JP2019508063A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019508063A5 JP2019508063A5 JP2018559162A JP2018559162A JP2019508063A5 JP 2019508063 A5 JP2019508063 A5 JP 2019508063A5 JP 2018559162 A JP2018559162 A JP 2018559162A JP 2018559162 A JP2018559162 A JP 2018559162A JP 2019508063 A5 JP2019508063 A5 JP 2019508063A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- cancer
- item
- recombinant hsv
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091070501 miRNA Proteins 0.000 claims description 65
- 210000004027 cell Anatomy 0.000 claims description 44
- 241000700584 Simplexvirus Species 0.000 claims description 31
- 108091056924 miR-124 stem-loop Proteins 0.000 claims description 28
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 201000011510 cancer Diseases 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108020005345 3' Untranslated Regions Proteins 0.000 claims description 13
- 108091051828 miR-122 stem-loop Proteins 0.000 claims description 11
- 108091007780 MiR-122 Proteins 0.000 claims description 10
- 101150027427 ICP4 gene Proteins 0.000 claims description 9
- 108091033319 polynucleotide Proteins 0.000 claims description 9
- 102000040430 polynucleotide Human genes 0.000 claims description 9
- 239000002157 polynucleotide Substances 0.000 claims description 9
- 230000010076 replication Effects 0.000 claims description 9
- 206010009944 Colon cancer Diseases 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 8
- 208000029742 colonic neoplasm Diseases 0.000 claims description 8
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
- 201000007270 liver cancer Diseases 0.000 claims description 7
- 208000014018 liver neoplasm Diseases 0.000 claims description 7
- 201000005202 lung cancer Diseases 0.000 claims description 7
- 208000020816 lung neoplasm Diseases 0.000 claims description 7
- 101710130522 mRNA export factor Proteins 0.000 claims description 7
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 6
- 230000000947 anti-immunosuppressive effect Effects 0.000 claims description 6
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 6
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims description 6
- 208000021937 marginal zone lymphoma Diseases 0.000 claims description 6
- 101150090364 ICP0 gene Proteins 0.000 claims description 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
- 201000001441 melanoma Diseases 0.000 claims description 5
- 201000002528 pancreatic cancer Diseases 0.000 claims description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 3
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims description 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 3
- 108700011259 MicroRNAs Proteins 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 3
- 239000002679 microRNA Substances 0.000 claims description 3
- 206010018338 Glioma Diseases 0.000 claims description 2
- 101100508081 Human herpesvirus 1 (strain 17) ICP34.5 gene Proteins 0.000 claims description 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims description 2
- 101150027249 RL1 gene Proteins 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 230000030833 cell death Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 208000029824 high grade glioma Diseases 0.000 claims description 2
- 201000011614 malignant glioma Diseases 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 244000309459 oncolytic virus Species 0.000 description 92
- -1 UL26.5 Proteins 0.000 description 57
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 25
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 25
- 108091025686 miR-199a stem-loop Proteins 0.000 description 17
- 108091029119 miR-34a stem-loop Proteins 0.000 description 17
- 230000029812 viral genome replication Effects 0.000 description 17
- 108091024038 miR-133a stem-loop Proteins 0.000 description 16
- 108700005077 Viral Genes Proteins 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 108091028606 miR-1 stem-loop Proteins 0.000 description 15
- 230000002100 tumorsuppressive effect Effects 0.000 description 15
- 108091028684 Mir-145 Proteins 0.000 description 14
- 108091027766 Mir-143 Proteins 0.000 description 12
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 description 12
- 108091083769 miR-199a-1 stem-loop Proteins 0.000 description 12
- 108091047470 miR-199a-2 stem-loop Proteins 0.000 description 12
- 108091048350 miR-199a-3 stem-loop Proteins 0.000 description 12
- 108091056793 miR-199a-4 stem-loop Proteins 0.000 description 12
- 108091092012 miR-199b stem-loop Proteins 0.000 description 12
- 108091040176 miR-218 stem-loop Proteins 0.000 description 12
- 108020003589 5' Untranslated Regions Proteins 0.000 description 11
- 108091079658 miR-142-1 stem-loop Proteins 0.000 description 11
- 108091071830 miR-142-2 stem-loop Proteins 0.000 description 11
- 108091073532 miR-143 stem-loop Proteins 0.000 description 11
- 108091053592 miR-145-1 stem-loop Proteins 0.000 description 11
- 108091056559 miR-145-2 stem-loop Proteins 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 11
- 108091028066 Mir-126 Proteins 0.000 description 10
- 108091062895 miR-144 stem-loop Proteins 0.000 description 10
- 108091090583 miR-34c stem-loop Proteins 0.000 description 10
- 108091007773 MIR100 Proteins 0.000 description 9
- 108091028141 MiR-203 Proteins 0.000 description 9
- 108091093189 Mir-375 Proteins 0.000 description 9
- 108091031494 miR-1-4 stem-loop Proteins 0.000 description 9
- 108091092839 miR-124-1 stem-loop Proteins 0.000 description 9
- 108091045380 miR-124-2 stem-loop Proteins 0.000 description 9
- 108091048120 miR-124-3 stem-loop Proteins 0.000 description 9
- 108091034147 miR-124-5 stem-loop Proteins 0.000 description 9
- 108091040501 miR-129 stem-loop Proteins 0.000 description 9
- 108091047757 miR-133a-1 stem-loop Proteins 0.000 description 9
- 108091057540 miR-133a-2 stem-loop Proteins 0.000 description 9
- 108091079016 miR-133b Proteins 0.000 description 9
- 108091043162 miR-133b stem-loop Proteins 0.000 description 9
- 108091047467 miR-136 stem-loop Proteins 0.000 description 9
- 108091058688 miR-141 stem-loop Proteins 0.000 description 9
- 108091027034 miR-148a stem-loop Proteins 0.000 description 9
- 108091027943 miR-16 stem-loop Proteins 0.000 description 9
- 108091089775 miR-200b stem-loop Proteins 0.000 description 9
- 108091074450 miR-200c stem-loop Proteins 0.000 description 9
- 108091043187 miR-30a stem-loop Proteins 0.000 description 9
- 108091082133 miR-34c-1 stem-loop Proteins 0.000 description 9
- 108091063340 miR-497 stem-loop Proteins 0.000 description 9
- 108091007772 MIRLET7C Proteins 0.000 description 8
- 108091062154 Mir-205 Proteins 0.000 description 8
- 108091044592 miR-1-1 stem-loop Proteins 0.000 description 8
- 108091045542 miR-1-2 stem-loop Proteins 0.000 description 8
- 108091047831 miR-1-3 stem-loop Proteins 0.000 description 8
- 108091079012 miR-133a Proteins 0.000 description 8
- 108091032320 miR-146 stem-loop Proteins 0.000 description 8
- 108091024530 miR-146a stem-loop Proteins 0.000 description 8
- 108091031479 miR-204 stem-loop Proteins 0.000 description 8
- 108091061970 miR-26a stem-loop Proteins 0.000 description 8
- 108091079013 miR-34b Proteins 0.000 description 8
- 108091084018 miR-34b stem-loop Proteins 0.000 description 8
- 108091063470 miR-34b-1 stem-loop Proteins 0.000 description 8
- 108091049916 miR-34b-2 stem-loop Proteins 0.000 description 8
- 108091057222 miR-34b-3 stem-loop Proteins 0.000 description 8
- 108091092639 miR-34b-4 stem-loop Proteins 0.000 description 8
- 108091032770 miR-451 stem-loop Proteins 0.000 description 8
- 108091030646 miR-451a stem-loop Proteins 0.000 description 8
- 108091061974 miR-559 stem-loop Proteins 0.000 description 8
- 108091023818 miR-7 stem-loop Proteins 0.000 description 8
- 108091007422 miR-98 Proteins 0.000 description 8
- 108091034054 MiR-138 Proteins 0.000 description 7
- 108091027966 Mir-137 Proteins 0.000 description 7
- 108091091807 let-7a stem-loop Proteins 0.000 description 7
- 108091057746 let-7a-4 stem-loop Proteins 0.000 description 7
- 108091028376 let-7a-5 stem-loop Proteins 0.000 description 7
- 108091024393 let-7a-6 stem-loop Proteins 0.000 description 7
- 108091091174 let-7a-7 stem-loop Proteins 0.000 description 7
- 108091007423 let-7b Proteins 0.000 description 7
- 108091033753 let-7d stem-loop Proteins 0.000 description 7
- 108091091360 miR-125b stem-loop Proteins 0.000 description 7
- 108091030496 miR-138 stem-loop Proteins 0.000 description 7
- 108091059199 miR-200a stem-loop Proteins 0.000 description 7
- 108091031484 miR-335 stem-loop Proteins 0.000 description 7
- 108091059135 miR-429 stem-loop Proteins 0.000 description 7
- 108091087492 miR-490 stem-loop Proteins 0.000 description 7
- 108091093142 MiR-144 Proteins 0.000 description 6
- 108091026807 MiR-214 Proteins 0.000 description 6
- 108091060585 Mir-31 Proteins 0.000 description 6
- 102000035195 Peptidases Human genes 0.000 description 6
- 108091005804 Peptidases Proteins 0.000 description 6
- 239000004365 Protease Substances 0.000 description 6
- 108091042844 let-7i stem-loop Proteins 0.000 description 6
- 108091047546 miR-124-4 stem-loop Proteins 0.000 description 6
