|
US4838925A
(en)
|
1986-04-25 |
1989-06-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
|
JP3763997B2
(ja)
|
1999-05-13 |
2006-04-05 |
富士写真フイルム株式会社 |
感熱記録材料
|
|
JP4331823B2
(ja)
|
1999-05-21 |
2009-09-16 |
富士フイルム株式会社 |
ピロロ［１，２−ａ］−１，３，５−トリアジン−４−オン系化合物
|
|
NZ519984A
(en)
|
2000-01-07 |
2004-03-26 |
Transform Pharmaceuticals Inc |
High-throughput formation, identification, and analysis of diverse solid-forms
|
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
|
JP4070966B2
(ja)
|
2001-06-28 |
2008-04-02 |
株式会社カネボウ化粧品 |
新規ガラクトシルセラミド類縁体及び用途
|
|
WO2003035649A1
(en)
|
2001-10-22 |
2003-05-01 |
Pfizer Japan Inc. |
Imidazopyridine compounds as 5-ht4 receptor modulators
|
|
US20050096322A1
(en)
|
2002-03-01 |
2005-05-05 |
Susumu Igarashi |
Nitrogen-containing heterocyclic compound
|
|
DOP2003000703A
(es)
|
2002-09-20 |
2004-03-31 |
Pfizer |
Compuestos de imidazopiradina como agonistas del receptor 5-ht4
|
|
EP1543004A1
(en)
|
2002-09-20 |
2005-06-22 |
Pfizer Inc. |
N-substituted piperidinyl-imidazopyridine compounds as 5-ht4 receptor modulators
|
|
AU2003299651A1
(en)
|
2002-12-11 |
2004-06-30 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ［１，５−ａ］ピリミジン誘導体
|
|
MXPA05011270A
(es)
|
2003-04-21 |
2006-01-24 |
Pfizer |
Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3.
|
|
WO2005046611A2
(en)
|
2003-11-12 |
2005-05-26 |
Amicus Therapeutics Inc. |
Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat gaucher disease
|
|
GB0329214D0
(en)
*
|
2003-12-17 |
2004-01-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0400812D0
(en)
|
2004-01-14 |
2004-02-18 |
Celltech R&D Ltd |
Novel compounds
|
|
CA2556404A1
(en)
|
2004-02-18 |
2005-08-25 |
Banyu Pharmaceutical Co., Ltd. |
Nitrogenous fused heteroaromatic ring derivative
|
|
ATE396725T1
(de)
|
2004-05-14 |
2008-06-15 |
Cleveland Clinic Foundation |
Kleinmolekülige hemmer für mrp1 und andere multiarzneimitteltransporter
|
|
JP4608542B2
(ja)
|
2004-06-21 |
2011-01-12 |
エフ．ホフマン−ラ ロシュ アーゲー |
ピラゾロピリミジン誘導体
|
|
US20080051409A1
(en)
|
2004-08-02 |
2008-02-28 |
Peter Gmeiner |
Indolizine Carboxamides and Aza and Diaza Derivatives Thereof
|
|
DE102004049363A1
(de)
|
2004-10-08 |
2006-04-13 |
Henkel Kgaa |
Mittel zum Färben von keratinhaltigen Fasern
|
|
DE602006010320D1
(de)
|
2005-01-19 |
2009-12-24 |
Merck & Co Inc |
Bicyclische pyrimidine als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes
|
|
RU2402553C2
(ru)
|
2005-02-11 |
2010-10-27 |
Ф. Хоффманн-Ля Рош Аг |
ПРОИЗВОДНЫЕ ПИРАЗОЛ-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
TW200720231A
(en)
|
2005-04-21 |
2007-06-01 |
Dainippon Sumitomo Pharma Co |
An n-substituted phenylacetamide derivative and a pharmaceutical composition thereof
|
|
JP5079500B2
(ja)
|
2005-04-28 |
2012-11-21 |
協和発酵キリン株式会社 |
２−アミノキナゾリン誘導体
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7723336B2
(en)
|
2005-09-22 |
2010-05-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
|
CA2624500A1
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
US8372851B2
(en)
|
2005-10-21 |
2013-02-12 |
Exelixis, Inc. |
Pyrazolo pyrimidines as casein kinase II (CK2) modulators
|
|
RU2008127263A
(ru)
|
2005-12-08 |
2010-01-20 |
Новартис АГ (CH) |
ПИРАЗОЛ [1,5-a] ПИРИДИН-3-КАРБОНОВЫЕ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ EphB-И VEGFR2-КИНАЗЫ
|
|
TW200800997A
(en)
*
|
2006-03-22 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
|
AU2007260812B2
(en)
|
2006-06-23 |
2012-08-16 |
Amicus Therapeutics, Inc. |
Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
WO2008019363A2
(en)
|
2006-08-07 |
2008-02-14 |
Albany Molecular Research, Inc. |
2-alkylbenzoxazole carboxamides as 5ht3 modulators
|
|
AU2007321924A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic metalloprotease inhibitors
|
|
AU2007321923A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic matrix metalloprotease inhibitors
|
|
CA2682016A1
