JP2019506872A5 - - Google Patents
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- JP2019506872A5 JP2019506872A5 JP2018543210A JP2018543210A JP2019506872A5 JP 2019506872 A5 JP2019506872 A5 JP 2019506872A5 JP 2018543210 A JP2018543210 A JP 2018543210A JP 2018543210 A JP2018543210 A JP 2018543210A JP 2019506872 A5 JP2019506872 A5 JP 2019506872A5
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- Japan
- Prior art keywords
- domain
- molecule
- hairpin
- subdomain
- tohold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000000295 complement effect Effects 0.000 claims 50
- 239000002773 nucleotide Substances 0.000 claims 46
- 125000003729 nucleotide group Chemical group 0.000 claims 46
- 230000003197 catalytic effect Effects 0.000 claims 36
- 150000007523 nucleic acids Chemical class 0.000 claims 35
- 102000039446 nucleic acids Human genes 0.000 claims 35
- 108020004707 nucleic acids Proteins 0.000 claims 35
- 238000006073 displacement reaction Methods 0.000 claims 20
- 230000000694 effects Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 14
- 239000003054 catalyst Substances 0.000 claims 13
- 239000011541 reaction mixture Substances 0.000 claims 13
- 239000005547 deoxyribonucleotide Substances 0.000 claims 7
- 235000011178 triphosphate Nutrition 0.000 claims 7
- 239000001226 triphosphate Substances 0.000 claims 7
- 238000000137 annealing Methods 0.000 claims 6
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 6
- 238000006116 polymerization reaction Methods 0.000 claims 6
- 239000011535 reaction buffer Substances 0.000 claims 6
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000001012 protector Effects 0.000 claims 2
- -1 deoxyribonucleotide triphosphates Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296310P | 2016-02-17 | 2016-02-17 | |
| US62/296,310 | 2016-02-17 | ||
| US201662299206P | 2016-02-24 | 2016-02-24 | |
| US62/299,206 | 2016-02-24 | ||
| US201662429149P | 2016-12-02 | 2016-12-02 | |
| US62/429,149 | 2016-12-02 | ||
| US201662432017P | 2016-12-09 | 2016-12-09 | |
| US62/432,017 | 2016-12-09 | ||
| PCT/US2017/018086 WO2017143006A1 (en) | 2016-02-17 | 2017-02-16 | Molecular programming tools |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506872A JP2019506872A (ja) | 2019-03-14 |
| JP2019506872A5 true JP2019506872A5 (https=) | 2020-03-26 |
| JP7085999B2 JP7085999B2 (ja) | 2022-06-17 |
Family
ID=59626272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543210A Active JP7085999B2 (ja) | 2016-02-17 | 2017-02-16 | 分子プログラミングツール |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11286517B2 (https=) |
| EP (4) | EP3417078B1 (https=) |
| JP (1) | JP7085999B2 (https=) |
| CN (2) | CN116949140A (https=) |
| WO (1) | WO2017143006A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011319755B2 (en) | 2010-10-27 | 2017-02-23 | President And Fellows Of Harvard College | Compositions of toehold primer duplexes and methods of use |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| ES2891085T3 (es) | 2015-01-30 | 2022-01-26 | Harvard College | Obtención de imágenes sin microscopio |
| CN116949140A (zh) * | 2016-02-17 | 2023-10-27 | 哈佛学院院长及董事 | 分子编程工具 |
