JP2019520365A5 - - Google Patents
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- Publication number
- JP2019520365A5 JP2019520365A5 JP2018568285A JP2018568285A JP2019520365A5 JP 2019520365 A5 JP2019520365 A5 JP 2019520365A5 JP 2018568285 A JP2018568285 A JP 2018568285A JP 2018568285 A JP2018568285 A JP 2018568285A JP 2019520365 A5 JP2019520365 A5 JP 2019520365A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- pharmaceutical composition
- exosomes
- thrombin
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 210000001808 exosome Anatomy 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 210000000130 stem cell Anatomy 0.000 claims 9
- 108090000190 Thrombin Proteins 0.000 claims 6
- 239000003102 growth factor Substances 0.000 claims 6
- 229960004072 thrombin Drugs 0.000 claims 6
- 206010072170 Skin wound Diseases 0.000 claims 5
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 3
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000002870 angiogenesis inducing agent Substances 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013583 drug formulation Substances 0.000 claims 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 210000001691 amnion Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940126534 drug product Drugs 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- -1 infusion Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000003954 umbilical cord Anatomy 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160083703 | 2016-07-01 | ||
| KR10-2016-0083703 | 2016-07-01 | ||
| KR1020170080366A KR101860266B1 (ko) | 2016-07-01 | 2017-06-26 | 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물 |
| KR10-2017-0080366 | 2017-06-26 | ||
| PCT/KR2017/006776 WO2018004237A1 (ko) | 2016-07-01 | 2017-06-27 | 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520365A JP2019520365A (ja) | 2019-07-18 |
| JP2019520365A5 true JP2019520365A5 (enExample) | 2020-04-09 |
| JP6826135B2 JP6826135B2 (ja) | 2021-02-03 |
Family
ID=60998515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568285A Active JP6826135B2 (ja) | 2016-07-01 | 2017-06-27 | トロンビン処理幹細胞に由来するエクソソームを含む皮膚傷治療用組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12239695B2 (enExample) |
| EP (1) | EP3479831B1 (enExample) |
| JP (1) | JP6826135B2 (enExample) |
| KR (1) | KR101860266B1 (enExample) |
| CN (1) | CN109641013B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101973284B1 (ko) | 2017-01-16 | 2019-04-29 | 사회복지법인 삼성생명공익재단 | 신생아 ｈｉｅ 치료용 조성물 |
| KR102278102B1 (ko) | 2018-07-27 | 2021-07-15 | 주식회사 엑소스템텍 | 엑소좀을 유효성분으로 포함하는 급성 간질환의 예방 또는 치료용 조성물 |
| WO2020022541A1 (ko) | 2018-07-27 | 2020-01-30 | 주식회사 엑소스템텍 | 엑소좀을 유효성분으로 포함하는 급성 간부전의 예방 또는 치료용 조성물 |
| KR102323056B1 (ko) * | 2019-05-02 | 2021-11-09 | 에스씨엠생명과학 주식회사 | hPL 함유 배지에서 배양된 중간엽 줄기세포의 배양액을 포함하는 화장료 조성물 |
| KR102159394B1 (ko) * | 2019-10-04 | 2020-09-24 | (주)에스디생명공학 | 바다제비집에서 유래된 엑소좀을 유효성분으로 포함하는 피부 상태 개선용 조성물 |
| US12491212B2 (en) | 2019-11-12 | 2025-12-09 | Brexogen Inc. | Composition for preventing or treating renal diseases, comprising exosomes derived from precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells |
| JP2021116228A (ja) * | 2020-01-22 | 2021-08-10 | 医薬資源研究所株式会社 | 抗酸化ストレス剤、化粧品、および医薬品 |
| US12077780B2 (en) | 2020-02-14 | 2024-09-03 | Allergan Sales, Llc | Conditioned medium from cells cultured under hypoxic conditions and uses thereof |
| KR20210127510A (ko) * | 2020-04-14 | 2021-10-22 | 사회복지법인 삼성생명공익재단 | 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 당뇨병성 피부질환 예방 또는 치료용 조성물 |
| CN111888379A (zh) * | 2020-08-17 | 2020-11-06 | 济宁医学院附属医院 | 干细胞来源的微囊泡在制备修复瘢痕的制剂中的应用 |
| EP4252761A4 (en) * | 2020-11-26 | 2024-06-05 | Samsung Life Public Welfare Foundation | COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES, COMPRISING EXOSOMES DERIVED FROM THROMBIN-PROCESSED STEM CELLS |
| CN114904043B (zh) * | 2022-04-28 | 2023-07-21 | 深圳市儿童医院 | 复合水凝胶及其制备方法和应用 |
| JP2025539861A (ja) * | 2022-11-25 | 2025-12-09 | エルピス・セル・セラピューティクス | ｖＭＳＣのセクレトームおよびその用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5911874B2 (ja) * | 2010-10-18 | 2016-04-27 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 発毛を促進又は増強するためのエキソソームの使用 |
| US20150125950A1 (en) | 2012-05-18 | 2015-05-07 | Agency For Science, Technology And Research (A*Sta (A*Star) | Umbilical cord mesenchymal stem cell exosomes |
| KR20140066456A (ko) | 2012-11-23 | 2014-06-02 | 호서대학교 산학협력단 | 피부각질세포 유래 엑소좀, 엑소좀을 포함하는 분획물의 피부재생용 화장품 조성물 및 이의 용도 |
| GB201317889D0 (en) * | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product and use |
| JP6343671B2 (ja) * | 2013-12-12 | 2018-06-13 | サムスン ライフ パブリック ウェルフェア ファウンデーション | トロンビンを利用した幹細胞由来のエキソソームの生成促進方法 |
| US9919011B2 (en) * | 2014-03-18 | 2018-03-20 | Samsung Life Public Welfare Foundation | Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome |
| CN105477016A (zh) * | 2015-11-13 | 2016-04-13 | 中国人民解放军第二军医大学 | 人间充质干细胞来源的外泌体在抗组织纤维化及瘢痕形成中的应用 |
-
2017
- 2017-06-26 KR KR1020170080366A patent/KR101860266B1/ko active Active
- 2017-06-27 EP EP17820513.4A patent/EP3479831B1/en active Active
- 2017-06-27 JP JP2018568285A patent/JP6826135B2/ja active Active
- 2017-06-27 US US16/314,725 patent/US12239695B2/en active Active
- 2017-06-27 CN CN201780047575.0A patent/CN109641013B/zh active Active
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