JP2019518739A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019518739A5 JP2019518739A5 JP2018559785A JP2018559785A JP2019518739A5 JP 2019518739 A5 JP2019518739 A5 JP 2019518739A5 JP 2018559785 A JP2018559785 A JP 2018559785A JP 2018559785 A JP2018559785 A JP 2018559785A JP 2019518739 A5 JP2019518739 A5 JP 2019518739A5
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- lipid
- peg
- mol
- pegylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims 23
- 150000002632 lipids Chemical class 0.000 claims 20
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
- 239000000556 agonist Substances 0.000 claims 7
- 102000002689 Toll-like receptor Human genes 0.000 claims 6
- 108020000411 Toll-like receptor Proteins 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 230000007935 neutral effect Effects 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 235000012000 cholesterol Nutrition 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 claims 2
- FVXDQWZBHIXIEJ-LNDKUQBDSA-N 1,2-di-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC FVXDQWZBHIXIEJ-LNDKUQBDSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 claims 1
- FBFJOZZTIXSPPR-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CCCCN)C3=C(N)N=C21 FBFJOZZTIXSPPR-UHFFFAOYSA-N 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 229940124613 TLR 7/8 agonist Drugs 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 150000008105 phosphatidylcholines Chemical class 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 0 CCC(*C(C(C)C(*NC(C)=CC)OC*)[C@@](C)C(C)C)=C Chemical compound CCC(*C(C(C)C(*NC(C)=CC)OC*)[C@@](C)C(C)C)=C 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022143788A JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337328P | 2016-05-16 | 2016-05-16 | |
| US62/337,328 | 2016-05-16 | ||
| PCT/US2017/032756 WO2017200957A1 (en) | 2016-05-16 | 2017-05-15 | Pegylated liposomes and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022143788A Division JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518739A JP2019518739A (ja) | 2019-07-04 |
| JP2019518739A5 true JP2019518739A5 (enExample) | 2020-06-25 |
| JP7195147B2 JP7195147B2 (ja) | 2022-12-23 |
Family
ID=58794159
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559785A Active JP7195147B2 (ja) | 2016-05-16 | 2017-05-15 | Ｐｅｇ化リポソームおよび使用方法 |
| JP2022143788A Pending JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022143788A Pending JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11266602B2 (enExample) |
| EP (1) | EP3458028A1 (enExample) |
| JP (2) | JP7195147B2 (enExample) |
| KR (1) | KR102483033B1 (enExample) |
| CN (1) | CN109562057A (enExample) |
| AU (2) | AU2017268175B2 (enExample) |
| BR (1) | BR112018073676B1 (enExample) |
| CA (1) | CA3023672A1 (enExample) |
| IL (3) | IL319503A (enExample) |
| MX (1) | MX2018013640A (enExample) |
| WO (1) | WO2017200957A1 (enExample) |
| ZA (1) | ZA201807128B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL319503A (en) * | 2016-05-16 | 2025-05-01 | Access To Advanced Health Inst | PEGylated liposomes and methods of use |
| CN107998070A (zh) * | 2017-12-12 | 2018-05-08 | 南京中医药大学 | 一种复合磷脂传递体及其在制备经皮给药制剂中的应用 |
| EP3886901A1 (en) * | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| CA3116146A1 (en) * | 2018-12-17 | 2020-06-25 | Eisai R&D Management Co., Ltd. | Formulation comprising liposomes |
| CN110151702A (zh) * | 2019-06-24 | 2019-08-23 | 昆明医科大学 | 聚乙二醇修饰流感疫苗脂质体及其制备方法 |
| US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
| KR102328531B1 (ko) * | 2020-01-23 | 2021-11-17 | 서울대학교산학협력단 | 체내 면역 세포 표적 황화수소 공여체 담지 리포좀을 포함하는 면역질환 치료 또는 예방용 약학 조성물 |
| KR20220156933A (ko) | 2020-03-23 | 2022-11-28 | 에이치디티 바이오 코포레이션 | Rna의 전달을 위한 조성물 및 방법 |
