|
US4369184A
(en)
|
1980-01-24 |
1983-01-18 |
Janssen Pharmaceutica N.V. |
1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
|
|
JPS56110674A
(en)
*
|
1980-01-24 |
1981-09-01 |
Janssen Pharmaceutica Nv |
Novel 11*cyclohexyl**44aryll44piperidine carboxylic acid derivative
|
|
US5852029A
(en)
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
GB9300194D0
(en)
|
1993-01-06 |
1993-03-03 |
Wyeth John & Brother Ltd |
Piperazine derivatives
|
|
US5446051A
(en)
*
|
1994-05-31 |
1995-08-29 |
Eli Lilly And Company |
Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
|
|
CA2200468A1
(en)
*
|
1994-10-27 |
1996-05-09 |
Wayne J. Thompson |
Muscarine antagonists
|
|
IL117149A0
(en)
|
1995-02-23 |
1996-06-18 |
Schering Corp |
Muscarinic antagonists
|
|
US5889006A
(en)
|
1995-02-23 |
1999-03-30 |
Schering Corporation |
Muscarinic antagonists
|
|
WO1997016187A1
(en)
*
|
1995-10-31 |
1997-05-09 |
Merck & Co., Inc. |
Muscarine antagonists
|
|
US5854245A
(en)
|
1996-06-28 |
1998-12-29 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
|
US6664258B1
(en)
*
|
1996-08-26 |
2003-12-16 |
Pfizer Inc |
Spirocyclic dopamine receptor subtype ligands
|
|
CA2293408A1
(en)
|
1997-06-18 |
1998-12-23 |
Merck & Co., Inc. |
Alpha 1a adrenergic receptor antagonists
|
|
GB9715892D0
(en)
|
1997-07-29 |
1997-10-01 |
Zeneca Ltd |
Heterocyclic compounds
|
|
AU2095099A
(en)
|
1997-12-23 |
1999-07-12 |
Alcon Laboratories, Inc. |
Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparationand their use as muscarinic receptor (ant-)agonists
|
|
WO1999032489A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
AU2307899A
(en)
|
1997-12-23 |
1999-07-12 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
WO1999032481A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
CZ286152B6
(cs)
|
1998-03-13 |
2000-01-12 |
Miroslav Ing. Csc. Vlček |
Transparentní a semitransparentní difrakční prvky
|
|
HUP0101511A3
(en)
|
1998-04-28 |
2002-12-28 |
Dainippon Pharmaceutical Co |
1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
|
|
US6387930B1
(en)
|
1999-05-04 |
2002-05-14 |
Schering Corporation |
Piperidine derivatives useful as CCR5 antagonists
|
|
EP1175224B1
(en)
|
1999-05-04 |
2005-02-23 |
Schering Corporation |
Pegylated interferon alfa-ccr5 antagonist combination hiv therapy
|
|
EP1175402B1
(en)
|
1999-05-04 |
2005-07-20 |
Schering Corporation |
Piperidine derivatives useful as ccr5 antagonists
|
|
US6420364B1
(en)
|
1999-09-13 |
2002-07-16 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compound useful as reversible inhibitors of cysteine proteases
|
|
HK1048807A1
(zh)
*
|
1999-09-13 |
2003-04-17 |
贝林格尔‧英格海姆药物公司 |
用作半胱氨酸蛋白酶的可逆抑制剂的新颖螺旋杂环化合物
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
WO2001027104A1
(en)
|
1999-10-13 |
2001-04-19 |
Banyu Pharmaceutical Co., Ltd. |
Substituted imidazolidinone derivatives
|
|
US7163938B2
(en)
|
2000-11-28 |
2007-01-16 |
Eli Lilly And Company |
Substituted carboxamides
|
|
CA2444595A1
(en)
|
2001-04-20 |
2002-10-31 |
Banyu Pharmaceutical Co., Ltd. |
Benzimidazolone derivatives
|
|
BR0210391A
(pt)
|
2001-06-12 |
2004-06-15 |
Elan Pharm Inc |
Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto
|
|
WO2004089942A2
(en)
|
2001-10-02 |
2004-10-21 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
GB0128378D0
(en)
|
2001-11-27 |
2002-01-16 |
Smithkline Beecham Plc |
Novel Compounds
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
NZ533566A
(en)
|
2001-12-28 |
2007-03-30 |
Acadia Pharm Inc |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
US7256186B2
(en)
|
2002-02-06 |
2007-08-14 |
Schering Corporation |
Gamma secretase inhibitors
|
|
US20040171614A1
(en)
|
2002-02-06 |
2004-09-02 |
Schering-Plough Corporation |
Novel gamma secretase inhibitors
|
|
ATE454381T1
(de)
|
2002-03-28 |
2010-01-15 |
Mitsubishi Tanabe Pharma Corp |
Benzofuranderivat
|
|
AU2003242252A1
(en)
|
2002-06-07 |
2003-12-22 |
Kyowa Hakko Kogyo Co., Ltd. |
Bicyclic pyrimidine derivatives
|
|
DE60226906D1
(de)
|
2002-07-31 |
2008-07-10 |
Ranbaxy Lab Ltd |
3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen
|
|
MXPA05003344A
(es)
|
2002-09-30 |
2005-11-23 |
Neurosearch As |
Derivados novedosos de 1,4-diazabicicloalcano, su preparacion y uso.
