JP2019536461A5 - - Google Patents
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- JP2019536461A5 JP2019536461A5 JP2019530100A JP2019530100A JP2019536461A5 JP 2019536461 A5 JP2019536461 A5 JP 2019536461A5 JP 2019530100 A JP2019530100 A JP 2019530100A JP 2019530100 A JP2019530100 A JP 2019530100A JP 2019536461 A5 JP2019536461 A5 JP 2019536461A5
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- 238000000034 method Methods 0.000 claims 37
- 210000001744 T-lymphocyte Anatomy 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 17
- 238000011534 incubation Methods 0.000 claims 13
- 108010002350 Interleukin-2 Proteins 0.000 claims 7
- 102000000588 Interleukin-2 Human genes 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 102000003812 Interleukin-15 Human genes 0.000 claims 5
- 108090000172 Interleukin-15 Proteins 0.000 claims 5
- 108091008874 T cell receptors Proteins 0.000 claims 5
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 102000006306 Antigen Receptors Human genes 0.000 claims 4
- 108010083359 Antigen Receptors Proteins 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 108010029697 CD40 Ligand Proteins 0.000 claims 3
- 102100032937 CD40 ligand Human genes 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 3
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 3
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 3
- 108010002586 Interleukin-7 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000022131 cell cycle Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 230000000284 resting effect Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022008417A JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430349P | 2016-12-05 | 2016-12-05 | |
| US62/430,349 | 2016-12-05 | ||
| PCT/US2017/064778 WO2018106732A1 (en) | 2016-12-05 | 2017-12-05 | Production of engineered cells for adoptive cell therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008417A Division JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019536461A JP2019536461A (ja) | 2019-12-19 |
| JP2019536461A5 true JP2019536461A5 (enExample) | 2021-01-21 |
Family
ID=60935957
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530100A Pending JP2019536461A (ja) | 2016-12-05 | 2017-12-05 | 養子細胞療法のための操作細胞の産生 |
| JP2022008417A Pending JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008417A Pending JP2022058727A (ja) | 2016-12-05 | 2022-01-24 | 養子細胞療法のための操作細胞の産生 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20190350978A1 (enExample) |
| EP (1) | EP3548611A1 (enExample) |
| JP (2) | JP2019536461A (enExample) |
| KR (1) | KR20190098747A (enExample) |
| CN (1) | CN110249046A (enExample) |
| AU (1) | AU2017370644A1 (enExample) |
| BR (1) | BR112019011207A2 (enExample) |
| CA (1) | CA3045338A1 (enExample) |
| MA (1) | MA46998A (enExample) |
| MX (1) | MX2019006438A (enExample) |
| WO (1) | WO2018106732A1 (enExample) |
Families Citing this family (56)
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| IL292038B2 (en) | 2014-04-23 | 2024-12-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| AU2015292744C1 (en) | 2014-07-21 | 2021-01-21 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| RU2761555C2 (ru) | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| WO2019051097A1 (en) | 2017-09-08 | 2019-03-14 | The Regents Of The University Of California | RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USING SAME |
| JP7357626B2 (ja) | 2017-11-01 | 2023-10-06 | ジュノー セラピューティクス インコーポレイテッド | 操作された細胞の治療用組成物を生成するためのプロセス |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| AU2018379091A1 (en) | 2017-12-08 | 2020-06-25 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| IL279367B2 (en) | 2018-06-13 | 2026-05-01 | Novartis Ag | BCMA chimeric antigen receptors and their uses |
| BR112021002390A2 (pt) | 2018-08-09 | 2021-05-11 | Juno Therapeutics Inc | processos para gerar células modificadas e suas composições |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
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| CN114600172A (zh) * | 2019-08-30 | 2022-06-07 | 朱诺治疗学股份有限公司 | 用于将细胞分类的机器学习方法 |
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-
2017
- 2017-12-05 WO PCT/US2017/064778 patent/WO2018106732A1/en not_active Ceased
- 2017-12-05 US US16/465,140 patent/US20190350978A1/en not_active Abandoned
- 2017-12-05 KR KR1020197019497A patent/KR20190098747A/ko not_active Ceased
- 2017-12-05 CA CA3045338A patent/CA3045338A1/en active Pending
- 2017-12-05 EP EP17825665.7A patent/EP3548611A1/en not_active Withdrawn
- 2017-12-05 JP JP2019530100A patent/JP2019536461A/ja active Pending
- 2017-12-05 AU AU2017370644A patent/AU2017370644A1/en not_active Abandoned
- 2017-12-05 MX MX2019006438A patent/MX2019006438A/es unknown
- 2017-12-05 MA MA046998A patent/MA46998A/fr unknown
- 2017-12-05 CN CN201780085444.1A patent/CN110249046A/zh active Pending
- 2017-12-05 BR BR112019011207A patent/BR112019011207A2/pt not_active IP Right Cessation
-
2022
- 2022-01-24 JP JP2022008417A patent/JP2022058727A/ja active Pending
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