| JP2023535405A (ja) * | 2020-07-22 | 2023-08-17 | ユニバーシティー オブ ヒューストン システム | 呼吸器疾患に関連する状態の処置および防止 |
| AU2021406131A1 (en) | 2020-12-23 | 2023-08-03 | Access To Advanced Health Institute | Solanesol vaccine adjuvants and methods of preparing same |
| US20240180834A1 (en) * | 2021-02-26 | 2024-06-06 | Univesity Of Virginia Patent Foundation | Development of covid-19 vaccine using a dual tlr ligand liposome adjuvant |
| EP4304567A1 (en) * | 2021-03-11 | 2024-01-17 | The Trustees of the University of Pennsylvania | Targeted therapeutic lipid nanoparticles and methods of use |
| KR102682082B1 (ko) * | 2021-06-01 | 2024-07-05 | 서울대학교산학협력단 | 리포좀 및 이를 포함하는 암 방사선 치료용 약학 조성물 |
| AU2022349251A1 (en) | 2021-09-22 | 2024-04-11 | Hdt Bio Corp. | Sars-cov-2 rna vaccine compositions and methods of use |
| WO2023048760A1 (en) | 2021-09-22 | 2023-03-30 | Hdt Bio Corp. | Rna vaccines against infectious diseases |
| KR20240088845A (ko) | 2021-09-22 | 2024-06-20 | 에이치디티 바이오 코포레이션 | 건조된 나노입자 조성물 |
| AU2022348995A1 (en) | 2021-09-22 | 2024-04-11 | Hdt Bio Corp. | Cancer therapy compositions and uses thereof |
| EP4637712A1 (en) * | 2022-12-19 | 2025-10-29 | Newimmune II, LLC | Nanoparticulate formulation |
| CN115737800B (zh) * | 2023-01-09 | 2023-05-23 | 江苏瑞科生物技术股份有限公司 | 一种复合脂质体佐剂及其制备方法 |
| WO2025245466A1 (en) * | 2024-05-24 | 2025-11-27 | Curevo, Inc. | Immunogenic compositions for the prevention of herpes zoster |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US4286592A (en) | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
| US4314557A (en) | 1980-05-19 | 1982-02-09 | Alza Corporation | Dissolution controlled active agent dispenser |
| US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US4568343A (en) | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| FI861417A0 (fi) | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
| US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
| US4948587A (en) | 1986-07-08 | 1990-08-14 | Massachusetts Institute Of Technology | Ultrasound enhancement of transbuccal drug delivery |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| EP0304578B1 (en) | 1987-06-22 | 2001-10-24 | Medeva Holdings Bv | Peptide comprising hepatitis B surface antigen |
| US4780212A (en) | 1987-07-31 | 1988-10-25 | Massachusetts Institute Of Technology | Ultrasound enchancement of membrane permeability |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| GB2232892B (en) | 1988-02-23 | 1991-07-24 | John Mark Tucker | Occlusive body for administering a physiologically active substance |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| GB8819209D0 (en) | 1988-08-12 | 1988-09-14 | Research Corp Ltd | Polypeptide & dna encoding same |
| US4999403A (en) | 1988-10-28 | 1991-03-12 | Exxon Chemical Patents Inc. | Graft polymers of functionalized ethylene-alpha-olefin copolymer with polypropylene, methods of preparation, and use in polypropylene compositions |
| ES2160570T3 (es) | 1988-12-16 | 2001-11-16 | Nederlanden Staat | Mutantes de neumolisina y vacunas de neumococos fabricadas a partir de los mismos. |
| SG48175A1 (en) | 1989-07-25 | 1998-04-17 | Smithkline Beecham Biolog | Novel antigens and method for their preparation |
| US5256643A (en) | 1990-05-29 | 1993-10-26 | The Government Of The United States | Human cripto protein |
| GB9106048D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccines |
| CA2113712C (en) | 1991-07-19 | 2007-06-12 | Ian Frazer | Papilloma virus vaccine |
| US5464387A (en) | 1991-07-24 | 1995-11-07 | Alza Corporation | Transdermal delivery device |
| KR100251505B1 (ko) | 1991-11-16 | 2000-05-01 | 장 스테판느 | 말라리아원충으로부터의 cs 및 hbsag 사이의 혼성 단백질(hybrid protein between cs from plasmodium and hbsag) |
| DE122007000101I1 (de) | 1992-06-25 | 2008-03-27 | Papillomavirus vakzine | |
