|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
DE2010115A1
(de)
|
1970-03-04 |
1971-09-16 |
Farbenfabriken Bayer Ag, 5090 Leverkusen |
Verfahren zur Herstellung von Mikrogranulaten
|
|
US4389330A
(en)
|
1980-10-06 |
1983-06-21 |
Stolle Research And Development Corporation |
Microencapsulation process
|
|
US4675189A
(en)
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
|
US4474572A
(en)
|
1981-09-29 |
1984-10-02 |
Syntex (U.S.A.) Inc. |
Implanting device and implant magazine
|
|
US4530840A
(en)
|
1982-07-29 |
1985-07-23 |
The Stolle Research And Development Corporation |
Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
|
|
US4758435A
(en)
|
1986-08-11 |
1988-07-19 |
American Cyanamid Company |
Estradiol implant composition and method for preparation
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US4900552A
(en)
|
1988-03-30 |
1990-02-13 |
Watson Laboratories, Inc. |
Mucoadhesive buccal dosage forms
|
|
AU6952391A
(en)
|
1989-11-29 |
1991-06-26 |
Brigham And Women's Hospital |
(ala il-8)77 as a leukocyte adhesion inhibitor
|
|
US5714167A
(en)
|
1992-06-15 |
1998-02-03 |
Emisphere Technologies, Inc. |
Active agent transport systems
|
|
US6221367B1
(en)
|
1992-06-15 |
2001-04-24 |
Emisphere Technologies, Inc. |
Active agent transport systems
|
|
US5122377A
(en)
*
|
1990-11-19 |
1992-06-16 |
A.H. Robins, Company, Incorporated |
Oral delivery system for veterinary drugs
|
|
EP0551626A1
(en)
|
1991-12-19 |
1993-07-21 |
LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. |
Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
US5981719A
(en)
|
1993-03-09 |
1999-11-09 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
|
CA2157793C
(en)
|
1993-03-09 |
1999-07-13 |
James E. Woiszwillo |
Macromolecular microparticles and methods of production
|
|
US6090925A
(en)
|
1993-03-09 |
2000-07-18 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
|
US5421818A
(en)
|
1993-10-18 |
1995-06-06 |
Inner Ear Medical Delivery Systems, Inc. |
Multi-functional inner ear treatment and diagnostic system
|
|
TW438601B
(en)
|
1994-05-18 |
2001-06-07 |
Janssen Pharmaceutica Nv |
New mucoadhesive emulsion compositions and a process for the preparation thereof
|
|
EP0766564A4
(en)
|
1994-06-24 |
1998-09-23 |
Immunex Corp |
SLOW RELEASE POLYPEPTIDES COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL CONDITIONS
|
|
GB9505032D0
(en)
|
1995-03-13 |
1995-05-03 |
Westminster Lab Ltd |
Improvements in or relating to organic compositions
|
|
IL112834A
(en)
|
1995-03-01 |
2000-12-06 |
Yeda Res & Dev |
Pharmaceutical compositions for controlled release of soluble receptors
|
|
FR2742357B1
(fr)
|
1995-12-19 |
1998-01-09 |
Rhone Poulenc Rorer Sa |
Nanoparticules stabilisees et filtrables dans des conditions steriles
|
|
US6379911B2
(en)
|
1996-02-23 |
2002-04-30 |
Albert Einstein College Of Medicine Of Yeshiva University |
Enzyme detection/assay method and substrates
|
|
EP0938499A1
(en)
|
1996-07-19 |
1999-09-01 |
Amgen Inc. |
Analogs of cationic proteins
|
|
US5945126A
(en)
|
1997-02-13 |
1999-08-31 |
Oakwood Laboratories L.L.C. |
Continuous microsphere process
|
|
US6045528A
(en)
|
1997-06-13 |
2000-04-04 |
Intraear, Inc. |
Inner ear fluid transfer and diagnostic system
|
|
US5939421A
(en)
|
1997-07-01 |
1999-08-17 |
