JP2019515924A5 - - Google Patents
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- JP2019515924A5 JP2019515924A5 JP2018556297A JP2018556297A JP2019515924A5 JP 2019515924 A5 JP2019515924 A5 JP 2019515924A5 JP 2018556297 A JP2018556297 A JP 2018556297A JP 2018556297 A JP2018556297 A JP 2018556297A JP 2019515924 A5 JP2019515924 A5 JP 2019515924A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- disease
- compound according
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 208000006673 asthma Diseases 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 102000001691 Member 3 Group F Nuclear Receptor Subfamily 1 Human genes 0.000 claims 1
- 108010029279 Member 3 Group F Nuclear Receptor Subfamily 1 Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002345 steroid group Chemical group 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662328074P | 2016-04-27 | 2016-04-27 | |
| US62/328,074 | 2016-04-27 | ||
| PCT/US2017/029531 WO2017189661A1 (en) | 2016-04-27 | 2017-04-26 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORγT |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515924A JP2019515924A (ja) | 2019-06-13 |
| JP2019515924A5 true JP2019515924A5 (enExample) | 2019-07-18 |
| JP6893218B2 JP6893218B2 (ja) | 2021-06-23 |
Family
ID=59215941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556297A Expired - Fee Related JP6893218B2 (ja) | 2016-04-27 | 2017-04-26 | ＲＯＲγｔのモジュレータとしての６−アミノピリジン−３−イルチアゾール |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US10975068B2 (enExample) |
| EP (1) | EP3448856B1 (enExample) |
| JP (1) | JP6893218B2 (enExample) |
| KR (1) | KR20180135962A (enExample) |
| CN (1) | CN109415358B (enExample) |
| AR (1) | AR108344A1 (enExample) |
| AU (1) | AU2017255525A1 (enExample) |
| BR (1) | BR112018071942A2 (enExample) |
| CA (1) | CA3022318A1 (enExample) |
| CL (1) | CL2018003044A1 (enExample) |
| CO (1) | CO2018011633A2 (enExample) |
| CR (1) | CR20180505A (enExample) |
| EA (1) | EA036318B1 (enExample) |
| EC (1) | ECSP18088146A (enExample) |
| ES (1) | ES2906258T3 (enExample) |
| IL (1) | IL262381A (enExample) |
| MA (1) | MA44772A (enExample) |
| MX (1) | MX2018013143A (enExample) |
| NI (1) | NI201800109A (enExample) |
| PE (1) | PE20190150A1 (enExample) |
| PH (1) | PH12018502209A1 (enExample) |
| SG (1) | SG11201809162XA (enExample) |
| SV (1) | SV2018005772A (enExample) |
| TW (1) | TW201803869A (enExample) |
| UY (1) | UY37213A (enExample) |
| WO (1) | WO2017189661A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| JP2021517563A (ja) | 2018-03-12 | 2021-07-26 | エスカリア バイオサイエンシーズ，ビーブイ | 二環式ＲＯＲγモジュレーター |
| BR112020018718A2 (pt) | 2018-03-12 | 2021-03-09 | Escalier Biosciences B.V. | Moduladores de ror-gama espirocíclicos |
| EP3807261B1 (en) * | 2018-06-18 | 2022-07-13 | Janssen Pharmaceutica NV | Pyridinyl pyrazoles as modulators of roryt |
| JP2021528405A (ja) | 2018-06-18 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール |
| US11345666B2 (en) | 2018-06-18 | 2022-05-31 | Janssen Pharmaceutica Nv | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT |
| EP3806958B1 (en) | 2018-06-18 | 2022-09-07 | Janssen Pharmaceutica NV | 6-aminopyridin-3-yl pyrazoles as modulators of roryt |
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| IL91418A (en) | 1988-09-01 | 1997-11-20 | Rhone Poulenc Agrochimie | (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them |
| WO1996003392A1 (en) | 1994-07-27 | 1996-02-08 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| JP4073786B2 (ja) | 2001-04-16 | 2008-04-09 | 田辺三菱製薬株式会社 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
| CN100502863C (zh) | 2001-08-13 | 2009-06-24 | 詹森药业有限公司 | 2,4,5-三取代噻唑衍生物和它们的抗炎活性 |
| DE60208815T2 (de) | 2001-10-12 | 2006-07-20 | Bayer Pharmaceuticals Corp., West Haven | Phenyl substituierte 5-gliedrige stickstoff enthaltende heterocyclen zur behandlung von fettleibigkeit |
| CA2597896A1 (en) | 2005-02-16 | 2006-08-24 | Solvay Pharmaceuticals B.V. | 1h-imidazole derivatives as cannabinoid cb2 receptor modulators |
