DK1626974T3 - Substituerede benzopyraner som selektive östrogenreceptor-beta-agonister - Google Patents
Substituerede benzopyraner som selektive östrogenreceptor-beta-agonisterInfo
- Publication number
- DK1626974T3 DK1626974T3 DK04759767T DK04759767T DK1626974T3 DK 1626974 T3 DK1626974 T3 DK 1626974T3 DK 04759767 T DK04759767 T DK 04759767T DK 04759767 T DK04759767 T DK 04759767T DK 1626974 T3 DK1626974 T3 DK 1626974T3
- Authority
- DK
- Denmark
- Prior art keywords
- estrogen receptor
- receptor beta
- beta agonists
- selective estrogen
- substituted benzopyrans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46440403P | 2003-04-21 | 2003-04-21 | |
| PCT/US2004/009272 WO2004094400A2 (en) | 2003-04-21 | 2004-04-08 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1626974T3 true DK1626974T3 (da) | 2008-11-17 |
Family
ID=33310882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04759767T DK1626974T3 (da) | 2003-04-21 | 2004-04-08 | Substituerede benzopyraner som selektive östrogenreceptor-beta-agonister |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7442812B2 (da) |
| EP (1) | EP1626974B1 (da) |
| JP (1) | JP4481300B2 (da) |
| CN (1) | CN100374444C (da) |
| AT (1) | ATE406373T1 (da) |
| AU (1) | AU2004232798B2 (da) |
| BR (1) | BRPI0409588A (da) |
| CA (1) | CA2518819A1 (da) |
| CY (1) | CY1110443T1 (da) |
| DE (1) | DE602004016150D1 (da) |
| DK (1) | DK1626974T3 (da) |
| ES (1) | ES2311838T3 (da) |
| MX (1) | MXPA05011243A (da) |
| PL (1) | PL1626974T3 (da) |
| PT (1) | PT1626974E (da) |
| SI (1) | SI1626974T1 (da) |
| WO (1) | WO2004094400A2 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101023085A (zh) | 2004-07-19 | 2007-08-22 | 詹森药业有限公司 | 用作雌激素受体调节剂的螺－苯并[c]色烯衍生物 |
| BRPI0514974A (pt) | 2004-09-07 | 2008-07-01 | Wyeth Corp | composto, composição, métodos de tratar ou inibir uma doença ou condição, estados de doença induzidos por radical livre em um mamìfero, dano à junta secundário aos procedimentos artroscópicos ou cirúrgicos em um mamìfero, infertilidade em um mamìfero, de diminuir os nìveis de colesterol, triglicerìdeos, lp(a), ou ldl, de fornecer realce na cognição ou neuroproteção, de contracepção em um mamìfero, e para preparar um composto, e, produto |
| ES2361031T3 (es) * | 2004-10-18 | 2011-06-13 | Eli Lilly And Company | Benzopiranos sustituidos como agonistas selectivos del receptor beta de estrógenos. |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| JP2006232727A (ja) * | 2005-02-24 | 2006-09-07 | Chisso Corp | クマリン誘導体、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子 |
| CN101641013B (zh) | 2007-01-22 | 2014-07-30 | Gtx公司 | 核受体结合剂 |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| WO2011014516A1 (en) | 2009-07-28 | 2011-02-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Estrogen antagonists as treatments for sclerosing disorders |
| CN109134493A (zh) * | 2018-09-19 | 2019-01-04 | 浙江师范大学 | 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用 |
| CN109400564B (zh) * | 2018-09-25 | 2021-03-12 | 信阳师范学院 | 一种含三氟甲基的苯并二氢吡喃-4-酮类化合物及其制备方法 |
| CN110128393B (zh) * | 2019-06-21 | 2022-09-30 | 华侨大学 | 一种取代异香豆素衍生物的制备方法 |
| CN112898263B (zh) * | 2021-01-28 | 2022-03-08 | 江西中医药大学 | 一种从佛手中分离的香豆素骈木脂素化合物及其保肝用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE792292T1 (de) | 1995-09-08 | 1998-09-03 | Karo Bio Ab, Huddinge | Waisen-rezeptor |
| WO1999002512A1 (en) | 1997-07-09 | 1999-01-21 | Novo Nordisk A/S | Dl-2,3-diaryl-2h-1-benzopyrans |
| JP2003521468A (ja) | 1999-03-17 | 2003-07-15 | シグナル ファーマシューティカルズ， インコーポレイテッド | エストロゲンレセプタを変調させるための化合物及び方法 |
| US6593322B1 (en) | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| BR0009814A (pt) | 1999-04-16 | 2002-01-08 | Astrazeneca Ab | Processo para tratar de uma doença associada com o receptor-beta estrogênico |