Signal Pharmaceuticals, Inc. |
Quinazoline analogs and related compounds and methods for treating inflammatory conditions
|
|
ATE314092T1
(de)
|
1997-09-26 |
2006-01-15 |
Noven Pharma |
Biologische kleber und verfahren zur topischen verabreichung von wirkstoffen
|
|
US5985848A
(en)
|
1997-10-14 |
1999-11-16 |
Albert Einstein College Of Medicine Of Yeshiva University |
Inhibitors of nucleoside metabolism
|
|
GB9812426D0
(en)
|
1998-06-10 |
1998-08-05 |
Reckitt & Colmann Prod Ltd |
Improvements in or relating to organic compositions
|
|
US20020009478A1
(en)
|
1998-08-24 |
2002-01-24 |
Douglas Joseph Dobrozsi |
Oral liquid mucoadhesive compositions
|
|
US6319513B1
(en)
|
1998-08-24 |
2001-11-20 |
The Procter & Gamble Company |
Oral liquid mucoadhesive compounds
|
|
US6270802B1
(en)
|
1998-10-28 |
2001-08-07 |
Oakwood Laboratories L.L.C. |
Method and apparatus for formulating microspheres and microcapsules
|
|
JP4430247B2
(ja)
|
1999-04-08 |
2010-03-10 |
インダストリアル リサーチ リミテッド |
ヌクレオシド代謝インヒビターの製造方法
|
|
PT1180159E
(pt)
|
1999-05-28 |
2008-12-05 |
Targeted Genetics Corp |
Métodos e composições para abaixamento do nível de factor de necrose tumoral (tnf) nos distúrbios associados a tnf
|
|
SI1194425T1
(sl)
|
1999-06-23 |
2005-12-31 |
Sanofi Aventis Deutschland |
Substituirani benzimidazoli
|
|
US6458387B1
(en)
|
1999-10-18 |
2002-10-01 |
Epic Therapeutics, Inc. |
Sustained release microspheres
|
|
DE19951360A1
(de)
|
1999-10-26 |
2001-05-03 |
Aventis Pharma Gmbh |
Substituierte Indole
|
|
JP4879433B2
(ja)
|
2000-01-13 |
2012-02-22 |
エミスフェアー・テクノロジーズ・インク |
活性剤を送達するための化合物および組成物
|
|
GB0003154D0
(en)
|
2000-02-12 |
2000-04-05 |
Astrazeneca Uk Ltd |
Novel compounds
|
|
WO2001068648A1
(en)
|
2000-03-15 |
2001-09-20 |
Aventis Pharma Deutschland Gmbh |
Substituted beta-carbolines with ikb-kinase inhibiting activity
|
|
MXPA02012602A
(es)
|
2000-06-22 |
2003-05-14 |
Genentech Inc |
Anticuerpos monoclonales agonistas anti-trk-c.
|
|
US20020013331A1
(en)
|
2000-06-26 |
2002-01-31 |
Williams Robert O. |
Methods and compositions for treating pain of the mucous membrane
|
|
UA81743C2
(uk)
|
2000-08-07 |
2008-02-11 |
Центокор, Инк. |
МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
|
|
WO2002018371A1
(en)
|
2000-08-29 |
2002-03-07 |
Industrial Research Limited |
Nucleoside metabolism inhibitors
|
|
JP4272338B2
(ja)
|
2000-09-22 |
2009-06-03 |
バイエル アクチェンゲゼルシャフト |
ピリジン誘導体
|
|
KR20030033076A
(ko)
*
|
2000-09-25 |
2003-04-26 |
바이엘 코포레이션 |
고막이 파열된 동물을 치료하기 위한 귀용 미생물 배합물
|
|
WO2002030423A1
(en)
|
2000-10-12 |
2002-04-18 |
Smithkline Beecham Corporation |
NF-λB INHIBITORS
|
|
AU2002211663A1
(en)
|
2000-10-12 |
2002-04-22 |
Smith Kline Beecham Corporation |
Nf-$g(k)b inhibitors
|
|
KR20030064773A
(ko)
|
2000-10-26 |
2003-08-02 |
툴라릭, 인코포레이티드 |
항염증제
|
|
JP2002193938A
(ja)
|
2000-12-01 |
2002-07-10 |
Bayer Ag |
４−アリールピリジン誘導体
|
|
US7122544B2
(en)
|
2000-12-06 |
2006-10-17 |
Signal Pharmaceuticals, Llc |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
|
|
CA2433840C
(en)
|
2001-01-04 |
2010-05-04 |
Albert Einstein College Of Medicine Of Yeshiva University |
Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases, and uses thereof
|
|
SE0100158D0
(sv)
|
2001-01-19 |
2001-01-19 |
Synphora Ab |