| US5786148A (en) | 1996-11-05 | 1998-07-28 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a novel prostate-specific kallikrein |
| US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| DE05075889T1 (de) | 1993-03-09 | 2006-10-05 | The University Of Rochester | Herstellung von menschlichem Papilloma-Virus HBV-11-Capsid-Protein L1 und virusähnlichen Teilchen |
| KR100341341B1 (ko) | 1993-07-15 | 2002-11-25 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 이미다조[4,5-c]피리딘-4-아민 |
| DE69433727T2 (de) | 1993-11-02 | 2004-09-30 | Matsushita Electric Industrial Co., Ltd., Kadoma | Halbleiterbauelement mit einem Aggregat von Mikro-Nadeln aus Halbleitermaterial |
| US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
| US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
| US5457041A (en) | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| US5591139A (en) | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
| ES2264563T3 (es) | 1994-10-07 | 2007-01-01 | Loyola University Of Chicago | Particulas semejantes al virus del papiloma, proteinas de fusion y procedimiento para su preparacion. |
| CA2211995A1 (en) | 1995-02-24 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation |
| US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
| US5981215A (en) | 1995-06-06 | 1999-11-09 | Human Genome Sciences, Inc. | Human criptin growth factor |
| US5618275A (en) | 1995-10-27 | 1997-04-08 | Sonex International Corporation | Ultrasonic method and apparatus for cosmetic and dermatological applications |
| US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
| US5955306A (en) | 1996-09-17 | 1999-09-21 | Millenium Pharmaceuticals, Inc. | Genes encoding proteins that interact with the tub protein |
| US7033598B2 (en) | 1996-11-19 | 2006-04-25 | Intrabrain International N.V. | Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal |
| US5840871A (en) | 1997-01-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Prostate-associated kallikrein |
| ATE302414T1 (de) | 1997-02-25 | 2005-09-15 | Corixa Corp | Verbindungen zur immundiagnose von prostatakrebs und deren verwendung |
| CA2297374A1 (en) | 1997-07-21 | 1999-01-28 | North American Vaccine, Inc. | Modified immunogenic pneumolysin, compositions and their use as vaccines |
| GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| US7459524B1 (en) | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
| EP1032676A2 (en) | 1997-11-28 | 2000-09-06 | Genset | $i(CHLAMYDIA TRACHOMATIS) GENOMIC SEQUENCE AND POLYPEPTIDES, FRAGMENTS THEREOF AND USES THEREOF, IN PARTICULAR FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INFECTION |
| UA67760C2 (uk) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| BR9907691B1 (pt) | 1998-02-05 | 2011-05-31 | derivado de antìgeno e antìgeno da famìlia mage associado a tumor, seqüência de ácido nucléico, codificando os mesmos, seus usos na preparação de vacina, processo para produção de vacina e vacina. | |
| CN1629185B (zh) | 1998-04-07 | 2011-11-02 | 科里克萨公司 | 结核杆菌抗原融合蛋白及其应用 |
| GB2336310B (en) | 1998-04-14 | 2003-09-10 | Stowic Resources Ltd | Method of manufacturing transdermal patches |
| AU3560399A (en) | 1998-04-15 | 1999-11-01 | Ludwig Institute For Cancer Research | Tumor associated nucleic acids and uses therefor |
| US6322532B1 (en) | 1998-06-24 | 2001-11-27 | 3M Innovative Properties Company | Sonophoresis method and apparatus |
| TW200728465A (en) | 1998-07-14 | 2007-08-01 | Corixa Corp | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6110929A (en) | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| CA2370697C (en) | 1999-04-19 | 2012-03-06 | Smithkline Beecham Biologicals S.A. | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
