JP2019522025A5 - - Google Patents
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- Publication number
- JP2019522025A5 JP2019522025A5 JP2019504002A JP2019504002A JP2019522025A5 JP 2019522025 A5 JP2019522025 A5 JP 2019522025A5 JP 2019504002 A JP2019504002 A JP 2019504002A JP 2019504002 A JP2019504002 A JP 2019504002A JP 2019522025 A5 JP2019522025 A5 JP 2019522025A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery system
- composition
- transdermal delivery
- sodium
- memantine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037317 transdermal delivery Effects 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 43
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 claims description 38
- 229960004640 memantine Drugs 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 23
- 239000010410 layer Substances 0.000 claims description 22
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 20
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 20
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 20
- 229920001577 copolymer Polymers 0.000 claims description 18
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 16
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 16
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 14
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 14
- 239000003961 penetration enhancing agent Substances 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- -1 polypropylene Polymers 0.000 claims description 12
- 150000001447 alkali salts Chemical class 0.000 claims description 11
- 239000002585 base Substances 0.000 claims description 10
- 238000011065 in-situ storage Methods 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 8
- 239000004821 Contact adhesive Substances 0.000 claims description 8
- 229920002367 Polyisobutene Polymers 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 229920000249 biocompatible polymer Polymers 0.000 claims description 8
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229940055577 oleyl alcohol Drugs 0.000 claims description 8
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 8
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 229920000058 polyacrylate Polymers 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 6
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 6
- 239000011736 potassium bicarbonate Substances 0.000 claims description 6
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical group [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- 229920005549 butyl rubber Polymers 0.000 claims description 4
- 208000015114 central nervous system disease Diseases 0.000 claims description 4
- 239000007884 disintegrant Substances 0.000 claims description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 4
- 229960000967 memantine hydrochloride Drugs 0.000 claims description 4
- 239000012982 microporous membrane Substances 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims description 4
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 235000011056 potassium acetate Nutrition 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- 235000011181 potassium carbonates Nutrition 0.000 claims description 4
- 239000001508 potassium citrate Substances 0.000 claims description 4
- 229960002635 potassium citrate Drugs 0.000 claims description 4
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 4
- 235000011082 potassium citrates Nutrition 0.000 claims description 4
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 4
