|
US1726514A
(en)
|
1926-11-01 |
1929-08-27 |
Firm Ferd Liebschner & Sohn |
Picker for looms
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4434150A
(en)
|
1981-10-19 |
1984-02-28 |
Ortho Diagnostic Systems, Inc. |
Immunological reagents employing polymeric backbone possessing reactive functional groups
|
|
ATE37983T1
(de)
|
1982-04-22 |
1988-11-15 |
Ici Plc |
Mittel mit verzoegerter freigabe.
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4510245A
(en)
|
1982-11-18 |
1985-04-09 |
Chiron Corporation |
Adenovirus promoter system
|
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
WO1986005803A1
(fr)
|
1985-03-30 |
1986-10-09 |
Marc Ballivet |
Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US4968615A
(en)
|
1985-12-18 |
1990-11-06 |
Ciba-Geigy Corporation |
Deoxyribonucleic acid segment from a virus
|
|
DE3600905A1
(de)
|
1986-01-15 |
1987-07-16 |
Ant Nachrichtentech |
Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
FR2601675B1
(fr)
|
1986-07-17 |
1988-09-23 |
Rhone Poulenc Sante |
Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
US5157049A
(en)
|
1988-03-07 |
1992-10-20 |
The United States Of America As Represented By The Department Of Health & Human Services |
Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
|
|
US4942184A
(en)
|
1988-03-07 |
1990-07-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
Water soluble, antineoplastic derivatives of taxol
|
|
AU631802B2
(en)
|
1988-06-14 |
1992-12-10 |
Cetus Oncology Corporation |
Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US4960790A
(en)
|
1989-03-09 |
1990-10-02 |
University Of Kansas |
Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
|
FI915411A7
(fi)
|
1989-05-16 |
1991-11-15 |
Scripps Research Inst |
Heteromeeristen reseptorien koe-ekspressio
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
WO1991005548A1
(en)
|
1989-10-10 |
1991-05-02 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
AU642932B2
(en)
|
1989-11-06 |
1993-11-04 |
Alkermes Controlled Therapeutics, Inc. |
Protein microspheres and methods of using them
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
DE69133566T2
(de)
|
1990-01-12 |
2007-12-06 |
Amgen Fremont Inc. |
Bildung von xenogenen Antikörpern
|
|
US5124471A
(en)
|
1990-03-26 |
1992-06-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Bifunctional dtpa-type ligand
|
|
US5407683A
(en)
|
1990-06-01 |
1995-04-18 |
Research Corporation Technologies, Inc. |
Pharmaceutical solutions and emulsions containing taxol
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
EP0544809B1
(en)
|
1990-08-24 |
1998-12-16 |
Ixsys, Inc. |
Methods of synthesizing oligonucleotides with random codons
|
|
US5278324A
(en)
|
1990-08-28 |
1994-01-11 |
Virginia Tech Intellectual Properties, Inc. |
Water soluble derivatives of taxol
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
CA2098824A1
(en)
|
1990-12-20 |
1992-06-21 |
William D. Huse |
Optimization of binding proteins
|
|
US5399363A
(en)
|
1991-01-25 |
1995-03-21 |
Eastman Kodak Company |
Surface modified anticancer nanoparticles
|
|
JPH06507404A
(ja)
|
1991-05-01 |
1994-08-25 |
ヘンリー エム.ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン |
感染性の呼吸性疾患の治療方法
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
US6287792B1
(en)
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
FR2678833B1
(fr)
|
1991-07-08 |
1995-04-07 |
Rhone Poulenc Rorer Sa |
Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes.
|
|
MX9204374A
(es)
|
1991-07-25 |
1993-03-01 |
Idec Pharma Corp |
Anticuerpo recombinante y metodo para su produccion.
|
|
JP3540315B2
(ja)
|
1991-09-23 |
2004-07-07 |
メディカル リサーチ カウンシル |
キメラ抗体の製造−組合せアプローチ
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
GB9126094D0
(en)
|
1991-12-09 |
1992-02-12 |
Immune Systems Ltd |
In vitro antibody production
|
|
DE69233204T2
(de)
|
1991-12-13 |
2004-07-15 |
Xoma Corp., Berkeley |
Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
GB9201755D0
(en)
|
1992-01-28 |
1992-03-11 |
British Bio Technology |
Compounds
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
|
ATE194767T1
(de)
|
1992-03-23 |
2000-08-15 |
Univ Georgetown |
In liposomen verkapseltes taxol und verwendungsverfahren
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
GB9213077D0
(en)
|
1992-06-19 |
1992-08-05 |
Erba Carlo Spa |
Polymerbound taxol derivatives
|
|
CA2086874E
(en)
|
1992-08-03 |
2000-01-04 |
Renzo Mauro Canetta |
Methods for administration of taxol
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
FR2696458B1
(fr)
|
1992-10-05 |
1994-11-10 |
Rhone Poulenc Rorer Sa |
Procédé de préparation de dérivés du taxane.