| EP3448886A4 (en) | 2016-04-26 | 2019-12-11 | Ultivue, Inc. | SUPER-HIGH-RESOLUTION IMMUNOFLUORESCENCE WITH BINDING-LIMITED PREVIEW |
| AU2017259794B2 (en) | 2016-05-02 | 2023-04-13 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| US11208676B2 (en) | 2016-05-27 | 2021-12-28 | President And Fellows Of Harvard College | Conditional primer extension for single-molecule detection |
| WO2018017914A1 (en) | 2016-07-22 | 2018-01-25 | President And Fellows Of Harvard College | Methods and compositions for protein identification |
| CN109923213B (zh) | 2016-09-20 | 2023-02-28 | 哈佛学院院长及董事 | 分子验证系统 |
| EP3568492B1 (en) | 2017-01-10 | 2025-01-01 | President and Fellows of Harvard College | Multiplexed signal amplification |
| MX2020004559A (es) | 2017-10-31 | 2020-10-05 | Encodia Inc | Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. |
| CN111630179B (zh) * | 2018-01-26 | 2024-07-19 | 哈佛学院院长及董事 | 邻近检测方法和组合物 |
| CN112189055B (zh) | 2018-03-22 | 2024-07-19 | 哈佛学院院长及董事 | 用于分子认证的方法和组合物 |
| WO2019236841A1 (en) | 2018-06-08 | 2019-12-12 | Ultivue, Inc. | Multiplexed catalyzed reporter deposition |
| WO2020069386A2 (en) * | 2018-09-28 | 2020-04-02 | California Institute Of Technology | Efficient combinatorial bead barcoding |
| JP2022513739A (ja) | 2018-12-14 | 2022-02-09 | アルティヴュー， インク． | 標的を逐次検出するための方法及び組成物 |
| WO2020185312A2 (en) * | 2019-01-25 | 2020-09-17 | President And Fellows Of Harvard College | Compositions and method for synthesizing nucleic acids |
| EP3963070A4 (en) | 2019-04-30 | 2023-02-22 | Encodia, Inc. | METHODS OF PREPARATION OF ANALYTES AND RELATED KITS |
| US20220356509A1 (en) | 2019-07-05 | 2022-11-10 | Ultivue, Inc. | Improved Multiplexing Method |
| CN114641581A (zh) * | 2019-10-28 | 2022-06-17 | 深圳华大智造科技股份有限公司 | Dna接头寡核苷酸 |
| WO2021138312A1 (en) | 2019-12-30 | 2021-07-08 | Ultivue, Inc. | Methods for reducing nonspecific interactions on biological samples |
| US12275984B2 (en) | 2021-03-02 | 2025-04-15 | 10X Genomics, Inc. | Sequential hybridization and quenching |
| CN113156122B (zh) * | 2021-04-29 | 2023-07-04 | 重庆医科大学 | 一种检测外泌体pd-l1的荧光传感器及其制备与应用 |
| US20220380838A1 (en) | 2021-06-01 | 2022-12-01 | 10X Genomics, Inc. | Methods and compositions for analyte detection and probe resolution |
| WO2022256422A1 (en) | 2021-06-02 | 2022-12-08 | 10X Genomics, Inc. | Sample analysis using asymmetric circularizable probes |
| WO2023283442A1 (en) | 2021-07-09 | 2023-01-12 | 10X Genomics, Inc. | Methods for detecting analytes using sparse labelling |
| CN117651855A (zh) | 2021-07-13 | 2024-03-05 | 10X基因组学有限公司 | 用于制备具有可控厚度的聚合基质的方法 |
| CA3224093A1 (en) | 2021-07-30 | 2023-02-02 | Jorge Ivan Hernandez Neuta | Methods and compositions for synchronizing reactions in situ |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| US12529096B2 (en) | 2021-08-03 | 2026-01-20 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid structures |
| US12435364B2 (en) | 2021-08-16 | 2025-10-07 | 10X Genomics, Inc. | Probes comprising a split barcode region and methods of use |
| WO2023108139A2 (en) | 2021-12-10 | 2023-06-15 | 10X Genomics, Inc. | Multi-resolution in situ decoding |
| WO2023129898A2 (en) | 2021-12-27 | 2023-07-06 | 10X Genomics, Inc. | Methods and compositions for rolling circle amplification |