| DK1246814T3 (da) | 1999-12-30 | 2005-05-30 | Signal Pharm Llc | Forbindelser og fremgangsmåder til modulation af östrogenreceptorer |
| JP4896335B2 (ja) * | 2000-03-01 | 2012-03-14 | ナームローゼ・フエンノートチヤツプ・オルガノン | エストロゲン化合物としてのクロマン誘導体 |
| ES2293986T3 (es) | 2000-03-27 | 2008-04-01 | N.V. Organon | Compuestos no esteroides tetraciclicos para tratamientos relacionados con el estrogeno. |
| GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
| US7147876B2 (en) | 2001-08-13 | 2006-12-12 | Michael Hargreaves Riley | Compositions for removal of toxins |
| WO2003044006A1 (en) | 2001-11-19 | 2003-05-30 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| TWI306450B (en) | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
| US6630508B1 (en) * | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
| DE602004025460D1 (de) | 2003-04-21 | 2010-03-25 | Lilly Co Eli | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
| ES2361031T3 (es) | 2004-10-18 | 2011-06-13 | Eli Lilly And Company | Benzopiranos sustituidos como agonistas selectivos del receptor beta de estrógenos. |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
-
2004
- 2004-04-08 MX MXPA05011243A patent/MXPA05011243A/es active IP Right Grant
- 2004-04-08 DE DE602004016150T patent/DE602004016150D1/de not_active Expired - Lifetime
- 2004-04-08 PL PL04759767T patent/PL1626974T3/pl unknown
- 2004-04-08 AT AT04759767T patent/ATE406373T1/de not_active IP Right Cessation
- 2004-04-08 DK DK04759767T patent/DK1626974T3/da active
- 2004-04-08 EP EP04759767A patent/EP1626974B1/en not_active Expired - Lifetime
- 2004-04-08 PT PT04759767T patent/PT1626974E/pt unknown
- 2004-04-08 JP JP2006509332A patent/JP4481300B2/ja not_active Expired - Lifetime
- 2004-04-08 US US10/552,504 patent/US7442812B2/en not_active Expired - Fee Related
- 2004-04-08 WO PCT/US2004/009272 patent/WO2004094400A2/en active Application Filing
- 2004-04-08 SI SI200430916T patent/SI1626974T1/sl unknown
- 2004-04-08 CA CA002518819A patent/CA2518819A1/en not_active Abandoned
- 2004-04-08 AU AU2004232798A patent/AU2004232798B2/en not_active Ceased
- 2004-04-08 CN CNB2004800108171A patent/CN100374444C/zh not_active Expired - Fee Related
- 2004-04-08 BR BRPI0409588-0A patent/BRPI0409588A/pt not_active IP Right Cessation
- 2004-04-08 ES ES04759767T patent/ES2311838T3/es not_active Expired - Lifetime
-
2008
- 2008-08-01 US US12/184,507 patent/US7585985B2/en not_active Expired - Fee Related
- 2008-10-23 CY CY20081101190T patent/CY1110443T1/el unknown
-
2009
- 2009-07-31 US US12/533,220 patent/US7842822B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1626974E (pt) | 2008-11-14 |
| CA2518819A1 (en) | 2004-11-04 |
| ES2311838T3 (es) | 2009-02-16 |
| EP1626974A2 (en) | 2006-02-22 |
| DE602004016150D1 (de) | 2008-10-09 |
| JP4481300B2 (ja) | 2010-06-16 |
| CN1777614A (zh) | 2006-05-24 |
| CY1110443T1 (el) | 2015-04-29 |
| SI1626974T1 (sl) | 2009-02-28 |
| MXPA05011243A (es) | 2005-12-15 |
| WO2004094400A2 (en) | 2004-11-04 |
| BRPI0409588A (pt) | 2006-04-18 |
| US7842822B2 (en) | 2010-11-30 |
| AU2004232798A1 (en) | 2004-11-04 |
| CN100374444C (zh) | 2008-03-12 |
| AU2004232798B2 (en) | 2010-04-22 |
| WO2004094400A3 (en) | 2005-02-24 |
| US20090298925A1 (en) | 2009-12-03 |
| US20080312312A1 (en) | 2008-12-18 |
| US7442812B2 (en) | 2008-10-28 |
| JP2006524240A (ja) | 2006-10-26 |
| EP1626974B1 (en) | 2008-08-27 |
| PL1626974T3 (pl) | 2009-01-30 |
| US20070106082A1 (en) | 2007-05-10 |
| US7585985B2 (en) | 2009-09-08 |
| ATE406373T1 (de) | 2008-09-15 |
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