Novel method and composition for local treatment of Meniere´s disease and tinnitus
|
|
EP1363993A4
(en)
|
2001-02-01 |
2008-11-12 |
Bristol Myers Squibb Co |
METHOD FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES USING I KAPPA B KINASE (IKK)
|
|
FR2823441B1
(fr)
*
|
2001-04-12 |
2004-09-10 |
Thea Lab |
Composition pharmaceutique a base de macrolides pour application locale en ophtalmologie et son procede de preparation
|
|
US20030045515A1
(en)
|
2001-05-24 |
2003-03-06 |
Lise Binderup |
Combination medicament for treatment of neoplastic diseases
|
|
WO2002094265A1
(en)
|
2001-05-24 |
2002-11-28 |
Leo Pharma A/S |
A method of modulating nf-$g(k)b activity
|
|
SE0102617D0
(sv)
|
2001-07-25 |
2001-07-25 |
Astrazeneca Ab |
Novel compounds
|
|
EP1427706B1
(en)
|
2001-09-19 |
2007-05-30 |
Pharmacia Corporation |
Substituted pyrazolo compounds for the treatment of inflammation
|
|
US6956052B2
(en)
|
2001-09-19 |
2005-10-18 |
Pharmacia Corporation |
Substituted pyrazolyl compounds for the treatment of inflammation
|
|
JP2005506334A
(ja)
|
2001-10-04 |
2005-03-03 |
スミスクライン・ビーチャム・コーポレイション |
ＮＦ−κＢ阻害剤
|
|
CN1310937C
(zh)
|
2001-11-21 |
2007-04-18 |
犹太大学阿尔伯特爱因斯坦医学院 |
Sir2产物及活性
|
|
PL373484A1
(en)
|
2001-12-10 |
2005-09-05 |
Amgen Inc. |
Vanilloid receptor ligands and their use in treatments
|
|
PL371587A1
(en)
|
2002-01-17 |
2005-06-27 |
Neurogen Corporation |
Substituted quinazolin-4-ylamine analogues as modulators of capsaicin receptors
|
|
JP2003277383A
(ja)
|
2002-03-14 |
2003-10-02 |
Bayer Ag |
光学活性ピリジン誘導体およびそれを含む医薬
|
|
US7098334B2
(en)
|
2002-03-25 |
2006-08-29 |
Industrial Research Limited |
4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
|
|
EP1542692B1
(en)
|
2002-05-22 |
2011-01-05 |
Amgen Inc. |
Aminopyrimidine derivatives for use as vanilloid receptor ligands for the treatment of pain
|
|
US7022680B2
(en)
|
2002-05-30 |
2006-04-04 |
Albert Einstein College Of Medicine Of Yeshiva University |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
|
|
FR2841243B1
(fr)
*
|
2002-06-19 |
2004-08-20 |
Servier Lab |
Nouveaux derives de 3-(4-oxo-4h-chromen-2yl)-(1h)-quinolein- 4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
JP4555082B2
(ja)
|
2002-08-08 |
2010-09-29 |
アムジエン・インコーポレーテツド |
バニロイド受容体リガンドおよびそれの治療での使用
|
|
US7220431B2
(en)
*
|
2002-11-27 |
2007-05-22 |
Regents Of The University Of Minnesota |
Methods and compositions for applying pharmacologic agents to the ear
|
|
US7582635B2
(en)
|
2002-12-24 |
2009-09-01 |
Purdue Pharma, L.P. |
Therapeutic agents useful for treating pain
|
|
US20040185047A1
(en)
|
2003-03-21 |
2004-09-23 |
Jill Giles-Komar |
Anti- TNF antibodies, compositions, methods and uses
|
|
ES2338119T3
(es)
|
2003-04-21 |
2010-05-04 |
Eli Lilly And Company |
Benzopiranos sustituidos como agonistas selectivos del receptor-beta de estrogeno.
|
|
US20040247575A1
(en)
|
2003-06-03 |
2004-12-09 |
Caplice Noel M. |
Smooth muscle progenitor cells
|
|
US7329664B2
(en)
|
2003-07-16 |
2008-02-12 |
Neurogen Corporation |
Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
|
|
HRP20090404T1
(hr)
|
2003-07-24 |
2009-08-31 |
Euro-Celtique S.A. |
Spojevi piperidina i farmaceutski sastavi koji ih sadržavaju
|
|
MXPA06003615A
(es)
|
2003-09-30 |
2006-06-05 |
Amgen Inc |
Ligandos del receptor vanilloide y su uso en tratamientos.