|
|
FR2697752B1
(fr)
|
1992-11-10 |
1995-04-14 |
Rhone Poulenc Rorer Sa |
Compositions antitumorales contenant des dérivés du taxane.
|
|
FR2698543B1
(fr)
|
1992-12-02 |
1994-12-30 |
Rhone Poulenc Rorer Sa |
Nouvelles compositions à base de taxoides.
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
US5380751A
(en)
|
1992-12-04 |
1995-01-10 |
Bristol-Myers Squibb Company |
6,7-modified paclitaxels
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
WO1994016729A1
(en)
|
1993-01-28 |
1994-08-04 |
Neorx Corporation |
Targeted nitric oxide pathway or nitric oxide synthase modulation
|
|
US5750106A
(en)
|
1993-01-28 |
1998-05-12 |
Novartis Ag |
Human monoclonal antibodies to cytomegalovirus
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
WO1994018219A1
(en)
|
1993-02-02 |
1994-08-18 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
US5433364A
(en)
|
1993-02-19 |
1995-07-18 |
Dynetics Engineering Corporation |
Card package production system with burster and carrier verification apparatus
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US5415869A
(en)
|
1993-11-12 |
1995-05-16 |
The Research Foundation Of State University Of New York |
Taxol formulation
|
|
WO1995015770A1
(en)
|
1993-12-09 |
1995-06-15 |
Neorx Corporation |
Pretargeting methods and compounds
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
IT1275043B
(it)
|
1994-07-21 |
1997-07-29 |
Agerbioss Snc Di Zanin R & C |
Metodo e relativo prodotto per la difesa delle piante dai parassiti vegetali
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
EP0805678B1
(en)
|
1995-01-05 |
2003-10-29 |
THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN |
Surface-modified nanoparticles and method of making and using same
|
|
US5840929A
(en)
|
1995-04-14 |
1998-11-24 |
Bristol-Myers Squibb Company |
C4 methoxy ether derivatives of paclitaxel
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
JP4312259B2
(ja)
|
1995-04-27 |
2009-08-12 |
アムジェン フレモント インク. |
免疫したゼノマウス(XenoMouse)に由来するヒト抗体
|
|
US5705503A
(en)
|
1995-05-25 |
1998-01-06 |
Goodall; Brian Leslie |
Addition polymers of polycycloolefins containing functional substituents
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US6127977A
(en)
|
1996-11-08 |
2000-10-03 |
Cohen; Nathan |
Microstrip patch antenna with fractal structure
|
|
AU710347B2
(en)
|
1995-08-31 |
1999-09-16 |
Alkermes Controlled Therapeutics, Inc. |
Composition for sustained release of an agent
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
US6331431B1
(en)
|
1995-11-28 |
2001-12-18 |
Ixsys, Inc. |
Vacuum device and method for isolating periplasmic fraction from cells
|
|
DK0871490T3
(da)
|
1995-12-22 |
2003-07-07 |
Bristol Myers Squibb Co |
Forgrenede hydrazonlinkere
|
|
DE69721548T2
(de)
|
1996-02-09 |
2004-04-01 |
Abbott Laboratories(Bermuda)Ltd. |
HUMANE ANTIKÖRPER WELCHE AN HUMANEN TNFalpha BINDEN
|
|
WO1997030173A1
(en)
|
1996-02-15 |
1997-08-21 |
Chugai Seiyaku Kabushiki Kaisha |
Monoclonal antibody that recognizes antigens present on the surface of endothelial cell of tumor vessel
|
|
IT1282692B1
(it)
|
1996-02-27 |
1998-03-31 |
San Raffaele Centro Fond |
Citochine modificate per l'uso in terapia
|
|
ATE508733T1
(de)
|
1996-03-04 |
2011-05-15 |
Penn State Res Found |
Materialien und verfahren zur steigerung der zellulären internalisierung
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US5821263A
(en)
|
1996-08-26 |
1998-10-13 |
Bristol-Myers Squibb Company |
Sulfenamide taxane derivatives
|
|
US5773464A
(en)
|
1996-09-30 |
1998-06-30 |
Bristol-Myers Squibb Company |
C-10 epoxy taxanes
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
AU4966597A
(en)
|
1996-11-19 |
1998-06-10 |
Daiichi Pharmaceutical Co., Ltd. |
Taxol derivatives
|
|
DE69738539T2
(de)
|
1996-12-03 |
2009-03-26 |
Amgen Fremont Inc. |
Vollkommen humane Antikörper die EGFR binden
|
|
US5977386A
(en)
|
1996-12-24 |
1999-11-02 |
Bristol-Myers Squibb Company |
6-thio-substituted paclitaxels
|
|
WO1998031346A1
(en)
|
1997-01-16 |
1998-07-23 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
AU750451B2
(en)
|
1997-02-13 |
2002-07-18 |
Bone Care International, Inc. |