- 108091028854 miR-124-6 stem-loop Proteins 0.000 description 6
- 108091064138 miR-129-2 stem-loop Proteins 0.000 description 6
- 108091090860 miR-150 stem-loop Proteins 0.000 description 6
- 108091037426 miR-152 stem-loop Proteins 0.000 description 6
- 108091063796 miR-206 stem-loop Proteins 0.000 description 6
- 108091053935 miR-212 stem-loop Proteins 0.000 description 6
- 108091025543 miR-219a-2 stem-loop Proteins 0.000 description 6
- 108091083275 miR-26b stem-loop Proteins 0.000 description 6
- 108091047189 miR-29c stem-loop Proteins 0.000 description 6
- 108091054490 miR-29c-2 stem-loop Proteins 0.000 description 6
- 108091055145 miR-342 stem-loop Proteins 0.000 description 6
- 108091028761 miR-409 stem-loop Proteins 0.000 description 6
- 108091030938 miR-424 stem-loop Proteins 0.000 description 6
- 108091036400 miR-490-1 stem-loop Proteins 0.000 description 6
- 108091057695 miR-490-2 stem-loop Proteins 0.000 description 6
- 108091007771 MIRLET7A1 Proteins 0.000 description 5
- 108091033773 MiR-155 Proteins 0.000 description 5
- 108091028108 MiR-212 Proteins 0.000 description 5
- 108091062170 Mir-22 Proteins 0.000 description 5
- 101150041636 NEC1 gene Proteins 0.000 description 5
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 5
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 5
- 108091047626 let-7a-2 stem-loop Proteins 0.000 description 5
- 108091047557 let-7a-3 stem-loop Proteins 0.000 description 5
- 108091024449 let-7e stem-loop Proteins 0.000 description 5
- 108091044227 let-7e-1 stem-loop Proteins 0.000 description 5
- 108091071181 let-7e-2 stem-loop Proteins 0.000 description 5
- 108091029710 let-7f-1 stem-loop Proteins 0.000 description 5
- 108091041587 let-7f-2 stem-loop Proteins 0.000 description 5
- 108091007427 let-7g Proteins 0.000 description 5
- 108091044988 miR-125a stem-loop Proteins 0.000 description 5
- 108091091207 miR-127 stem-loop Proteins 0.000 description 5
- 108091038720 miR-129-1 stem-loop Proteins 0.000 description 5
- 108091045757 miR-129-3 stem-loop Proteins 0.000 description 5
- 108091090758 miR-129-4 stem-loop Proteins 0.000 description 5
- 108091065139 miR-129-5 stem-loop Proteins 0.000 description 5
- 108091028466 miR-130b stem-loop Proteins 0.000 description 5
- 108091055152 miR-133a-3 stem-loop Proteins 0.000 description 5
- 108091029379 miR-139 stem-loop Proteins 0.000 description 5
- 108091031326 miR-15b stem-loop Proteins 0.000 description 5
- 108091039097 miR-193b stem-loop Proteins 0.000 description 5
- 108091032382 miR-204-1 stem-loop Proteins 0.000 description 5
- 108091085803 miR-204-2 stem-loop Proteins 0.000 description 5
- 108091089766 miR-204-3 stem-loop Proteins 0.000 description 5
- 108091073500 miR-204-4 stem-loop Proteins 0.000 description 5
- 108091053626 miR-204-5 stem-loop Proteins 0.000 description 5
- 108091028397 miR-212-1 stem-loop Proteins 0.000 description 5
- 108091028945 miR-212-2 stem-loop Proteins 0.000 description 5
- 108091026331 miR-214 stem-loop Proteins 0.000 description 5
- 108091048888 miR-214-1 stem-loop Proteins 0.000 description 5
- 108091078347 miR-214-2 stem-loop Proteins 0.000 description 5
- 108091035552 miR-214-3 stem-loop Proteins 0.000 description 5
- 108091086421 miR-223 stem-loop Proteins 0.000 description 5
- 108091088477 miR-29a stem-loop Proteins 0.000 description 5
- 108091029716 miR-29a-1 stem-loop Proteins 0.000 description 5
- 108091092089 miR-29a-2 stem-loop Proteins 0.000 description 5
- 108091066559 miR-29a-3 stem-loop Proteins 0.000 description 5
- 108091007432 miR-29b Proteins 0.000 description 5
- 108091070038 miR-338 stem-loop Proteins 0.000 description 5
- 108091074070 miR-338-3 stem-loop Proteins 0.000 description 5
- 108091037327 miR-449 stem-loop Proteins 0.000 description 5
- 108091040525 miR-449a stem-loop Proteins 0.000 description 5
- 108091076732 miR-99a stem-loop Proteins 0.000 description 5
- 108091064318 miR-99a-1 stem-loop Proteins 0.000 description 5
- 108091086202 miR-99a-2 stem-loop Proteins 0.000 description 5
- 108091033409 CRISPR Proteins 0.000 description 4
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 4
- 108091007774 MIR107 Proteins 0.000 description 4
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 4
- 108091028080 MiR-132 Proteins 0.000 description 4
- 108091062140 Mir-223 Proteins 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 101100047461 Rattus norvegicus Trpm8 gene Proteins 0.000 description 4
- 108091064157 miR-106a stem-loop Proteins 0.000 description 4
- 108091026523 miR-135a stem-loop Proteins 0.000 description 4
- 108091043612 miR-146b stem-loop Proteins 0.000 description 4
- 108091026495 miR-148b stem-loop Proteins 0.000 description 4
- 108091047577 miR-149 stem-loop Proteins 0.000 description 4
- 108091035696 miR-149-1 stem-loop Proteins 0.000 description 4
- 108091031096 miR-149-2 stem-loop Proteins 0.000 description 4
- 108091033783 miR-153 stem-loop Proteins 0.000 description 4
- 108091091751 miR-17 stem-loop Proteins 0.000 description 4
- 108091031103 miR-181a stem-loop Proteins 0.000 description 4
- 108091046591 miR-181a-4 stem-loop Proteins 0.000 description 4
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 description 4
- 108091047758 miR-185 stem-loop Proteins 0.000 description 4
- 108091086416 miR-192 stem-loop Proteins 0.000 description 4
- 108091063348 miR-193 stem-loop Proteins 0.000 description 4
- 108091036762 miR-193a stem-loop Proteins 0.000 description 4
- 108091046261 miR-198 stem-loop Proteins 0.000 description 4
- 108091058987 miR-199b-1 stem-loop Proteins 0.000 description 4
- 108091090366 miR-199b-2 stem-loop Proteins 0.000 description 4
- 108091073659 miR-199b-3 stem-loop Proteins 0.000 description 4
- 108091062762 miR-21 stem-loop Proteins 0.000 description 4
- 108091035328 miR-217 stem-loop Proteins 0.000 description 4
- 108091039135 miR-217-1 stem-loop Proteins 0.000 description 4
- 108091029206 miR-217-2 stem-loop Proteins 0.000 description 4
- 108091055059 miR-30c stem-loop Proteins 0.000 description 4
- 108091057431 miR-30d stem-loop Proteins 0.000 description 4
- 108091036633 miR-370 stem-loop Proteins 0.000 description 4
- 108091092564 miR-494 stem-loop Proteins 0.000 description 4
- 108091033331 miR-503 stem-loop Proteins 0.000 description 4
- ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 description 3
- 108091079001 CRISPR RNA Proteins 0.000 description 3
- 238000010354 CRISPR gene editing Methods 0.000 description 3
- 108010042407 Endonucleases Proteins 0.000 description 3
- 101150047390 MCP gene Proteins 0.000 description 3
- 108091046841 MiR-150 Proteins 0.000 description 3
- 108091028695 MiR-224 Proteins 0.000 description 3
- 108091028232 Mir-184 Proteins 0.000 description 3
- 108091028049 Mir-221 microRNA Proteins 0.000 description 3
- 108091080995 Mir-9/mir-79 microRNA precursor family Proteins 0.000 description 3
- 108091028113 Trans-activating crRNA Proteins 0.000 description 3
- 101150109748 UL19 gene Proteins 0.000 description 3
- 101150068034 UL30 gene Proteins 0.000 description 3
- 101150019585 UL31 gene Proteins 0.000 description 3
- 101150066971 UL49 gene Proteins 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 208000005017 glioblastoma Diseases 0.000 description 3
- 108091064399 miR-10b stem-loop Proteins 0.000 description 3
- 108091055434 miR-124a stem-loop Proteins 0.000 description 3
- 108091082871 miR-124a-2 stem-loop Proteins 0.000 description 3
- 108091050112 miR-124a-4 stem-loop Proteins 0.000 description 3
- 108091054623 miR-124a-5 stem-loop Proteins 0.000 description 3
- 108091024680 miR-124a-6 stem-loop Proteins 0.000 description 3
- 108091023084 miR-126 stem-loop Proteins 0.000 description 3
- 108091065272 miR-126-1 stem-loop Proteins 0.000 description 3
- 108091081187 miR-126-2 stem-loop Proteins 0.000 description 3
- 108091030790 miR-126-3 stem-loop Proteins 0.000 description 3
- 108091092317 miR-126-4 stem-loop Proteins 0.000 description 3
- 108091045872 miR-135 stem-loop Proteins 0.000 description 3
- 108091060382 miR-140 stem-loop Proteins 0.000 description 3
- 108091059964 miR-154 stem-loop Proteins 0.000 description 3
- 108091074057 miR-16-1 stem-loop Proteins 0.000 description 3
- 108091044046 miR-17-1 stem-loop Proteins 0.000 description 3
- 108091065423 miR-17-3 stem-loop Proteins 0.000 description 3
- 108091049641 miR-181-1 stem-loop Proteins 0.000 description 3
- 108091053227 miR-181a-1 stem-loop Proteins 0.000 description 3
- 108091092591 miR-181a-2 stem-loop Proteins 0.000 description 3
- 108091043222 miR-181b stem-loop Proteins 0.000 description 3
- 108091073055 miR-193a-1 stem-loop Proteins 0.000 description 3
- 108091040345 miR-193a-2 stem-loop Proteins 0.000 description 3
- 108091045665 miR-202 stem-loop Proteins 0.000 description 3
- 108091049679 miR-20a stem-loop Proteins 0.000 description 3
- 108091041631 miR-21-1 stem-loop Proteins 0.000 description 3
- 108091044442 miR-21-2 stem-loop Proteins 0.000 description 3
- 108091050113 miR-211 stem-loop Proteins 0.000 description 3
- 108091086642 miR-216a stem-loop Proteins 0.000 description 3
- 108091030639 miR-219a-1 stem-loop Proteins 0.000 description 3
- 108091092722 miR-23b stem-loop Proteins 0.000 description 3