|
|
AU2004308482A1
(en)
|
2003-12-23 |
2005-07-14 |
Rinat Neuroscience Corp. |
Agonist anti-trkC antibodies and methods using same
|
|
US7312330B2
(en)
|
2003-12-24 |
2007-12-25 |
Renovis, Inc. |
Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
|
|
TW200530235A
(en)
|
2003-12-24 |
2005-09-16 |
Renovis Inc |
Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
|
|
US20060063802A1
(en)
*
|
2004-03-29 |
2006-03-23 |
Matthieu Guitton |
Methods for the treatment of tinnitus induced by cochlear excitotoxicity
|
|
US8268866B2
(en)
|
2004-03-29 |
2012-09-18 |
Matthieu Guitton |
Methods for the treatment of tinnitus induced by cochlear excitotoxicity
|
|
CA2566213A1
(en)
|
2004-05-12 |
2005-12-11 |
Aventis Pharmaceuticals Inc. |
Substantially pure 2-{[2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carbonyl]-amino}-3-(phenylpyridin-2-yl-amino)-propionic acid as an ikb kinase inhibitor
|
|
CA2568028A1
(en)
|
2004-05-24 |
2005-12-08 |
Auris Medical, Llc. |
Combined otic aspirator and medication dispenser
|
|
US8498681B2
(en)
|
2004-10-05 |
2013-07-30 |
Tomophase Corporation |
Cross-sectional mapping of spectral absorbance features
|
|
US20060105967A1
(en)
|
2004-11-18 |
2006-05-18 |
Advanced Gene Technology, Corp. |
Flavone derivatives as TNFalpha inhibitors or antagonists
|
|
AU2005313601B2
(en)
*
|
2004-12-09 |
2012-05-24 |
Bayer Intellectual Property Gmbh |
Stabilisation of glucocorticoid esters with acids
|
|
DE102005055385A1
(de)
*
|
2004-12-09 |
2006-06-14 |
Bayer Healthcare Ag |
Arzneimittel zur hygienischen Applikation im Ohr
|
|
CN101107014B
(zh)
*
|
2004-12-09 |
2011-01-26 |
拜尔动物保健有限责任公司 |
用酸稳定糖皮质激素酯
|
|
AR053114A1
(es)
|
2005-01-12 |
2007-04-25 |
Aventis Pharma Inc |
Sal monopotasica del acido 2-{[2-(-2-metilamino-pirimidin-4-il)-1h-indol-5-carbonil]-amino}-3-(fenilpiridin-2-il-amino)-propionico,inhibidora de ikk-2 quinasa
|
|
AU2006204699B2
(en)
|
2005-01-13 |
2012-04-26 |
Sirtris Pharmaceuticals, Inc. |
Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
|
|
CN101103028A
(zh)
|
2005-01-14 |
2008-01-09 |
神经能质公司 |
经杂芳基取代的喹啉-4-基氨类似物
|
|
CA2594998A1
(en)
|
2005-01-25 |
2006-08-03 |
Neurogen Corporation |
Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues
|
|
US20060221197A1
(en)
|
2005-03-30 |
2006-10-05 |
Jung Edward K |
Image transformation estimator of an imaging device
|
|
US7576099B2
(en)
|
2005-02-28 |
2009-08-18 |
Renovis, Inc. |
Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
|
|
US20060205789A1
(en)
*
|
2005-03-04 |
2006-09-14 |
Neurosystec Corporation |
Gacyclidine formulations
|
|
WO2006095263A1
(en)
|
2005-03-10 |
2006-09-14 |
Pfizer Japan Inc. |
Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds
|
|
JP2008533154A
(ja)
|
2005-03-14 |
2008-08-21 |
レノビス， インコーポレイテッド |
イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物およびそれらを使用する方法
|
|
BRPI0608436A2
(pt)
|
2005-03-17 |
2009-12-29 |
Pfizer |
derivados de n-(n-sulfonilaminometil) ciclopropanocarboxamida utilizáveis para o tratamento de dor
|
|
EP1893583B1
(en)
|
2005-05-31 |
2012-04-04 |
Pfizer Inc. |
Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists
|
|
US7785834B2
(en)
|
2005-11-10 |
2010-08-31 |
Ercole Biotech, Inc. |
Soluble TNF receptors and their use in treatment of disease
|
|
US20070219272A1
(en)
|
2006-02-06 |
2007-09-20 |
Johan Stjernschantz |
Novel method and compositions for treatment of tinnitus