Targeted therapeutic delivery of vitamin D compounds
|
|
DE69832158T2
(de)
|
1997-02-25 |
2006-08-10 |
Arizona Board Of Regents, Tempe |
Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
EP1007967A2
(en)
|
1997-08-04 |
2000-06-14 |
Ixsys, Incorporated |
Methods for identifying ligand specific binding molecules
|
|
US7288665B1
(en)
|
1997-08-18 |
2007-10-30 |
Florida State University |
Process for selective derivatization of taxanes
|
|
JPH1192468A
(ja)
|
1997-09-17 |
1999-04-06 |
Yakult Honsha Co Ltd |
新規なタキサン誘導体
|
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
|
DE69729128T2
(de)
|
1997-10-08 |
2005-04-28 |
Bio Research Corporation Of Yokohama, Yokohama |
Taxoid-derivate und verfahren zu ihrer herstellung
|
|
AU9692498A
(en)
|
1997-10-10 |
1999-05-03 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Complex of biotinylated viral vector and ligand for targeted gene delivery
|
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
|
JP4334141B2
(ja)
|
1998-04-20 |
2009-09-30 |
グリカート バイオテクノロジー アクチェンゲゼルシャフト |
抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
|
|
CA2336139C
(en)
|
1998-06-24 |
2008-10-14 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
AU2472400A
(en)
|
1998-10-20 |
2000-05-08 |
City Of Hope |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
CA2369292C
(en)
|
1999-04-09 |
2010-09-21 |
Kyowa Hakko Kogyo Co. Ltd. |
Method of modulating the activity of functional immune molecules
|
|
CN1269087C
(zh)
|
1999-07-31 |
2006-08-09 |
朴奎珍 |
使用数字音频和字幕数据的学习方法和装置
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
AU2001271273A1
(en)
|
2000-05-24 |
2001-12-03 |
Ludwig Institute For Cancer Research |
Multicomponent conjugates which bind to target molecules and stimulate cell lysis
|
|
KR100787073B1
(ko)
|
2000-06-28 |
2007-12-21 |
글리코파이, 인크. |
변형된 당단백질의 제조방법
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US20040192898A1
(en)
|
2001-08-17 |
2004-09-30 |
Jia Audrey Yunhua |
Anti-abeta antibodies
|
|
ATE430580T1
(de)
|
2001-10-25 |
2009-05-15 |
Genentech Inc |
Glycoprotein-zusammensetzungen
|
|
US20040028687A1
(en)
|
2002-01-15 |
2004-02-12 |
Waelti Ernst Rudolf |
Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
|
|
AU2003234327B2
(en)
|
2002-05-01 |
2008-05-29 |
Trellis Bioscience, Inc. |
Binary or polynary targeting and uses thereof
|
|
EP1565489B1
(en)
|
2002-06-19 |
2010-11-17 |
Raven Biotechnologies, Inc. |
Internalizing antibodies specific for the RAAG10 cell surface target
|
|
CA2802205C
(en)
|
2002-07-31 |
2016-01-19 |
Seattle Genetics, Inc. |
Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
|
|
JP2006500364A
(ja)
|
2002-08-16 |
2006-01-05 |
イムノージェン インコーポレーテッド |
高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用
|
|
WO2004019993A1
(en)
|
2002-08-30 |
2004-03-11 |
Ramot At Tel Aviv University Ltd. |
Self-immolative dendrimers releasing many active moieties upon a single activating event
|
|
CA2506080A1
(en)
|
2002-11-14 |
2004-05-27 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
WO2004073656A2
(en)
|
2003-02-20 |
2004-09-02 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
CA2517145C
(en)
|
2003-03-05 |
2017-08-01 |
Halozyme, Inc. |
Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof
|
|
AU2004280333A1
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Llc |
Humanization of antibodies
|
|
NZ583292A
(en)
|
2003-11-06 |
2012-03-30 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US7906624B2
(en)
|
2004-02-20 |
2011-03-15 |
The Trustees Of The University Of Pennsylvania |
Binding peptidomimetics and uses of the same
|
|
AU2005216251B2
(en)
|
2004-02-23 |
2011-03-10 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
CA2558195C
(en)
|
2004-03-01 |
2012-11-06 |
Spirogen Limited |
11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
|
|
US20050226882A1
(en)
|
2004-04-08 |
2005-10-13 |
Awdalla Essam T |
Method and multicomponent conjugates for treating cancer
|
|
AU2005233387B2
(en)
|
2004-04-15 |
2011-05-26 |
Glycofi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
MXPA06014065A
(es)
|
2004-06-01 |
2007-01-31 |
Genentech Inc |
Conjugados de droga-anticuerpo y metodos.