- 108091031298 miR-23b-1 stem-loop Proteins 0.000 description 3
- 108091082339 miR-23b-2 stem-loop Proteins 0.000 description 3
- 108091039812 miR-28 stem-loop Proteins 0.000 description 3
- 108091029750 miR-30a-1 stem-loop Proteins 0.000 description 3
- 108091030035 miR-30a-2 stem-loop Proteins 0.000 description 3
- 108091063344 miR-30b stem-loop Proteins 0.000 description 3
- 108091023108 miR-30e stem-loop Proteins 0.000 description 3
- 108091064010 miR-31 stem-loop Proteins 0.000 description 3
- 108091049902 miR-33a stem-loop Proteins 0.000 description 3
- 108091030670 miR-365 stem-loop Proteins 0.000 description 3
- 108091036688 miR-365-3 stem-loop Proteins 0.000 description 3
- 108091043953 miR-373 stem-loop Proteins 0.000 description 3
- 108091087125 miR-376a stem-loop Proteins 0.000 description 3
- 108091073138 miR-376a-3 stem-loop Proteins 0.000 description 3
- 108091048468 miR-383 stem-loop Proteins 0.000 description 3
- 108091029369 miR-410 stem-loop Proteins 0.000 description 3
- 108091062761 miR-448 stem-loop Proteins 0.000 description 3
- 108091080309 miR-483 stem-loop Proteins 0.000 description 3
- 108091051048 miR-6080 stem-loop Proteins 0.000 description 3
- 108091085620 miR-6130 stem-loop Proteins 0.000 description 3
- 108091056454 miR-625 stem-loop Proteins 0.000 description 3
- 108091047084 miR-9 stem-loop Proteins 0.000 description 3
- 108091086713 miR-96 stem-loop Proteins 0.000 description 3
- 108091024443 miRa-135-1 stem-loop Proteins 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 101150072608 CVC1 gene Proteins 0.000 description 2
- 101150010802 CVC2 gene Proteins 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 2
- 102000005600 Cathepsins Human genes 0.000 description 2
- 108010084457 Cathepsins Proteins 0.000 description 2
- 101150026402 DBP gene Proteins 0.000 description 2
- 102000004533 Endonucleases Human genes 0.000 description 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 description 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 101150109586 Gk gene Proteins 0.000 description 2
- 101150064935 HELI gene Proteins 0.000 description 2
- 101100048372 Human cytomegalovirus (strain AD169) H301 gene Proteins 0.000 description 2
- 101100427508 Human cytomegalovirus (strain AD169) UL39 gene Proteins 0.000 description 2
- 101100048373 Human cytomegalovirus (strain Merlin) UL18 gene Proteins 0.000 description 2
- 101001042049 Human herpesvirus 1 (strain 17) Transcriptional regulator ICP22 Proteins 0.000 description 2
- 101000999690 Human herpesvirus 2 (strain HG52) E3 ubiquitin ligase ICP22 Proteins 0.000 description 2
- 102100026799 Matrix metalloproteinase-28 Human genes 0.000 description 2
- 102000005741 Metalloproteases Human genes 0.000 description 2
- 108010006035 Metalloproteases Proteins 0.000 description 2
- 108091093073 MiR-134 Proteins 0.000 description 2
- 108091033433 MiR-191 Proteins 0.000 description 2
- 108091028076 Mir-127 Proteins 0.000 description 2
- 108091060302 Mir-320 Proteins 0.000 description 2
- 108091061758 Mir-433 Proteins 0.000 description 2
- 108091027559 Mir-96 microRNA Proteins 0.000 description 2
- 101150098384 NEC2 gene Proteins 0.000 description 2
- 101710163270 Nuclease Proteins 0.000 description 2
- 108700020796 Oncogene Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 101150093191 RIR1 gene Proteins 0.000 description 2
- 101150030723 RIR2 gene Proteins 0.000 description 2
- 101150103019 SCP gene Proteins 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 238000010459 TALEN Methods 0.000 description 2
- 101150110861 TRM2 gene Proteins 0.000 description 2
- 101150048584 TRM3 gene Proteins 0.000 description 2
- 101150102071 TRX1 gene Proteins 0.000 description 2
- 101150037769 TRX2 gene Proteins 0.000 description 2
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 description 2
- 101150111135 UL1 gene Proteins 0.000 description 2
- 101150087840 UL11 gene Proteins 0.000 description 2
- 101150023763 UL12 gene Proteins 0.000 description 2
- 101150036407 UL14 gene Proteins 0.000 description 2
- 101150104047 UL17 gene Proteins 0.000 description 2
- 101150050388 UL20 gene Proteins 0.000 description 2
- 101150004957 UL25 gene Proteins 0.000 description 2
- 101150060044 UL26 gene Proteins 0.000 description 2
- 101150003230 UL27 gene Proteins 0.000 description 2
- 101150072074 UL28 gene Proteins 0.000 description 2
- 101150008036 UL29 gene Proteins 0.000 description 2
- 101150017804 UL33 gene Proteins 0.000 description 2
- 101150087430 UL34 gene Proteins 0.000 description 2
- 101150023000 UL35 gene Proteins 0.000 description 2
- 101150085237 UL36 gene Proteins 0.000 description 2
- 101150036065 UL37 gene Proteins 0.000 description 2
- 101150090946 UL38 gene Proteins 0.000 description 2
- 101150100826 UL40 gene Proteins 0.000 description 2
- 101150099321 UL42 gene Proteins 0.000 description 2
- 101150004685 UL48 gene Proteins 0.000 description 2
- 101150099617 UL5 gene Proteins 0.000 description 2
- 101150009795 UL54 gene Proteins 0.000 description 2
- 101150033660 UL6 gene Proteins 0.000 description 2
- 101150095805 UL7 gene Proteins 0.000 description 2
- 101150033561 UL8 gene Proteins 0.000 description 2
- 101150026859 UL9 gene Proteins 0.000 description 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 101150029683 gB gene Proteins 0.000 description 2
- 101150055782 gH gene Proteins 0.000 description 2
- 101150015940 gL gene Proteins 0.000 description 2
- 108091063986 let-7f stem-loop Proteins 0.000 description 2
- 108091079786 miR-105 stem-loop Proteins 0.000 description 2
- 108091035155 miR-10a stem-loop Proteins 0.000 description 2
- 108091062447 miR-10b-1 stem-loop Proteins 0.000 description 2
- 108091069028 miR-10b-4 stem-loop Proteins 0.000 description 2
- 108091040341 miR-1236 stem-loop Proteins 0.000 description 2
- 108091057630 miR-1264 stem-loop Proteins 0.000 description 2
- 108091047499 miR-1271 stem-loop Proteins 0.000 description 2
- 108091070946 miR-128 stem-loop Proteins 0.000 description 2
- 108091084874 miR-128-2 stem-loop Proteins 0.000 description 2
- 108091031925 miR-138-2 stem-loop Proteins 0.000 description 2
- 108091046685 miR-139-1 stem-loop Proteins 0.000 description 2
- 108091049185 miR-139-2 stem-loop Proteins 0.000 description 2
- 108091030617 miR-140-1 stem-loop Proteins 0.000 description 2
- 108091023370 miR-140-2 stem-loop Proteins 0.000 description 2
- 108091056204 miR-16-2 stem-loop Proteins 0.000 description 2
- 108091041042 miR-18 stem-loop Proteins 0.000 description 2
- 108091074194 miR-181b-1 stem-loop Proteins 0.000 description 2
- 108091038599 miR-181b-2 stem-loop Proteins 0.000 description 2
- 108091064825 miR-181c stem-loop Proteins 0.000 description 2
- 108091044400 miR-181c-1 stem-loop Proteins 0.000 description 2
- 108091048818 miR-181c-2 stem-loop Proteins 0.000 description 2
- 108091032779 miR-181c-3 stem-loop Proteins 0.000 description 2
- 108091073628 miR-181d stem-loop Proteins 0.000 description 2
- 108091023796 miR-182 stem-loop Proteins 0.000 description 2
- 108091029500 miR-183 stem-loop Proteins 0.000 description 2
- 108091047641 miR-186 stem-loop Proteins 0.000 description 2
- 108091028751 miR-188 stem-loop Proteins 0.000 description 2
- 108091062221 miR-18a stem-loop Proteins 0.000 description 2
- 108091054642 miR-194 stem-loop Proteins 0.000 description 2
- 108091088515 miR-197 stem-loop Proteins 0.000 description 2
- 108091047268 miR-208b stem-loop Proteins 0.000 description 2
- 108091063841 miR-219 stem-loop Proteins 0.000 description 2
- 108091090052 miR-219-1 stem-loop Proteins 0.000 description 2
- 108091073060 miR-219-2 stem-loop Proteins 0.000 description 2
- 108091079034 miR-219-3 stem-loop Proteins 0.000 description 2
- 108091054264 miR-219-4 stem-loop Proteins 0.000 description 2
- 108091061917 miR-221 stem-loop Proteins 0.000 description 2
- 108091063489 miR-221-1 stem-loop Proteins 0.000 description 2
- 108091055391 miR-221-2 stem-loop Proteins 0.000 description 2
- 108091031076 miR-221-3 stem-loop Proteins 0.000 description 2
- 108091085564 miR-25 stem-loop Proteins 0.000 description 2
- 108091080167 miR-25-1 stem-loop Proteins 0.000 description 2
- 108091083056 miR-25-2 stem-loop Proteins 0.000 description 2
- 108091084454 miR-302a stem-loop Proteins 0.000 description 2
- 108091066670 miR-31-1 stem-loop Proteins 0.000 description 2
- 108091054015 miR-31-2 stem-loop Proteins 0.000 description 2
- 108091028785 miR-31-3 stem-loop Proteins 0.000 description 2
- 108091075059 miR-3189 stem-loop Proteins 0.000 description 2
- 108091024082 miR-32 stem-loop Proteins 0.000 description 2
- 108091059501 miR-320a stem-loop Proteins 0.000 description 2
- 108091088570 miR-320a-1 stem-loop Proteins 0.000 description 2
- 108091070041 miR-320a-2 stem-loop Proteins 0.000 description 2
- 108091065447 miR-320a-3 stem-loop Proteins 0.000 description 2
- 108091054114 miR-320a-4 stem-loop Proteins 0.000 description 2
- 108091042879 miR-326 stem-loop Proteins 0.000 description 2
- 108091029997 miR-328 stem-loop Proteins 0.000 description 2
- 108091023968 miR-330 stem-loop Proteins 0.000 description 2
- 108091091696 miR-331 stem-loop Proteins 0.000 description 2