| US6685699B1 (en) | 1999-06-09 | 2004-02-03 | Spectrx, Inc. | Self-removing energy absorbing structure for thermal tissue ablation |
| JP4162813B2 (ja) | 1999-10-28 | 2008-10-08 | 久光製薬株式会社 | イオントフォレーシス装置 |
| US6974588B1 (en) | 1999-12-07 | 2005-12-13 | Elan Pharma International Limited | Transdermal patch for delivering volatile liquid drugs |
| US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| US6676961B1 (en) | 2002-03-06 | 2004-01-13 | Automated Carrier Technologies, Inc. | Transdermal patch assembly |
| US7018345B2 (en) | 2002-12-06 | 2006-03-28 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis system |
| MY146124A (en) | 2003-10-03 | 2012-06-29 | 3M Innovative Properties Co | Pyrazolopyridines and analogs thereof |
| DE102005032175A1 (de) | 2005-07-09 | 2007-01-18 | Krones Ag | Behälter-Behandlungsmaschine und Verfahren zum Laden und Entladen einer Behälter-Behandlungsmaschine |
| DE502005002538D1 (de) | 2005-07-19 | 2008-03-06 | Holzapfel Gmbh & Co Kg Geb | Auftriebshilfe |
| US9333250B2 (en) * | 2006-04-06 | 2016-05-10 | The Johns Hopkins University | Methods and compositions for treating bacterial infection |
| WO2008153541A1 (en) * | 2006-09-26 | 2008-12-18 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| ES2456964T3 (es) * | 2007-02-07 | 2014-04-24 | The Regents Of The University Of California | Conjugados de agonistas de TLR sintéticos y usos de los mismos |
| EP3199176B1 (en) | 2007-04-04 | 2020-02-19 | Infectious Disease Research Institute | Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof |
| US8793881B2 (en) | 2008-08-15 | 2014-08-05 | Stanley Black & Decker, Inc. | Utility knife with blade lock |
| EA201100268A1 (ru) * | 2008-08-28 | 2011-10-31 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| CN102395600B (zh) * | 2009-02-17 | 2015-03-25 | 葛兰素史密斯克莱生物公司 | 含有无铝佐剂的灭活的登革热病毒疫苗 |
| LT2437753T (lt) | 2009-06-05 | 2016-12-12 | Infectious Disease Research Institute | Sintetiniai gliukopiranozillipidų adjuvantai ir juos turinčios vakcinų kompozicijos |
| US20120148663A1 (en) * | 2009-06-08 | 2012-06-14 | Epitarget As | Lipophilic drug carrier |
| TWI397428B (zh) * | 2009-12-29 | 2013-06-01 | Ind Tech Res Inst | 標的第四介白素受體之傳輸系統 |
| US20120014866A1 (en) | 2010-07-15 | 2012-01-19 | Ivor Bull | Copper Containing ZSM-34, OFF And/Or ERI Zeolitic Material For Selective Reduction Of NOx |
| LT2606047T (lt) | 2010-08-17 | 2017-04-10 | 3M Innovative Properties Company | Imuninio atsako modifikatoriaus junginio lipidizuotos kompozicijos, sudėtys ir būdai |
| EP4066857B1 (en) * | 2010-08-31 | 2022-12-21 | GlaxoSmithKline Biologicals SA | Pegylated liposomes for delivery of immunogen-encoding rna |
| ES2855474T3 (es) * | 2011-10-06 | 2021-09-23 | Immunovaccine Technologies Inc | Composiciones de liposomas que comprenden un adyuvante que activa o incrementa la actividad de TLR2 y usos del mismo |
| CN104023793B (zh) | 2011-10-31 | 2017-11-24 | 马林克罗特有限公司 | 用于治疗癌症的联合脂质体组合物 |
| WO2013086526A1 (en) * | 2011-12-09 | 2013-06-13 | The Regents Of The University Of California | Liposomal drug encapsulation |
| CN110339160A (zh) * | 2012-02-07 | 2019-10-18 | 传染性疾病研究院 | 包含tlr4激动剂的改进佐剂制剂及其使用方法 |
| PL2836234T3 (pl) * | 2012-04-12 | 2020-02-28 | Yale University | Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych |
| WO2013188699A1 (en) | 2012-06-13 | 2013-12-19 | Incytu, Inc. | Compositions, methods and devices for activating an immune response |
| WO2014008406A2 (en) * | 2012-07-05 | 2014-01-09 | Children's Medical Center Corporation | The bacterial biofilm matrix as a platform for protein delivery |
| CA2879356A1 (en) | 2012-07-26 | 2014-01-30 | National Oilwell Varco, L.P. | Telescoping core barrel |
| US8638146B1 (en) | 2012-07-31 | 2014-01-28 | Cambridge Silicon Radio Limited | Dual mode phase detection |
