JP2019519491A5 - - Google Patents

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Publication number

JP2019519491A5

JP2019519491A5 JP2018558662A JP2018558662A JP2019519491A5 JP 2019519491 A5 JP2019519491 A5 JP 2019519491A5 JP 2018558662 A JP2018558662 A JP 2018558662A JP 2018558662 A JP2018558662 A JP 2018558662A JP 2019519491 A5 JP2019519491 A5 JP 2019519491A5

Authority

JP

Japan

Prior art keywords

compound

compound according

groups

formula

substituted

Prior art date

2017-05-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 51
• 229910052739 hydrogen Inorganic materials 0.000 claims 7
• 239000001257 hydrogen Substances 0.000 claims 7
• 150000001408 amides Chemical class 0.000 claims 6
• 150000002148 esters Chemical class 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
• 229920000858 Cyclodextrin Polymers 0.000 claims 4
• 239000013522 chelant Substances 0.000 claims 4
• 150000003983 crown ethers Chemical class 0.000 claims 4
• 229940097362 cyclodextrins Drugs 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 4
• 150000004032 porphyrins Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 229910052736 halogen Inorganic materials 0.000 claims 3
• 150000002367 halogens Chemical class 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 108010069514 Cyclic Peptides Proteins 0.000 claims 2
• 102000001189 Cyclic Peptides Human genes 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000000314 lubricant Substances 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• OZFJRKAKSNINHF-KKUMJFAQSA-N (2s)-2-[[[(4s)-4-[[(4s)-4-(6-aminohexanoylamino)-4-carboxybutanoyl]amino]-4-carboxybutoxy]-hydroxyphosphoryl]amino]pentanedioic acid Chemical compound NCCCCCC(=O)N[C@H](C(O)=O)CCC(=O)N[C@H](C(O)=O)CCCOP(O)(=O)N[C@H](C(O)=O)CCC(O)=O OZFJRKAKSNINHF-KKUMJFAQSA-N 0.000 claims 1
• 108091023037 Aptamer Proteins 0.000 claims 1
• IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 1
• 108010051479 Bombesin Proteins 0.000 claims 1
• 102000013585 Bombesin Human genes 0.000 claims 1
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
• 102000006992 Interferon-alpha Human genes 0.000 claims 1
• 108010047761 Interferon-alpha Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 claims 1
• 101710200814 Melanotropin alpha Proteins 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
• 229940120638 avastin Drugs 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims 1
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
• 229940127093 camptothecin Drugs 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 239000003086 colorant Substances 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 239000003995 emulsifying agent Substances 0.000 claims 1
• 229940082789 erbitux Drugs 0.000 claims 1
• 239000000796 flavoring agent Substances 0.000 claims 1
• 235000019634 flavors Nutrition 0.000 claims 1
• 229940022353 herceptin Drugs 0.000 claims 1
• 239000003906 humectant Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• CFODQUSMSYDHBS-UHFFFAOYSA-N octreotate Chemical compound O=C1NC(CC=2C=CC=CC=2)C(=O)NC(CC=2[C]3C=CC=CC3=NC=2)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(C(=O)NC(C(O)C)C(O)=O)CSSCC1NC(=O)C(N)CC1=CC=CC=C1 CFODQUSMSYDHBS-UHFFFAOYSA-N 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000003755 preservative agent Substances 0.000 claims 1
• 230000002335 preservative effect Effects 0.000 claims 1
• 239000003381 stabilizer Substances 0.000 claims 1
• 239000004094 surface-active agent Substances 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 229960004964 temozolomide Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 claims 1
• WJLROCPIZOQIAS-UHFFFAOYSA-N CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O Chemical compound CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O WJLROCPIZOQIAS-UHFFFAOYSA-N 0.000 description 1
• ZJBDNCHDNHMUKT-QWRGUYRKSA-N C[C@@H](CCC(N[C@@H](CCCOP(NCCCC(O)=O)(O)=O)C(O)=O)=O)C(O)=O Chemical compound C[C@@H](CCC(N[C@@H](CCCOP(NCCCC(O)=O)(O)=O)C(O)=O)=O)C(O)=O ZJBDNCHDNHMUKT-QWRGUYRKSA-N 0.000 description 1