| CN114438079B (zh) * | 2021-12-31 | 2023-08-08 | 上海交通大学医学院附属仁济医院 | 一种仿病毒dna多面体框架结构及其制备方法与应用 |
| EP4733410A2 (en) | 2022-01-21 | 2026-04-29 | 10X Genomics, Inc. | Multiple readout signals for analyzing a sample |
| EP4490737A1 (en) | 2022-03-08 | 2025-01-15 | 10X Genomics, Inc. | In situ code design methods for minimizing optical crowding |
| WO2023183881A2 (en) | 2022-03-24 | 2023-09-28 | Digital Biology Inc. | Tissue spatial omics |
| EP4500481A1 (en) | 2022-03-29 | 2025-02-05 | 10X Genomics, Inc. | Spectral unmixing combined with decoding for super-multiplexed in situ analysis |
| AU2023243205A1 (en) | 2022-04-01 | 2024-09-19 | 10X Genomics, Inc. | Compositions and methods for targeted masking of autofluorescence |
| CN119234045A (zh) | 2022-04-06 | 2024-12-31 | 10X基因组学有限公司 | 用于多重细胞分析的方法 |
| WO2023215612A1 (en) | 2022-05-06 | 2023-11-09 | 10X Genomics, Inc. | Analysis of antigen and antigen receptor interactions |
| CN119213143A (zh) | 2022-05-11 | 2024-12-27 | 10X基因组学有限公司 | 用于原位测序的组合物和方法 |
| WO2023245190A1 (en) | 2022-06-17 | 2023-12-21 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| CA3261351A1 (en) | 2022-07-12 | 2024-01-18 | Abrus Bio, Inc. | DETERMINATION OF PROTEIN INFORMATION BY RECODED AMINO ACID POLYMERS INTO DNA POLYMERS |
| CN115948605A (zh) * | 2022-07-13 | 2023-04-11 | 宁波华岳生物科技有限公司 | 一种基于dna链置换反应与per扩增的病毒检测试剂盒 |
| EP4558647A2 (en) | 2022-07-19 | 2025-05-28 | Digital Biology Inc. | Barcode diffusion-based spatial omics |
| WO2024040236A2 (en) | 2022-08-19 | 2024-02-22 | Abrus Bio, Inc. | Determination of protein information by recoding amino acid polymers into dna polymers |
| EP4602344A1 (en) | 2022-10-14 | 2025-08-20 | 10X Genomics, Inc. | Methods for analysis of biological samples |
| US12372771B2 (en) | 2022-11-18 | 2025-07-29 | 10X Genomics, Inc. | Systems and methods for actively mitigating vibrations |
| US12581050B2 (en) | 2022-11-23 | 2026-03-17 | 10X Genomics, Inc. | Optical assemblies for machine vision calibration |
| CN116334185A (zh) * | 2023-04-10 | 2023-06-27 | 江苏甬泽生物科技有限公司 | 一种基于PER-Cas12a的核酸检测试剂盒 |
| EP4720336A1 (en) * | 2023-06-01 | 2026-04-08 | Sherlock Biosciences, Inc. | Condensed loop-mediated isothermal amplification |
| WO2025014758A1 (en) | 2023-07-07 | 2025-01-16 | 10X Genomics, Inc. | Systems and methods for tissue bounds detection |
| WO2025038914A1 (en) | 2023-08-16 | 2025-02-20 | 10X Genomics, Inc. | Systems and methods for image segmentation |
| WO2025076421A1 (en) | 2023-10-06 | 2025-04-10 | 10X Genomics, Inc. | Feature pyramiding for in situ data visualizations |
| US20250188524A1 (en) | 2023-12-07 | 2025-06-12 | 10X Genomics, Inc. | Graphical user interface and method of estimating an instrument run completion time |
| WO2025160489A1 (en) | 2024-01-25 | 2025-07-31 | 10X Genomics, Inc. | Systems and methods for image segmentation using multiple stain indicators |
| WO2025189080A1 (en) | 2024-03-08 | 2025-09-12 | 10X Genomics, Inc. | Multi-focus image fusion with background removal |
| US20250288988A1 (en) | 2024-03-15 | 2025-09-18 | 10X Genomics, Inc. | Systems and methods for covering and sealing an open well |
