capaz de detectar contaminantes pirogénicos sem serem endotoxinas em produtos médicos
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
WO2008127347A1 (en) 2006-07-21 2008-10-23 Diadexus, Inc. Pro115 antibody compositions and methods of use
MX2009008334A (es) 2007-02-05 2009-08-12 Nicox Sa Esteroides que liberan oxido nitrico.
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
US7985557B2 (en) 2007-05-23 2011-07-26 Ventana Medical Systems, Inc. Polymeric carriers for immunohistochemistry and in situ hybridization
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
CA2692021A1 (en) 2007-06-28 2008-12-31 Capsutech Ltd Targeting conjugates comprising active agents encapsulated in cyclodextrin-containing polymers
CN101397328A (zh) 2007-09-27 2009-04-01 天津药业研究院有限公司 一氧化氮供体型糖皮质激素
EP2214646B1 (en) 2007-10-05 2021-06-23 Wayne State University Dendrimers for sustained release of compounds
US20110262368A1 (en) 2007-12-21 2011-10-27 Schering Corporation C21 thioethers as glucocorticoid receptor agonists
CN101970452A (zh) * 2007-12-21 2011-02-09 先灵公司 C20-c21取代的糖皮质激素受体激动剂
UA108598C2 (xx) 2008-04-30 2015-05-25 Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери)
EP2294077A1 (en) 2008-06-10 2011-03-16 Gilead Sciences, Inc. Corticosteroid linked beta-agonist compounds for use in therapy
ES2560807T3 (es) 2008-07-21 2016-02-22 Polytherics Limited Nuevos reactivos y procedimiento de conjugación de moléculas biológicas
US9034325B2 (en) 2008-07-22 2015-05-19 Ablynx N.V. Amino acid sequences directed against multitarget scavenger receptors and polypeptides
ES2471145T3 (es) 2009-03-09 2014-06-25 Mikasa Seiyaku Co,. Ltd. Compuesto esteroide
WO2010126953A1 (en) 2009-04-29 2010-11-04 Gilead Sciences, Inc. Corticosteroid linked beta-agonist compounds for use in therapy
WO2010132743A1 (en) 2009-05-15 2010-11-18 Gilead Sciences, Inc. Corticosteroid beta-agonist compounds for use in therapy
DK2889624T3 (en) 2009-08-10 2018-12-10 Ucl Business Plc Reversible covalent bonding of functional molecules
WO2011020107A2 (en) 2009-08-14 2011-02-17 Georgetown University Compositions and methods for detection and treatment of breast cancer
GB0917044D0 (en) 2009-09-29 2009-11-18 Cytoguide As Agents, uses and methods
GB0917054D0 (en) 2009-09-29 2009-11-11 Cytoguide As Agents, uses and methods
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
WO2011090940A1 (en) 2010-01-19 2011-07-28 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
WO2011103389A1 (en) 2010-02-19 2011-08-25 Cornell University Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases
PT2528625E (pt) 2010-04-15 2013-10-17 Spirogen Sarl Pirrolobenzodiazepinas e conjugados das mesmas
US20130244905A1 (en) 2010-07-06 2013-09-19 Ed Grabczyk Reporter for RNA Polymerase II Termination
US9023858B2 (en) 2010-07-23 2015-05-05 Takeda Pharmaceutical Company Limited Substituted pyrido[2,3-d]pyrimidines as delta-5-desaturase inhibitors
EP2601298B1 (en) 2010-08-02 2016-11-30 Regeneron Pharmaceuticals, Inc. Mice that make binding proteins comprising vl domains
EP2611785B1 (de) 2010-09-01 2014-06-04 Bayer Intellectual Property GmbH N-(tetrazol-5-yl)- und n-(triazol-5-yl)arylcarbonsäureamide und ihre verwendung als herbizide
JP5828902B2 (ja) 2010-10-29 2015-12-09 イミュノジェン, インコーポレイテッド 非拮抗性egfr結合分子およびその免疫複合体
US20120302505A1 (en) 2011-04-21 2012-11-29 Fetzer Oliver S Cyclodextrin-based polymers for therapeutic delivery
DK2714685T3 (en) 2011-05-27 2017-01-09 Ambrx Inc FORMATIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID BOUND dolastatin
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
JP6166728B2 (ja) 2011-10-14 2017-07-19 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピンの製造に有用な合成方法及び中間体
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
AU2012322934B2 (en) 2011-10-14 2016-09-08 Medimmune Limited Pyrrolobenzodiazepines
WO2013068874A1 (en) 2011-11-11 2013-05-16 Pfizer Inc. Antibody-drug conjugates
BR112014013526A8 (pt) 2011-12-05 2017-06-13 Igenica Biotherapeutics Inc conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados
GB201122325D0 (en) 2011-12-23 2012-02-01 Cytoguide As Novel formulations
SG10201704846VA (en) 2012-03-14 2017-07-28 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
MX2014015205A (es) 2012-06-14 2015-08-14 Ambrx Inc Anticuerpos anti-psma conjugados a polipeptidos de ligando de receptor nuclear.