|
|
AU2003293006A1
(en)
*
|
2002-11-22 |
2004-06-18 |
Japan Tobacco Inc. |
Fused bicyclic nitrogen-containing heterocycles
|
|
CA2507501C
(en)
*
|
2002-11-27 |
2011-10-04 |
Incyte Corporation |
3-aminopyrrolidine derivatives as modulators of chemokine receptors
|
|
WO2004069828A1
(ja)
|
2003-02-04 |
2004-08-19 |
Mitsubishi Pharma Corporation |
ピペリジン化合物およびその医薬用途
|
|
EP1647553A4
(en)
|
2003-07-17 |
2008-12-31 |
Astellas Pharma Inc |
2-ACYLAMINOTHIAZOL DERIVATIVE OR SALT THEREOF
|
|
EP1679069A4
(en)
|
2003-10-21 |
2009-05-13 |
Dainippon Sumitomo Pharma Co |
NEW PIPERIDINE DERIVATIVE
|
|
DE602005013931D1
(enExample)
|
2004-02-05 |
2009-05-28 |
Schering Corp |
|
|
JP2007522160A
(ja)
|
2004-02-10 |
2007-08-09 |
エフ．ホフマン−ラ ロシュ アーゲー |
ケモカインｃｃｒ５受容体モジュレーター
|
|
US7488745B2
(en)
|
2004-07-16 |
2009-02-10 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US7504424B2
(en)
|
2004-07-16 |
2009-03-17 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US7786141B2
(en)
|
2004-08-19 |
2010-08-31 |
Vertex Pharmaceuticals Incorporated |
Dihydrospiroindene modulators of muscarinic receptors
|
|
JP2008521821A
(ja)
|
2004-11-29 |
2008-06-26 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ムスカリン受容体のモジュレーター
|
|
JP4774995B2
(ja)
|
2005-01-12 |
2011-09-21 |
アステラス製薬株式会社 |
アシルアミノチアゾール誘導体を有効成分とする医薬組成物
|
|
WO2006105035A2
(en)
|
2005-03-28 |
2006-10-05 |
Vertex Pharmaceuticals Incorporated |
Muscarinic modulators
|
|
EP1900732A4
(en)
|
2005-06-24 |
2009-11-18 |
Toyama Chemical Co Ltd |
NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF
|
|
AU2006330866A1
(en)
|
2005-12-22 |
2007-07-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
WO2007079164A2
(en)
|
2005-12-29 |
2007-07-12 |
Abbott Laboratories |
Protein kinase inhibitors
|
|
RU2008137593A
(ru)
|
2006-02-22 |
2010-03-27 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Модуляторы мускариновых рецепторов
|
|
RU2008137583A
(ru)
|
2006-02-22 |
2010-03-27 |
Вертекс Фармасьютикалз Инкорпорейшн (Us) |
Спиропиперидины в качестве модуляторов мускариновых рецепторов
|
|
EP2051712A2
(en)
|
2006-08-15 |
2009-04-29 |
Vertex Pharmceuticals Incorporated |
Modulators of muscarinic receptors
|
|
MX2009006756A
(es)
*
|
2006-12-22 |
2009-06-30 |
Novartis Ag |
Derivados de 1-amino-metil-l-fenil-ciclohexano como inhibidores de dpp-iv.
|
|
WO2008117229A1
(en)
|
2007-03-23 |
2008-10-02 |
Ranbaxy Laboratories Limited |
Muscarinic receptor antagonists
|
|
US8119661B2
(en)
|
2007-09-11 |
2012-02-21 |
Astrazeneca Ab |
Piperidine derivatives and their use as muscarinic receptor modulators
|
|
UY31672A1
(es)
|
2008-02-28 |
2009-09-30 |
|
"agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación"
|
|
AU2009228931B2
(en)
|
2008-03-27 |
2013-05-23 |
Janssen Pharmaceutica Nv |
Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
|
|
MX2011004340A
(es)
|
2008-10-29 |
2011-05-23 |
Gruenenthal Gmbh |
Espiroaminas sustituidas.
