JP2019519587A5 - - Google Patents
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- JP2019519587A5 JP2019519587A5 JP2018568810A JP2018568810A JP2019519587A5 JP 2019519587 A5 JP2019519587 A5 JP 2019519587A5 JP 2018568810 A JP2018568810 A JP 2018568810A JP 2018568810 A JP2018568810 A JP 2018568810A JP 2019519587 A5 JP2019519587 A5 JP 2019519587A5
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- 150000001875 compounds Chemical class 0.000 claims description 76
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 208000035475 disorder Diseases 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 6
- 235000003702 sterols Nutrition 0.000 claims description 6
- 238000003786 synthesis reaction Methods 0.000 claims description 6
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 206010002091 Anaesthesia Diseases 0.000 claims description 2
- 208000016583 Anus disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000014644 Brain disease Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 208000016621 Hearing disease Diseases 0.000 claims description 2
- 208000019022 Mood disease Diseases 0.000 claims description 2
- 208000016285 Movement disease Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 208000028017 Psychotic disease Diseases 0.000 claims description 2
- 206010039897 Sedation Diseases 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 208000013521 Visual disease Diseases 0.000 claims description 2
- 208000012826 adjustment disease Diseases 0.000 claims description 2
- 230000037005 anaesthesia Effects 0.000 claims description 2
- 208000029560 autism spectrum disease Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010009887 colitis Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 208000018459 dissociative disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 230000036407 pain Effects 0.000 claims description 2
- 230000001314 paroxysmal effect Effects 0.000 claims description 2
- 208000022821 personality disease Diseases 0.000 claims description 2
- 208000014081 polyp of colon Diseases 0.000 claims description 2
- 201000000980 schizophrenia Diseases 0.000 claims description 2
- 230000036280 sedation Effects 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 125000002328 sterol group Chemical group 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 208000029257 vision disease Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 8
- 238000000034 method Methods 0.000 description 10
- 238000011282 treatment Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021132225A JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359532P | 2016-07-07 | 2016-07-07 | |
| US62/359,532 | 2016-07-07 | ||
| PCT/US2017/041199 WO2018009867A1 (en) | 2016-07-07 | 2017-07-07 | Oxysterols and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132225A Division JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519587A JP2019519587A (ja) | 2019-07-11 |
| JP2019519587A5 true JP2019519587A5 (cg-RX-API-DMAC7.html) | 2020-08-13 |
| JP6966486B2 JP6966486B2 (ja) | 2021-11-17 |
Family
ID=59383635
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568810A Active JP6966486B2 (ja) | 2016-07-07 | 2017-07-07 | オキシステロールおよびその使用方法 |
| JP2021132225A Withdrawn JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132225A Withdrawn JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10781231B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3919502A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6966486B2 (cg-RX-API-DMAC7.html) |
| AU (3) | AU2017292870B2 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1124631T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3481846T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2884071T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20211272T8 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE055263T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT3481846T (cg-RX-API-DMAC7.html) |
| MA (1) | MA45598B1 (cg-RX-API-DMAC7.html) |
| MD (1) | MD3481846T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3481846T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3481846T (cg-RX-API-DMAC7.html) |
| RS (1) | RS62222B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI3481846T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT202100468T1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI752976B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018009867A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202300232T1 (it) | 2011-09-08 | 2023-09-06 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e relativi usi |
| AU2014243773B2 (en) | 2013-03-13 | 2018-12-13 | Sage Therapeutics, Inc. | Neuroactive steroids and methods of use thereof |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| AU2016289971C1 (en) | 2015-07-06 | 2022-12-08 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| BR122021005552B1 (pt) | 2015-07-06 | 2024-01-02 | Sage Therapeutics, Inc | Compostos oxiesteróis, seus usos e composição farmacêutica |
| EP3436022B1 (en) | 2016-04-01 | 2022-03-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PT3481846T (pt) | 2016-07-07 | 2021-08-13 | Sage Therapeutics Inc | 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda |
| WO2018064649A1 (en) | 2016-09-30 | 2018-04-05 | Sage Therapeutics, Inc. | C7 substituted oxysterols and methods as nmda modulators |
| RU2019115112A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
| RU2019115113A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| CN111777654B (zh) * | 2020-06-11 | 2021-08-10 | 浙江神洲药业有限公司 | 一种泼尼松的制备方法 |
| MX2023014719A (es) | 2021-06-11 | 2024-02-15 | Sage Therapeutics Inc | Esteroide neuroactivo para el tratamiento de la enfermedad de alzheimer. |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| CN115057906B (zh) * | 2022-07-28 | 2022-12-02 | 中节能万润股份有限公司 | 利用去氢表雄酮合成胆固醇的方法 |
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