JP2019520369A5 - - Google Patents
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- JP2019520369A5 JP2019520369A5 JP2018568727A JP2018568727A JP2019520369A5 JP 2019520369 A5 JP2019520369 A5 JP 2019520369A5 JP 2018568727 A JP2018568727 A JP 2018568727A JP 2018568727 A JP2018568727 A JP 2018568727A JP 2019520369 A5 JP2019520369 A5 JP 2019520369A5
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- Prior art keywords
- aryl
- salt
- formula
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- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16178030 | 2016-07-05 | ||
| EP16178030.9 | 2016-07-05 | ||
| PCT/IB2017/053971 WO2018007919A1 (en) | 2016-07-05 | 2017-06-30 | New process for early sacubitril intermediates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520369A JP2019520369A (ja) | 2019-07-18 |
| JP2019520369A5 true JP2019520369A5 (enExample) | 2020-08-13 |
| JP6944473B2 JP6944473B2 (ja) | 2021-10-06 |
Family
ID=56363778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568727A Expired - Fee Related JP6944473B2 (ja) | 2016-07-05 | 2017-06-30 | 初期サクビトリル中間体のための新規な方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190256454A1 (enExample) |
| EP (1) | EP3481799A1 (enExample) |
| JP (1) | JP6944473B2 (enExample) |
| CN (1) | CN109415308B (enExample) |
| WO (1) | WO2018007919A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110214148A (zh) | 2016-10-14 | 2019-09-06 | Xencor股份有限公司 | 含有IL-15/IL-15Rα Fc融合蛋白和PD-1抗体片段的双特异性异源二聚体融合蛋白 |
| AU2018291497A1 (en) | 2017-06-30 | 2020-01-16 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains |
| EP3781598A1 (en) | 2018-04-18 | 2021-02-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| AU2019256539A1 (en) | 2018-04-18 | 2020-11-26 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
| CA3097625A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Il-15/il-15ra heterodimeric fc fusion proteins and uses thereof |
| CR20210239A (es) | 2018-10-12 | 2021-12-15 | Xencor Inc | Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas |
| US11618776B2 (en) | 2018-12-20 | 2023-04-04 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| CN111205204A (zh) * | 2020-01-16 | 2020-05-29 | 南京红杉生物科技有限公司 | 沙库必曲中间体及其合成方法、应用 |
| CN115745841B (zh) * | 2021-09-03 | 2024-04-16 | 凯特立斯（深圳）科技有限公司 | 一种沙库必曲中间体的制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2516098A (en) * | 1949-03-26 | 1950-07-25 | Parke Davis & Co | Biphenyl compounds |
| US2543267A (en) * | 1950-01-04 | 1951-02-27 | Parke Davis & Co | Hydroxyethyl-acylamidobiphenylyl ketones |
| IT1194593B (it) * | 1978-11-25 | 1988-09-22 | Nippon Kayaku Kk | Procedimento per la produzione di acidi treo-3-ammino-2-idrossibutanoilamminoacetici nonche' di loro intermedi |
| JPS5690050A (en) * | 1979-11-20 | 1981-07-21 | Microbial Chem Res Found | Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid |
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US7329775B2 (en) * | 2003-10-30 | 2008-02-12 | Northwestern University | Compounds and related methods for mutant p53 reactivation |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| EP1980622B1 (en) | 2006-01-17 | 2010-08-18 | Sumitomo Chemical Company, Limited | Method for production of an optically active biphenylalanine compound or salt or ester thereof |
| WO2007083774A1 (ja) | 2006-01-17 | 2007-07-26 | Sumitomo Chemical Company, Limited | ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法 |
| EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