| CN105209017A (zh) * | 2013-03-13 | 2015-12-30 | 马林克罗特有限公司 | 用于癌症疗法的脂质体顺铂组合物 |
| US20160058852A1 (en) | 2014-02-14 | 2016-03-03 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| CN106456546A (zh) * | 2014-03-12 | 2017-02-22 | 葛兰素史密丝克莱恩生物有限公司 | 用于黏膜递送的脂质体组合物 |
| CN105534908B (zh) * | 2016-01-15 | 2018-12-14 | 徐州医学院 | 一种包载核酸药物的具缺氧响应能力和放疗增敏功能脂质体 |
| IL319503A (en) * | 2016-05-16 | 2025-05-01 | Access To Advanced Health Inst | PEGylated liposomes and methods of use |
-
2017
- 2017-05-15 IL IL319503A patent/IL319503A/en unknown
- 2017-05-15 CA CA3023672A patent/CA3023672A1/en active Pending
- 2017-05-15 JP JP2018559785A patent/JP7195147B2/ja active Active
- 2017-05-15 KR KR1020187034749A patent/KR102483033B1/ko active Active
- 2017-05-15 CN CN201780030294.4A patent/CN109562057A/zh active Pending
- 2017-05-15 EP EP17726411.6A patent/EP3458028A1/en not_active Withdrawn
- 2017-05-15 US US16/098,619 patent/US11266602B2/en active Active
- 2017-05-15 BR BR112018073676-7A patent/BR112018073676B1/pt active IP Right Grant
- 2017-05-15 AU AU2017268175A patent/AU2017268175B2/en active Active
- 2017-05-15 MX MX2018013640A patent/MX2018013640A/es unknown
- 2017-05-15 WO PCT/US2017/032756 patent/WO2017200957A1/en not_active Ceased
- 2017-05-15 IL IL313085A patent/IL313085B2/en unknown
- 2017-05-15 IL IL263030A patent/IL263030B2/en unknown
-
2018
- 2018-10-25 ZA ZA2018/07128A patent/ZA201807128B/en unknown
-
2021
- 2021-12-23 US US17/560,594 patent/US12318484B2/en active Active
-
2022
- 2022-09-09 JP JP2022143788A patent/JP2022177112A/ja active Pending
-
2023
- 2023-02-01 AU AU2023200515A patent/AU2023200515B2/en active Active
-
2025
- 2025-01-17 US US19/027,710 patent/US20250241857A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019518739A5 (enExample) | ||
| Pedersen et al. | Immunocorrelates of CAF family adjuvants | |
| Tandrup Schmidt et al. | Liposome-based adjuvants for subunit vaccines: formulation strategies for subunit antigens and immunostimulators | |
| Marasini et al. | Liposomes as a vaccine delivery system | |
| Davidsen et al. | Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6, 6′-dibehenate)—a novel adjuvant inducing both strong CMI and antibody responses | |
| Felnerova et al. | Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs | |
| JP2026001042A (ja) | ポリサルコシンを含むｒｎａ粒子 | |
| Giddam et al. | Liposome-based delivery system for vaccine candidates: constructing an effective formulation | |
| EP3964200A1 (en) | Compositions and methods for delivery of therapeutic agents | |
| CN103476431B (zh) | 包含阳离子脂质的用于带负电荷的药物的载体及其制备方法 | |
| AU2015320980B2 (en) | Stable formulations of lipids and liposomes | |
| Obeid et al. | Examination of the effect of niosome preparation methods in encapsulating model antigens on the vesicle characteristics and their ability to induce immune responses | |
| Nordly et al. | Immunity by formulation design: induction of high CD8+ T-cell responses by poly (I: C) incorporated into the CAF01 adjuvant via a double emulsion method | |
| US4117113A (en) | Immunological preparations | |
| FR2726764A1 (fr) | Adjuvant pour composition vaccinale | |
| EP3423037A1 (en) | Orally administrable composition | |
| JP2012532200A5 (enExample) | ||
| CN115335084A (zh) | 包含聚肌氨酸的rna颗粒 | |
| Nordly et al. | Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo | |
| JP2020526530A5 (enExample) | ||
| JP2017507968A (ja) | 粘膜送達用のリポソーム組成物 | |
| Soni et al. | The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems | |
| Shanmugam et al. | Nanostructured self assembled lipid materials for drug delivery and tissue engineering | |
| Lendemans et al. | Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid | |
| WO2024209013A1 (en) | Lipid nanoparticle compositions |