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 4
- 235000011009 potassium phosphates Nutrition 0.000 claims description 4
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000017550 sodium carbonate Nutrition 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- NVIFVTYDZMXWGX-UHFFFAOYSA-N sodium metaborate Chemical compound [Na+].[O-]B=O NVIFVTYDZMXWGX-UHFFFAOYSA-N 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 229960004025 sodium salicylate Drugs 0.000 claims description 4
- 229940074404 sodium succinate Drugs 0.000 claims description 4
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 claims description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229960001790 sodium citrate Drugs 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 201000004810 Vascular dementia Diseases 0.000 claims description 2
- 239000012790 adhesive layer Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000004927 clay Substances 0.000 claims description 2
- 239000011243 crosslinked material Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 235000014786 phosphorus Nutrition 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 239000004584 polyacrylic acid Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229960004109 potassium acetate Drugs 0.000 claims description 2
- 229940093956 potassium carbonate Drugs 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 235000011008 sodium phosphates Nutrition 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 159000000011 group IA salts Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066862A JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367502P | 2016-07-27 | 2016-07-27 | |
| US62/367,502 | 2016-07-27 | ||
| US201662423133P | 2016-11-16 | 2016-11-16 | |
| US62/423,133 | 2016-11-16 | ||
| US201762444745P | 2017-01-10 | 2017-01-10 | |
| US201762444763P | 2017-01-10 | 2017-01-10 | |
| US62/444,745 | 2017-01-10 | ||
| US62/444,763 | 2017-01-10 | ||
| US201762457794P | 2017-02-10 | 2017-02-10 | |
| US201762457791P | 2017-02-10 | 2017-02-10 | |
| US62/457,794 | 2017-02-10 | ||
| US62/457,791 | 2017-02-10 | ||
| US201762504391P | 2017-05-10 | 2017-05-10 | |
| US62/504,391 | 2017-05-10 | ||
| PCT/US2017/044051 WO2018022818A1 (en) | 2016-07-27 | 2017-07-26 | Memantine transdermal delivery systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066862A Division JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522025A JP2019522025A (ja) | 2019-08-08 |
| JP2019522025A5 true JP2019522025A5 (https=) | 2020-08-27 |
| JP7071958B2 JP7071958B2 (ja) | 2022-05-19 |
Family
ID=59523315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504002A Active JP7071958B2 (ja) | 2016-07-27 | 2017-07-26 | メマンチン経皮送達システム |
| JP2022066862A Pending JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066862A Pending JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10945968B2 (https=) |
| EP (1) | EP3490544A1 (https=) |
| JP (2) | JP7071958B2 (https=) |
| KR (1) | KR102508993B1 (https=) |
| CN (1) | CN109789113A (https=) |
| AU (1) | AU2017301929B2 (https=) |
| CA (1) | CA3032103A1 (https=) |
| MX (1) | MX2019001104A (https=) |
| RU (1) | RU2764764C2 (https=) |
| SG (1) | SG11201900712SA (https=) |
| WO (1) | WO2018022818A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017117554A1 (en) | 2015-12-30 | 2017-07-06 | Corium International, Inc. | Systems and methods for long term transdermal administration |
| AU2017281789B2 (en) | 2016-06-23 | 2023-04-13 | Corium, LLC. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| US10300025B2 (en) | 2016-07-27 | 2019-05-28 | Corium, Inc. | Donepezil transdermal delivery system |