|
|
TWI446757B
(zh)
|
2006-03-24 |
2014-07-21 |
Lg Electronics Inc |
在無線通訊系統中設定前文以支援資料符號之傳輸的方法和架構
|
|
US7744746B2
(en)
|
2006-03-31 |
2010-06-29 |
Exxonmobil Research And Engineering Company |
FCC catalyst stripper configuration
|
|
CN101516334B
(zh)
*
|
2006-09-26 |
2013-07-10 |
塔罗制药北美有限公司 |
用于抗生素的稳定组合物以及应用方法
|
|
US8377898B2
(en)
|
2006-10-12 |
2013-02-19 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
US20100086997A1
(en)
|
2006-12-20 |
2010-04-08 |
Rinat Enuroscience Corp |
TrkB Agonists for Treating Autoimmune Disorders
|
|
EP2732819B1
(en)
|
2008-02-07 |
2019-10-16 |
Massachusetts Eye & Ear Infirmary |
Compounds that enhance Atoh-1 expression
|
|
EP2278999B1
(en)
*
|
2008-04-21 |
2025-01-29 |
Dompé farmaceutici S.p.A. |
Auris formulations for treating otic diseases and conditions
|
|
US9200080B2
(en)
|
2010-09-03 |
2015-12-01 |
Horacio Uri Saragovi |
Agonistic antibodies to TrkC receptors and uses thereof
|
|
US9125894B2
(en)
|
2010-10-06 |
2015-09-08 |
Massachusetts Eye & Ear Infirmary |
Methods for promoting reinnervation of auditory hair cells
|
|
CA2823719A1
(en)
|
2011-01-24 |
2012-08-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for generating inner ear cells in vitro
|
|
EP2765992A4
(en)
*
|
2011-10-10 |
2015-04-08 |
Otic Pharma Ltd |
FOAM FORMULATIONS
|
|
DE202012100195U1
(de)
|
2012-01-19 |
2012-03-01 |
Nordmark Arzneimittel Gmbh & Co. Kg |
Neue Verwendung einer pharmazeutischen Zusammensetzung, enthaltend Ancrod
|
|
EP2817009A1
(en)
|
2012-02-23 |
2014-12-31 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Calcineurin inhibitors for use in the treatment of lesional vestibular disorders
|
|
WO2013173803A2
(en)
*
|
2012-05-17 |
2013-11-21 |
Michael Spector |
Formulations of amoxicillin and clavulanate potassium and methods for using same
|
|
WO2013178763A1
(en)
|
2012-05-30 |
2013-12-05 |
Sensorion |
Methods for treating vestibulotoxicity
|
|
ES2683380T3
(es)
|
2012-06-08 |
2018-09-26 |
Sensorion |
Inhibidores del receptor H4 para tratar el tinnitus
|
|
EP3970725B1
(en)
|
2012-09-07 |
2025-08-20 |
Massachusetts Eye & Ear Infirmary |
A gamma secretase inhibitor for treating hearing loss
|
|
EP2853533A1
(de)
|
2013-09-29 |
2015-04-01 |
Audiocure Pharma GmbH |
6-Fluor-9-methyl-ß-carbolin
|
|
WO2015168149A2
(en)
|
2014-04-28 |
2015-11-05 |
Massachusetts Eye & Ear Infirmary |
Sensorineural hair cell differentiation
|
|
AU2015296616A1
(en)
*
|
2014-07-29 |
2017-03-02 |
Otonomy, Inc. |
Otic formulations for the treatment of ceruminosis
|
|
FR3024361B1
(fr)
|
2014-07-30 |
2017-11-24 |
Affichem |
Utilisation de derives de sterols pour traitement de la perte auditive neurosensorielle et composition correspondante
|
|
EP2982382A1
(en)
|
2014-08-04 |
2016-02-10 |
Sensorion |
Compounds for preventing ototoxicity
|
|
WO2016022776A2
(en)
|
2014-08-06 |
2016-02-11 |
Massachusetts Eye And Ear Infirmary |
Increasing atoh1 life to drive sensorineural hair cell differentiantion
|
|
DE202015100655U1
(de)
*
|
2015-02-03 |
2016-02-04 |
Bio.Lo.Ga. S.R.L. |
Pharmazeutische Zusammensetzung zur topischen Anwendung im Gehörgang
|
|
BR112017016909A2
(pt)
|
2015-02-11 |
2018-03-27 |
Support Venture Gmbh |
método de prevenção ou tratamento de perda de audição
|
|
JO3491B1
(ar)
|
2015-07-07 |
2020-07-05 |
Audion Therapeutics |
مركبات مثبطة لإشارات مسار notch
|