JP2019520823A5 - - Google Patents
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- JP2019520823A5 JP2019520823A5 JP2018567129A JP2018567129A JP2019520823A5 JP 2019520823 A5 JP2019520823 A5 JP 2019520823A5 JP 2018567129 A JP2018567129 A JP 2018567129A JP 2018567129 A JP2018567129 A JP 2018567129A JP 2019520823 A5 JP2019520823 A5 JP 2019520823A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- antigens
- memory
- antigen
- gvhd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 50
- 239000000427 antigen Substances 0.000 claims 29
- 102000036639 antigens Human genes 0.000 claims 29
- 108091007433 antigens Proteins 0.000 claims 29
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 18
- 238000000034 method Methods 0.000 claims 15
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 13
- 208000024908 graft versus host disease Diseases 0.000 claims 13
- 230000003612 virological effect Effects 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 8
- 238000012258 culturing Methods 0.000 claims 8
- 238000002054 transplantation Methods 0.000 claims 7
- 108010002586 Interleukin-7 Proteins 0.000 claims 6
- 102000000704 Interleukin-7 Human genes 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 4
- 210000001165 lymph node Anatomy 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 3
- 230000000779 depleting effect Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 108091008048 CMVpp65 Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 239000003981 vehicle Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 241000829111 Human polyomavirus 1 Species 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662354950P | 2016-06-27 | 2016-06-27 | |
| US62/354,950 | 2016-06-27 | ||
| PCT/IL2017/050716 WO2018002924A1 (en) | 2016-06-27 | 2017-06-27 | Veto cells generated from memory t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520823A JP2019520823A (ja) | 2019-07-25 |
| JP2019520823A5 true JP2019520823A5 (enExample) | 2020-08-06 |
| JP7334043B2 JP7334043B2 (ja) | 2023-08-28 |
Family
ID=59351006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567129A Active JP7334043B2 (ja) | 2016-06-27 | 2017-06-27 | メモリーｔ細胞から作られるベト細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10961504B2 (enExample) |
| EP (1) | EP3475414B1 (enExample) |
| JP (1) | JP7334043B2 (enExample) |
| KR (1) | KR102444170B1 (enExample) |
| CN (1) | CN109661463B (enExample) |
| AU (1) | AU2017289879B2 (enExample) |
| CA (1) | CA3029001A1 (enExample) |
| ES (1) | ES3034019T3 (enExample) |
| IL (1) | IL263924B2 (enExample) |
| MX (1) | MX2019000022A (enExample) |
| SG (1) | SG11201811563RA (enExample) |
| WO (1) | WO2018002924A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2753351B1 (en) | 2011-09-08 | 2017-06-21 | Yeda Research and Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| US11179448B2 (en) | 2015-07-16 | 2021-11-23 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory T cells and use of same in immunotherapy |
| KR102444170B1 (ko) | 2016-06-27 | 2022-09-16 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 기억 t 세포로부터 생성된 베토 세포 |
| KR102501827B1 (ko) * | 2016-09-16 | 2023-02-22 | 베이롤 칼리지 오브 메드신 | 바이러스-특이적인 t-세포의 활성화 및 확장을 위한 플랫폼 |
| IL268126B2 (en) | 2017-01-18 | 2024-02-01 | Yeda Res & Dev | Genetically engineered Veto cells and their uses in immunotherapy |
| JP7337373B2 (ja) * | 2019-07-29 | 2023-09-04 | サイアス株式会社 | 抗原特異的ｔ細胞の製造方法 |
| CN114466925A (zh) * | 2019-08-06 | 2022-05-10 | 耶达研究及发展有限公司 | 单倍体相合的干细胞移植中的抗病毒中央型记忆cd8+反抑细胞 |
| BR112022008700A2 (pt) * | 2019-11-05 | 2022-07-19 | Yeda Res & Dev | Método para tratar ou prevenir uma doença falciforme, e, transplante de células hematopoiéticas imaturas e uma quantidade terapeuticamente eficaz de uma população isolada de células anti-terceiros não indutoras de doença do enxerto versus hospedeiro |
| CN115175688A (zh) * | 2019-11-05 | 2022-10-11 | 耶达研究及发展有限公司 | 在数个t细胞介导的自身免疫性疾病的治疗中的数个否决细胞的用途 |
| CA3189051A1 (en) * | 2020-08-11 | 2022-02-17 | Yair Reisner | Veto car-t cells |
| WO2024091794A1 (en) * | 2022-10-28 | 2024-05-02 | Nant Holdings IP, LLP | Vaccine composition for stimulation of broad-spectrum memory of b cell expansion |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| AU2101600A (en) | 1998-12-24 | 2000-07-31 | Novartis Ag | Porcine cells incapable of expressing cd40 antigen, for xenotransplantation |
| US6544506B2 (en) | 2000-01-05 | 2003-04-08 | Yeda Research & Development Co. Ltd. | Veto cells effective in preventing graft rejection and devoid of graft versus host potential |
| US20030147859A1 (en) | 2001-06-18 | 2003-08-07 | Yair Reisner | Methods of utilizing cultured hematopoietic progenitor cells for inducing immunological tolerance |
| EP1928479B1 (en) | 2005-08-24 | 2016-06-08 | Yeda Research And Development Co., Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
| ES2615861T3 (es) * | 2008-10-30 | 2017-06-08 | Yeda Research And Development Company Ltd. | Células T de memoria central anti-terceros, métodos de producción de las mismas y uso de las mismas en trasplante y tratamiento de enfermedades |
| CN105907713A (zh) | 2010-09-08 | 2016-08-31 | 耶达研究及发展有限公司 | 抗第三方中枢记忆性t细胞在抗白血病/淋巴瘤治疗中的用途 |
| EP2753351B1 (en) * | 2011-09-08 | 2017-06-21 | Yeda Research and Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| JP6483082B2 (ja) | 2013-03-15 | 2019-03-13 | ジェネンテック， インコーポレイテッド | Ｐｄ−１及びｐｄ−ｌ１に関連する状態を治療するためのバイオマーカー及び方法 |
| US11179448B2 (en) | 2015-07-16 | 2021-11-23 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory T cells and use of same in immunotherapy |
| KR102444170B1 (ko) | 2016-06-27 | 2022-09-16 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 기억 t 세포로부터 생성된 베토 세포 |
-
2017
- 2017-06-27 KR KR1020197002824A patent/KR102444170B1/ko active Active
- 2017-06-27 CA CA3029001A patent/CA3029001A1/en active Pending
- 2017-06-27 AU AU2017289879A patent/AU2017289879B2/en active Active
- 2017-06-27 ES ES17740119T patent/ES3034019T3/es active Active
- 2017-06-27 JP JP2018567129A patent/JP7334043B2/ja active Active
- 2017-06-27 SG SG11201811563RA patent/SG11201811563RA/en unknown
- 2017-06-27 US US16/313,486 patent/US10961504B2/en active Active
- 2017-06-27 IL IL263924A patent/IL263924B2/en unknown
- 2017-06-27 CN CN201780052593.8A patent/CN109661463B/zh active Active
- 2017-06-27 MX MX2019000022A patent/MX2019000022A/es unknown
- 2017-06-27 WO PCT/IL2017/050716 patent/WO2018002924A1/en not_active Ceased
- 2017-06-27 EP EP17740119.7A patent/EP3475414B1/en active Active
-
2021
- 2021-03-25 US US17/211,863 patent/US11773372B2/en active Active
-
2023
- 2023-08-10 US US18/232,437 patent/US12391916B2/en active Active
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