- 108091049667 miR-340 stem-loop Proteins 0.000 description 2
- 108091057189 miR-340-2 stem-loop Proteins 0.000 description 2
- 108091068963 miR-361 stem-loop Proteins 0.000 description 2
- 108091062109 miR-372 stem-loop Proteins 0.000 description 2
- 108091071616 miR-376c stem-loop Proteins 0.000 description 2
- 108091055954 miR-377 stem-loop Proteins 0.000 description 2
- 108091024291 miR-378 stem-loop Proteins 0.000 description 2
- 108091027983 miR-378-1 stem-loop Proteins 0.000 description 2
- 108091089716 miR-378-2 stem-loop Proteins 0.000 description 2
- 108091025661 miR-378a stem-loop Proteins 0.000 description 2
- 108091086215 miR-379 stem-loop Proteins 0.000 description 2
- 108091041657 miR-381 stem-loop Proteins 0.000 description 2
- 108091092877 miR-3943 stem-loop Proteins 0.000 description 2
- 108091023805 miR-411 stem-loop Proteins 0.000 description 2
- 108091044721 miR-422a stem-loop Proteins 0.000 description 2
- 108091063388 miR-4485 stem-loop Proteins 0.000 description 2
- 108091039994 miR-486 stem-loop Proteins 0.000 description 2
- 108091062429 miR-487b stem-loop Proteins 0.000 description 2
- 108091053306 miR-493 stem-loop Proteins 0.000 description 2
- 108091031190 miR-495 stem-loop Proteins 0.000 description 2
- 108091049470 miR-498 stem-loop Proteins 0.000 description 2
- 108091048196 miR-5 stem-loop Proteins 0.000 description 2
- 108091082444 miR-5-1 stem-loop Proteins 0.000 description 2
- 108091078363 miR-5-2 stem-loop Proteins 0.000 description 2
- 108091058133 miR-502 stem-loop Proteins 0.000 description 2
- 108091090896 miR-506 stem-loop Proteins 0.000 description 2
- 108091057331 miR-509 stem-loop Proteins 0.000 description 2
- 108091091880 miR-509-1 stem-loop Proteins 0.000 description 2
- 108091051359 miR-509-2 stem-loop Proteins 0.000 description 2
- 108091053449 miR-511 stem-loop Proteins 0.000 description 2
- 108091060330 miR-520a stem-loop Proteins 0.000 description 2
- 108091056921 miR-532 stem-loop Proteins 0.000 description 2
- 108091055140 miR-574 stem-loop Proteins 0.000 description 2
- 108091065430 miR-610 stem-loop Proteins 0.000 description 2
- 108091086737 miR-630 stem-loop Proteins 0.000 description 2
- 108091038240 miR-638 stem-loop Proteins 0.000 description 2
- 108091035662 miR-646 stem-loop Proteins 0.000 description 2
- 108091026036 miR-655 stem-loop Proteins 0.000 description 2
- 108091037014 miR-7-1 stem-loop Proteins 0.000 description 2
- 108091030520 miR-7-2 stem-loop Proteins 0.000 description 2
- 108091025113 miR-7-3 stem-loop Proteins 0.000 description 2
- 108091089851 miR-7-4 stem-loop Proteins 0.000 description 2
- 108091058491 miR-877 stem-loop Proteins 0.000 description 2
- 108091053417 miR-885 stem-loop Proteins 0.000 description 2
- 108091030569 miR-940 stem-loop Proteins 0.000 description 2
- 108091070961 miR-96-3 stem-loop Proteins 0.000 description 2
- 108091053257 miR-99b stem-loop Proteins 0.000 description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
- 230000002985 oncosuppressive effect Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 description 2
- 101150046896 trm1 gene Proteins 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 description 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 description 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 102000004149 Annexin A2 Human genes 0.000 description 1
- 108090000668 Annexin A2 Proteins 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 description 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 1
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 1
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 1
- 102100032912 CD44 antigen Human genes 0.000 description 1
- 101710172824 CRISPR-associated endonuclease Cas9 Proteins 0.000 description 1
- 101150069031 CSN2 gene Proteins 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 101100274575 Caenorhabditis elegans clh-3 gene Proteins 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000003908 Cathepsin D Human genes 0.000 description 1
- 108090000258 Cathepsin D Proteins 0.000 description 1
- 102000004178 Cathepsin E Human genes 0.000 description 1
- 108090000611 Cathepsin E Proteins 0.000 description 1
- 102000004171 Cathepsin K Human genes 0.000 description 1
- 108090000625 Cathepsin K Proteins 0.000 description 1
- 102000004172 Cathepsin L Human genes 0.000 description 1
- 108090000624 Cathepsin L Proteins 0.000 description 1
- 102100027995 Collagenase 3 Human genes 0.000 description 1
- 108050005238 Collagenase 3 Proteins 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 101150074775 Csf1 gene Proteins 0.000 description 1
- 101800001224 Disintegrin Proteins 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 102100031780 Endonuclease Human genes 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- 102100022623 Hepatocyte growth factor receptor Human genes 0.000 description 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 1
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 1
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 1
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 101000972946 Homo sapiens Hepatocyte growth factor receptor Proteins 0.000 description 1
- 101001011896 Homo sapiens Matrix metalloproteinase-19 Proteins 0.000 description 1
- 101000627854 Homo sapiens Matrix metalloproteinase-26 Proteins 0.000 description 1
- 101000627861 Homo sapiens Matrix metalloproteinase-28 Proteins 0.000 description 1
- 101000645296 Homo sapiens Metalloproteinase inhibitor 2 Proteins 0.000 description 1
- 101000831266 Homo sapiens Metalloproteinase inhibitor 4 Proteins 0.000 description 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 1
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 description 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 description 1
- 101000766306 Homo sapiens Serotransferrin Proteins 0.000 description 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 description 1
- 101000622304 Homo sapiens Vascular cell adhesion protein 1 Proteins 0.000 description 1
- 102100022339 Integrin alpha-L Human genes 0.000 description 1
- 102000004560 Interleukin-12 Receptors Human genes 0.000 description 1
- 108010017515 Interleukin-12 Receptors Proteins 0.000 description 1
- 102000003812 Interleukin-15 Human genes 0.000 description 1
- 108090000172 Interleukin-15 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 102100030703 Interleukin-22 Human genes 0.000 description 1
- 102000001399 Kallikrein Human genes 0.000 description 1
- 108060005987 Kallikrein Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 1
- 101710150918 Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 1
- 102100027998 Macrophage metalloelastase Human genes 0.000 description 1
- 101710187853 Macrophage metalloelastase Proteins 0.000 description 1
- 241001372913 Maraba virus Species 0.000 description 1
- 102100030417 Matrilysin Human genes 0.000 description 1
- 108090000855 Matrilysin Proteins 0.000 description 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 1
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 1
- 108010076557 Matrix Metalloproteinase 14 Proteins 0.000 description 1
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 description 1
- 102100030201 Matrix metalloproteinase-15 Human genes 0.000 description 1
- 108090000560 Matrix metalloproteinase-15 Proteins 0.000 description 1
- 102100030200 Matrix metalloproteinase-16 Human genes 0.000 description 1
- 108090000561 Matrix metalloproteinase-16 Proteins 0.000 description 1
- 102100030219 Matrix metalloproteinase-17 Human genes 0.000 description 1
- 108090000585 Matrix metalloproteinase-17 Proteins 0.000 description 1
- 102100030218 Matrix metalloproteinase-19 Human genes 0.000 description 1
- 108090000587 Matrix metalloproteinase-19 Proteins 0.000 description 1
- 102000004055 Matrix metalloproteinase-19 Human genes 0.000 description 1
- 101710082411 Matrix metalloproteinase-21 Proteins 0.000 description 1
- 102100024130 Matrix metalloproteinase-23 Human genes 0.000 description 1
- 102100024129 Matrix metalloproteinase-24 Human genes 0.000 description 1
- 108050005214 Matrix metalloproteinase-24 Proteins 0.000 description 1
- 102100024128 Matrix metalloproteinase-26 Human genes 0.000 description 1
- 102100024132 Matrix metalloproteinase-27 Human genes 0.000 description 1
- 108050005201 Matrix metalloproteinase-27 Proteins 0.000 description 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 description 1
- 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 description 1
- 102100024289 Metalloproteinase inhibitor 4 Human genes 0.000 description 1
- 108091093085 MiR-338 Proteins 0.000 description 1
- 108091080933 Mir-192/215 microRNA precursor Proteins 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 1
- 101100007538 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cpc-1 gene Proteins 0.000 description 1
- 101100385413 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) csm-3 gene Proteins 0.000 description 1
- 102100030411 Neutrophil collagenase Human genes 0.000 description 1
- 101710118230 Neutrophil collagenase Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 description 1
