JP2019524674A5 - - Google Patents
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- Publication number
- JP2019524674A5 JP2019524674A5 JP2018568296A JP2018568296A JP2019524674A5 JP 2019524674 A5 JP2019524674 A5 JP 2019524674A5 JP 2018568296 A JP2018568296 A JP 2018568296A JP 2018568296 A JP2018568296 A JP 2018568296A JP 2019524674 A5 JP2019524674 A5 JP 2019524674A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- protecting group
- hydroxyl protecting
- alkyl
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 132
- 125000000217 alkyl group Chemical group 0.000 claims 67
- 125000000547 substituted alkyl group Chemical group 0.000 claims 64
- 125000004429 atom Chemical group 0.000 claims 62
- 150000001875 compounds Chemical class 0.000 claims 42
- 229910052799 carbon Inorganic materials 0.000 claims 25
- 125000004432 carbon atom Chemical group C* 0.000 claims 25
- 125000003107 substituted aryl group Chemical group 0.000 claims 22
- 125000003710 aryl alkyl group Chemical group 0.000 claims 20
- 125000004043 oxo group Chemical group O=* 0.000 claims 20
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 16
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 16
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical class C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 8
- 239000005977 Ethylene Substances 0.000 claims 8
- 102100034184 Macrophage scavenger receptor types I and II Human genes 0.000 claims 8
- 101710134306 Macrophage scavenger receptor types I and II Proteins 0.000 claims 8
- 125000002877 alkyl aryl group Chemical group 0.000 claims 8
- 125000001118 alkylidene group Chemical group 0.000 claims 8
- 125000004103 aminoalkyl group Chemical group 0.000 claims 8
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 150000005676 cyclic carbonates Chemical class 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000003106 haloaryl group Chemical group 0.000 claims 8
- 125000002034 haloarylalkyl group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 150000002430 hydrocarbons Chemical group 0.000 claims 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000005027 hydroxyaryl group Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 8
- 239000002841 Lewis acid Substances 0.000 claims 7
- 125000002947 alkylene group Chemical group 0.000 claims 7
- 150000007517 lewis acids Chemical class 0.000 claims 7
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 7
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 150000002009 diols Chemical class 0.000 claims 4
- 239000000543 intermediate Substances 0.000 claims 4
- 229930195695 Halichondrin Natural products 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002577 pseudohalo group Chemical group 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 229910015900 BF3 Inorganic materials 0.000 claims 1
- 125000000746 allylic group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 0 CC(*)CCCNC Chemical compound CC(*)CCCNC 0.000 description 5
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022073976A JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357031P | 2016-06-30 | 2016-06-30 | |
| US62/357,031 | 2016-06-30 | ||
| PCT/US2017/040401 WO2018006031A1 (en) | 2016-06-30 | 2017-06-30 | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022073976A Division JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524674A JP2019524674A (ja) | 2019-09-05 |
| JP2019524674A5 true JP2019524674A5 (cg-RX-API-DMAC7.html) | 2020-08-06 |
| JP7068204B2 JP7068204B2 (ja) | 2022-05-16 |
Family
ID=60786711
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568296A Active JP7068204B2 (ja) | 2016-06-30 | 2017-06-30 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2022073976A Active JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A Pending JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022073976A Active JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A Pending JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11136335B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3478691A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP7068204B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102404629B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN109641917B (cg-RX-API-DMAC7.html) |
| IL (2) | IL263845B (cg-RX-API-DMAC7.html) |
| MX (1) | MX390072B (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201811671XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018006031A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| JP5735277B2 (ja) | 2007-10-03 | 2015-06-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体の合成のための中間体および方法 |