| WO2018022818A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Memantine transdermal delivery systems |
| WO2018160613A1 (en) * | 2017-02-28 | 2018-09-07 | Temple University-Of The Commonwealth System Of Higher Education | Novel econazole nitrate medical patch and methods of use thereof |
| US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| CN114007595A (zh) * | 2019-07-09 | 2022-02-01 | 罗曼治疗系统股份公司 | 包括包含丙烯酸类聚合物的含活性剂层和包含硅酮凝胶粘合剂的皮肤接触层的透皮治疗系统 |
| JP7812050B2 (ja) * | 2021-09-30 | 2026-02-09 | ａｒｔｉｅｎｃｅ株式会社 | 貼付剤 |
| CN115957200A (zh) * | 2023-02-23 | 2023-04-14 | 广州新济药业科技有限公司 | 一种美金刚透皮贴剂及制备方法 |
| EP4520317A1 (en) * | 2023-09-06 | 2025-03-12 | Luye Pharma Switzerland AG | Transdermal therapeutic system of lumateperone |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3391142A (en) | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
| NL134681C (https=) | 1966-04-26 | |||
| US3546141A (en) | 1966-08-08 | 1970-12-08 | Mc Donnell Douglas Corp | Phosphorus-nitrogen polymers and process |
| ES413944A1 (es) | 1972-04-20 | 1976-06-01 | Merz & Co | Procedimiento para la preparacion de compuestos de adamen- tano trisustituidos en las posiciones 1,3,5. |
| DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
| US4752478A (en) * | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
| ATE45735T1 (de) | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
| US4880633A (en) | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US4837027A (en) | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device |
| US4781924A (en) | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
| US4849224A (en) | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
| US5026556A (en) | 1988-11-10 | 1991-06-25 | Norwich Eaton Pharmaceuticals, Inc. | Compositions for the transdermal delivery of pharmaceutical actives |
| DE58905637D1 (de) | 1989-04-14 | 1993-10-21 | Merz & Co Gmbh & Co | Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie. |
| DE69010076T2 (de) * | 1989-05-25 | 1994-12-08 | Takeda Chemical Industries Ltd | Transdermales therapeutisches Mittel. |
| US5252588A (en) | 1990-04-27 | 1993-10-12 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation |
| IE62597B1 (en) | 1990-07-23 | 1995-02-08 | Alza Corp | Oral osmotic device for delivering nicotine |
| IT1243745B (it) * | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5123900A (en) | 1991-08-16 | 1992-06-23 | Bertek, Inc. | Moisture permeable double disk |
| JPH06199659A (ja) | 1992-10-28 | 1994-07-19 | Hisamitsu Pharmaceut Co Inc | 経皮治療用装置 |
| US5424077A (en) | 1993-07-13 | 1995-06-13 | Church & Dwight Co., Inc. | Co-micronized bicarbonate salt compositions |
| WO1996008229A2 (en) | 1994-09-14 | 1996-03-21 | Minnesota Mining And Manufacturing Company | Matrix for transdermal drug delivery |
| US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
| AU695170B2 (en) | 1994-12-21 | 1998-08-06 | Theratech, Inc. | Transdermal delivery system with adhesive overlay and peel seal disc |
| AU6032696A (en) | 1995-06-07 | 1996-12-30 | Cygnus Therapeutic Systems | Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group |
| DE19531342B4 (de) | 1995-08-25 | 2007-11-29 | Merz Pharma Gmbh & Co. Kgaa | Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren |
| US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| US6512010B1 (en) | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US5958919A (en) | 1996-09-20 | 1999-09-28 | Washington University | Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration |
