JP2019524674A5 - - Google Patents
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- JP2019524674A5 JP2019524674A5 JP2018568296A JP2018568296A JP2019524674A5 JP 2019524674 A5 JP2019524674 A5 JP 2019524674A5 JP 2018568296 A JP2018568296 A JP 2018568296A JP 2018568296 A JP2018568296 A JP 2018568296A JP 2019524674 A5 JP2019524674 A5 JP 2019524674A5
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- 0 CC(*)CCCNC Chemical compound CC(*)CCCNC 0.000 description 5
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022073976A JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357031P | 2016-06-30 | 2016-06-30 | |
| US62/357,031 | 2016-06-30 | ||
| PCT/US2017/040401 WO2018006031A1 (en) | 2016-06-30 | 2017-06-30 | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022073976A Division JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524674A JP2019524674A (ja) | 2019-09-05 |
| JP2019524674A5 true JP2019524674A5 (https=) | 2020-08-06 |
| JP7068204B2 JP7068204B2 (ja) | 2022-05-16 |
Family
ID=60786711
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568296A Active JP7068204B2 (ja) | 2016-06-30 | 2017-06-30 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2022073976A Active JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A Pending JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022073976A Active JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A Pending JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11136335B2 (https=) |
| EP (1) | EP3478691A4 (https=) |
| JP (3) | JP7068204B2 (https=) |
| KR (1) | KR102404629B1 (https=) |
| CN (2) | CN114805322B (https=) |
| IL (2) | IL263845B (https=) |
| MX (1) | MX390072B (https=) |
| SG (1) | SG11201811671XA (https=) |
| WO (1) | WO2018006031A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| BR112016009452B1 (pt) | 2013-11-04 | 2022-06-07 | Eisai R&D Management Co., Ltd | Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários |
| EP3077399B1 (en) | 2013-12-06 | 2019-02-20 | Eisai R&D Management Co., Ltd. | Methods useful in the synthesis of halichondrin b analogs |
| MX392296B (es) | 2015-05-07 | 2025-03-24 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| CN108601760A (zh) | 2016-02-12 | 2018-09-28 | 卫材R&D管理有限公司 | 艾日布林的合成中的中间体及相关的合成方法 |
| IL275729B2 (en) | 2018-01-03 | 2023-09-01 | Eisai R&D Man Co Ltd | Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs |
| WO2019166019A1 (zh) * | 2018-03-02 | 2019-09-06 | 北京天一绿甫医药科技有限公司 | 吡喃稠环类化合物、其制备方法和用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (ru) | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | 1(Фурил-2,)-2-(2-,, формилфурил-5,, ) этилен или его метильное производное как промежуточный продукт дл синтеза фуран-2,5-дикарбоновой кислоты и способ его получени |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (https=) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| AU4255697A (en) | 1996-09-06 | 1998-03-26 | Eli Lilly And Company | Catalytic selective sulfonylation process |
| US6870058B2 (en) | 1996-12-03 | 2005-03-22 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| JP4454151B2 (ja) | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| DE10106647A1 (de) | 2001-02-12 | 2002-08-22 | Univ Hannover | Ratjadon-Derivate zum Hemmen des Zellwachstums |
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| US20060154312A1 (en) | 2004-12-09 | 2006-07-13 | Sergei Agoulnik | Tubulin isotype screening in cancer therapy using halichondrin B analogs |
| JP2009510005A (ja) | 2005-09-26 | 2009-03-12 | シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト | 分子内プリンス反応および該反応に適する触媒 |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| US8119839B2 (en) | 2007-07-20 | 2012-02-21 | Yamada Apiculture Center, Inc. | Carboxylic acid and antidepressant composition containing the same as active ingredient |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| CN101910180A (zh) | 2007-11-16 | 2010-12-08 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的新颖中间体和用于该中间体的新颖脱磺酰化反应 |
| CA2720632C (en) | 2008-04-04 | 2016-12-20 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| JP5371091B2 (ja) | 2009-01-23 | 2013-12-18 | 三菱レイヨン株式会社 | モノスルホン酸エステルの製造方法 |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| WO2013078559A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| EP3016957A4 (en) | 2013-07-03 | 2016-11-30 | Alphora Res Inc | SYNTHETIC METHOD FOR THE PRODUCTION OF CYCLIC C1-KETO ANALOGUE OF HALICHONDRIN B AND USEFUL INTERMEDIATE PRODUCTS, INCLUDING INTERMEDIATE PRODUCTS WITH -SO2- (P-TOLYL) GROUPS |
| BR112016009452B1 (pt) | 2013-11-04 | 2022-06-07 | Eisai R&D Management Co., Ltd | Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários |
| EP3077399B1 (en) | 2013-12-06 | 2019-02-20 | Eisai R&D Management Co., Ltd. | Methods useful in the synthesis of halichondrin b analogs |
| US10208058B2 (en) | 2014-09-09 | 2019-02-19 | Cipla Limited | Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof |
| MX392296B (es) * | 2015-05-07 | 2025-03-24 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| CN108601760A (zh) | 2016-02-12 | 2018-09-28 | 卫材R&D管理有限公司 | 艾日布林的合成中的中间体及相关的合成方法 |
| WO2018217894A1 (en) | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| IL275729B2 (en) | 2018-01-03 | 2023-09-01 | Eisai R&D Man Co Ltd | Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs |
-
2017
- 2017-06-30 KR KR1020197002930A patent/KR102404629B1/ko active Active
- 2017-06-30 SG SG11201811671XA patent/SG11201811671XA/en unknown
- 2017-06-30 MX MX2018016329A patent/MX390072B/es unknown
- 2017-06-30 CN CN202210653392.6A patent/CN114805322B/zh active Active
- 2017-06-30 CN CN201780052964.2A patent/CN109641917B/zh active Active
- 2017-06-30 US US16/313,196 patent/US11136335B2/en active Active
- 2017-06-30 JP JP2018568296A patent/JP7068204B2/ja active Active
- 2017-06-30 WO PCT/US2017/040401 patent/WO2018006031A1/en not_active Ceased
- 2017-06-30 EP EP17821400.3A patent/EP3478691A4/en not_active Withdrawn
-
2018
- 2018-12-19 IL IL263845A patent/IL263845B/en unknown
-
2021
- 2021-11-28 IL IL288460A patent/IL288460B2/en unknown
-
2022
- 2022-04-28 JP JP2022073976A patent/JP7440563B2/ja active Active
-
2024
- 2024-02-15 JP JP2024020885A patent/JP2024056892A/ja active Pending
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