JP2014512404A5 - - Google Patents
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- Publication number
- JP2014512404A5 JP2014512404A5 JP2014506863A JP2014506863A JP2014512404A5 JP 2014512404 A5 JP2014512404 A5 JP 2014512404A5 JP 2014506863 A JP2014506863 A JP 2014506863A JP 2014506863 A JP2014506863 A JP 2014506863A JP 2014512404 A5 JP2014512404 A5 JP 2014512404A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- compounds
- jak1
- hormones
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 description 2
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 description 1
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 229940116839 Janus kinase 1 inhibitor Drugs 0.000 description 1
- 229940121730 Janus kinase 2 inhibitor Drugs 0.000 description 1
- 208000003456 Juvenile Arthritis Diseases 0.000 description 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 description 1
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161479956P | 2011-04-28 | 2011-04-28 | |
| US61/479,956 | 2011-04-28 | ||
| PCT/EP2012/057652 WO2012146657A1 (en) | 2011-04-28 | 2012-04-26 | Novel compound useful for the treatment of degenerative and inflammatory diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512404A JP2014512404A (ja) | 2014-05-22 |
| JP2014512404A5 true JP2014512404A5 (enExample) | 2015-05-28 |
| JP5947371B2 JP5947371B2 (ja) | 2016-07-06 |
Family
ID=46017860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506863A Active JP5947371B2 (ja) | 2011-04-28 | 2012-04-26 | 変性疾患及び炎症性疾患の治療に有用な新規化合物 |
| JP2014506865A Active JP5947372B2 (ja) | 2011-04-28 | 2012-04-26 | 変性疾患及び炎症性疾患の治療に有用な新規化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506865A Active JP5947372B2 (ja) | 2011-04-28 | 2012-04-26 | 変性疾患及び炎症性疾患の治療に有用な新規化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8975406B2 (enExample) |
| EP (2) | EP2702059B1 (enExample) |
| JP (2) | JP5947371B2 (enExample) |
| KR (1) | KR101934707B1 (enExample) |
| CN (2) | CN103492386B (enExample) |
| AR (1) | AR086042A1 (enExample) |
| AU (2) | AU2012247482B2 (enExample) |
| BR (1) | BR112013027338A2 (enExample) |
| CA (2) | CA2833942A1 (enExample) |
| EA (1) | EA024743B1 (enExample) |
| IL (1) | IL228786A (enExample) |
| MX (2) | MX355653B (enExample) |
| SG (1) | SG194508A1 (enExample) |
| TW (1) | TWI536990B (enExample) |
| UY (1) | UY34037A (enExample) |
| WO (2) | WO2012146657A1 (enExample) |
| ZA (1) | ZA201307793B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR086042A1 (es) * | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
| MX2015015150A (es) * | 2013-04-29 | 2016-02-18 | Sanofi Sa | Composiciones farmaceuticas inhalables y los dispositivos inhaladores que las contienen. |
| GB201321733D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| KR101690760B1 (ko) * | 2014-11-05 | 2016-12-30 | 조길래 | 피부자극완화, 탈모방지 및 발모촉진 효과를 나타내는 카페오일펜타펩타이드 및 이를 함유하는 탈모방지 및 발모촉진용 화장료 조성물 |
| TW201705961A (zh) * | 2015-06-11 | 2017-02-16 | 阿爾米雷爾有限公司 | 作為ｊａｋ抑制劑的２－（吡唑并吡啶－３－基）嘧啶衍生物 |
| KR20180026459A (ko) * | 2015-06-18 | 2018-03-12 | 세파론, 인코포레이티드 | 1,4-치환된 피페리딘 유도체 |
| WO2016205590A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| DE102015215820A1 (de) * | 2015-08-19 | 2017-02-23 | Siemens Healthcare Gmbh | Steuern eines medizintechnischen Geräts |
| KR102598246B1 (ko) * | 2016-07-26 | 2023-11-02 | 톈진 롱보진 파마시우티컬 씨오., 엘티디. | Jak 저해제로서 헤테로사이클릭 화합물, 및 이의 염 및 치료학적 용도 |
| TWI752098B (zh) * | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
| WO2018163971A1 (ja) * | 2017-03-09 | 2018-09-13 | 富士フイルム株式会社 | 音響レンズ用樹脂材料、音響レンズ、音響波プローブ、音響波測定装置、超音波診断装置、光音響波測定装置および超音波内視鏡 |
| EA035568B1 (ru) * | 2017-09-29 | 2020-07-08 | Эррей Биофарма Инк. | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |
| EA037208B1 (ru) * | 2017-09-29 | 2021-02-19 | Эррей Биофарма Инк. | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI783057B (zh) * | 2017-10-10 | 2022-11-11 | 美商絡速藥業公司 | 製備6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈的方法 |
| US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
| EP3740490A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物 |
| CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
| US20210379056A1 (en) * | 2018-09-30 | 2021-12-09 | Applied Pharmaceutical Science, Inc. | Substituted pyrazole fused ring derivative, preparation method therefor, and application thereof |