- 102100040120 Prominin-1 Human genes 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 108010007945 Smad Proteins Proteins 0.000 description 1
- 102000007374 Smad Proteins Human genes 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 description 1
- 101000910035 Streptococcus pyogenes serotype M1 CRISPR-associated endonuclease Cas9/Csn1 Proteins 0.000 description 1
- 102100030416 Stromelysin-1 Human genes 0.000 description 1
- 101710108790 Stromelysin-1 Proteins 0.000 description 1
- 102100028848 Stromelysin-2 Human genes 0.000 description 1
- 101710108792 Stromelysin-2 Proteins 0.000 description 1
- 102100028847 Stromelysin-3 Human genes 0.000 description 1
- 108050005271 Stromelysin-3 Proteins 0.000 description 1
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 description 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 description 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 description 1
- 101150081727 UL32 gene Proteins 0.000 description 1
- 101150011902 UL52 gene Proteins 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 101001011890 Xenopus laevis Matrix metalloproteinase-18 Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000005975 antitumor immune response Effects 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 101150055601 cops2 gene Proteins 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 108010074108 interleukin-21 Proteins 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 108091045440 let-7a-1 stem-loop Proteins 0.000 description 1
- 108091043994 let-7g stem-loop Proteins 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108090000440 matrix metalloproteinase 25 Proteins 0.000 description 1
- 108091092359 miR-10b-2 stem-loop Proteins 0.000 description 1
- 108091041893 miR-10b-3 stem-loop Proteins 0.000 description 1
- 108091026955 miR-1180 stem-loop Proteins 0.000 description 1
- 108091090911 miR-1181 stem-loop Proteins 0.000 description 1
- 108091066112 miR-122-1 stem-loop Proteins 0.000 description 1
- 108091057488 miR-122-2 stem-loop Proteins 0.000 description 1
- 108091026501 miR-122a stem-loop Proteins 0.000 description 1
- 108091063365 miR-1247 stem-loop Proteins 0.000 description 1
- 108091070774 miR-1250 stem-loop Proteins 0.000 description 1
- 108091037074 miR-1251 stem-loop Proteins 0.000 description 1
- 108091025483 miR-1258 stem-loop Proteins 0.000 description 1
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 description 1
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 description 1
- 108091023935 miR-1266 stem-loop Proteins 0.000 description 1
- 108091059786 miR-128-1 stem-loop Proteins 0.000 description 1
- 108091078862 miR-128-3 stem-loop Proteins 0.000 description 1
- 108091073005 miR-128-4 stem-loop Proteins 0.000 description 1
- 108091032903 miR-1285 stem-loop Proteins 0.000 description 1
- 108091074094 miR-1291 stem-loop Proteins 0.000 description 1
- 108091054928 miR-1293 stem-loop Proteins 0.000 description 1
- 108091040930 miR-1295b stem-loop Proteins 0.000 description 1
- 108091087161 miR-1296 stem-loop Proteins 0.000 description 1
- 108091048147 miR-1297 stem-loop Proteins 0.000 description 1
- 108091081029 miR-1298 stem-loop Proteins 0.000 description 1
- 108091063445 miR-13 stem-loop Proteins 0.000 description 1
- 108091071567 miR-1307 stem-loop Proteins 0.000 description 1
- 108091047111 miR-135a-1 stem-loop Proteins 0.000 description 1
- 108091047375 miR-135a-2 stem-loop Proteins 0.000 description 1
- 108091040005 miR-135a-3 stem-loop Proteins 0.000 description 1
- 108091025226 miR-1469 stem-loop Proteins 0.000 description 1
- 108091072763 miR-151 stem-loop Proteins 0.000 description 1
- 108091069239 miR-17-2 stem-loop Proteins 0.000 description 1
- 108091085286 miR-181a-3 stem-loop Proteins 0.000 description 1
- 108091084881 miR-182-1 stem-loop Proteins 0.000 description 1
- 108091078636 miR-182-2 stem-loop Proteins 0.000 description 1
- 108091058104 miR-187 stem-loop Proteins 0.000 description 1
- 108091023683 miR-187-1 stem-loop Proteins 0.000 description 1
- 108091046933 miR-18b stem-loop Proteins 0.000 description 1
- 108091054189 miR-196a stem-loop Proteins 0.000 description 1
- 108091050874 miR-19a stem-loop Proteins 0.000 description 1
- 108091068975 miR-19a-3 stem-loop Proteins 0.000 description 1
- 108091087148 miR-20 stem-loop Proteins 0.000 description 1
- 108091066984 miR-20-1 stem-loop Proteins 0.000 description 1
- 108091076199 miR-20-2 stem-loop Proteins 0.000 description 1
- 108091073472 miR-202-1 stem-loop Proteins 0.000 description 1
- 108091038627 miR-202-2 stem-loop Proteins 0.000 description 1
- 108091047942 miR-203b stem-loop Proteins 0.000 description 1
- 108091030733 miR-205 stem-loop Proteins 0.000 description 1
- 108091088730 miR-215 stem-loop Proteins 0.000 description 1
- 108091074368 miR-216 stem-loop Proteins 0.000 description 1
- 108091051988 miR-216b stem-loop Proteins 0.000 description 1
- 108091080321 miR-222 stem-loop Proteins 0.000 description 1
- 108091089977 miR-2278 stem-loop Proteins 0.000 description 1
- 108091035591 miR-23a stem-loop Proteins 0.000 description 1
- 108091092825 miR-24 stem-loop Proteins 0.000 description 1
- 108091048857 miR-24-1 stem-loop Proteins 0.000 description 1
- 108091047483 miR-24-2 stem-loop Proteins 0.000 description 1
- 108091070404 miR-27b stem-loop Proteins 0.000 description 1
- 108091057475 miR-29b-1 stem-loop Proteins 0.000 description 1
- 108091025088 miR-29b-2 stem-loop Proteins 0.000 description 1
- 108091040861 miR-300 stem-loop Proteins 0.000 description 1
- 108091029203 miR-301 stem-loop Proteins 0.000 description 1
- 108091026505 miR-301a stem-loop Proteins 0.000 description 1
- 108091030637 miR-301b stem-loop Proteins 0.000 description 1
- 108091039462 miR-301b-1 stem-loop Proteins 0.000 description 1
- 108091028786 miR-301b-2 stem-loop Proteins 0.000 description 1
- 108091050195 miR-302b stem-loop Proteins 0.000 description 1
- 108091056763 miR-302c stem-loop Proteins 0.000 description 1
- 108091091870 miR-30a-3 stem-loop Proteins 0.000 description 1
- 108091067477 miR-30a-4 stem-loop Proteins 0.000 description 1
- 108091072917 miR-30c-1 stem-loop Proteins 0.000 description 1
- 108091066131 miR-30c-2 stem-loop Proteins 0.000 description 1
- 108091090925 miR-30d-1 stem-loop Proteins 0.000 description 1
- 108091047055 miR-30d-2 stem-loop Proteins 0.000 description 1
- 108091027549 miR-30e-1 stem-loop Proteins 0.000 description 1
- 108091029213 miR-30e-2 stem-loop Proteins 0.000 description 1
- 108091085488 miR-30e-3 stem-loop Proteins 0.000 description 1
- 108091041555 miR-3182 stem-loop Proteins 0.000 description 1
- 108091041315 miR-3195 stem-loop Proteins 0.000 description 1
- 108091087311 miR-320c stem-loop Proteins 0.000 description 1
- 108091054873 miR-320c-1 stem-loop Proteins 0.000 description 1
- 108091025794 miR-320c-2 stem-loop Proteins 0.000 description 1
- 108091062225 miR-323 stem-loop Proteins 0.000 description 1
- 108091089005 miR-329 stem-loop Proteins 0.000 description 1
- 108091090692 miR-337 stem-loop Proteins 0.000 description 1
- 108091065159 miR-339 stem-loop Proteins 0.000 description 1
- 108091023791 miR-339-1 stem-loop Proteins 0.000 description 1
- 108091037290 miR-33b stem-loop Proteins 0.000 description 1
- 108091088856 miR-345 stem-loop Proteins 0.000 description 1
- 108091040342 miR-34a-1 stem-loop Proteins 0.000 description 1
- 108091035608 miR-34a-2 stem-loop Proteins 0.000 description 1
- 108091084066 miR-34c-2 stem-loop Proteins 0.000 description 1
- 108091041426 miR-365b stem-loop Proteins 0.000 description 1
- 108091057188 miR-369 stem-loop Proteins 0.000 description 1
- 108091047175 miR-374a stem-loop Proteins 0.000 description 1
- 108091048101 miR-374b stem-loop Proteins 0.000 description 1
- 108091079007 miR-376b stem-loop Proteins 0.000 description 1
- 108091056437 miR-376c-1 stem-loop Proteins 0.000 description 1
- 108091079015 miR-379 Proteins 0.000 description 1
- 108091090987 miR-425 stem-loop Proteins 0.000 description 1
- 108091063235 miR-4266 stem-loop Proteins 0.000 description 1
- 108091029445 miR-432 stem-loop Proteins 0.000 description 1
- 108091057166 miR-4327 stem-loop Proteins 0.000 description 1
- 108091053086 miR-4458 stem-loop Proteins 0.000 description 1
- 108091029599 miR-4487 stem-loop Proteins 0.000 description 1
- 108091056281 miR-449b stem-loop Proteins 0.000 description 1
- 108091091051 miR-4500 stem-loop Proteins 0.000 description 1
- 108091070255 miR-4507 stem-loop Proteins 0.000 description 1
- 108091036674 miR-450a stem-loop Proteins 0.000 description 1
- 108091027743 miR-450b stem-loop Proteins 0.000 description 1
- 108091026346 miR-450b-1 stem-loop Proteins 0.000 description 1
- 108091041548 miR-450b-2 stem-loop Proteins 0.000 description 1
- 108091083237 miR-451b stem-loop Proteins 0.000 description 1
- 108091059056 miR-452 stem-loop Proteins 0.000 description 1
- 108091072779 miR-455 stem-loop Proteins 0.000 description 1
- 108091056879 miR-455-2 stem-loop Proteins 0.000 description 1
- 108091029231 miR-4723 stem-loop Proteins 0.000 description 1
- 108091088998 miR-4782 stem-loop Proteins 0.000 description 1
- 108091080700 miR-484 stem-loop Proteins 0.000 description 1