|
|
CN102256963B
(zh)
|
2008-12-19 |
2014-06-11 |
贝林格尔.英格海姆国际有限公司 |
作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
|
|
KR20120006544A
(ko)
|
2009-04-17 |
2012-01-18 |
얀센 파마슈티카 엔.브이. |
Ｃｃｒ2의 4-아제티디닐-1-페닐-사이클로헥산 길항제
|
|
FR2945531A1
(fr)
|
2009-05-12 |
2010-11-19 |
Sanofi Aventis |
Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
|
|
WO2011112825A2
(en)
|
2010-03-10 |
2011-09-15 |
Vanderbilt University |
Heterocyclyl-azabicyclo[3.2.1]octane analogs as selective m1 agonists and methods of making and using same
|
|
EP2560962B1
(en)
|
2010-04-22 |
2015-05-20 |
Janssen Pharmaceutica NV |
Indazole compounds useful as ketohexokinase inhibitors
|
|
WO2011137012A1
(en)
|
2010-04-27 |
2011-11-03 |
Merck Sharp & Dohme Corp. |
Prolylcarboxypeptidase inhibitors
|
|
EP2568812B1
(en)
*
|
2010-05-11 |
2016-10-26 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
EP2576520A1
(en)
|
2010-05-28 |
2013-04-10 |
GE Healthcare UK Limited |
Radiolabeled compounds and methods thereof
|
|
KR20130099970A
(ko)
|
2010-09-17 |
2013-09-06 |
어레이 바이오파마 인크. |
Gpr119 조절제로서의 피페리디닐-치환된 락탐류
|
|
US20140005165A1
(en)
*
|
2011-03-17 |
2014-01-02 |
Anilkumar G. Nair |
Substituted 3-azabicyclo[3.1.0]hexane derivatives useful as ccr2 antagonists
|
|
JP2013010719A
(ja)
*
|
2011-06-30 |
2013-01-17 |
Dainippon Sumitomo Pharma Co Ltd |
ベンズイミダゾロンおよびオキシインドール誘導体ならびにそれらの医薬用途
|
|
JP6083818B2
(ja)
|
2011-11-18 |
2017-02-22 |
ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ |
ムスカリンｍ１受容体アゴニスト
|
|
DK2897948T3
(en)
|
2012-09-18 |
2016-12-05 |
Heptares Therapeutics Ltd |
BICYCLIC AZA RELATIONS AS MUSCARIN M1 RECEPTOR AGONISTS
|
|
ES2694299T3
(es)
*
|
2013-02-07 |
2018-12-19 |
Heptares Therapeutics Limited |
Carboxilatos de piperidin-1-ilo y azepin-1-ilo como agonistas del receptor muscarínico M4
|
|
JP6199091B2
(ja)
*
|
2013-06-26 |
2017-09-20 |
旭電機化成株式会社 |
ライター点火補助具
|
|
PL3102568T3
(pl)
|
2014-02-06 |
2019-01-31 |
Heptares Therapeutics Limited |
Bicykliczne związki aza w postaci agonistów receptorów muskarynowych m1
|
|
GB201404922D0
(en)
|
2014-03-19 |
2014-04-30 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
NZ734400A
(en)
|
2015-02-13 |
2018-03-23 |
Suven Life Sciences Ltd |
Amide compounds as 5-ht4 receptor agonists
|
|
GB201504675D0
(en)
|
2015-03-19 |
2015-05-06 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201513740D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonist
|
|
GB201513743D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonists
|
|
GB201513742D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonists
|
|
GB201519352D0
(en)
|
2015-11-02 |
2015-12-16 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
US10259787B2
(en)
|
2016-10-14 |
2019-04-16 |
Heptares Therapeutics Limited |
Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
|
|
GB201709652D0
(en)
|
2017-06-16 |
2017-08-02 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
US10501483B2
(en)
|
2017-10-24 |
2019-12-10 |
Allergan, Inc. |
Enamines and diastereo-selective reduction of enamines
|
|
GB201810239D0
(en)
|
2018-06-22 |
2018-08-08 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201810245D0
(en)
|
2018-06-22 |
2018-08-08 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201819960D0
(en)
|
2018-12-07 |
2019-01-23 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201819961D0
(en)
|
2018-12-07 |
2019-01-23 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB202020191D0
(en)
|
2020-12-18 |
2021-02-03 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB202103211D0
(en)
|
2021-03-08 |
2021-04-21 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds for use in therapy
|