|
|
WO2006042146A2
(en)
|
2004-10-07 |
2006-04-20 |
Emory University |
Multifunctional nanoparticles conjugates and their use
|
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
|
EP1695717A1
(en)
|
2005-02-23 |
2006-08-30 |
Ludwig-Maximilians-Universität |
Transport of nano-and macromolecular structures into cytoplasm and nucleus of cells
|
|
US7964089B2
(en)
|
2005-04-15 |
2011-06-21 |
Agamatrix, Inc. |
Analyte determination method and analyte meter
|
|
AU2006238686B2
(en)
|
2005-04-21 |
2011-10-06 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
PT3248613T
(pt)
|
2005-07-18 |
2022-03-16 |
Seagen Inc |
Conjugados de ligante de fármaco e beta-glucuronida
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
EP1800695A1
(en)
|
2005-12-21 |
2007-06-27 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Immuno-RNA-constructs
|
|
BRPI0707426A2
(pt)
|
2006-02-02 |
2011-05-03 |
Syntarga Bv |
composto, conjugado, uso de um composto, composição farmacêutica, processo para preparar uma composição farmacêutica, e, métodos de tratamento de um mamìfero estando em necessidade do mesmo, e de tratamento ou prevenção de um tumor em um mamìfero
|
|
EP2041175A4
(en)
|
2006-06-23 |
2011-03-16 |
Augmenta Biolog Llc |
TARGETED IMMUNOJUGATE
|
|
GB0615662D0
(en)
|
2006-08-07 |
2006-09-13 |
Affitech As |
Antibody
|
|
CA2668800A1
(en)
|
2006-11-08 |
2008-06-05 |
Macrogenics West, Inc. |
Tes7 and antibodies that bind thereto
|
|
US7598028B2
(en)
|
2006-11-28 |
2009-10-06 |
The Regents Of The University Of Michigan |
Compositions and methods for detecting and treating prostate disorders
|
|
BRPI0807160A2
(pt)
|
2007-02-02 |
2018-09-25 |
Baylor Res Institute |
vacinas baseadas no direcionamento de antígeno ao dcir expresso em células apresentadoras de antígeno
|
|
TWI422594B
(zh)
|
2007-02-02 |
2014-01-11 |
Baylor Res Inst |
經由樹狀細胞去唾液酸糖蛋白受體(dc-asgpr)接合抗原呈現細胞之藥劑
|
|
HRP20131113T1
(hr)
|
2007-02-16 |
2014-01-17 |
Merrimack Pharmaceuticals, Inc. |
Protutijela protiv erbb3 i njihova uporaba
|
|
CA2717656A1
(en)
|
2007-02-23 |
2008-08-28 |
Baylor Research Institute |
Activation of human antigen-presenting cells through clec-6
|
|
EP2132226B1
(en)
|
2007-02-23 |
2019-03-27 |
Baylor Research Institute |
Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized ldl receptor-1 (lox-1)
|
|
PT2856876T
(pt)
|
2007-03-30 |
2018-03-28 |
Memorial Sloan Kettering Cancer Center |
Expressão constitutiva de ligantes co-estimulatórios em linfócitos t adotivamente transferidos
|
|
EP2208737B1
(en)
|
2007-05-03 |
2017-07-05 |
Lysomab GmbH |
Complement factor H-derived short consensus repeat-antibody constructs
|
|
JP5557746B2
(ja)
|
2007-11-28 |
2014-07-23 |
メルサナ セラピューティックス,インク. |
生体適合性生分解性フマギリンアナログ複合体
|
|
JP5470817B2
(ja)
|
2008-03-10 |
2014-04-16 |
日産自動車株式会社 |
電池用電極およびこれを用いた電池、並びにその製造方法
|
|
CN102076355B
(zh)
|
2008-04-29 |
2014-05-07 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
BRPI0911442A2
(pt)
|
2008-04-30 |
2019-03-12 |
Immunogen, Inc. |
conjugados potentes e ligantes hidrofílicos
|
|
CN102076717B
(zh)
|
2008-04-30 |