| WO2026009634A1 (ja) * | 2024-07-03 | 2026-01-08 | パナソニックＩｐマネジメント株式会社 | 情報処理方法、情報処理システム、および情報処理プログラム |
| WO2026076066A1 (en) | 2024-10-01 | 2026-04-09 | 10X Genomics, Inc. | Systems and methods for illumination of a sample |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030566A (en) | 1989-01-04 | 1991-07-09 | Board Of Regents, The University Of Texas System | Concatemeric DNA length standards |
| US5543507A (en) | 1992-03-05 | 1996-08-06 | Isis Pharmaceuticals, Inc. | Covalently cross-linked oligonucleotides |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| WO2000034527A2 (en) | 1998-12-11 | 2000-06-15 | The Regents Of The University Of California | Targeted molecular bar codes |
| ES2546450T3 (es) * | 2000-04-07 | 2015-09-23 | Eiken Kagaku Kabushiki Kaisha | Método para amplificar y detectar un ácido nucleico usando ácido nucleico bicatenario como molde |
| US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
| AU2002367750A1 (en) | 2001-08-14 | 2003-11-03 | Discovery, Inc. | Isothermal amplification in nucleic acid analysis |
| US20030148335A1 (en) | 2001-10-10 | 2003-08-07 | Li Shen | Detecting targets by unique identifier nucleotide tags |
| ATE352594T1 (de) | 2001-11-02 | 2007-02-15 | November Ag Molekulare Medizin | Markierungslösung zur fälschungssicheren kennzeichnung eines wertgegenstands, aus der markierungslösung hergestellte markierung sowie verfahren zur markierung eines wertgegenstands |
| WO2004046321A2 (en) | 2002-11-15 | 2004-06-03 | Trustees Of Boston University | Cis/trans riboregulators |
| US20040166520A1 (en) | 2003-01-03 | 2004-08-26 | Connolly D. Michael | Identifying items with nucleic acid taggants |
| US20070048761A1 (en) | 2005-05-20 | 2007-03-01 | Applied Dna Sciences, Inc. | System and method for authenticating multiple components associated with a particular product |
| US20050112610A1 (en) | 2003-04-16 | 2005-05-26 | Applied Dna Sciences, Inc. | System and method for marking textiles with nucleic acids |
| US8415164B2 (en) | 2003-04-16 | 2013-04-09 | Apdn (B.V.I.) Inc. | System and method for secure document printing and detection |
| US8426216B2 (en) | 2003-04-16 | 2013-04-23 | APDN (B.V.I.), Inc. | Methods for authenticating articles with optical reporters |
| AU2004232976B2 (en) | 2003-04-18 | 2011-02-10 | Becton, Dickinson And Company | Immuno-amplification |
| NZ544959A (en) | 2003-07-07 | 2009-02-28 | One Cell Systems Inc | Hairpin-labeled probes and methods of use |
| US20050064435A1 (en) | 2003-09-24 | 2005-03-24 | Xing Su | Programmable molecular barcodes |
| CN101048505A (zh) | 2004-10-25 | 2007-10-03 | 德福根有限公司 | 用于递送双链rna至有害生物的包含至少一个适配子的多结构域rna分子 |
| AU2006204087B2 (en) | 2005-01-03 | 2010-09-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Primer for nucleic acid detection |
| US20060286569A1 (en) | 2005-03-10 | 2006-12-21 | Bar-Or Yuval A | Method, apparatus, and system for authentication using labels containing nucleotide sequences |
| EP1896617B1 (en) | 2005-05-31 | 2013-01-02 | Life Technologies Corporation | Multiplex amplification of short nucleic acids |