MY186106A (en) 2012-10-11 2021-06-22 Ascendis Pharma As Diagnosis, prevention and treatment of diseases of the joint
EA201590622A1 (ru) 2012-10-16 2015-10-30 Эндосайт, Инк. Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения
HRP20180268T4 (hr) 2012-10-23 2026-03-27 Synaffix B.V. Modificirano antitijelo, konjugat antitijela i postupak za njihovu pripremu
WO2014065575A1 (ko) 2012-10-25 2014-05-01 주식회사유한양행 4,5-다이하이드로-1h-피라졸 유도체 또는 그의 염 및 이를 포함하는 약학 조성물
DK2935331T3 (en) 2012-12-24 2018-06-06 Abbvie Inc PROLACTIN RECEPTOR BINDING PROTEINS AND APPLICATIONS THEREOF
HK1220698A1 (zh) 2013-03-13 2017-05-12 Seattle Genetics, Inc. 环糊精和抗体药物偶联物制剂
EP2988786A4 (en) 2013-04-22 2016-12-21 Avelas Biosciences Inc COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE
DK2991683T3 (da) 2013-05-02 2019-11-04 Glykos Finland Oy Konjugater af et glykoprotein eller en glykan med en toksisk ladning
US11229711B2 (en) 2013-06-06 2022-01-25 Magenta Therapeutics, Inc. Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
KR20160042871A (ko) 2013-06-21 2016-04-20 이나뜨 파르마, 에스.아. 폴리펩티드의 효소적 콘쥬게이션
WO2015005459A1 (ja) 2013-07-10 2015-01-15 生化学工業株式会社 呼吸器投与用の医薬組成物
TWI641620B (zh) 2013-08-21 2018-11-21 再生元醫藥公司 抗-prlr抗體及其用途
PT3057585T (pt) 2013-10-15 2020-10-21 Seagen Inc Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
GB201320091D0 (en) 2013-11-14 2014-01-01 Univ Manchester Selective glucocorticoid receptor ligands
CN103694375B (zh) 2013-12-13 2016-10-05 北京大学 一种三萜-环糊精共价化合物及其制备方法和用途
WO2015110609A1 (en) 2014-01-24 2015-07-30 Centre National De La Recherche Scientifique Orally available compounds, a process for preparing the same and their uses as anti-adhesive drugs for treating e. coli induced inflammatory bowel diseases such as crohn's disease
EP3125943B1 (en) 2014-04-04 2026-04-22 Merck Sharp & Dohme LLC Phosphate based linkers for intracellular delivery of drug conjugates
TWI871999B (zh) 2014-04-10 2025-02-01 日商第一三共股份有限公司 抗her3抗體-藥物結合物
DK3166638T3 (da) 2014-06-13 2025-10-06 Glykos Finland Oy Nyttelagt-polymer-proteinkonjugater
KR20170086536A (ko) 2014-12-03 2017-07-26 제넨테크, 인크. 항-스타필로코커스 아우레우스 항체 리파마이신 접합체 및 이의 용도
MX2017007231A (es) 2014-12-03 2017-11-08 Genentech Inc Conjugados de rifamicina y anticuerpos contra el staphylococcuss aureus y usos de estos.
JP2018502839A (ja) 2014-12-09 2018-02-01 アッヴィ・インコーポレイテッド Bcl−xL阻害性化合物およびこれを含む抗体薬物コンジュゲート
RU2017123942A (ru) 2014-12-09 2019-01-11 Эббви Инк. Ингибирующие bcl-xl соединения, обладающие низкой клеточной проницаемостью, и коньюгаты антитело-лекарственное средство, включающие их
EP3250211B1 (en) 2015-01-30 2021-12-22 Coral Drugs Pvt. Ltd. Novel process for preparation of glucocorticoid steroids
US20170224835A1 (en) 2015-02-06 2017-08-10 Sorrento Therapeutics, Inc. Antibody Drug Conjugates
JP6993958B2 (ja) 2015-07-06 2022-02-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 多重特異性抗原結合分子およびその使用
WO2017006279A1 (en) 2015-07-08 2017-01-12 Aten Porus Lifesciences Cyclodextrin-polymer complexes and compostions and methods of making and using the same
CN108135857A (zh) 2015-09-10 2018-06-08 沙思奇公司 生物正交组合物
WO2017062271A2 (en) 2015-10-06 2017-04-13 Merck Sharp & Dohme Corp. Antibody drug conjugate for anti-inflammatory applications
EP3407916B1 (en) 2016-01-29 2023-12-20 Merck Sharp & Dohme LLC Phosphonate linkers and their use to facilitate cellular retention of compounds
EP3419670A2 (en) 2016-02-26 2019-01-02 Regeneron Pharmaceuticals, Inc. Optimized transglutaminase site-specific antibody conjugation
EP3433278A4 (en) 2016-03-25 2019-11-06 Seattle Genetics, Inc. METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF
GB201608936D0 (en) 2016-05-20 2016-07-06 Polytherics Ltd Novel conjugates and novel conjugating reagents
RS62040B1 (sr) 2016-06-02 2021-07-30 Abbvie Inc Agonist receptora glukokortikoida i njegovi imunokonjugati
MX2018015272A (es) 2016-06-08 2019-08-12 Abbvie Inc Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco.