- 108091035982 miR-485 stem-loop Proteins 0.000 description 1
- 108091041063 miR-488 stem-loop Proteins 0.000 description 1
- 108091069917 miR-491 stem-loop Proteins 0.000 description 1
- 108091048941 miR-499a stem-loop Proteins 0.000 description 1
- 108091037417 miR-508 stem-loop Proteins 0.000 description 1
- 108091038238 miR-509-3 stem-loop Proteins 0.000 description 1
- 108091026919 miR-512 stem-loop Proteins 0.000 description 1
- 108091077010 miR-512-1 stem-loop Proteins 0.000 description 1
- 108091032013 miR-512-2 stem-loop Proteins 0.000 description 1
- 108091062489 miR-514a-1 stem-loop Proteins 0.000 description 1
- 108091046053 miR-514a-2 stem-loop Proteins 0.000 description 1
- 108091047994 miR-514a-3 stem-loop Proteins 0.000 description 1
- 108091032275 miR-517a stem-loop Proteins 0.000 description 1
- 108091040524 miR-518a-1 stem-loop Proteins 0.000 description 1
- 108091028747 miR-518a-2 stem-loop Proteins 0.000 description 1
- 108091045883 miR-518a-3 stem-loop Proteins 0.000 description 1
- 108091050322 miR-518a-4 stem-loop Proteins 0.000 description 1
- 108091041877 miR-519d stem-loop Proteins 0.000 description 1
- 108091024613 miR-520b stem-loop Proteins 0.000 description 1
- 108091086222 miR-520c stem-loop Proteins 0.000 description 1
- 108091063385 miR-526b stem-loop Proteins 0.000 description 1
- 108091040490 miR-545 stem-loop Proteins 0.000 description 1
- 108091049915 miR-551a stem-loop Proteins 0.000 description 1
- 108091047658 miR-564 stem-loop Proteins 0.000 description 1
- 108091087825 miR-5683 stem-loop Proteins 0.000 description 1
- 108091040489 miR-5694 stem-loop Proteins 0.000 description 1
- 108091058526 miR-573 stem-loop Proteins 0.000 description 1
- 108091045118 miR-576 stem-loop Proteins 0.000 description 1
- 108091048173 miR-577 stem-loop Proteins 0.000 description 1
- 108091059757 miR-582 stem-loop Proteins 0.000 description 1
- 108091046601 miR-584 stem-loop Proteins 0.000 description 1
- 108091041487 miR-584-1 stem-loop Proteins 0.000 description 1
- 108091091335 miR-584-2 stem-loop Proteins 0.000 description 1
- 108091072614 miR-584-3 stem-loop Proteins 0.000 description 1
- 108091042285 miR-584-4 stem-loop Proteins 0.000 description 1
- 108091035690 miR-584-5 stem-loop Proteins 0.000 description 1
- 108091059440 miR-584-6 stem-loop Proteins 0.000 description 1
- 108091082246 miR-584-7 stem-loop Proteins 0.000 description 1
- 108091088867 miR-584-8 stem-loop Proteins 0.000 description 1
- 108091024411 miR-590 stem-loop Proteins 0.000 description 1
- 108091041816 miR-6089-1 stem-loop Proteins 0.000 description 1
- 108091050321 miR-6089-2 stem-loop Proteins 0.000 description 1
- 108091080596 miR-614 stem-loop Proteins 0.000 description 1
- 108091090051 miR-615 stem-loop Proteins 0.000 description 1
- 108091041759 miR-622 stem-loop Proteins 0.000 description 1
- 108091062477 miR-627 stem-loop Proteins 0.000 description 1
- 108091046673 miR-628 stem-loop Proteins 0.000 description 1
- 108091079010 miR-632 stem-loop Proteins 0.000 description 1
- 108091069529 miR-637 stem-loop Proteins 0.000 description 1
- 108091056346 miR-642a stem-loop Proteins 0.000 description 1
- 108091089548 miR-656 stem-loop Proteins 0.000 description 1
- 108091063151 miR-660 stem-loop Proteins 0.000 description 1
- 108091041014 miR-663-1 stem-loop Proteins 0.000 description 1
- 108091050799 miR-663-10 stem-loop Proteins 0.000 description 1
- 108091038412 miR-663-11 stem-loop Proteins 0.000 description 1
- 108091062556 miR-663-2 stem-loop Proteins 0.000 description 1
- 108091036836 miR-663-3 stem-loop Proteins 0.000 description 1
- 108091056984 miR-663-4 stem-loop Proteins 0.000 description 1
- 108091064096 miR-663-5 stem-loop Proteins 0.000 description 1
- 108091089306 miR-663-6 stem-loop Proteins 0.000 description 1
- 108091074126 miR-663-7 stem-loop Proteins 0.000 description 1
- 108091074471 miR-663-8 stem-loop Proteins 0.000 description 1
- 108091053580 miR-663-9 stem-loop Proteins 0.000 description 1
- 108091025542 miR-668 stem-loop Proteins 0.000 description 1
- 108091040808 miR-675 stem-loop Proteins 0.000 description 1
- 108091024540 miR-7158 stem-loop Proteins 0.000 description 1
- 108091055142 miR-7515 stem-loop Proteins 0.000 description 1
- 108091080296 miR-758 stem-loop Proteins 0.000 description 1
- 108091049937 miR-759 stem-loop Proteins 0.000 description 1
- 108091043776 miR-765 stem-loop Proteins 0.000 description 1
- 108091056169 miR-770 stem-loop Proteins 0.000 description 1
- 108091029509 miR-802 stem-loop Proteins 0.000 description 1
- 108091034121 miR-92a stem-loop Proteins 0.000 description 1
- 108091041519 miR-92a-3 stem-loop Proteins 0.000 description 1
- 108091032902 miR-93 stem-loop Proteins 0.000 description 1
- 108091071148 miR-935 stem-loop Proteins 0.000 description 1
- 108091073613 miR-941-1 stem-loop Proteins 0.000 description 1
- 108091039878 miR-941-2 stem-loop Proteins 0.000 description 1
- 108091035558 miR-941-3 stem-loop Proteins 0.000 description 1
- 108091031187 miR-941-4 stem-loop Proteins 0.000 description 1
- 108091085604 miR-941-5 stem-loop Proteins 0.000 description 1
- 108091078206 miR-9500 stem-loop Proteins 0.000 description 1
- 108091028482 miR-96-1 stem-loop Proteins 0.000 description 1
- 108091090007 miR-96-2 stem-loop Proteins 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 208000007538 neurilemmoma Diseases 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
- 206010039667 schwannoma Diseases 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 description 1
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021089151A JP7174109B2 (ja) | 2016-01-27 | 2021-05-27 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2022177413A JP2023001236A (ja) | 2016-01-27 | 2022-11-04 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2024028567A JP2024052881A (ja) | 2016-01-27 | 2024-02-28 | 腫瘍溶解性ウイルスベクター及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662287619P | 2016-01-27 | 2016-01-27 | |
| US62/287,619 | 2016-01-27 | ||
| PCT/US2017/015417 WO2017132552A1 (en) | 2016-01-27 | 2017-01-27 | Oncolytic viral vectors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021089151A Division JP7174109B2 (ja) | 2016-01-27 | 2021-05-27 | 腫瘍溶解性ウイルスベクター及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508063A JP2019508063A (ja) | 2019-03-28 |
| JP2019508063A5 true JP2019508063A5 (enExample) | 2020-06-18 |
Family
ID=57995301
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559162A Pending JP2019508063A (ja) | 2016-01-27 | 2017-01-27 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2021089151A Active JP7174109B2 (ja) | 2016-01-27 | 2021-05-27 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2022177413A Withdrawn JP2023001236A (ja) | 2016-01-27 | 2022-11-04 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2024028567A Pending JP2024052881A (ja) | 2016-01-27 | 2024-02-28 | 腫瘍溶解性ウイルスベクター及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021089151A Active JP7174109B2 (ja) | 2016-01-27 | 2021-05-27 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2022177413A Withdrawn JP2023001236A (ja) | 2016-01-27 | 2022-11-04 | 腫瘍溶解性ウイルスベクター及びその使用 |
| JP2024028567A Pending JP2024052881A (ja) | 2016-01-27 | 2024-02-28 | 腫瘍溶解性ウイルスベクター及びその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10391132B2 (enExample) |
| EP (2) | EP3408382B1 (enExample) |
| JP (4) | JP2019508063A (enExample) |
| KR (1) | KR20180136435A (enExample) |
| CN (2) | CN116904404A (enExample) |
| AR (1) | AR107469A1 (enExample) |
| AU (1) | AU2017212713B2 (enExample) |
| BR (1) | BR112018015390A2 (enExample) |
| CA (1) | CA3011933A1 (enExample) |
| DK (1) | DK3408382T3 (enExample) |
| ES (1) | ES2919953T3 (enExample) |
| IL (2) | IL260790B (enExample) |
| MX (1) | MX2018009126A (enExample) |
| PT (1) | PT3408382T (enExample) |
| RU (2) | RU2749050C2 (enExample) |
| SG (2) | SG10202107138TA (enExample) |
| TW (1) | TWI798168B (enExample) |
| WO (1) | WO2017132552A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018015390A2 (pt) | 2016-01-27 | 2018-12-18 | Oncorus, Inc. | vetores virais oncolíticos e usos dos mesmos |
| PL3377637T3 (pl) * | 2016-04-08 | 2020-09-07 | Krystal Biotech, Inc. | Kompozycje do stosowania w sposobach leczenia ran, zaburzeń i chorób skóry |
| WO2018006005A1 (en) | 2016-06-30 | 2018-01-04 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| US10682425B2 (en) * | 2016-12-14 | 2020-06-16 | The Regents Of The University Of California | Engineered B lymphocytes and compositions having micro-RNA and methods for making and using them |
| US12121573B2 (en) | 2019-07-14 | 2024-10-22 | Tianxin Wang | Methods and agents including STING agonist to treat tumor |
| EP3594329A4 (en) * | 2017-04-19 | 2021-02-24 | The University Of Tokyo | GENETICALLY MODIFIED COXSACKIE VIRUS, AND PHARMACEUTICAL COMPOSITION |
| CA3059480A1 (en) * | 2017-04-28 | 2018-11-01 | Toray Industries, Inc. | Kit, device, and method for detecting ovarian tumor |
| WO2019023483A1 (en) * | 2017-07-26 | 2019-01-31 | Oncorus, Inc. | ONCOLYTIC VIRAL VECTORS AND USES THEREOF |
| GB201714430D0 (en) * | 2017-09-07 | 2017-10-25 | Micol Romain | Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue |
| JP2021514190A (ja) * | 2018-02-19 | 2021-06-10 | コンバインド セラピューティクス インコーポレイテッドＣｏｍｂｉｎｅｄ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | コード化リボ核酸の器官保護発現および調節のための組成物および方法 |
| CA3074901A1 (en) | 2017-09-11 | 2019-03-14 | Imba - Institut Fur Molekulare Biotechnologie Gmbh | Tumor organoid model |
| TWI666321B (zh) * | 2017-10-23 | 2019-07-21 | 大陸商深圳市亦諾微醫藥科技有限公司 | 用於癌症治療的溶瘤性單純皰疹病毒（ｏＨＳＶ）專性載體及其建構體的建構 |
| CN107723367A (zh) * | 2017-10-27 | 2018-02-23 | 青岛大学 | miRNA‑885‑3p的应用和应用其的产品 |
| CN107674918A (zh) * | 2017-11-10 | 2018-02-09 | 上海交通大学医学院 | has‑mir‑195‑5p作为生物标志物在制备肺癌诊断试剂盒中的应用 |
| US11865081B2 (en) | 2017-12-29 | 2024-01-09 | Virogin Biotech Canada Ltd. | Oncolytic viral delivery of therapeutic polypeptides |
| CA3096938A1 (en) | 2018-04-10 | 2019-10-17 | Ottawa Hospital Research Institute | Microrna-based compositions and methods used in disease treatment |
| EP3781188A4 (en) * | 2018-04-13 | 2022-03-02 | 2seventy bio, Inc. | ADOPTIVE CELL THERAPY |
| CN108707625B (zh) * | 2018-07-03 | 2021-09-21 | 云笛生物科技有限公司 | mir-124和HER2-shRNA双基因表达盒病毒载体、构建方法、病毒、应用 |
| CN109091491A (zh) * | 2018-08-02 | 2018-12-28 | 广州安镝声生物医药科技有限公司 | lncRNA H19的靶miRNA miR19a-3p及其应用 |
| CN109091492A (zh) * | 2018-08-02 | 2018-12-28 | 广州安镝声生物医药科技有限公司 | lncRNA H19的靶miRNA miR-106b-5p及其应用 |
| CN111117973A (zh) * | 2018-10-30 | 2020-05-08 | 中国科学院武汉病毒研究所 | 一种受microRNA调控的重组溶瘤肠道病毒71型及应用 |
| EP3880812A4 (en) * | 2018-11-13 | 2022-09-07 | Oncorus, Inc. | ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE |
| TWI690597B (zh) * | 2018-11-14 | 2020-04-11 | 國立中央大學 | 泌尿上皮癌的檢測套組及檢測方法 |
| KR20210098483A (ko) * | 2018-11-29 | 2021-08-10 | 바이로진 바이오테크 캐나다 리미티드 | 신경독성이 감소된 hsv 벡터 |
| KR20200069259A (ko) * | 2018-12-06 | 2020-06-16 | 국립암센터 | nc886을 포함하는 암살상 바이러스 활성 증진 또는 생산 증진용 조성물 |
| AU2020204989A1 (en) * | 2019-01-04 | 2021-07-08 | Elevatebio Technologies, Inc. | Encapsulated RNA polynucleotides and methods of use |
| CN109762903B (zh) * | 2019-01-31 | 2022-02-01 | 山东大学齐鲁医院 | miR-1246和/或TERF2IP在诊治胶质瘤中的应用 |
| US12209250B2 (en) * | 2019-03-14 | 2025-01-28 | Massachusetts Institute Of Technology | Engineered Herpes Simplex Virus-1 (HSV-1) vectors and uses thereof |
| CN110283794B (zh) * | 2019-05-30 | 2021-04-23 | 伍泽堂 | 重组溶瘤病毒以及制备方法、应用和药物 |
| CN112011570B (zh) * | 2019-05-31 | 2023-04-18 | 北京合生基因科技有限公司 | 特异杀伤肿瘤细胞的溶瘤病毒系统及其应用 |
| JP2022541197A (ja) * | 2019-07-16 | 2022-09-22 | ユニヴェルシテ・コート・ダジュール | 腫瘍溶解性ウイルスに対する対象の感受性又は抵抗性を評価する方法、組換えウイルス、その調製、及び使用 |
| AU2020326774A1 (en) * | 2019-08-05 | 2022-03-03 | Virogin Biotech Canada Ltd | Genetically modified enterovirus vectors |
| CN110468132B (zh) * | 2019-08-15 | 2022-11-25 | 西南大学 | 一种sgRNA及转基因表达载体、表达品系、筛选方法 |
| CN110433171B (zh) * | 2019-08-20 | 2022-08-19 | 中山大学附属第六医院 | miRNA-1293在制备抗结直肠肿瘤药物中的应用 |
| US20220380735A1 (en) | 2019-10-10 | 2022-12-01 | Oncorus, Inc. | Dual viruses and dual oncolytic viruses and methods of treatment |
| KR102320430B1 (ko) * | 2020-01-29 | 2021-11-03 | 서울대학교병원 | 수모세포종에 대한 miR-135b, miR-135a 및 이들의 표적 유전자 AMOTL2의 용도 |
| EP4136241A2 (en) * | 2020-04-14 | 2023-02-22 | Eidgenössische Technische Hochschule Zürich | Cell classifier circuits and methods of use thereof |
| CN113583977B (zh) * | 2020-04-30 | 2025-06-06 | 杭州康万达医药科技有限公司 | 可受微小rna调控的分离的重组溶瘤痘病毒及其应用 |
| WO2021244628A1 (zh) * | 2020-06-05 | 2021-12-09 | 上海宝济药业有限公司 | 一种酶和病毒的药物组合及其应用 |
| JP7539739B2 (ja) * | 2020-07-10 | 2024-08-26 | 上海米然生物科技有限公司 | 蛍光架橋型ＲＮａｓｅ Ｈ突然変異体コンジュゲート、ｍｉＲＮＡの組み合わせ及びその使用 |
| CA3187345A1 (en) | 2020-07-31 | 2022-02-17 | Romain MICOL | Compositions and methods for improved vaccination |
| CA3197748A1 (en) * | 2020-11-13 | 2022-05-19 | Henry Fechner | Mir-375- and mir-1-regulated coxsackievirus b3 has no pancreas and heart toxicity but strong antitumor efficiency in colorectal carcinomas |
| CN116744951A (zh) * | 2020-12-25 | 2023-09-12 | 苏州系统医学研究所 | 一种包含溶瘤病毒的组合物及其在肿瘤治疗中的应用 |
| TW202305123A (zh) * | 2021-03-24 | 2023-02-01 | 加拿大商復諾健生物科技加拿大有限公司 | 轉錄及轉譯雙重調節之溶瘤單純疱疹病毒載體 |
| BR112023020209A2 (pt) | 2021-04-02 | 2023-12-19 | Krystal Biotech Inc | Genoma do vírus do herpes recombinante, vírus do herpes, composição farmacêutica, uso do vírus do herpes ou da composição farmacêutica, método para expressar, realçar, aumentar, ampliar e/ou suplementar os níveis de um polipeptídeo imunomodulatório, método para prover alívio profilático, paliativo ou terapêutico, e, método para tratar câncer |
| US20250049867A1 (en) * | 2021-08-31 | 2025-02-13 | Virogin Biotech Canada Ltd. | Engineered oncolytic herpesviruses |
| CN113637761B (zh) * | 2021-10-15 | 2025-01-24 | 北京百奥思科生物医学技术有限公司 | 用于黑色素瘤诊断和治疗的miRNA标志物及其相关产品 |
| WO2023142040A1 (en) * | 2022-01-29 | 2023-08-03 | Virogin Biotech Canada Ltd. | Transcriptional and translational dual regulated oncolytic herpes simplex virus vectors |
| CN118634241A (zh) * | 2022-06-27 | 2024-09-13 | 浙江大学 | 抗口腔肿瘤药物活性成分及其用途 |
| KR102726438B1 (ko) * | 2022-11-29 | 2024-11-06 | 주식회사 신렉스 | 암 세포를 표적으로 하는 복수 개의 miRNA를 발현하도록 유전적 조작된 박테리아 균주 |
| GB2634272A (en) * | 2023-10-04 | 2025-04-09 | Averywell Ltd | Methods |
| KR20250051170A (ko) * | 2023-10-06 | 2025-04-17 | 아주대학교산학협력단 | 자궁경부암 환자의 조기 사망 예측용 바이오마커 |
| CN119932194A (zh) * | 2025-01-23 | 2025-05-06 | 上海市第十人民医院 | 一种用于靶标rna多重分析的共价荧光编码组装体、dna荧光条形码及应用 |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244792A (en) | 1984-04-06 | 1993-09-14 | Chiron Corporation | Expression of recombinant glyoprotein B from herpes simplex virus |
| JPH0668B2 (ja) | 1985-08-30 | 1994-01-05 | 財団法人化学及血清療法研究所 | 単純ヘルペスウイルス遺伝子が組込まれた組換えプラスミド |
| GB8918616D0 (en) | 1989-08-15 | 1989-09-27 | Univ Glasgow | Herpes simplex virus type 1 mutant |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| US5849571A (en) | 1990-10-10 | 1998-12-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Latency active herpes virus promoters and their use |
| US5849572A (en) | 1990-10-10 | 1998-12-15 | Regents Of The University Of Michigan | HSV-1 vector containing a lat promoter |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| ATE155681T1 (de) | 1992-05-18 | 1997-08-15 | Minnesota Mining & Mfg | Einrichtung zur transmucosalen wirkstoffabgabe |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| US5658724A (en) | 1992-07-31 | 1997-08-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains deficient for the essential immediate early genes ICP4 and ICP27 and methods for their production, growth and use |
| US5879934A (en) | 1992-07-31 | 1999-03-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| GB9415319D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
| GB9415369D0 (en) | 1994-07-29 | 1994-09-21 | Lynxvale Ltd | Mutant virus |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US6261552B1 (en) | 1997-05-22 | 2001-07-17 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus vectors |
| GB9700411D0 (en) | 1997-01-10 | 1997-02-26 | Univ London | Eukaryotic gene expression cassette and uses thereof |
| US6071742A (en) | 1997-03-05 | 2000-06-06 | Board Of Regents Of The University Of Nebraska | Coxsackie virus as a vector for delivery of anti-inflammatory cytokines |
| US5998174A (en) | 1997-05-12 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Multigene vectors |
| WO1999006583A1 (en) | 1997-07-31 | 1999-02-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Targeted hsv vectors |
| ATE305510T1 (de) | 1997-12-17 | 2005-10-15 | Immunex Corp | Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden |
| EP1002864A1 (en) | 1998-11-10 | 2000-05-24 | Universita' degli studi di Bologna | HIgR and related V domain for the manufacture of a medicament for preventing or treating HSV-1, HSV-2 and BHV infections |
| US6897057B1 (en) | 1999-08-31 | 2005-05-24 | The General Hospital Corporation | Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression |
| GB9930418D0 (en) | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
| EP1381280B1 (en) | 2001-03-27 | 2011-05-11 | Catherex, Inc. | Viral vectors and their use in therapeutic methods |
| US20020187126A1 (en) | 2001-04-06 | 2002-12-12 | Mount Sinai School Of Medicine | Methods for viral oncoapoptosis in cancer therapy |
| MXPA04003057A (es) | 2001-10-04 | 2005-06-20 | Immunex Corp | Proteina 4 de enlace ul16. |
| KR100900249B1 (ko) | 2001-12-07 | 2009-05-29 | 포항공과대학교 산학협력단 | ＳＩＶｍａｃ239의 면역원성 플라스미드 및 이들을 함유한ＡＩＤＳ ＤＮＡ 백신 |
| US8927251B2 (en) | 2002-10-07 | 2015-01-06 | The University Of Chicago | Targeting of herpes simplex virus to specific receptors |
| GB0406389D0 (en) | 2004-03-22 | 2004-04-21 | Istituto Superiore Di Sanito | Recombinant herpes simplex virus and uses therefor |
| US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| JP5054522B2 (ja) | 2004-08-20 | 2012-10-24 | ヴィラリティクス リミテッド | 血液ガンを治療するための方法および組成物 |
| EP1805213B1 (en) | 2004-10-28 | 2015-11-18 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain |
| US20080160031A1 (en) | 2005-01-17 | 2008-07-03 | Viralytics Limited | Method and Composition for Treatment of Neoplasms |
| SI2002003T1 (sl) | 2005-05-27 | 2016-05-31 | Ospedale San Raffaele S.R.L. | Genski vektor, ki vsebuje mi-RNA |
| DK2341149T3 (en) | 2005-08-26 | 2017-02-27 | Dupont Nutrition Biosci Aps | Use of CRISPR-associated genes (Cas) |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| US20080008686A1 (en) | 2006-07-10 | 2008-01-10 | The Brigham And Women's Hospital, Inc. | Tetracycline repressor regulated oncolytic viruses |