| US20070048759A1 (en) | 2005-06-10 | 2007-03-01 | Dan Luo | Detection of target molecules with labeled nucleic acid detection molecules |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| US8458475B2 (en) | 2005-06-20 | 2013-06-04 | Authentiform Technologies, L.L.C. | Systems and methods for product authentication |
| US20070026430A1 (en) | 2005-06-30 | 2007-02-01 | Applera Corporation | Proximity probing of target proteins comprising restriction and/or extension |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| EP2522751B1 (en) | 2006-06-01 | 2018-11-21 | Third Wave Technologies, Inc. | Detection of nucleic acids by an improved INVADER assay |
| DE102006031015A1 (de) | 2006-07-03 | 2008-01-10 | Identif Gmbh | Verfahren und Vorrichtung zur Authentifizierung von mit einer Markierung versehenen Gegenständen |
| US20100216978A1 (en) | 2007-04-17 | 2010-08-26 | Dsna-Farber Cancer Institute Inc. | Wireframe nanostructures |
| US20080287668A1 (en) | 2007-05-14 | 2008-11-20 | Tihamer Thomas Toth-Fejel | Nanostructures and methods of making |
| WO2008144562A1 (en) | 2007-05-16 | 2008-11-27 | California Institute Of Technology | A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
| US9340416B2 (en) | 2008-08-13 | 2016-05-17 | California Institute Of Technology | Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems |
| US20110294116A1 (en) | 2008-12-11 | 2011-12-01 | The Regents of the Unicersity of California | Methods and systems for direct sequencing of single dna molecules |
| GB0910302D0 (en) | 2009-06-15 | 2009-07-29 | Lumora Ltd | Nucleic acid amplification |
| WO2011066330A2 (en) | 2009-11-24 | 2011-06-03 | Life Technologies Corporation | Selective amplification of polynucleotide sequences |
| US9238832B2 (en) * | 2009-12-11 | 2016-01-19 | Roche Molecular Systems, Inc. | Allele-specific amplification of nucleic acids |
| EP2524056A4 (en) | 2010-01-15 | 2013-08-14 | Univ British Columbia | MULTIPLEX REINFORCEMENT FOR DETECTING NUCLEIC ACID VARIATIONS |
| EP2576839B1 (en) | 2010-06-07 | 2017-05-10 | Firefly Bioworks, Inc. | Nucleic acid detection and quantification by post-hybridization labeling and universal encoding |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| AU2011319755B2 (en) * | 2010-10-27 | 2017-02-23 | President And Fellows Of Harvard College | Compositions of toehold primer duplexes and methods of use |
| EP2633081B1 (en) | 2010-10-29 | 2017-01-11 | Olink Bioscience AB | Proximity ligation technology for western blot applications |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| CN103502448B (zh) | 2010-11-12 | 2017-03-29 | Gen9股份有限公司 | 核酸合成的方法和设备 |
| US20130123121A1 (en) | 2010-11-22 | 2013-05-16 | The University Of Chicago | Methods and/or Use of Oligonucleotide-Bead Conjugates for Assays and Detections |
| US20120178081A1 (en) | 2010-12-31 | 2012-07-12 | Affymetrix. Inc. | Methods of Labeling Cells, Labeled Cells, and uses Thereof |
| KR101350919B1 (ko) | 2011-03-14 | 2014-01-14 | (주)바이오니아 | 핵산을 포함하는 물체의 식별 방법 |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| WO2013012434A1 (en) | 2011-07-15 | 2013-01-24 | University Of Miami | Bioluminescent stem-loop probes, compositions containing the same and methods utilizing the same |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| WO2013138300A1 (en) | 2012-03-13 | 2013-09-19 | Authentiform Technologies, Llc | Nucleic acid-based authentication codes |