| WO2006124687A1 (en) | 2005-05-12 | 2006-11-23 | University Of Medicine And Dentistry Of New Jersey | Opioid receptor subtype-selective agents |
| EP1983980A4 (en) | 2006-01-25 | 2010-05-05 | Synta Pharmaceuticals Corp | THIAZOL AND THIADIAZOL COMPOUNDS FOR USES IN RELATION TO INFLAMMATION AND IMMUNITY |
| WO2008064317A1 (en) | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Lipophilic opioid receptor active compounds |
| WO2008064318A2 (en) | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Peripheral opioid receptor active compounds |
| WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| MX2011000477A (es) | 2008-07-17 | 2011-03-15 | Bayer Cropscience Ag | Compuestos heterociclicos como pesticidas. |
| TWI548411B (zh) | 2009-04-28 | 2016-09-11 | Kyowa Hakko Kirin Co Ltd | Exercise disorder treatment |
| UA110097C2 (uk) | 2009-09-02 | 2015-11-25 | Терапевтичний агент для лікування розладів настрою | |
| NZ598269A (en) | 2009-09-18 | 2014-12-24 | Zalicus Pharmaceuticals Ltd | Aryl sulphone derivatives as calcium channel blockers |
| AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
| US9101600B2 (en) | 2010-03-11 | 2015-08-11 | New York University | Compounds as RORγt modulators and uses thereof |
| WO2011112263A1 (en) | 2010-03-11 | 2011-09-15 | New York University | AMIDO COMPOUNDS AS RORγt MODULATORS AND USES THEREOF |
| WO2011115892A1 (en) | 2010-03-15 | 2011-09-22 | Griffin Patrick R | Modulators of the retinoic acid receptor-related orphan receptors |
| WO2012027965A1 (en) | 2010-09-01 | 2012-03-08 | Glaxo Group Limited | Novel compounds |
| US9505798B2 (en) | 2010-11-29 | 2016-11-29 | New York University | Steroid compounds as RORyt modulators and uses thereof |
| CN103282774B (zh) | 2010-12-28 | 2015-08-05 | 狮王株式会社 | 口腔状态的判定方法及其所使用的分析用具、装置以及程序 |
| US9012651B2 (en) | 2011-03-24 | 2015-04-21 | Abbvie Inc. | TRPV3 modulators |
| WO2012158784A2 (en) | 2011-05-16 | 2012-11-22 | Theodore Mark Kamenecka | Modulators of the nuclear hormone receptor ror |
| US9133128B2 (en) | 2011-06-17 | 2015-09-15 | Research Triangle Institute | Pyrazole derivatives as cannabinoid receptor 1 antagonists |
| US9156837B2 (en) | 2011-07-29 | 2015-10-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2013029338A1 (en) | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
| JP2014528933A (ja) | 2011-09-09 | 2014-10-30 | ニューヨーク ユニバーシティ | ＲＯＲγｔモジュレーターとしてのアミド化合物およびその使用 |
| US9815851B2 (en) | 2011-12-02 | 2017-11-14 | Phenex Pharmaceuticals Ag | Pyrrolo carboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
| US20130190356A1 (en) | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| WO2013178362A1 (en) * | 2012-05-31 | 2013-12-05 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma] |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| EP2931281B1 (en) | 2012-12-12 | 2018-01-17 | Merck Sharp & Dohme Corp. | Amino-pyrimidine-containing spleen tyrosine kinase inhibitors |
| WO2013171729A2 (en) | 2013-01-08 | 2013-11-21 | Glenmark Pharmaceuticals S.A. | Aryl and heteroaryl amide compounds as rorgamat modulator |
| WO2014195321A1 (en) | 2013-06-04 | 2014-12-11 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
| CN105705501B (zh) | 2013-09-09 | 2019-04-19 | 百时美施贵宝公司 | RORγ调节剂 |
| US20150072890A1 (en) | 2013-09-11 | 2015-03-12 | 20/20 Gene Systems, Inc. | Methods and compositions for aiding in the detection of lung cancer |
| CN105555768B (zh) | 2013-09-20 | 2018-10-16 | 百时美施贵宝公司 | RORγ调节剂 |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| KR20160070823A (ko) * | 2013-10-15 | 2016-06-20 | 얀센 파마슈티카 엔.브이. | RORγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
| KR20160068956A (ko) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | RORyT의 퀴놀리닐 조절제 |
| PL3077372T3 (pl) | 2013-12-05 | 2019-09-30 | Lead Pharma Holding B.V. | MODULATORY ROR GAMMA (RORγ) |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| MX369347B (es) | 2014-01-06 | 2019-11-06 | Bristol Myers Squibb Co | Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma). |