(en)
|
2007-03-28 |
2008-10-02 |
Inovacia Ab |
Pyrazolo [1,5-a]pyrimidines as inhibitors of stearoyl-coa desaturase
|
|
AR067326A1
(es)
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
EA201000003A1
(ru)
|
2007-06-21 |
2010-06-30 |
Айрм Ллк |
Ингибиторы протеинкиназ и способы их применения
|
|
WO2009060835A1
(ja)
|
2007-11-05 |
2009-05-14 |
Kyoto University |
新規ユビキリン結合性小分子
|
|
US20110046127A1
(en)
|
2007-11-08 |
2011-02-24 |
Paolo Pevarello |
Imidazopyridazines for Use as Protein Kinase Inhibitors
|
|
EP2225247A1
(en)
|
2007-11-28 |
2010-09-08 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
EP2240488B1
(en)
|
2008-02-06 |
2016-11-02 |
Bristol-Myers Squibb Company |
Substituted imidazopyridazines useful as kinase inhibitors
|
|
CA2718727A1
(en)
|
2008-03-25 |
2009-10-01 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
SG190603A1
(en)
|
2008-05-01 |
2013-06-28 |
Sirtris Pharmaceuticals Inc |
Quinolines and related analogs as sirtuin modulators
|
|
AU2009305203B2
(en)
|
2008-10-14 |
2013-03-07 |
Entasis Therapeutics Limited |
Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
|
|
CA2740792C
(en)
*
|
2008-10-31 |
2016-06-21 |
Genentech, Inc. |
Pyrazolopyrimidine jak inhibitor compounds and methods
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
AU2010284254B2
(en)
|
2009-08-17 |
2015-09-17 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
|
MX358682B
(es)
*
|
2010-07-13 |
2018-08-31 |
Hoffmann La Roche |
Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
TW201217312A
(en)
|
2010-09-22 |
2012-05-01 |
Gruenenthal Gmbh |
Substituted benzamide compounds
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
US9353117B2
(en)
*
|
2010-12-08 |
2016-05-31 |
The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services |
Substituted pyrazolopyrimidines as glucocerebrosidase activators
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
EP2688872A4
(en)
*
|
2011-03-22 |
2014-08-27 |
Merck Sharp & Dohme |
AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES
|
|
EP2723384B1
(en)
|
2011-06-22 |
2018-08-29 |
The General Hospital Corporation |
Treatment of proteinopathies
|
|
HUE026671T2
(en)
|
2011-08-18 |
2016-07-28 |
Nippon Shinyaku Co Ltd |
Heterocyclic derivatives as microsomal prostaglandin E synthetase inhibitors (mPGEs)
|
|
EP2751106B1
(de)
|
2011-09-02 |
2017-10-18 |
Bayer Intellectual Property GmbH |
Substituierte annellierte pyrimidine und ihre verwendung
|
|
WO2013059119A1
(en)
|
2011-10-17 |
2013-04-25 |
The Regents Of The University Of Michigan |
Glucosylceramide synthase inhibitors and therapeutic methods using the same
|
|
CN104394869A
(zh)
|
2011-10-20 |
2015-03-04 |
葛兰素史密斯克莱有限责任公司 |
用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物
|
|
BR112014015339A8
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos para inibição da interação de bcl2 com parceiros de ligação
|
|
EP2822944A1
(en)
|
2012-03-05 |
2015-01-14 |
Amgen, Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
EP3235499A3
(en)
|
2012-03-09 |
2018-01-17 |
Lexicon Pharmaceuticals, Inc. |
Inhibition of adaptor associated kinase 1 for the treatment of pain
|
|
MX347917B
(es)
|
2012-03-09 |
2017-05-17 |
Lexicon Pharmaceuticals Inc |
Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
|
|
EP2831039A1
(en)
|
2012-03-28 |
2015-02-04 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Salicylic acid derivatives useful as glucocerebrosidase activators
|
|
CA2870407A1
(en)
|
2012-05-31 |
2013-12-05 |
F. Hoffmann-La Roche Ag |
Aminoquinazoline and pyridopyrimidine derivatives
|
|
JP6311603B2
(ja)
|
2012-06-22 |
2018-04-18 |
住友化学株式会社 |
縮合複素環化合物
|
|
WO2014025651A1
(en)
|
2012-08-06 |
2014-02-13 |
Amgen Inc. |
Chroman derivatives as trpm8 inhibitors
|
|
JP2015532650A
(ja)
|
2012-09-05 |
2015-11-12 |
バイエル・クロップサイエンス・アクチェンゲゼルシャフト |
非生物的植物ストレスに対する活性物質としての置換された２−アミドベンズイミダゾール類、２−アミドベンゾオキサゾール類および２−アミドベンゾチアゾール類またはそれらの塩の使用