| SG185318A1 (en) * | 2007-01-12 | 2012-11-29 | Novartis Ag | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid |
| WO2008120567A1 (ja) | 2007-03-20 | 2008-10-09 | Sumitomo Chemical Company, Limited | Ｌ－ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法 |
| KR100817977B1 (ko) | 2007-05-03 | 2008-03-31 | 엘에스전선 주식회사 | 2차 전지용 음극재 및 이를 이용한 2차 전지 |
| AR070176A1 (es) | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| CN101774941A (zh) | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| EP2480523B1 (en) | 2009-09-23 | 2017-03-01 | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. | Process for manufacture of n-acylbphenyl alanine |
| CN104262228B (zh) | 2010-01-22 | 2017-01-18 | 诺华股份有限公司 | 中性内肽酶抑制剂中间体和其制备方法 |
| CN102260177A (zh) | 2010-05-25 | 2011-11-30 | 中国医学科学院药物研究所 | 丙二醇类衍生物、其制备方法和其药物组合物与用途 |
| ES2608780T3 (es) | 2010-08-23 | 2017-04-17 | Novartis Ag | Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP |
| ES2576179T3 (es) | 2010-08-23 | 2016-07-06 | Novartis Ag | Proceso para la preparación de intermediarios para la elaboración de inhibidores de NEP |
| JP6150179B2 (ja) | 2011-08-19 | 2017-06-21 | パセオン オーストリア ゲーエムベーハー ウント ツェーオー カーゲー | Ｒ−ビフェニルアラニノールの合成 |
| AR092278A1 (es) * | 2012-08-31 | 2015-04-08 | Novartis Ag | Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados |
| BR112016003736A2 (pt) | 2013-08-21 | 2018-12-04 | Dpx Holdings Bv | síntese de bifenilalaninol via novos intermed!ários |
| CN103483201A (zh) | 2013-09-12 | 2014-01-01 | 江苏弘和药物研发有限公司 | 一种(r)-2-甲基-4-硝基-1-丁醇的合成方法 |
| CN104557600B (zh) | 2015-01-26 | 2016-05-04 | 苏州明锐医药科技有限公司 | 沙库比曲的制备方法 |
| CN104725256B (zh) | 2015-02-11 | 2018-03-16 | 威海迪素制药有限公司 | 一种联苯丙氨酸衍生物的制备方法 |
| CN104725279B (zh) | 2015-02-12 | 2018-03-02 | 威海迪素制药有限公司 | 一种N‑Boc‑联苯丙氨酸衍生物的制备方法 |
| CN105017082B (zh) | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | 一种心衰药Entresto 关键中间体(R)‑叔丁基 (1‑([1,1`‑联苯]‑4‑基)‑3‑羟基丙烷‑2‑基)氨基甲酸酯的制备方法 |
| CN105061263B (zh) | 2015-08-11 | 2017-03-15 | 苏州楚凯药业有限公司 | 一种nep抑制剂中间体的制备方法 |
| CN105085322B (zh) | 2015-08-15 | 2017-10-03 | 浙江永宁药业股份有限公司 | Ahu‑377中间体的制备方法及其中间体和中间体的制备方法 |
| CN105168205A (zh) | 2015-08-18 | 2015-12-23 | 泰力特医药（湖北）有限公司 | 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法 |
| CN105152980B (zh) | 2015-09-11 | 2017-03-29 | 浙江永宁药业股份有限公司 | N‑叔丁氧羰基‑（4s）‑（对苯基苯基甲基）‑4‑氨基‑（2r）‑甲基丁酸的手性制备方法 |
| CN105330569A (zh) | 2015-09-11 | 2016-02-17 | 天台宜生生化科技有限公司 | 一种(r)-2-(n-叔丁氧羰基氨基)联苯丙醇的制备方法 |
| CN105198775B (zh) | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
| CN105237560B (zh) | 2015-10-15 | 2018-07-06 | 上海博氏医药科技有限公司 | 一种lzc696中间体及其合成方法 |
| CN105481622A (zh) | 2015-12-14 | 2016-04-13 | 武汉凯特立斯科技有限公司 | 一种α-氧代-α,β-不饱和羧酸的不对称氢化方法 |
| CN105566194A (zh) | 2016-02-01 | 2016-05-11 | 张伯引 | 一种Sacubitril中间体的制备方法 |
| CN105601524B (zh) | 2016-03-17 | 2017-09-29 | 海门慧聚药业有限公司 | Lcz696关键中间体的制备 |
| WO2017203474A1 (en) * | 2016-05-27 | 2017-11-30 | Dr. Reddy's Laboratories Limited | Process for preparation of sacubutril intermediate |
-
2017
- 2017-06-30 EP EP17743393.5A patent/EP3481799A1/en not_active Withdrawn
- 2017-06-30 WO PCT/IB2017/053971 patent/WO2018007919A1/en not_active Ceased
- 2017-06-30 US US16/314,933 patent/US20190256454A1/en not_active Abandoned
- 2017-06-30 CN CN201780041934.1A patent/CN109415308B/zh not_active Expired - Fee Related
- 2017-06-30 JP JP2018568727A patent/JP6944473B2/ja not_active Expired - Fee Related
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