| WO1998017315A2 (en) | 1996-10-24 | 1998-04-30 | Alza Corporation | Permeation enhancers for transdermal drug delivery compositions, devices, and methods |
| US5866585A (en) | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US6193993B1 (en) | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US20020192243A1 (en) | 1999-12-16 | 2002-12-19 | Tsung-Min Hsu | Transdermal and topical administration of drugs for the treatment of Alzheimer's disease using basic enhancers |
| US6562368B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
| US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| EP1331929A1 (en) | 2000-11-06 | 2003-08-06 | Samyang Corporation | Transdermal drug delivery system with improved water absorbability and adhesion properties |
| WO2002087645A1 (en) | 2001-05-01 | 2002-11-07 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions |
| WO2003015713A2 (en) | 2001-08-20 | 2003-02-27 | Maiken Nedergaard | Treatment of glial tumors with glutamate antagonists |
| AU2002333799B2 (en) * | 2001-09-04 | 2007-09-06 | Trommsdorff Gmbh & Co. Kg Arzneimittel | Plaster for the treatment of dysfunctions and disorders of nails, comprising sertaconazole |
| US7273619B2 (en) | 2002-01-17 | 2007-09-25 | Samyang Corporation | Transdermal composition of an antivomiting agent |
| KR100777904B1 (ko) | 2002-10-24 | 2007-11-28 | 메르츠 파마 게엠베하 운트 코. 카가아 | 1-아미노시클로헥산 유도체 및 아세틸콜린에스테라제 저해제를 포함하는 약학적 제품 및 이를 이용한 복합 치료 |
| DK1670433T3 (da) | 2003-10-10 | 2012-03-12 | Ferring Bv | Transdermal farmaceutisk formulering til mindskelse af hudrester |
| CN1870984A (zh) | 2003-10-22 | 2006-11-29 | 莫茨药物股份两合公司 | 1－氨基环己烷衍生物用于调节淀粉样病变中原纤维生成Aβ肽的沉积的用途 |
| WO2005051389A1 (en) | 2003-11-21 | 2005-06-09 | Memory Pharmaceuticals Corporation | Using of (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dymethyl-pyridine-3,5-dicarboxylate in the treatment of memory disorders |
| US7176185B2 (en) | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
| JP5179757B2 (ja) | 2004-02-17 | 2013-04-10 | トランセプト ファーマシューティカルズ， インコーポレイティド | 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法 |
| US7670838B2 (en) | 2004-05-24 | 2010-03-02 | The Board Of Trustees Of The Leland Stanford Junior University | Coupling of excitation and neurogenesis in neural stem/progenitor cells |
| WO2005115355A1 (ja) | 2004-05-28 | 2005-12-08 | Hisamitsu Pharmaceutical Co., Inc. | 貼付製剤 |
| TW200616608A (en) | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| TW200628175A (en) | 2004-10-08 | 2006-08-16 | Noven Pharma | Transdermal drug delivert device including an occlusive backing |
| DE602005010812D1 (de) | 2004-11-22 | 2008-12-18 | Hisamitsu Pharmaceutical Co | Transdermales Pflaster enthaltend einen schmelzpunktsenkenden Hilfsstoff |
| US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| US20060205822A1 (en) | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| CA2591666A1 (en) | 2005-01-11 | 2006-07-20 | Teva Pharmaceutical Fine Chemicals S.R.L. | Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride |
| WO2006082728A1 (ja) | 2005-02-04 | 2006-08-10 | Hisamitsu Pharmaceutical Co., Inc. | 経皮吸収貼付剤 |
| JP5666087B2 (ja) | 2005-04-06 | 2015-02-12 | アダマス・ファーマシューティカルズ・インコーポレーテッド | Ｃｎｓ関連疾患の治療のための方法及び組成物 |
| US7888422B2 (en) | 2005-11-09 | 2011-02-15 | Mylan Technologies Inc. | Long-wearing removable pressure sensitive adhesive |
| DK2001671T3 (da) | 2006-03-28 | 2010-08-09 | Amcor Flexibles Transpac B V B | Halogenfri flerlagsfilm, som er impermeabel for aromaforbindelser |