|
|
EP2920181B1
(en)
|
2012-11-16 |
2019-01-09 |
University Health Network |
Pyrazolopyrimidine compounds
|
|
US9938258B2
(en)
|
2012-11-29 |
2018-04-10 |
Karyopharm Therapeutics Inc. |
Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
|
|
EP3418281B1
(en)
*
|
2012-12-07 |
2020-09-30 |
Vertex Pharmaceuticals Inc. |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of atr kinase for the treatment of cancer diseases
|
|
KR20140086002A
(ko)
|
2012-12-28 |
2014-07-08 |
한미약품 주식회사 |
Fms 키나아제 저해 활성을 갖는 피리다진 접합고리 유도체
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
EP2970266B1
(en)
|
2013-03-15 |
2018-01-31 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
|
|
EP3026051A4
(en)
|
2013-07-24 |
2017-03-08 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
US20160199372A1
(en)
|
2013-08-20 |
2016-07-14 |
Bristol-Myers Squibb Company |
Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia
|
|
WO2015027124A1
(en)
|
2013-08-23 |
2015-02-26 |
Incyte Corporation |
Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
|
|
AR097543A1
(es)
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
TW201542550A
(zh)
|
2013-09-06 |
2015-11-16 |
Lexicon Pharmaceuticals Inc |
吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
|
|
WO2015073267A1
(en)
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
ES2895490T3
(es)
|
2014-03-27 |
2022-02-21 |
Acad Medisch Ct |
Iminoazúcares N-(5-(bifen-4-ilmetiloxi)pentil)-sustituidos como inhibidores de glucosilceramida sintasa
|
|
TW201613925A
(en)
|
2014-07-10 |
2016-04-16 |
Incyte Corp |
Imidazopyrazines as LSD1 inhibitors
|
|
WO2016073891A1
(en)
|
2014-11-06 |
2016-05-12 |
Lysosomal Therapeutics Inc. |
Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
|
|
DK3215511T3
(da)
|
2014-11-06 |
2024-05-13 |
Bial R&D Invest S A |
Substituerede pyrazolo(1,5-a)pyrimidiner og deres anvendelse i behandlingen af medicinske lidelser
|
|
US20170333435A1
(en)
|
2014-11-06 |
2017-11-23 |
Lysosomal Therapeutics Inc. |
Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
|
|
CN108290855A
(zh)
|
2015-07-01 |
2018-07-17 |
西北大学 |
被取代的喹唑啉化合物及其调节葡糖脑苷脂酶活性的用途
|
|
US9802942B2
(en)
|
2015-07-01 |
2017-10-31 |
Northwestern University |
Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
|
|
EP3344632A4
(en)
|
2015-09-04 |
2019-03-20 |
Lysosomal Therapeutics Inc. |
Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders
|
|
PT3371190T
(pt)
|
2015-11-06 |
2022-07-08 |
Incyte Corp |
Compostos heterocíclicos como inibidores de pi3k-gamma
|
|
US10479793B2
(en)
|
2015-11-18 |
2019-11-19 |
Bristol-Myers Squibb Company |
Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
|
|
CN108473501B
(zh)
|
2016-02-18 |
2021-07-16 |
豪夫迈·罗氏有限公司 |
治疗化合物、其组合物及使用方法
|
|
EP3440081A4
(en)
|
2016-04-06 |
2019-09-18 |
Lysosomal Therapeutics Inc. |
PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
|
|
EP3440083A4
(en)
|
2016-04-06 |
2019-09-18 |
Lysosomal Therapeutics Inc. |
IMIDAZO [1,5-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
|
|
JP7038063B2
(ja)
|
2016-04-06 |
2022-03-17 |
リソソーマル・セラピューティクス・インコーポレイテッド |
ピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
|
|
EP3452045A1
(en)
|
2016-05-04 |
2019-03-13 |
Lysosomal Therapeutics Inc. |
Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
|
|
AU2017261291C1
(en)
|
2016-05-05 |
2022-05-26 |
Bial - R&D Investments, S.A. |
Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders
|
|
US11345698B2
(en)
|
2016-05-05 |
2022-05-31 |
Bial—R&D Investments, S.A. |
Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders
|
|
US20190389865A1
(en)
|
2016-05-05 |
2019-12-26 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED PYRROLO[1,2-a]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
US20200339587A1
(en)
|
2017-12-21 |
2020-10-29 |
Lysosomal Therapeutics Inc. |
Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof
|