|
JPS56110674A
(en)
*
|
1980-01-24 |
1981-09-01 |
Janssen Pharmaceutica Nv |
Novel 11*cyclohexyl**44aryll44piperidine carboxylic acid derivative
|
|
US4369184A
(en)
|
1980-01-24 |
1983-01-18 |
Janssen Pharmaceutica N.V. |
1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
|
|
US5852029A
(en)
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
GB9300194D0
(en)
|
1993-01-06 |
1993-03-03 |
Wyeth John & Brother Ltd |
Piperazine derivatives
|
|
US5446051A
(en)
*
|
1994-05-31 |
1995-08-29 |
Eli Lilly And Company |
Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
|
|
AU701127B2
(en)
*
|
1994-10-27 |
1999-01-21 |
Merck & Co., Inc. |
Muscarine antagonists
|
|
US5889006A
(en)
|
1995-02-23 |
1999-03-30 |
Schering Corporation |
Muscarinic antagonists
|
|
IL117149A0
(en)
|
1995-02-23 |
1996-06-18 |
Schering Corp |
Muscarinic antagonists
|
|
WO1997016187A1
(en)
*
|
1995-10-31 |
1997-05-09 |
Merck & Co., Inc. |
Muscarine antagonists
|
|
US5854245A
(en)
|
1996-06-28 |
1998-12-29 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
|
DE69734774D1
(de)
*
|
1996-08-26 |
2006-01-05 |
Pfizer |
Spirocyclische dopaminrezeptor-subtyp-liganden
|
|
AU734892B2
(en)
|
1997-06-18 |
2001-06-28 |
Merck & Co., Inc. |
Alpha 1a adrenergic receptor antagonists
|
|
GB9715892D0
(en)
|
1997-07-29 |
1997-10-01 |
Zeneca Ltd |
Heterocyclic compounds
|
|
WO1999032481A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
AU2206699A
(en)
|
1997-12-23 |
1999-07-12 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
AU2095099A
(en)
|
1997-12-23 |
1999-07-12 |
Alcon Laboratories, Inc. |
Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparationand their use as muscarinic receptor (ant-)agonists
|
|
AU2307899A
(en)
|
1997-12-23 |
1999-07-12 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
CZ286152B6
(cs)
|
1998-03-13 |
2000-01-12 |
Miroslav Ing. Csc. Vlček |
Transparentní a semitransparentní difrakční prvky
|
|
KR20010043032A
(ko)
|
1998-04-28 |
2001-05-25 |
도모따께 다께시 |
1-[(1-치환-4-피페리디닐)메틸]-4-피페리딘 유도체, 그의제조방법, 그것을 함유하는의약조성물 및 이 화합물의중간체
|
|
US6387930B1
(en)
|
1999-05-04 |
2002-05-14 |
Schering Corporation |
Piperidine derivatives useful as CCR5 antagonists
|
|
WO2000066141A2
(en)
|
1999-05-04 |
2000-11-09 |
Schering Corporation |
Pegylated interferon alfa-ccr5 antagonist combination hiv therapy
|
|
PL203117B1
(pl)
|
1999-05-04 |
2009-08-31 |
Schering Corp |
Piperydynopiperydynowa pochodna użyteczna jako antagonista CCR5, zawierająca ją kompozycja farmaceutyczna i jej zastosowanie
|
|
HUP0302380A2
(hu)
*
|
1999-09-13 |
2004-03-01 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Cisztein-proteázok reverzibilis inhibitoraiként alkalmazható új spiroheterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
|
|
US6420364B1
(en)
|
1999-09-13 |
2002-07-16 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compound useful as reversible inhibitors of cysteine proteases
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
ES2223588T3
(es)
|
1999-10-13 |
2005-03-01 |
Banyu Pharmaceutical Co., Ltd. |
Derivados de imidazolidinona sustituidos.