2016-02-03 |
伊缪诺金公司 |
交联剂和它们的用途
|
|
US20090285757A1
(en)
|
2008-05-16 |
2009-11-19 |
Northeastern University |
Methods of targeting cells for diagnosis and therapy
|
|
PL3006459T3
(pl)
|
2008-08-26 |
2022-01-17 |
City Of Hope |
Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu
|
|
US20100152725A1
(en)
|
2008-12-12 |
2010-06-17 |
Angiodynamics, Inc. |
Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
|
|
WO2010080503A1
(en)
|
2008-12-19 |
2010-07-15 |
Genentech, Inc. |
Heterocyclic compounds and methods of use
|
|
AU2010229192A1
(en)
|
2009-03-06 |
2011-09-29 |
Agensys, Inc. |
Antibody drug conjugates (ADC) that bind to 24P4C12 proteins
|
|
CN104861066B
(zh)
|
2009-03-23 |
2018-05-08 |
夸克制药公司 |
治疗癌症和纤维化疾病的化合物组合物和方法
|
|
US8524214B2
(en)
|
2009-05-28 |
2013-09-03 |
Mersana Therapeutics, Inc. |
Polyal drug conjugates comprising variable rate-releasing linkers
|
|
DE102009026075A1
(de)
|
2009-06-30 |
2011-01-05 |
Röhm Gmbh |
Bohrvorrichtung
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
WO2011057216A1
(en)
|
2009-11-06 |
2011-05-12 |
The Pennsylvania State Research Foundation |
Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo
|
|
GB0919751D0
(en)
|
2009-11-11 |
2009-12-30 |
King S College Hospital Nhs Fo |
Conjugate molecule
|
|
NZ599405A
(en)
*
|
2009-11-24 |
2014-09-26 |
Medimmune Ltd |
Targeted binding agents against b7-h1
|
|
US9150656B2
(en)
|
2010-03-04 |
2015-10-06 |
Macrogenics, Inc. |
Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
|
|
PH12012501751A1
(en)
*
|
2010-03-04 |
2012-11-12 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
US20110217363A1
(en)
|
2010-03-05 |
2011-09-08 |
Bionanox |
Two-step targeted tumor therapy with prodrug encapsulated in nanocarrier
|
|
WO2011120053A1
(en)
|
2010-03-26 |
2011-09-29 |
Mersana Therapeutics, Inc. |
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
|
|
NZ602932A
(en)
|
2010-04-15 |
2014-08-29 |
Seattle Genetics Inc |
Targeted pyrrolobenzodiazapine conjugates
|
|
US20110256157A1
(en)
|
2010-04-15 |
2011-10-20 |
Spirogen Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2012027494A1
(en)
|
2010-08-24 |
2012-03-01 |
Regents Of The University Of Minnesota |
Bispecific targeting reagents
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
DE102010064282B4
(de)
|
2010-12-28 |
2012-09-06 |
GLOBALFOUNDRIES Dresden Module One Ltd. Liability Company & Co. KG |
Transistor mit eingebetteten sigma-förmigen sequenziell hergestellten Halbleiterlegierungen
|
|
LT2703486T
(lt)
*
|
2011-04-25 |
2018-05-25 |
Daiichi Sankyo Company, Limited |
Anti-b7-h3 antikūnas
|
|
TWI571466B
(zh)
|
2011-10-14 |
2017-02-21 |
艾伯維有限公司 |
用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑
|
|
CN104302669A
(zh)
|
2011-11-23 |
2015-01-21 |
伊格尼卡生物治疗公司 |
抗cd98抗体及其使用方法
|
|
BR112014013526A8
(pt)
|
2011-12-05 |
2017-06-13 |
Igenica Biotherapeutics Inc |
conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados
|
|
TW201332574A
(zh)
|
2011-12-23 |
2013-08-16 |
Mersana Therapeutics Inc |
煙曲黴素衍生物-phf共軛物之醫藥調配物
|
|
JP2015520752A
(ja)
|
2012-05-11 |