| IL175338A0 (en) | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| BRPI0621655A2 (pt) * | 2006-05-08 | 2011-12-20 | Teikoku Seiyaku Kk | preparação para a absorção percutánea de uma droga antidemência básica |
| JP5097359B2 (ja) | 2006-05-09 | 2012-12-12 | 久光製薬株式会社 | ドネペジル経皮吸収型製剤 |
| WO2007132476A2 (en) * | 2006-05-15 | 2007-11-22 | Matrix Laboratories Limited | A process for the preparation of memantine hydrochloride |
| US9248104B2 (en) | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| US20080107719A1 (en) | 2006-11-08 | 2008-05-08 | Sukhon Likitlersuang | Transdermal drug delivery system |
| US20100048628A1 (en) | 2006-12-01 | 2010-02-25 | Sumiyo Nishi | Method for suppressing discoloration over time of adhesive preparation containing donepezil |
| JP5237112B2 (ja) | 2006-12-01 | 2013-07-17 | 日東電工株式会社 | 経皮吸収製剤 |
| JP5110711B2 (ja) | 2006-12-01 | 2012-12-26 | 日東電工株式会社 | 安定化されたドネペジル含有貼付製剤 |
| JP5403948B2 (ja) * | 2007-06-07 | 2014-01-29 | 久光製薬株式会社 | メマンチン含有経皮吸収製剤 |
| EA020208B1 (ru) | 2007-07-10 | 2014-09-30 | Эджайл Терапьютикс, Инк. | Устройство доставки в кожу с изолирующим слоем in situ |
| JP2009203213A (ja) | 2008-02-28 | 2009-09-10 | Kosumedei Seiyaku Kk | 経皮吸収医薬組成物 |
| DE102008013701A1 (de) * | 2008-03-11 | 2009-09-17 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit stabilisierter Membran |
| KR101454362B1 (ko) | 2008-03-24 | 2014-10-23 | 아이큐어 주식회사 | 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제 |
| US20090291127A1 (en) | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| PE20100371A1 (es) | 2008-10-31 | 2010-06-01 | Lexicon Pharmaceuticals Inc | Agonistas del receptor s1p para el tratamiento de malaria cerebral |
| US20100178037A1 (en) | 2009-01-12 | 2010-07-15 | Te-Wei Chen | Display apparatus, video generation apparatus, and method thereof |
| CA2751884C (en) | 2009-01-14 | 2018-09-25 | Corium International, Inc. | Transdermal administration of tamsulosin |
| TWI552773B (zh) | 2009-05-01 | 2016-10-11 | 久光製藥股份有限公司 | 經皮吸收型製劑 |
| CN102630160B (zh) | 2009-09-16 | 2014-05-07 | 株式会社三养生物制药 | 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法 |
| BR112012011334A2 (pt) | 2009-10-21 | 2020-08-25 | Teikoku Seiyaku Co., Ltd. | formulação transdermicamente absorvível contendo donepezil |
| CN102048678A (zh) | 2009-10-30 | 2011-05-11 | 北京隆旗生物科技有限公司 | 一种奥昔布宁的透皮吸收制剂及其制备方法与药物应用 |
| GB0921481D0 (en) | 2009-12-08 | 2010-01-20 | Vectura Ltd | Process and product |
| JP2012236773A (ja) | 2009-12-16 | 2012-12-06 | Goto Takeshi | 抗認知症薬物の経皮吸収製剤 |
| HUE025446T2 (en) | 2009-12-30 | 2016-04-28 | Novartis Ag | Melt extruded nicotine thin strips |
| US20110244023A1 (en) | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
| WO2011136288A1 (ja) | 2010-04-28 | 2011-11-03 | 久光製薬株式会社 | ドネペジル含有経皮吸収製剤 |
| US9012511B2 (en) | 2010-05-19 | 2015-04-21 | Alkermes Pharma Ireland Limited | Nanoparticulate cinacalcet compositions |
| RU2578971C2 (ru) * | 2010-06-17 | 2016-03-27 | Лтс Ломанн Терапи-Системе Аг | Трансдермальное введение мемантина |
| DE102010024105A1 (de) | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin |
| US20140370076A1 (en) | 2010-06-30 | 2014-12-18 | Nal Pharmaceuticals, Ltd. | Transdermal drug delivery system containing donepezil |
| EP2627323A4 (en) * | 2010-10-12 | 2014-03-12 | Univ Johns Hopkins | HUSTENSTILLENDE COMPOSITIONS WITH MEMANTINE |
| JP5813652B2 (ja) * | 2010-10-28 | 2015-11-17 | 久光製薬株式会社 | 経皮吸収型製剤 |
| JP5699554B2 (ja) | 2010-11-11 | 2015-04-15 | 富士通株式会社 | ベクトル処理回路、命令発行制御方法、及びプロセッサシステム |
| WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
| TWI433904B (zh) | 2011-01-12 | 2014-04-11 | Taiwan Biotech Co Ltd | 多奈哌齊經皮貼片 |
| US8673338B2 (en) | 2011-07-29 | 2014-03-18 | Massachusetts Eye And Ear Infirmary | Methods of delivering pharmaceutical agents |
| JP5820207B2 (ja) | 2011-09-13 | 2015-11-24 | 日東電工株式会社 | 経皮吸収促進用組成物および貼付製剤 |
| KR101239150B1 (ko) | 2012-02-28 | 2013-03-06 | 에스케이케미칼주식회사 | 도네페질-함유 경피흡수제제 및 그의 제조방법 |
| US20140256690A1 (en) | 2013-03-08 | 2014-09-11 | Agile Therapeutics, Inc. | Contraceptive method |
| WO2014174564A1 (ja) | 2013-04-22 | 2014-10-30 | 祐徳薬品工業株式会社 | メマンチン含有経皮吸収型貼付製剤 |
| JP5415645B1 (ja) | 2013-06-28 | 2014-02-12 | 久光製薬株式会社 | 貼付剤の製造方法、貼付剤及び包装体 |
| KR101827980B1 (ko) | 2013-10-07 | 2018-02-13 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| JP6401257B2 (ja) | 2013-10-11 | 2018-10-10 | テイコク ファーマ ユーエスエー インコーポレーテッド | 局所用スフィンゴシン−１−リン酸受容体アゴニスト製剤及びその使用方法 |
| KR101485822B1 (ko) | 2014-01-22 | 2015-01-23 | 주식회사 대웅제약 | 도네페질 또는 그의 염을 함유하는 경피흡수제제 |
| JP2015151370A (ja) | 2014-02-14 | 2015-08-24 | 日東電工株式会社 | 貼付製剤 |
| EP3160461A1 (en) | 2014-06-24 | 2017-05-03 | KAT Transdermals LLC | Transdermal delivery system |
| US10238648B2 (en) | 2014-07-18 | 2019-03-26 | Buzzz Pharmaceuticals Ltd. | Abuse deterrent opioid/opioid-antagonist transdermal patch |
| JP6577795B2 (ja) * | 2014-09-03 | 2019-09-18 | 日東電工株式会社 | ビスホスホネート剤を含む細胞性免疫用ワクチン医薬組成物 |
| WO2016046675A1 (en) | 2014-09-28 | 2016-03-31 | Mohan M Alapati | Compositions and methods for the treatment of neurological diseases |
| JP6793648B2 (ja) | 2014-12-18 | 2020-12-02 | アイキュア ファーマスーティカル インク． | ドネペジルを有効成分として含有する経皮吸収製剤 |
| CN108135860A (zh) | 2015-06-22 | 2018-06-08 | 考里安国际公司 | 包含难溶性治疗剂的透皮粘合剂组合物 |
| KR102005201B1 (ko) | 2015-07-27 | 2019-07-29 | 히사미쓰 세이야꾸 가부시키가이샤 | 아세나핀 함유 첩부제의 제조 방법 |
| WO2017117554A1 (en) * | 2015-12-30 | 2017-07-06 | Corium International, Inc. | Systems and methods for long term transdermal administration |
| CN105693556A (zh) | 2016-03-01 | 2016-06-22 | 巴斯特医药科技（常州）有限公司 | 卡巴拉汀酒石酸盐的转化方法及其产物制成的贴片 |
| AU2017281789B2 (en) | 2016-06-23 | 2023-04-13 | Corium, LLC. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| US10300025B2 (en) | 2016-07-27 | 2019-05-28 | Corium, Inc. | Donepezil transdermal delivery system |
| WO2018022818A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Memantine transdermal delivery systems |
| EP3490559A1 (en) | 2016-07-27 | 2019-06-05 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
| AU2018307792B2 (en) | 2017-07-26 | 2024-08-08 | Corium, LLC. | Transdermal delivery system with a microporous membrane having solvent-filled pores |
-
2017
- 2017-07-26 WO PCT/US2017/044051 patent/WO2018022818A1/en not_active Ceased
- 2017-07-26 EP EP17749060.4A patent/EP3490544A1/en not_active Withdrawn
- 2017-07-26 AU AU2017301929A patent/AU2017301929B2/en not_active Ceased
- 2017-07-26 CN CN201780059395.4A patent/CN109789113A/zh active Pending
- 2017-07-26 CA CA3032103A patent/CA3032103A1/en active Pending
- 2017-07-26 RU RU2019105280A patent/RU2764764C2/ru active
- 2017-07-26 US US15/660,929 patent/US10945968B2/en not_active Expired - Fee Related
- 2017-07-26 MX MX2019001104A patent/MX2019001104A/es unknown
- 2017-07-26 KR KR1020197005636A patent/KR102508993B1/ko active Active
- 2017-07-26 JP JP2019504002A patent/JP7071958B2/ja active Active
- 2017-07-26 SG SG11201900712SA patent/SG11201900712SA/en unknown
-
2022
- 2022-04-14 JP JP2022066862A patent/JP2022087276A/ja active Pending
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