| SG182612A1 (en) | 2010-01-26 | 2012-08-30 | Eisai R&D Man Co Ltd | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| JP6625533B2 (ja) | 2013-11-04 | 2019-12-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂの類縁体の合成において有用な大環化反応および中間体 |
| MX376869B (es) | 2013-12-06 | 2025-03-07 | Eisai R&D Man Co Ltd | Metodos utiles en la sintesis de analogos de halicondrina b. |
| US10308661B2 (en) | 2015-05-07 | 2019-06-04 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX377663B (es) | 2016-02-12 | 2025-03-11 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| CN118894868A (zh) | 2018-01-03 | 2024-11-05 | 卫材R&D管理有限公司 | 可用于合成软海绵素大环内酯及其类似物的普林斯反应和化合物 |
| EP3608323B1 (en) * | 2018-03-02 | 2021-11-03 | Beijing Tienyi Lufu Pharmatech Co. Ltd. | Pyran fused ring compound, preparation method therefor and use thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (ru) | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | 1(Фурил-2,)-2-(2-,, формилфурил-5,, ) этилен или его метильное производное как промежуточный продукт дл синтеза фуран-2,5-дикарбоновой кислоты и способ его получени |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (cg-RX-API-DMAC7.html) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| CA2264298A1 (en) | 1996-09-06 | 1998-03-12 | Eli Lilly And Company | Catalytic selective sulfonylation process |
| US6870058B2 (en) | 1996-12-03 | 2005-03-22 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
| EP2272839B1 (en) | 1998-06-17 | 2012-08-22 | Eisai R&D Management Co., Ltd. | Intermediate compounds for the preparation of halichondrin analogs |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| DE10106647A1 (de) | 2001-02-12 | 2002-08-22 | Univ Hannover | Ratjadon-Derivate zum Hemmen des Zellwachstums |
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| WO2006076100A2 (en) | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| JP2009510005A (ja) | 2005-09-26 | 2009-03-12 | シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト | 分子内プリンス反応および該反応に適する触媒 |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| JPWO2009014105A1 (ja) | 2007-07-20 | 2010-10-07 | 株式会社山田養蜂場本社 | 新規カルボン酸およびそれを有効成分とする抗うつ用組成物 |
| JP5735277B2 (ja) | 2007-10-03 | 2015-06-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体の合成のための中間体および方法 |
| CN101910180A (zh) | 2007-11-16 | 2010-12-08 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的新颖中间体和用于该中间体的新颖脱磺酰化反应 |
| US8598373B2 (en) | 2008-04-04 | 2013-12-03 | Eisai R&D Management Co., Ltd. | Halichondrin B analogs |
| JP5371091B2 (ja) | 2009-01-23 | 2013-12-18 | 三菱レイヨン株式会社 | モノスルホン酸エステルの製造方法 |
| SG182612A1 (en) | 2010-01-26 | 2012-08-30 | Eisai R&D Man Co Ltd | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| AU2012344697A1 (en) | 2011-11-30 | 2014-07-10 | Alphora Research Inc. | Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene |
| AU2013239290B2 (en) | 2012-03-30 | 2017-08-03 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein |
| CN105431438A (zh) | 2013-07-03 | 2016-03-23 | 阿方拉研究股份有限公司 | 用于制备软海绵素b 的大环c1-酮基类似物的合成方法和可用于其中的中间体、包括含有-so2-(对甲苯基)基团的中间体 |
| JP6625533B2 (ja) | 2013-11-04 | 2019-12-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂの類縁体の合成において有用な大環化反応および中間体 |
| MX376869B (es) | 2013-12-06 | 2025-03-07 | Eisai R&D Man Co Ltd | Metodos utiles en la sintesis de analogos de halicondrina b. |
| US10208058B2 (en) | 2014-09-09 | 2019-02-19 | Cipla Limited | Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof |
| US10308661B2 (en) | 2015-05-07 | 2019-06-04 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX377663B (es) | 2016-02-12 | 2025-03-11 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| WO2018217894A1 (en) | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| CN118894868A (zh) | 2018-01-03 | 2024-11-05 | 卫材R&D管理有限公司 | 可用于合成软海绵素大环内酯及其类似物的普林斯反应和化合物 |
-
2017
- 2017-06-30 CN CN201780052964.2A patent/CN109641917B/zh active Active
- 2017-06-30 WO PCT/US2017/040401 patent/WO2018006031A1/en not_active Ceased
- 2017-06-30 CN CN202210653392.6A patent/CN114805322B/zh active Active
- 2017-06-30 EP EP17821400.3A patent/EP3478691A4/en not_active Withdrawn
- 2017-06-30 MX MX2018016329A patent/MX390072B/es unknown
- 2017-06-30 US US16/313,196 patent/US11136335B2/en active Active
- 2017-06-30 SG SG11201811671XA patent/SG11201811671XA/en unknown
- 2017-06-30 KR KR1020197002930A patent/KR102404629B1/ko active Active
- 2017-06-30 JP JP2018568296A patent/JP7068204B2/ja active Active
-
2018
- 2018-12-19 IL IL263845A patent/IL263845B/en unknown
-
2021
- 2021-11-28 IL IL288460A patent/IL288460B2/en unknown
-
2022
- 2022-04-28 JP JP2022073976A patent/JP7440563B2/ja active Active
-
2024
- 2024-02-15 JP JP2024020885A patent/JP2024056892A/ja active Pending
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