|
|
AU2001297648A1
(en)
|
2000-11-28 |
2002-08-28 |
Eli Lilly And Company |
Substituted carboxamides as inhibitors of factor xa
|
|
US7164024B2
(en)
|
2001-04-20 |
2007-01-16 |
Banyu Pharmaceutical Co., Ltd. |
Benzimidazolone derivatives
|
|
EP1395257A1
(en)
|
2001-06-12 |
2004-03-10 |
Elan Pharmaceuticals, Inc. |
Macrocycles useful in the treatment of alzheimer's disease
|
|
WO2004089942A2
(en)
|
2001-10-02 |
2004-10-21 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
GB0128378D0
(en)
|
2001-11-27 |
2002-01-16 |
Smithkline Beecham Plc |
Novel Compounds
|
|
AU2002359875B2
(en)
|
2001-12-28 |
2009-01-08 |
Acadia Pharmaceuticals Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
US7256186B2
(en)
|
2002-02-06 |
2007-08-14 |
Schering Corporation |
Gamma secretase inhibitors
|
|
US20040171614A1
(en)
|
2002-02-06 |
2004-09-02 |
Schering-Plough Corporation |
Novel gamma secretase inhibitors
|
|
IL163923A0
(en)
|
2002-03-28 |
2005-12-18 |
Tanabe Seiyaku Co |
Benzofuran derivatives
|
|
AU2003242252A1
(en)
|
2002-06-07 |
2003-12-22 |
Kyowa Hakko Kogyo Co., Ltd. |
Bicyclic pyrimidine derivatives
|
|
EP1546098B1
(en)
|
2002-07-31 |
2008-05-28 |
Ranbaxy Laboratories Limited |
3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
|
|
PT1551835E
(pt)
|
2002-09-30 |
2007-03-30 |
Neurosearch As |
Novos derivados de 1, 4-diazabicicloalcano, sua preparação e utilização
|
|
EP1562956A4
(en)
*
|
2002-11-22 |
2007-10-10 |
Japan Tobacco Inc |
HETEROCYCLES CONTAINING FUSED BICYCLIC NITROGEN
|
|
WO2004050024A2
(en)
*
|
2002-11-27 |
2004-06-17 |
Incyte Corporation |
3-aminopyrrolidine derivatives as modulators of chemokine receptors
|
|
WO2004069828A1
(ja)
|
2003-02-04 |
2004-08-19 |
Mitsubishi Pharma Corporation |
ピペリジン化合物およびその医薬用途
|
|
JP4324791B2
(ja)
|
2003-07-17 |
2009-09-02 |
アステラス製薬株式会社 |
２−アシルアミノチアゾール誘導体又はその塩
|
|
WO2005037269A1
(ja)
*
|
2003-10-21 |
2005-04-28 |
Dainippon Sumitomo Pharma Co., Ltd. |
新規ピペリジン誘導体
|
|
EP1725235B1
(en)
|
2004-02-05 |
2009-04-15 |
Schering Corporation |
Piperidine derivatives useful as ccr3 antagonists
|
|
EP1716156A2
(en)
|
2004-02-10 |
2006-11-02 |
F.Hoffmann-La Roche Ag |
Chemokine ccr5 receptor modulators
|
|
US7488745B2
(en)
|
2004-07-16 |
2009-02-10 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US7504424B2
(en)
|
2004-07-16 |
2009-03-17 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US7786141B2
(en)
|
2004-08-19 |
2010-08-31 |
Vertex Pharmaceuticals Incorporated |
Dihydrospiroindene modulators of muscarinic receptors
|
|
JP2008521821A
(ja)
|
2004-11-29 |
2008-06-26 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ムスカリン受容体のモジュレーター
|
|
JP4774995B2
(ja)
|
2005-01-12 |
2011-09-21 |
アステラス製薬株式会社 |
アシルアミノチアゾール誘導体を有効成分とする医薬組成物
|
|
US7786308B2
(en)
|
2005-03-28 |
2010-08-31 |
Vertex Pharmaceuticals Incorporated |
Muscarinic modulators
|
|
EP2468743A1
(en)
|
2005-06-24 |
2012-06-27 |
Toyama Chemical Co., Ltd. |
Nitrogen-containing bicyclic compounds useful as antibacterial agents
|
|
CA2634456A1
(en)
|
2005-12-22 |
2007-07-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
US7772231B2
(en)
|
2005-12-29 |
2010-08-10 |
Abbott Laboratories |
Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors
|
|
US8003660B2
(en)
|
2006-02-22 |
2011-08-23 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
RU2008137583A
(ru)
|
2006-02-22 |
2010-03-27 |
Вертекс Фармасьютикалз Инкорпорейшн (Us) |
Спиропиперидины в качестве модуляторов мускариновых рецепторов
|
|
CN101553231A
(zh)
|
2006-08-15 |
2009-10-07 |
弗特克斯药品有限公司 |
毒蕈碱受体调节剂
|
|
EA200900821A1
(ru)
*
|
2006-12-22 |
2010-02-26 |
Новартис Аг |
Производные 1-аминометил-l-фенилциклогексана как ингибиторы дпп-iv (дипептидилпептидазы-iv)
|
|
WO2008117229A1
(en)
|
2007-03-23 |
2008-10-02 |
Ranbaxy Laboratories Limited |
Muscarinic receptor antagonists
|
|
US8119661B2
(en)
|
2007-09-11 |
2012-02-21 |
Astrazeneca Ab |
Piperidine derivatives and their use as muscarinic receptor modulators