2015-07-23 |
アッヴィ・インコーポレイテッド |
Nampt阻害薬としてのピリダジンおよびピリジン誘導体
|
|
KR102144069B1
(ko)
|
2012-05-15 |
2020-08-13 |
시애틀 지네틱스, 인크. |
자가-안정화 링커 접합체
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
US20140017265A1
(en)
|
2012-07-05 |
2014-01-16 |
Mersana Therapeutics, Inc. |
Terminally Modified Polymers and Conjugates Thereof
|
|
KR102498405B1
(ko)
*
|
2012-10-11 |
2023-02-09 |
다이이찌 산쿄 가부시키가이샤 |
글리신아미드 화합물의 제조 방법
|
|
EP2928504B1
(en)
|
2012-12-10 |
2019-02-20 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
US10226535B2
(en)
|
2012-12-10 |
2019-03-12 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
|
US9872918B2
(en)
|
2012-12-12 |
2018-01-23 |
Mersana Therapeutics, Inc. |
Hydroxyl-polymer-drug-protein conjugates
|
|
WO2014093786A1
(en)
|
2012-12-14 |
2014-06-19 |
Abbvie, Inc. |
Methods for increasing the efficiency of hybridoma generation
|
|
US9089614B2
(en)
|
2012-12-21 |
2015-07-28 |
Bioalliance C.V. |
Hydrophilic self-immolative linkers and conjugates thereof
|
|
JP6136279B2
(ja)
|
2013-01-15 |
2017-05-31 |
株式会社ジェイテクト |
転がり軸受装置
|
|
SG11201505896YA
(en)
|
2013-02-20 |
2015-09-29 |
Novartis Ag |
Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
|
|
WO2014152199A1
(en)
|
2013-03-15 |
2014-09-25 |
Abbvie Inc. |
Antibody drug conjugate (adc) purification
|
|
TWI503850B
(zh)
|
2013-03-22 |
2015-10-11 |
Polytronics Technology Corp |
過電流保護元件
|
|
TWI510996B
(zh)
|
2013-10-03 |
2015-12-01 |
Acer Inc |
控制觸控面板的方法以及使用該方法的可攜式電腦
|
|
CN110845616A
(zh)
|
2014-03-21 |
2020-02-28 |
艾伯维公司 |
抗-egfr抗体及抗体药物偶联物
|
|
JP2017114763A
(ja)
|
2014-03-26 |
2017-06-29 |
第一三共株式会社 |
抗cd98抗体−薬物コンジュゲート
|
|
US20190209704A1
(en)
|
2014-10-20 |
2019-07-11 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions and methods of use
|
|
SG11201704710PA
(en)
|
2014-12-09 |
2017-07-28 |
Abbvie Inc |
Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same
|
|
AU2015360609A1
(en)
*
|
2014-12-09 |
2017-06-29 |
Abbvie Inc. |
Antibody drug conjugates with cell permeable Bcl-xL inhibitors
|
|
WO2016094517A1
(en)
|
2014-12-09 |
2016-06-16 |
Abbvie Inc. |
Bcl-xl inhibitory compounds and antibody drug conjugates including the same
|
|
JP2019521106A
(ja)
|
2016-06-08 |
2019-07-25 |
アッヴィ・インコーポレイテッド |
抗egfr抗体薬物コンジュゲート
|
|
MX2018015272A
(es)
|
2016-06-08 |
2019-08-12 |
Abbvie Inc |
Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco.
|
|
CN109563167A
(zh)
*
|
2016-06-08 |
2019-04-02 |
艾伯维公司 |
抗b7-h3抗体和抗体药物偶联物
|
|
WO2017214339A1
(en)
*
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-b7-h3 antibodies and antibody drug conjugates
|
|
WO2017214456A1
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-cd98 antibodies and antibody drug conjugates
|
|
MX2018015268A
(es)
|
2016-06-08 |
2019-08-12 |
Abbvie Inc |
Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco.
|
|
AU2017277422A1
(en)
|
2016-06-08 |
2019-01-03 |
Abbvie Inc. |
Anti-EGFR antibody drug conjugates
|
|
JP2019521975A
(ja)
|
2016-06-08 |
2019-08-08 |
アッヴィ・インコーポレイテッド |
抗egfr抗体薬物コンジュゲート
|
|
US9816280B1
(en)
|
2016-11-02 |
2017-11-14 |
Matthew Reitnauer |
Portable floor
|