CY1110443T1 - Υποκατεστημενα βενζοπυρανια ως εκλεκτικοι αγωνιστες υποδοχεα-βητα οιστρογονων - Google Patents

Υποκατεστημενα βενζοπυρανια ως εκλεκτικοι αγωνιστες υποδοχεα-βητα οιστρογονων

Info

Publication number
CY1110443T1
CY1110443T1 CY20081101190T CY081101190T CY1110443T1 CY 1110443 T1 CY1110443 T1 CY 1110443T1 CY 20081101190 T CY20081101190 T CY 20081101190T CY 081101190 T CY081101190 T CY 081101190T CY 1110443 T1 CY1110443 T1 CY 1110443T1
Authority
CY
Cyprus
Prior art keywords
estrogen receptor
substituted
benzopyranas
selective estrogen
beta receptors
Prior art date
Application number
CY20081101190T
Other languages
English (en)
Inventor
Gregory Lee Durst
Bryan Hurst Norman
Lance Allen Pfeifer
Timothy Ivo Richardson
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1110443T1 publication Critical patent/CY1110443T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέες ετεροκυκλικές ενώσεις οι οποίες είναι ανταγωνιστές του ορμονικού υποδοχέα 1 συγκέντρωσης της μελανίνης (MCHR1), που επίσης αναφέρεται ως 11CBy, σε φαρμακευτικές συνθέσεις που περιέχουν αυτές, σε διαδικασίες για την παρασκευή τους, και στη χρησιμοποίησή τους σε φάρμακα. Οι ενώσεις της εφεύρεσης έχουν τον τύπο (Ι).
CY20081101190T 2003-04-21 2008-10-23 Υποκατεστημενα βενζοπυρανια ως εκλεκτικοι αγωνιστες υποδοχεα-βητα οιστρογονων CY1110443T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46440403P 2003-04-21 2003-04-21
EP04759767A EP1626974B1 (en) 2003-04-21 2004-04-08 Substituted benzopyrans as selective estrogen receptor-beta agonists

Publications (1)

Publication Number Publication Date
CY1110443T1 true CY1110443T1 (el) 2015-04-29

Family

ID=33310882

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101190T CY1110443T1 (el) 2003-04-21 2008-10-23 Υποκατεστημενα βενζοπυρανια ως εκλεκτικοι αγωνιστες υποδοχεα-βητα οιστρογονων

Country Status (17)

Country Link
US (3) US7442812B2 (el)
EP (1) EP1626974B1 (el)
JP (1) JP4481300B2 (el)
CN (1) CN100374444C (el)
AT (1) ATE406373T1 (el)
AU (1) AU2004232798B2 (el)
BR (1) BRPI0409588A (el)
CA (1) CA2518819A1 (el)
CY (1) CY1110443T1 (el)
DE (1) DE602004016150D1 (el)
DK (1) DK1626974T3 (el)
ES (1) ES2311838T3 (el)
MX (1) MXPA05011243A (el)
PL (1) PL1626974T3 (el)
PT (1) PT1626974E (el)
SI (1) SI1626974T1 (el)
WO (1) WO2004094400A2 (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023085A (zh) 2004-07-19 2007-08-22 詹森药业有限公司 用作雌激素受体调节剂的螺－苯并[c]色烯衍生物
JP2008512458A (ja) 2004-09-07 2008-04-24 ワイス ６Ｈ−［１］ベンゾピラノ［４，３−ｂ］キノリン及びエストロゲン様物質としてのそれらの使用
US7354951B2 (en) 2004-10-18 2008-04-08 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
EP1853578A1 (en) 2005-02-15 2007-11-14 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-beta agonists
JP2006232727A (ja) * 2005-02-24 2006-09-07 Chisso Corp クマリン誘導体、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
EP2647376A1 (en) 2007-01-22 2013-10-09 Gtx, Inc. Nuclear receptor binding agents
WO2011014516A1 (en) 2009-07-28 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Estrogen antagonists as treatments for sclerosing disorders
CN109134493A (zh) * 2018-09-19 2019-01-04 浙江师范大学 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN109400564B (zh) * 2018-09-25 2021-03-12 信阳师范学院 一种含三氟甲基的苯并二氢吡喃-4-酮类化合物及其制备方法
CN110128393B (zh) * 2019-06-21 2022-09-30 华侨大学 一种取代异香豆素衍生物的制备方法
CN112898263B (zh) * 2021-01-28 2022-03-08 江西中医药大学 一种从佛手中分离的香豆素骈木脂素化合物及其保肝用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100263137B1 (ko) 1995-09-08 2000-08-01 오테스코그 페르 오판 수용체
AU8102398A (en) 1997-07-09 1999-02-08 Central Drug Research Institute (dl)-2,3-diaryl-2h-1-benzopyrans
US6593322B1 (en) * 1999-03-17 2003-07-15 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
WO2000055137A1 (en) * 1999-03-17 2000-09-21 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
CN1358091A (zh) * 1999-04-16 2002-07-10 阿斯特拉曾尼卡有限公司 雌激素受体－β配体
DE60018215T2 (de) 1999-12-30 2006-02-09 Signal Pharmaceuticals Llc, San Diego Verbindungen und verfahren zur modulation von estrogen rezeptoren
US7214706B2 (en) * 2000-03-01 2007-05-08 Akzo Nobel N.V. Chroman derivatives as estrogenic compounds
EP1272471B1 (en) 2000-03-27 2007-10-03 N.V. Organon Non-steroidal, tetracyclic compounds for estrogen-related treatments
GB2361642A (en) 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
US7147876B2 (en) 2001-08-13 2006-12-12 Michael Hargreaves Riley Compositions for removal of toxins
EA007382B1 (ru) * 2001-11-19 2006-10-27 Эли Лилли Энд Компани Замещенные бензопираны в качестве селективных агонистов бета-рецептора эстрогена
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6914074B2 (en) 2001-12-13 2005-07-05 Wyeth Substituted phenyl naphthalenes as estrogenic agents
US6630508B1 (en) * 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists
ATE457308T1 (de) * 2003-04-21 2010-02-15 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
US7354951B2 (en) * 2004-10-18 2008-04-08 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
EP1853578A1 (en) 2005-02-15 2007-11-14 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-beta agonists

Also Published As

Publication number Publication date
BRPI0409588A (pt) 2006-04-18
ES2311838T3 (es) 2009-02-16
PL1626974T3 (pl) 2009-01-30
US20090298925A1 (en) 2009-12-03
DE602004016150D1 (de) 2008-10-09
DK1626974T3 (da) 2008-11-17
ATE406373T1 (de) 2008-09-15
AU2004232798A1 (en) 2004-11-04
MXPA05011243A (es) 2005-12-15
CN100374444C (zh) 2008-03-12
US7842822B2 (en) 2010-11-30
US20070106082A1 (en) 2007-05-10
CN1777614A (zh) 2006-05-24
PT1626974E (pt) 2008-11-14
EP1626974A2 (en) 2006-02-22
WO2004094400A2 (en) 2004-11-04
US7585985B2 (en) 2009-09-08
US20080312312A1 (en) 2008-12-18
US7442812B2 (en) 2008-10-28
SI1626974T1 (sl) 2009-02-28
AU2004232798B2 (en) 2010-04-22
WO2004094400A3 (en) 2005-02-24
JP2006524240A (ja) 2006-10-26
EP1626974B1 (en) 2008-08-27
CA2518819A1 (en) 2004-11-04
JP4481300B2 (ja) 2010-06-16

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