| CN106132931B (zh) | 2014-01-06 | 2019-08-02 | 百时美施贵宝公司 | 碳环砜RORγ调节剂 |
| EP3092221B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror-gamma modulators |
| CN106061947B (zh) | 2014-01-06 | 2019-12-03 | 百时美施贵宝公司 | 环己基砜RORγ调节剂 |
| TWI659019B (zh) | 2014-02-28 | 2019-05-11 | 日商帝人製藥股份有限公司 | 吡唑醯胺衍生物 |
| CN104926733B (zh) * | 2014-03-18 | 2019-05-10 | 北京韩美药品有限公司 | 作为RORγ调节剂的化合物 |
| CA2942871A1 (en) | 2014-03-27 | 2015-10-01 | Piramal Enterprises Limited | Ror-gamma modulators and uses thereof |
| CN103833672A (zh) | 2014-03-28 | 2014-06-04 | 中国药科大学 | 一种n-丁基-5-苯基噻唑-4-甲酰胺类衍生物的制备方法 |
| WO2016039408A1 (ja) | 2014-09-11 | 2016-03-17 | 武田薬品工業株式会社 | 複素環化合物 |
| PL3212641T3 (pl) | 2014-10-30 | 2019-05-31 | Janssen Pharmaceutica Nv | Tiazole jako modulatory RORYT |
| JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
| DK3212642T3 (da) * | 2014-10-30 | 2019-11-25 | Janssen Pharmaceutica Nv | Amid-substituerede thiazoler som modulatorer af rorgammat |
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| AR108326A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| JP2020059651A (ja) | 2016-12-26 | 2020-04-16 | 科研製薬株式会社 | ピラゾール誘導体及びそれを含有する医薬 |
| FR3065000A1 (fr) | 2017-04-06 | 2018-10-12 | Galderma Research & Development | Derives pyrazoles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
| US11345666B2 (en) | 2018-06-18 | 2022-05-31 | Janssen Pharmaceutica Nv | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT |
| JP2021528405A (ja) | 2018-06-18 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール |
| EP3807261B1 (en) | 2018-06-18 | 2022-07-13 | Janssen Pharmaceutica NV | Pyridinyl pyrazoles as modulators of roryt |
| EP3806958B1 (en) | 2018-06-18 | 2022-09-07 | Janssen Pharmaceutica NV | 6-aminopyridin-3-yl pyrazoles as modulators of roryt |
-
2017
- 2017-04-25 TW TW106113710A patent/TW201803869A/zh unknown
- 2017-04-26 EP EP17733165.9A patent/EP3448856B1/en active Active
- 2017-04-26 CN CN201780040332.4A patent/CN109415358B/zh not_active Expired - Fee Related
- 2017-04-26 KR KR1020187033945A patent/KR20180135962A/ko not_active Ceased
- 2017-04-26 BR BR112018071942A patent/BR112018071942A2/pt not_active Application Discontinuation
- 2017-04-26 PE PE2018002176A patent/PE20190150A1/es unknown
- 2017-04-26 CR CR20180505A patent/CR20180505A/es unknown
- 2017-04-26 AU AU2017255525A patent/AU2017255525A1/en not_active Abandoned
- 2017-04-26 CA CA3022318A patent/CA3022318A1/en active Pending
- 2017-04-26 WO PCT/US2017/029531 patent/WO2017189661A1/en not_active Ceased
- 2017-04-26 SG SG11201809162XA patent/SG11201809162XA/en unknown
- 2017-04-26 MX MX2018013143A patent/MX2018013143A/es unknown
- 2017-04-26 EA EA201892438A patent/EA036318B1/ru not_active IP Right Cessation
- 2017-04-26 MA MA044772A patent/MA44772A/fr unknown
- 2017-04-26 US US15/497,565 patent/US10975068B2/en not_active Expired - Fee Related
- 2017-04-26 ES ES17733165T patent/ES2906258T3/es active Active
- 2017-04-26 JP JP2018556297A patent/JP6893218B2/ja not_active Expired - Fee Related
- 2017-04-27 UY UY0001037213A patent/UY37213A/es unknown
- 2017-04-27 AR ARP170101078A patent/AR108344A1/es unknown
-
2018
- 2018-10-15 IL IL262381A patent/IL262381A/en unknown
- 2018-10-16 PH PH12018502209A patent/PH12018502209A1/en unknown
- 2018-10-25 CL CL2018003044A patent/CL2018003044A1/es unknown
- 2018-10-26 NI NI201800109A patent/NI201800109A/es unknown
- 2018-10-26 SV SV2018005772A patent/SV2018005772A/es unknown
- 2018-10-29 CO CONC2018/0011633A patent/CO2018011633A2/es unknown
- 2018-11-26 EC ECSENADI201888146A patent/ECSP18088146A/es unknown
-
2021
- 2021-02-23 US US17/182,363 patent/US20210221804A1/en not_active Abandoned
- 2021-02-23 US US17/182,375 patent/US20210198251A1/en not_active Abandoned
- 2021-02-23 US US17/182,387 patent/US20210188836A1/en not_active Abandoned
-
2022
- 2022-12-19 US US18/084,427 patent/US20230123208A1/en not_active Abandoned
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