KR102520731B1 (ko) 2016-09-23 2023-04-14 리제너론 파아마슈티컬스, 인크. 항-steap2 항체, 항체-약물 컨쥬게이트, 및 steap2 및 cd3에 결합하는 이중특이적 항원-결합 분자, 및 이의 용도
CA3042428A1 (en) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
IL298414B2 (en) 2017-02-28 2024-12-01 Immunogen Inc Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof
EP3625209A1 (en) 2017-05-18 2020-03-25 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
KR20250008984A (ko) * 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
EP3630189A4 (en) 2017-05-24 2021-06-23 The Board of Regents of The University of Texas System LINKER FOR ANTIBODY MEDICINAL CONJUGATES
CN109106951A (zh) 2017-08-18 2019-01-01 四川百利药业有限责任公司 一种喜树碱-抗体偶联物
WO2019034177A1 (zh) 2017-08-18 2019-02-21 四川百利药业有限责任公司 具有两种不同药物的抗体药物偶联物
CA3247730A1 (en) 2017-11-07 2025-10-30 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
EP3658192B1 (en) 2017-12-01 2021-04-28 AbbVie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
MA50259A1 (fr) 2018-01-08 2021-07-29 Regeneron Pharma Stéroïdes et leurs conjugués-anticorps
CN111936169A (zh) 2018-04-06 2020-11-13 西雅图遗传学公司 喜树碱肽缀合物
WO2019217591A1 (en) 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof
CA3120528A1 (en) 2018-11-20 2020-05-28 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists
WO2020132483A1 (en) 2018-12-21 2020-06-25 Regeneron Pharmaceuticals, Inc. Rifamycin analogs and antibody-drug conjugates thereof
JP2022517767A (ja) 2019-01-08 2022-03-10 レゲネロン ファーマシューティカルス,インコーポレーテッド 無痕跡型リンカー及びそのタンパク質-コンジュゲート
US20230119539A1 (en) 2019-01-08 2023-04-20 Regeneron Pharmaceuticals, Inc. Traceless linkers and protein-conjugates thereof

Similar Documents

Publication Publication Date Title
TWI851577B (zh) 喜樹鹼結合物
US20250312467A1 (en) Compound for preparation of antibody-payload conjugate and use thereof
AU2020205851B2 (en) Conjugate comprising ligand, spacer, peptide linker, and biomolecule
JP7330101B2 (ja) ステロイド及びそのタンパク質コンジュゲート
CA3103151A1 (en) Compound having affinity substance to antibody and bioorthogonal functional group, or salt thereof
CN106414465B (zh) 带电荷链接体及其在共轭反应上的应用
JP2018502047A (ja) 生物学的物質及びその使用
CN112218663A (zh) 剪接调节抗体-药物缀合物及其使用方法
JP2020518581A (ja) 縮合イミダゾピペリジンjak阻害剤化合物
JP2018524377A (ja) 細胞結合分子の共役のための架橋連結体
CN104619350A (zh) 结合到核受体配体多肽的抗psma抗体
JP2021528431A (ja) Il−17に結合するためのペプチドリガンド
JP2018523639A (ja) 細胞結合分子の特異的共役体
JP2019502650A5 (ja) 抗ErbB2抗体−薬物コンジュゲート及びその組成物、そのための調製方法、並びにその使用
JP2025510606A (ja) B7h4抗体薬物複合体及びその使用
CN108699108A (zh) 放射性标记药物
CN117915956A (zh) M6pr细胞表面受体结合化合物和缀合物
JP2021513990A (ja) 疎水性アウリスタチンf化合物およびそのコンジュゲート
CA3107305A1 (en) Tlr7/8 agonists and liposome compositions
EP2991687A1 (en) Prosthetic compounds for labeling internalizing biomolecules
EP3096742A1 (en) Compositions and methods for modifying the surface of cells and methods of use
JP2023159139A (ja) 新規な連結体及び生体分子と薬物との特異的共役におけるその使用
JP7670072B2 (ja) 化合物またはその塩、およびそれらにより得られる抗体
JP7687350B2 (ja) 化合物またはその塩、およびそれらにより得られる抗体
WO2017083604A1 (en) Triazine mediated pharmacokinetic enhancement of therapeutics