JP2019527696A - プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置 - Google Patents

プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置 Download PDF

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JP2019527696A
JP2019527696A JP2019505190A JP2019505190A JP2019527696A JP 2019527696 A JP2019527696 A JP 2019527696A JP 2019505190 A JP2019505190 A JP 2019505190A JP 2019505190 A JP2019505190 A JP 2019505190A JP 2019527696 A JP2019527696 A JP 2019527696A
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car
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amino acid
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acid sequence
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サール・ギル
マルコ・ルエッラ
マイケル・クリチンスキー
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ノバルティス アーゲー
ノバルティス アーゲー
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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JP2019505190A 2016-08-01 2017-08-01 プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置 Withdrawn JP2019527696A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022003134A JP2022062040A (ja) 2016-08-01 2022-01-12 プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369589P 2016-08-01 2016-08-01
US62/369,589 2016-08-01
PCT/US2017/044909 WO2018026819A2 (en) 2016-08-01 2017-08-01 Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule

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JP2022003134A Division JP2022062040A (ja) 2016-08-01 2022-01-12 プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置

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JP2019527696A true JP2019527696A (ja) 2019-10-03
JP2019527696A5 JP2019527696A5 (https=) 2020-09-10

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JP2019505190A Withdrawn JP2019527696A (ja) 2016-08-01 2017-08-01 プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置
JP2022003134A Pending JP2022062040A (ja) 2016-08-01 2022-01-12 プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置

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US (1) US20190161542A1 (https=)
EP (1) EP3490590A2 (https=)
JP (2) JP2019527696A (https=)
KR (1) KR20190036551A (https=)
CN (1) CN110267677A (https=)
AU (1) AU2017306267A1 (https=)
BR (1) BR112019002035A2 (https=)
CA (1) CA3032581A1 (https=)
IL (1) IL264588A (https=)
MX (1) MX2019001469A (https=)
RU (1) RU2019105693A (https=)
SG (1) SG11201900885VA (https=)
WO (1) WO2018026819A2 (https=)

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WO2013126729A1 (en) * 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Use of the cd2 signaling domain in second-generation chimeric antigen receptors
WO2014124280A1 (en) 2013-02-08 2014-08-14 Institute For Myeloma & Bone Cancer Research Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma
US9573988B2 (en) 2013-02-20 2017-02-21 Novartis Ag Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
JP6647868B2 (ja) 2013-02-20 2020-02-14 ノバルティス アーゲー ヒト化抗ＥＧＦＲｖＩＩＩキメラ抗原受容体を用いたがんの処置
WO2014145252A2 (en) 2013-03-15 2014-09-18 Milone Michael C Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
WO2015112626A1 (en) 2014-01-21 2015-07-30 June Carl H Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
SG10201913782UA (en) 2014-07-21 2020-03-30 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
TWI719942B (zh) 2014-07-21 2021-03-01 瑞士商諾華公司 使用ｃｄ３３嵌合抗原受體治療癌症
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
MX2017002205A (es) 2014-08-19 2017-08-21 Novartis Ag Receptor quimerico de antigeno (car) anti-cd123 para uso en el tratamiento de cancer.
JP6839074B2 (ja) 2014-09-17 2021-03-03 ノバルティス アーゲー 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング
KR20170068504A (ko) 2014-10-08 2017-06-19 노파르티스 아게 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
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