CN110249046A - 用于过继细胞疗法的工程化细胞的产生 - Google Patents

用于过继细胞疗法的工程化细胞的产生 Download PDF

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CN110249046A
CN110249046A CN201780085444.1A CN201780085444A CN110249046A CN 110249046 A CN110249046 A CN 110249046A CN 201780085444 A CN201780085444 A CN 201780085444A CN 110249046 A CN110249046 A CN 110249046A
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cell
cells
antigen
composition
receptor
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P·博切斯
S·U·塔瑞恩
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Juno Therapeutics Inc
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Juno Therapeutics Inc
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CN201780085444.1A 2016-12-05 2017-12-05 用于过继细胞疗法的工程化细胞的产生 Pending CN110249046A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662430349P 2016-12-05 2016-12-05
US62/430,349 2016-12-05
PCT/US2017/064778 WO2018106732A1 (en) 2016-12-05 2017-12-05 Production of engineered cells for adoptive cell therapy

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CN110249046A true CN110249046A (zh) 2019-09-17

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US (1) US20190350978A1 (enExample)
EP (1) EP3548611A1 (enExample)
JP (2) JP2019536461A (enExample)
KR (1) KR20190098747A (enExample)
CN (1) CN110249046A (enExample)
AU (1) AU2017370644A1 (enExample)
BR (1) BR112019011207A2 (enExample)
CA (1) CA3045338A1 (enExample)
MA (1) MA46998A (enExample)
MX (1) MX2019006438A (enExample)
WO (1) WO2018106732A1 (enExample)

Cited By (7)

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CN111542596A (zh) * 2017-11-01 2020-08-14 朱诺治疗学股份有限公司 产生工程化细胞的治疗性组合物的方法
CN112831525A (zh) * 2020-10-21 2021-05-25 东莞清实生物科技有限公司 一种简单高效的慢病毒冻存液及其应用
WO2021148019A1 (zh) * 2020-01-22 2021-07-29 科济生物医药（上海）有限公司 病毒载体转导细胞的方法
CN113846099A (zh) * 2021-09-23 2021-12-28 中国农业科学院兰州兽医研究所 用于敲低猪SAMHD1基因表达的siRNA、试剂盒及其应用
CN115135148A (zh) * 2020-01-21 2022-09-30 武田药品工业株式会社 冷冻保存细胞的组合物和方法
CN115380045A (zh) * 2020-02-11 2022-11-22 Hcw生物科技公司 激活调节性t细胞的方法
CN115485370A (zh) * 2020-03-20 2022-12-16 美国卫生和人力服务部 通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法

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EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
AU2015292744C1 (en) 2014-07-21 2021-01-21 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
RU2761555C2 (ru) 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
MX2019011570A (es) 2017-03-27 2019-11-18 Nat Univ Singapore Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
CN117363636A (zh) 2017-03-27 2024-01-09 新加坡国立大学 一种编码嵌合受体的多核苷酸
WO2019051097A1 (en) 2017-09-08 2019-03-14 The Regents Of The University Of California RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USING SAME
CN119193493A (zh) 2017-12-08 2024-12-27 朱诺治疗学股份有限公司 生产工程化t细胞组合物的过程
AU2018379091A1 (en) 2017-12-08 2020-06-25 Juno Therapeutics, Inc. Serum-free media formulation for culturing cells and methods of use thereof
JP7360174B2 (ja) 2018-02-09 2023-10-12 ナショナル ユニヴァーシティー オブ シンガポール ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
IL279367B2 (en) 2018-06-13 2026-05-01 Novartis Ag BCMA chimeric antigen receptors and their uses
BR112021002390A2 (pt) 2018-08-09 2021-05-11 Juno Therapeutics Inc processos para gerar células modificadas e suas composições
WO2020044239A1 (en) 2018-08-29 2020-03-05 National University Of Singapore A method to specifically stimulate survival and expansion of genetically-modified immune cells
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
SI3844267T1 (sl) * 2018-08-31 2025-10-30 Novartis Ag Postopki izdelave celic, ki izražajo receptorje himernega antigena
US20210171909A1 (en) * 2018-08-31 2021-06-10 Novartis Ag Methods of making chimeric antigen receptor?expressing cells
WO2020092696A1 (en) * 2018-10-31 2020-05-07 Musc Foundation For Research Development Ex vivo activation and expansion of t cells for adoptive cell transfer therapy
EP4578507A3 (en) 2018-11-01 2025-11-12 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
WO2020102701A1 (en) * 2018-11-16 2020-05-22 Rapa Therapeutics, Llc Methods for the manufacture of th1/tc1 phenotype t cells
US10918667B2 (en) * 2018-11-20 2021-02-16 Innovative Cellular Therapeutics CO., LTD. Modified cell expressing therapeutic agent and uses thereof
CN113226340A (zh) 2018-11-26 2021-08-06 恩卡尔塔公司 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途
CN113365654A (zh) * 2019-01-29 2021-09-07 Gpb科学有限公司 具有改进的生产和治疗特征的细胞群
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
WO2020210678A1 (en) * 2019-04-12 2020-10-15 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
EP4778585A2 (en) 2019-05-07 2026-07-22 Gracell Bioscience (Shanghai) Co., Ltd. Engineered immune cell targeting bcma and use thereof
CN113966394A (zh) * 2019-05-28 2022-01-21 美天施生物科技有限两合公司 产生遗传修饰的t细胞的方法
US12702708B2 (en) 2019-08-21 2026-08-11 Innovative Cellular Therapeutics Holdings, Ltd. Presenting cell and use thereof in cell therapy
CN114600172A (zh) * 2019-08-30 2022-06-07 朱诺治疗学股份有限公司 用于将细胞分类的机器学习方法
JP7805928B2 (ja) 2019-11-26 2026-01-26 ノバルティス アーゲー Ｃｄ１９及びｃｄ２２キメラ抗原受容体及びその使用
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