| EP3891148A4 (en) * | 2018-12-07 | 2022-09-07 | Sunshine Lake Pharma Co., Ltd. | RET INHIBITOR, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| WO2020114487A1 (en) * | 2018-12-07 | 2020-06-11 | Sunshine Lake Pharma Co., Ltd. | Ret inhibitors, pharmaceutical compositions and uses thereof |
| CN115605477B (zh) * | 2020-04-22 | 2024-07-05 | 深圳众格生物科技有限公司 | 一种吡唑并[1,5-a]吡啶类衍生物及其制备方法，组合物以及用途 |
| CN113713083A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种用于治疗脱发的药物组合 |
| BR112023003835A2 (pt) | 2020-09-01 | 2023-04-04 | Syngenta Crop Protection Ag | Derivados heterocíclicos com substituintes contendo enxofre ativos em termos pesticidas |
| WO2022064459A1 (en) | 2020-09-28 | 2022-03-31 | 1ST Biotherapeutics, Inc. | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
| US20240174662A1 (en) * | 2021-02-01 | 2024-05-30 | Janssen Biotech, Inc. | Small molecule inhibitors of salt inducible kinases |
| WO2022165529A1 (en) * | 2021-02-01 | 2022-08-04 | Janssen Biotech, Inc. | Small molecule inhibitors of salt inducible kinases |
| US20250145640A1 (en) | 2021-08-10 | 2025-05-08 | Syngenta Crop Protection Ag | 2,2-difluoro-5h-[1,3]dioxolo[4,5-f]isoindol-7-one derivatives as pesticides |
| CN114409675B (zh) * | 2022-01-07 | 2023-08-04 | 重庆医科大学 | 螺环异恶唑酮色满衍生物在制备用于治疗jak1介导的疾病药物中的用途 |
| UY40202A (es) | 2022-04-01 | 2023-10-31 | Syngenta Crop Protection Ag | Derivados de pirazolopiridina activos como pesticidas con sustituyentes que contienen azufre |
| PY2404178A (es) | 2023-01-23 | 2024-11-12 | Syngenta Crop Protection Ag | Derivados heterocíclicos activos como pesticidas con sustituyentes que contienen azufre |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008503712A (ja) | 2004-06-21 | 2008-02-07 | ガラパゴス・ナムローゼ・フェンノートシャップ | 骨関節炎治療の方法及び手段 |
| BRPI0716239A2 (pt) * | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| WO2009017954A1 (en) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| CN102131389A (zh) * | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
| WO2010010186A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| JO3041B1 (ar) * | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| AR086042A1 (es) * | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
-
2012
- 2012-04-24 AR ARP120101411A patent/AR086042A1/es unknown
- 2012-04-26 CA CA2833942A patent/CA2833942A1/en not_active Abandoned
- 2012-04-26 EP EP12717289.8A patent/EP2702059B1/en active Active
- 2012-04-26 CN CN201280020782.4A patent/CN103492386B/zh active Active
- 2012-04-26 MX MX2013012281A patent/MX355653B/es active IP Right Grant
- 2012-04-26 JP JP2014506863A patent/JP5947371B2/ja active Active
- 2012-04-26 UY UY0001034037A patent/UY34037A/es not_active Application Discontinuation
- 2012-04-26 SG SG2013077060A patent/SG194508A1/en unknown
- 2012-04-26 KR KR1020137029055A patent/KR101934707B1/ko not_active Expired - Fee Related
- 2012-04-26 US US14/114,218 patent/US8975406B2/en active Active
- 2012-04-26 JP JP2014506865A patent/JP5947372B2/ja active Active
- 2012-04-26 MX MX2013012282A patent/MX360697B/es active IP Right Grant
- 2012-04-26 WO PCT/EP2012/057652 patent/WO2012146657A1/en not_active Ceased
- 2012-04-26 EP EP12717288.0A patent/EP2702058B1/en active Active
- 2012-04-26 WO PCT/EP2012/057654 patent/WO2012146659A1/en not_active Ceased
- 2012-04-26 BR BR112013027338A patent/BR112013027338A2/pt not_active Application Discontinuation
- 2012-04-26 EA EA201391584A patent/EA024743B1/ru not_active IP Right Cessation
- 2012-04-26 AU AU2012247482A patent/AU2012247482B2/en not_active Ceased
- 2012-04-26 TW TW101115010A patent/TWI536990B/zh not_active IP Right Cessation
- 2012-04-26 AU AU2012247484A patent/AU2012247484B2/en not_active Ceased
- 2012-04-26 CA CA2833963A patent/CA2833963C/en active Active
- 2012-04-26 CN CN201280020639.5A patent/CN103492385B/zh active Active
- 2012-04-27 US US13/459,055 patent/US8802682B2/en active Active
-
2013
- 2013-10-08 IL IL228786A patent/IL228786A/en active IP Right Grant
- 2013-10-18 ZA ZA2013/07793A patent/ZA201307793B/en unknown
-
2014
- 2014-08-11 US US14/457,071 patent/US9241931B2/en active Active
-
2016
- 2016-01-25 US US15/005,442 patent/US9987272B2/en active Active
-
2017
- 2017-09-01 US US15/694,454 patent/US20180078547A1/en not_active Abandoned
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