|
|
US20090221567A1
(en)
|
2008-02-28 |
2009-09-03 |
Astrazeneca Ab |
Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof 177
|
|
WO2009118370A1
(en)
|
2008-03-27 |
2009-10-01 |
Janssen Pharmaceutica Nv |
Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
|
|
AU2009309988A1
(en)
|
2008-10-29 |
2010-05-06 |
Grunenthal Gmbh |
Substituted spiroamines
|
|
ES2551557T3
(es)
|
2008-12-19 |
2015-11-19 |
Boehringer Ingelheim International Gmbh |
Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC
|
|
ES2528625T3
(es)
|
2009-04-17 |
2015-02-11 |
Janssen Pharmaceutica Nv |
Antagonistas de 4-azetidinil-1-fenil-ciclohexano de CCR2
|
|
FR2945531A1
(fr)
|
2009-05-12 |
2010-11-19 |
Sanofi Aventis |
Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
|
|
US20130197027A1
(en)
|
2010-03-10 |
2013-08-01 |
Craig Lindsley |
Heterocyclyl-azabicyclo[3.2.1]octane analogs as selective m1 agonists and methods of making and using same
|
|
US8822447B2
(en)
|
2010-04-22 |
2014-09-02 |
Janssen Pharmaceutica Nv |
Indazole compounds useful as ketohexokinase inhibitors
|
|
WO2011137012A1
(en)
|
2010-04-27 |
2011-11-03 |
Merck Sharp & Dohme Corp. |
Prolylcarboxypeptidase inhibitors
|
|
WO2011143057A1
(en)
*
|
2010-05-11 |
2011-11-17 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
JP2013528180A
(ja)
|
2010-05-28 |
2013-07-08 |
ジーイー・ヘルスケア・リミテッド |
放射性標識化合物及びその製造方法
|
|
CN103221046A
(zh)
|
2010-09-17 |
2013-07-24 |
阵列生物制药公司 |
作为gpr119调节剂的哌啶基取代的内酰胺
|
|
EP2685828A4
(en)
*
|
2011-03-17 |
2014-08-13 |
Merck Sharp & Dohme |
SUBSTITUTED 3-AZABICYCLO [3,1,0-] HEXAN DERIVATIVES AS CCR2 ANTAGONISTS
|
|
JP2013010719A
(ja)
*
|
2011-06-30 |
2013-01-17 |
Dainippon Sumitomo Pharma Co Ltd |
ベンズイミダゾロンおよびオキシインドール誘導体ならびにそれらの医薬用途
|
|
ES2619829T3
(es)
|
2011-11-18 |
2017-06-27 |
Heptares Therapeutics Limited |
Agonistas del receptor muscarínico M1
|
|
EP2897948B1
(en)
|
2012-09-18 |
2016-08-31 |
Heptares Therapeutics Limited |
Bicyclic aza compounds as muscarinic m1 receptor agonists
|
|
US9593106B2
(en)
|
2013-02-07 |
2017-03-14 |
Heptares Therapeutics Limited |
Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
|
|
JP6199091B2
(ja)
*
|
2013-06-26 |
2017-09-20 |
旭電機化成株式会社 |
ライター点火補助具
|
|
RU2685230C2
(ru)
|
2014-02-06 |
2019-04-17 |
Хептарес Терапьютикс Лимитед |
Бициклические азотсодержащие соединения как агонисты М1 мускариновых рецепторов
|
|
GB201404922D0
(en)
|
2014-03-19 |
2014-04-30 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
CN107406434B
(zh)
|
2015-02-13 |
2020-09-11 |
苏文生命科学有限公司 |
作为5-ht4受体激动剂的酰胺化合物
|
|
GB201504675D0
(en)
|
2015-03-19 |
2015-05-06 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201513742D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonists
|
|
GB201513740D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonist
|
|
GB201513743D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonists
|
|
GB201519352D0
(en)
|
2015-11-02 |
2015-12-16 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
US10259787B2
(en)
|
2016-10-14 |
2019-04-16 |
Heptares Therapeutics Limited |
Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
|
|
GB201709652D0
(en)
|
2017-06-16 |
2017-08-02 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
US10501483B2
(en)
|
2017-10-24 |
2019-12-10 |
Allergan, Inc. |
Enamines and diastereo-selective reduction of enamines
|
|
GB201810239D0
(en)
|
2018-06-22 |
2018-08-08 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201810245D0
(en)
|
2018-06-22 |
2018-08-08 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201819961D0
(en)
|
2018-12-07 |
2019-01-23 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201819960D0
(en)
|
2018-12-07 |
2019-01-23 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB202020191D0
(en)
|
2020-12-18 |
2021-02-03 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB202103211D0
(en)
|
2021-03-08 |
2021-04-21 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds for use in therapy
|