ATE457308T1 - Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta - Google Patents

Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta

Info

Publication number
ATE457308T1
ATE457308T1 AT04759766T AT04759766T ATE457308T1 AT E457308 T1 ATE457308 T1 AT E457308T1 AT 04759766 T AT04759766 T AT 04759766T AT 04759766 T AT04759766 T AT 04759766T AT E457308 T1 ATE457308 T1 AT E457308T1
Authority
AT
Austria
Prior art keywords
estrogen receptor
receptor beta
selective antagonists
substituted benzopyrans
substituted
Prior art date
Application number
AT04759766T
Other languages
English (en)
Inventor
Gregory Durst
Bryan Norman
Lance Pfeifer
Timothy Richardson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE457308T1 publication Critical patent/ATE457308T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT04759766T 2003-04-21 2004-04-08 Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta ATE457308T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46440503P 2003-04-21 2003-04-21
PCT/US2004/009271 WO2004094401A1 (en) 2003-04-21 2004-04-08 Substituted benzopyrans as selective estrogen receptor-beta agonists

Publications (1)

Publication Number Publication Date
ATE457308T1 true ATE457308T1 (de) 2010-02-15

Family

ID=33310883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04759766T ATE457308T1 (de) 2003-04-21 2004-04-08 Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta

Country Status (6)

Country Link
US (1) US7279499B2 (de)
EP (1) EP1618102B1 (de)
AT (1) ATE457308T1 (de)
DE (1) DE602004025460D1 (de)
ES (1) ES2338119T3 (de)
WO (1) WO2004094401A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1626974T3 (pl) * 2003-04-21 2009-01-30 Lilly Co Eli Podstawione benzopirany jako selektywne związki agonistyczne receptora beta estrogenu
RU2007106870A (ru) 2004-09-07 2008-10-20 Вайет (Us) 6Н-[1]БЕНЗОПИРАНО[4,3-b]ХИНОЛИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЭСТРОГЕННЫХ АГЕНТОВ
EP1805160B1 (de) 2004-10-18 2011-04-06 Eli Lilly And Company Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonisten
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
US8093302B2 (en) 2005-02-15 2012-01-10 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-β agonists
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
AR056695A1 (es) * 2005-10-17 2007-10-17 Wyeth Corp Tetrahidroquinolinas, su sintesis e intermediarios
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
CN101641013B (zh) 2007-01-22 2014-07-30 Gtx公司 核受体结合剂
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
WO2009132050A2 (en) 2008-04-21 2009-10-29 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
CA2731769C (en) 2008-07-21 2013-09-10 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
WO2011014516A1 (en) 2009-07-28 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Estrogen antagonists as treatments for sclerosing disorders
WO2011035174A1 (en) * 2009-09-17 2011-03-24 Vanderbilt University Substituted heteroarylamine carboxamide analogs as mglur5 negative allosteric modulators and methods of making and using the same
CA2931097A1 (en) 2013-11-19 2015-05-28 Vanderbilt University Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5
WO2015077375A1 (en) 2013-11-20 2015-05-28 Signalchem Lifesciences Corp. Quinazoline derivatives as tam family kinase inhibitors
US9974776B2 (en) 2013-12-05 2018-05-22 Karo Pharma Ab Estrogen receptor beta agonists for use in treating mesothelioma
US9533982B2 (en) 2014-03-20 2017-01-03 Vanderbilt University Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
US9550778B2 (en) 2014-10-03 2017-01-24 Vanderbilt University Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5
WO2018005830A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE183516T1 (de) 1995-09-08 1999-09-15 Karobio Ab Waisen-rezeptor
WO1999002512A1 (en) 1997-07-09 1999-01-21 Novo Nordisk A/S Dl-2,3-diaryl-2h-1-benzopyrans
WO2001049673A2 (en) 1999-12-30 2001-07-12 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
JP4896335B2 (ja) 2000-03-01 2012-03-14 ナームローゼ・フエンノートチヤツプ・オルガノン エストロゲン化合物としてのクロマン誘導体
DE60130748T2 (de) 2000-03-27 2008-07-17 N.V. Organon Nicht-steroidale tetracyclische verbindungen für östrogen-verwandte behandlungen
GB2361642A (en) 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
HU229351B1 (en) * 2001-11-19 2013-11-28 Lilly Co Eli Substituted benzopyrans as selective estrogen receptor-beta agonists
US6914074B2 (en) 2001-12-13 2005-07-05 Wyeth Substituted phenyl naphthalenes as estrogenic agents
US6630508B1 (en) 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists

Also Published As

Publication number Publication date
DE602004025460D1 (de) 2010-03-25
US7279499B2 (en) 2007-10-09
US20060199858A1 (en) 2006-09-07
EP1618102A1 (de) 2006-01-25
WO2004094401A1 (en) 2004-11-04
ES2338119T3 (es) 2010-05-04
EP1618102B1 (de) 2010-02-10

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Legal Events

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