| US9428756B2 (en) | 2006-08-11 | 2016-08-30 | Dow Agrosciences Llc | Zinc finger nuclease-mediated homologous recombination |
| EP2125032A4 (en) | 2007-02-20 | 2011-02-23 | Mayo Foundation | CANCER TREATMENT WITH VIRAL NUCLEIC ACID |
| US8586028B2 (en) | 2007-05-09 | 2013-11-19 | Board Of Supervisors Of Lousiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses type-1 for treatment of cancers |
| WO2008143875A1 (en) | 2007-05-14 | 2008-11-27 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Targeted delivery of glycine receptors to excitable cells |
| WO2009111892A1 (en) | 2008-03-14 | 2009-09-17 | Ottawa Health Research Institute | Microrna mediated oncolytic targeting |
| NO2700405T3 (enExample) | 2008-05-29 | 2018-09-01 | ||
| EP2307033A4 (en) | 2008-05-29 | 2012-06-13 | Gen Hospital Corp | USE OF ONCOLYTIC HERPESVIRUS FOR THE KILLING OF CANCER STEM CELLS |
| GB0810912D0 (en) | 2008-06-13 | 2008-07-23 | Inst Animal Health Ltd | Vector |
| WO2010011961A2 (en) | 2008-07-25 | 2010-01-28 | University Of Georgia Research Foundation, Inc. | Prokaryotic rnai-like system and methods of use |
| US20100076057A1 (en) | 2008-09-23 | 2010-03-25 | Northwestern University | TARGET DNA INTERFERENCE WITH crRNA |
| US9404098B2 (en) | 2008-11-06 | 2016-08-02 | University Of Georgia Research Foundation, Inc. | Method for cleaving a target RNA using a Cas6 polypeptide |
| MX337838B (es) | 2008-11-07 | 2016-03-22 | Dupont Nutrition Biosci Aps | Secuencias de repetidos palindromicos cortos regularmente intercalados agrupados de bifidobacterias. |
| CA2755245A1 (en) | 2009-03-13 | 2010-09-16 | Egen, Inc. | Compositions and methods for the delivery of biologically active rnas |
| US20100297072A1 (en) | 2009-05-19 | 2010-11-25 | Depinho Ronald A | Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy |
| CA2795695A1 (en) | 2010-04-09 | 2011-10-13 | The University Of Tokyo | Microrna-controlled recombinant vaccinia virus and use thereof |
| WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
| WO2012006181A2 (en) | 2010-06-29 | 2012-01-12 | Mount Sinai School Of Medicine | Compositions and methods for inhibiting oncogenic micrornas and treatment of cancer |
| EA201390586A1 (ru) | 2010-10-20 | 2014-11-28 | ДюПон НЬЮТРИШН БАЙОСАЙЕНСИЗ АпС | Последовательности crispr-cas lactococcus |
| JP6158170B2 (ja) | 2011-04-27 | 2017-07-12 | アミリス， インコーポレイテッド | ゲノム修飾のための方法 |
| WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
| AU2012322999B2 (en) | 2011-10-11 | 2017-08-10 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising IL-12 and an agent for blockade of T-cell inhibitory molecules for tumour therapy |
| US11951157B2 (en) | 2011-10-11 | 2024-04-09 | Universitat Zurich | Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody |
| EP2591796A1 (en) | 2011-11-10 | 2013-05-15 | Universität Zürich | Combination medicament comprising IL-12 and an anti-CTLA-4 ligand for tumor therapy |
| US20130156808A1 (en) | 2011-11-22 | 2013-06-20 | Stipan Jonjic | Vaccine comprising beta-herpesvirus |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| WO2013109604A1 (en) * | 2012-01-19 | 2013-07-25 | Alnylam Pharmaceuticals, Inc. | Viral attenuation and vaccine production |
| SG10201606959PA (en) | 2012-02-24 | 2016-09-29 | Hutchinson Fred Cancer Res | Compositions and methods for the treatment of hemoglobinopathies |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| AU2014204015A1 (en) | 2013-01-04 | 2015-07-09 | Cytomx Therapeutics, Inc. | Compositions and methods for detecting protease activity in biological systems |
| KR20250012194A (ko) | 2013-06-17 | 2025-01-23 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
| KR102382295B1 (ko) | 2013-07-17 | 2022-04-04 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 효율적인 유전자 전달 적용을 위한 비독성 hsv 벡터 및 이의 생산을 위한 보완 세포 |
| JP6588024B2 (ja) | 2013-10-28 | 2019-10-09 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 腫瘍溶解性ｈｓｖベクター |
| CA2940570A1 (en) | 2014-02-27 | 2015-09-03 | Viralytics Limited | Combination method for treatment of cancer |
| EP3552615B8 (en) | 2014-07-16 | 2022-03-02 | Transgene | Oncolytic virus for expression of immune checkpoint modulators |
| US10647964B2 (en) | 2015-03-05 | 2020-05-12 | Northwestern University | Non-neuroinvasive viruses and uses thereof |
| US10083137B2 (en) | 2015-04-02 | 2018-09-25 | Atmel Corporation | Peripheral interface circuit for serial memory |
| ES2994611T3 (en) | 2015-10-19 | 2025-01-27 | Cg Oncology Inc | Methods of treating solid or lymphatic tumors by combination therapy |
| CA3010987A1 (en) | 2016-01-08 | 2017-07-13 | Replimune Limited | Oncolytic herpes simplex virus type 1 strain |
| BR112018015390A2 (pt) | 2016-01-27 | 2018-12-18 | Oncorus, Inc. | vetores virais oncolíticos e usos dos mesmos |
| PL3426271T3 (pl) | 2016-03-10 | 2025-11-24 | Cg Oncology, Inc. | Sposoby leczenia guzów litych terapią skojarzoną |
| EP3380621A4 (en) | 2016-04-22 | 2019-05-08 | Immvira Co., Limited | CONSTRUCTION OF THE VECTOR OF OBLIGATES ONCOLYTIC HERPES SIMPLEX VIRUSES (OHSV) AND CANCER THERAPY CONSTRUCTIONS |
| JP7200104B2 (ja) | 2016-08-01 | 2023-01-06 | ヴァイロジン バイオテック カナダ リミテッド | 免疫系刺激分子を発現する腫瘍溶解性単純ヘルペスウイルスベクター |
| CN118436692A (zh) | 2016-08-09 | 2024-08-06 | 图恩斯通有限合伙公司 | 表达il12的溶瘤弹状病毒 |
| TW201825674A (zh) | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | 表現雙特異性接合分子的溶瘤病毒 |
| US20190275092A1 (en) | 2016-11-01 | 2019-09-12 | Dnatrix, Inc. | Combination therapy for treatment of brain cancers |
| WO2018118967A1 (en) | 2016-12-21 | 2018-06-28 | Memgen, Llc | Armed replication-competent oncolytic adenoviruses |
| US11298420B2 (en) | 2016-12-21 | 2022-04-12 | Memgen, Llc | Armed oncolytic viruses |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| WO2019023483A1 (en) * | 2017-07-26 | 2019-01-31 | Oncorus, Inc. | ONCOLYTIC VIRAL VECTORS AND USES THEREOF |
-
2017
- 2017-01-27 BR BR112018015390-7A patent/BR112018015390A2/pt not_active Application Discontinuation
- 2017-01-27 CA CA3011933A patent/CA3011933A1/en active Pending
- 2017-01-27 PT PT177041506T patent/PT3408382T/pt unknown
- 2017-01-27 EP EP17704150.6A patent/EP3408382B1/en active Active
- 2017-01-27 KR KR1020187024583A patent/KR20180136435A/ko not_active Ceased
- 2017-01-27 CN CN202211588793.4A patent/CN116904404A/zh active Pending
- 2017-01-27 CN CN201780019076.0A patent/CN108884448B/zh active Active
- 2017-01-27 AU AU2017212713A patent/AU2017212713B2/en not_active Expired - Fee Related
- 2017-01-27 RU RU2018130673A patent/RU2749050C2/ru active
- 2017-01-27 WO PCT/US2017/015417 patent/WO2017132552A1/en not_active Ceased
- 2017-01-27 ES ES17704150T patent/ES2919953T3/es active Active
- 2017-01-27 MX MX2018009126A patent/MX2018009126A/es unknown
- 2017-01-27 AR ARP170100218A patent/AR107469A1/es not_active Application Discontinuation
- 2017-01-27 SG SG10202107138TA patent/SG10202107138TA/en unknown
- 2017-01-27 JP JP2018559162A patent/JP2019508063A/ja active Pending
- 2017-01-27 SG SG11201806134SA patent/SG11201806134SA/en unknown
- 2017-01-27 RU RU2021114137A patent/RU2021114137A/ru unknown
- 2017-01-27 DK DK17704150.6T patent/DK3408382T3/da active
- 2017-01-27 EP EP22161034.8A patent/EP4089166A1/en active Pending
- 2017-02-02 TW TW106103584A patent/TWI798168B/zh not_active IP Right Cessation
-
2018
- 2018-07-26 IL IL260790A patent/IL260790B/en unknown
- 2018-07-27 US US16/047,499 patent/US10391132B2/en active Active
-
2019
- 2019-07-10 US US16/507,789 patent/US11452750B2/en active Active
-
2021
- 2021-05-27 JP JP2021089151A patent/JP7174109B2/ja active Active
-
2022
- 2022-01-25 IL IL290102A patent/IL290102B2/en unknown
- 2022-08-18 US US17/820,694 patent/US20230115116A1/en active Pending
- 2022-11-04 JP JP2022177413A patent/JP2023001236A/ja not_active Withdrawn
-
2024
- 2024-02-28 JP JP2024028567A patent/JP2024052881A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019508063A5 (enExample) | ||
| RU2018130673A (ru) | Онколитические вирусные векторы и их применение | |
| JP7652823B2 (ja) | 腫瘍溶解性ウイルスベクター及びその使用 | |
| ES2544713T3 (es) | Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos | |
| US9821009B2 (en) | Method for modulating microRNA content in living beings and the use thereof | |
| EP2865393B1 (en) | Compositions comprising mir-143 and/or mir-145 or (an) expression vector(s) thereof, for use as medicaments | |
| JP2008519606A5 (enExample) | ||
| JP2015509366A5 (enExample) | ||
| JP2015504307A5 (enExample) | ||
| CN102218144A (zh) | 一种调节生物体内微小核糖核酸含量的方法及其用途 | |
| US20250049867A1 (en) | Engineered oncolytic herpesviruses | |
| Sheervalilou et al. | A review on microRNAs’ function, detection and evaluation methods, expression dysregulation mechanisms and possible applications in clinical phase as diagnostic, prognostic and therapeutic biomarkers of lung cancer patients | |
| Noorali et al. | Effec t of Differentially Expressed MicroRNAs 602 and 323-5p on Hepatitis C Viru s Genotype 1b Viral Load in Infected Liver Cells | |
| İmir et al. | OVER KANSERİ HÜCRELERİNDE PRİMA-1 Met TEDAVİSİNE YANIT OLARAK DEĞİŞEN miRNA EKSPRESYON ANALİZİ |