JP2019518739A5 - - Google Patents
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- Publication number
- JP2019518739A5 JP2019518739A5 JP2018559785A JP2018559785A JP2019518739A5 JP 2019518739 A5 JP2019518739 A5 JP 2019518739A5 JP 2018559785 A JP2018559785 A JP 2018559785A JP 2018559785 A JP2018559785 A JP 2018559785A JP 2019518739 A5 JP2019518739 A5 JP 2019518739A5
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- lipid
- peg
- mol
- pegylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims 23
- 150000002632 lipids Chemical class 0.000 claims 20
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
- 239000000556 agonist Substances 0.000 claims 7
- 102000002689 Toll-like receptor Human genes 0.000 claims 6
- 108020000411 Toll-like receptor Proteins 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 230000007935 neutral effect Effects 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 235000012000 cholesterol Nutrition 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 claims 2
- FVXDQWZBHIXIEJ-LNDKUQBDSA-N 1,2-di-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC FVXDQWZBHIXIEJ-LNDKUQBDSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 claims 1
- FBFJOZZTIXSPPR-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CCCCN)C3=C(N)N=C21 FBFJOZZTIXSPPR-UHFFFAOYSA-N 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 229940124613 TLR 7/8 agonist Drugs 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 150000008105 phosphatidylcholines Chemical class 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 0 CCC(*C(C(C)C(*NC(C)=CC)OC*)[C@@](C)C(C)C)=C Chemical compound CCC(*C(C(C)C(*NC(C)=CC)OC*)[C@@](C)C(C)C)=C 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022143788A JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337328P | 2016-05-16 | 2016-05-16 | |
| US62/337,328 | 2016-05-16 | ||
| PCT/US2017/032756 WO2017200957A1 (en) | 2016-05-16 | 2017-05-15 | Pegylated liposomes and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022143788A Division JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518739A JP2019518739A (ja) | 2019-07-04 |
| JP2019518739A5 true JP2019518739A5 (enExample) | 2020-06-25 |
| JP7195147B2 JP7195147B2 (ja) | 2022-12-23 |
Family
ID=58794159
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559785A Active JP7195147B2 (ja) | 2016-05-16 | 2017-05-15 | Ｐｅｇ化リポソームおよび使用方法 |
| JP2022143788A Pending JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022143788A Pending JP2022177112A (ja) | 2016-05-16 | 2022-09-09 | Ｐｅｇ化リポソームおよび使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11266602B2 (enExample) |
| EP (1) | EP3458028A1 (enExample) |
| JP (2) | JP7195147B2 (enExample) |
| KR (1) | KR102483033B1 (enExample) |
| CN (1) | CN109562057A (enExample) |
| AU (2) | AU2017268175B2 (enExample) |
| BR (1) | BR112018073676B1 (enExample) |
| IL (3) | IL313085B2 (enExample) |
| MX (1) | MX2018013640A (enExample) |
| WO (1) | WO2017200957A1 (enExample) |
| ZA (1) | ZA201807128B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102483033B1 (ko) | 2016-05-16 | 2022-12-30 | 액세스 투 어드밴스드 헬스 인스티튜트 | 페길화된 리포솜 및 이의 용도 |
| BR112019025104A2 (pt) | 2017-05-30 | 2020-06-23 | Glaxosmithkline Biologicals S.A. | Método de fabricar um sistema de entrega não viral, sistema de entrega não viral, e, composição |
| CN107998070A (zh) * | 2017-12-12 | 2018-05-08 | 南京中医药大学 | 一种复合磷脂传递体及其在制备经皮给药制剂中的应用 |
| EP3886901A1 (en) | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| AU2019400340A1 (en) * | 2018-12-17 | 2021-05-20 | Eisai R&D Management Co., Ltd. | Formulation comprising liposomes |
| CN110151702A (zh) * | 2019-06-24 | 2019-08-23 | 昆明医科大学 | 聚乙二醇修饰流感疫苗脂质体及其制备方法 |
| WO2021194672A1 (en) | 2020-03-23 | 2021-09-30 | Hdt Bio Corp. | Compositions and methods for delivery of rna |
| US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
| KR102328531B1 (ko) * | 2020-01-23 | 2021-11-17 | 서울대학교산학협력단 | 체내 면역 세포 표적 황화수소 공여체 담지 리포좀을 포함하는 면역질환 치료 또는 예방용 약학 조성물 |
| JP2023535405A (ja) * | 2020-07-22 | 2023-08-17 | ユニバーシティー オブ ヒューストン システム | 呼吸器疾患に関連する状態の処置および防止 |
| JP2024501949A (ja) | 2020-12-23 | 2024-01-17 | アクセス ツー アドバンスト ヘルス インスティチュート | ソラネソールワクチンアジュバント及びその調製方法 |
| WO2022183120A1 (en) * | 2021-02-26 | 2022-09-01 | University Of Virginia Patent Foundation | Development of covid-19 vaccine using a dual tlr ligand liposome adjuvant |
| WO2022192674A1 (en) * | 2021-03-11 | 2022-09-15 | The Trustees Of The University Of Pennsylvania | Targeted therapeutic lipid nanoparticles and methods of use |
| CN117327270B (zh) * | 2021-04-08 | 2026-07-07 | 厦门赛诺邦格生物科技股份有限公司 | 一种聚乙二醇化脂质及其修饰的脂质体、含该脂质体的药物组合物及其制剂和应用 |
| KR102682082B1 (ko) * | 2021-06-01 | 2024-07-05 | 서울대학교산학협력단 | 리포좀 및 이를 포함하는 암 방사선 치료용 약학 조성물 |
| AU2022352486A1 (en) | 2021-09-22 | 2024-04-11 | Hdt Bio Corp. | Dried nanoparticle compositions |
| CA3232658A1 (en) | 2021-09-22 | 2023-03-30 | Steven Gregory REED | Rna vaccines against infectious diseases |
| WO2023049636A2 (en) | 2021-09-22 | 2023-03-30 | Hdt Bio Corp. | Cancer therapy compositions and uses thereof |
| JP2024535352A (ja) | 2021-09-22 | 2024-09-30 | エイチディーティー バイオ コーポレーション | Ｓａｒｓ－ｃｏｖ－２ ｒｎａワクチン組成物および使用方法 |
| EP4637712A1 (en) * | 2022-12-19 | 2025-10-29 | Newimmune II, LLC | Nanoparticulate formulation |
| CN115737800B (zh) * | 2023-01-09 | 2023-05-23 | 江苏瑞科生物技术股份有限公司 | 一种复合脂质体佐剂及其制备方法 |
| WO2025245466A1 (en) * | 2024-05-24 | 2025-11-27 | Curevo, Inc. | Immunogenic compositions for the prevention of herpes zoster |
| CN121533991A (zh) * | 2026-01-20 | 2026-02-17 | 杭州英妙生物科技有限公司 | 靶向B细胞或靶向CD11b+细胞的纳米脂质体及其应用 |
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- 2017-05-15 EP EP17726411.6A patent/EP3458028A1/en not_active Withdrawn
- 2017-05-15 WO PCT/US2017/032756 patent/WO2017200957A1/en not_active Ceased
- 2017-05-15 CN CN201780030294.4A patent/CN109562057A/zh active Pending
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