| CA2867916C (en) | 2012-03-22 | 2020-05-26 | Lgc Genomics Limited | Polymerase chain reaction detection system using oligonucleotides comprising a phosphorothioate group |
| AU2013202354A1 (en) * | 2012-06-18 | 2014-01-16 | Speedx Pty Ltd | Target detection and signal amplification |
| SG11201501820TA (en) | 2012-09-11 | 2015-04-29 | Theranos Inc | Information management systems and methods using a biological signature |
| US20140272097A1 (en) | 2013-03-12 | 2014-09-18 | Applied Dna Sciences, Inc. | Dna marking of previously undistinguished items for traceability |
| EP3216870A1 (en) | 2012-11-06 | 2017-09-13 | President and Fellows of Harvard College | Riboregulator compositions and methods of use |
| US9243283B2 (en) | 2012-11-19 | 2016-01-26 | Src, Inc. | System and method for authentication and tamper detection using nucleic acid taggants |
| CN103014168A (zh) | 2012-12-28 | 2013-04-03 | 北京大学 | 基于DNA hairpin和RCA的核酸检测方法 |
| CN106062211A (zh) * | 2013-12-15 | 2016-10-26 | 哈佛学院院长等 | 与光学超分辨率图案化相关的方法和组合物 |
| WO2015095633A1 (en) | 2013-12-20 | 2015-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions related to nucleic acid circuits and signal transducers |
| JP6739339B2 (ja) | 2014-01-15 | 2020-08-12 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | カバーされた配列変換ｄｎａおよび検出方法 |
| WO2015178978A2 (en) * | 2014-02-14 | 2015-11-26 | The Board Of Regents Of The University Of Texas System | Strand exchange hairpin primers that give high allelic discrimination |
| CN104164488B (zh) | 2014-07-09 | 2016-11-02 | 青岛艾菲生物技术有限公司 | 一种单引物引发的核酸恒温扩增方法 |
| WO2016011089A1 (en) | 2014-07-14 | 2016-01-21 | President And Fellows Of Harvard College | Compositions comprising riboregulators and methods of use thereof |
| US20160024558A1 (en) | 2014-07-23 | 2016-01-28 | 10X Genomics, Inc. | Nucleic acid binding proteins and uses thereof |
| WO2016140726A2 (en) | 2014-12-16 | 2016-09-09 | President And Fellows Of Harvard College | Triggered assembly of metafluorophores |
| ES2891085T3 (es) | 2015-01-30 | 2022-01-26 | Harvard College | Obtención de imágenes sin microscopio |
| CN116949140A (zh) * | 2016-02-17 | 2023-10-27 | 哈佛学院院长及董事 | 分子编程工具 |
| CN109923213B (zh) | 2016-09-20 | 2023-02-28 | 哈佛学院院长及董事 | 分子验证系统 |
| EP3568492B1 (en) | 2017-01-10 | 2025-01-01 | President and Fellows of Harvard College | Multiplexed signal amplification |
| CN111630179B (zh) | 2018-01-26 | 2024-07-19 | 哈佛学院院长及董事 | 邻近检测方法和组合物 |
| CN112189055B (zh) | 2018-03-22 | 2024-07-19 | 哈佛学院院长及董事 | 用于分子认证的方法和组合物 |
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2017
- 2017-02-16 CN CN202310113607.XA patent/CN116949140A/zh active Pending
- 2017-02-16 EP EP17753794.1A patent/EP3417078B1/en active Active
- 2017-02-16 WO PCT/US2017/018086 patent/WO2017143006A1/en not_active Ceased
- 2017-02-16 EP EP23166340.2A patent/EP4239079B1/en active Active
- 2017-02-16 US US15/999,245 patent/US11286517B2/en active Active
- 2017-02-16 CN CN201780019856.5A patent/CN108779486B/zh active Active
- 2017-02-16 JP JP2018543210A patent/JP7085999B2/ja active Active
- 2017-02-16 EP EP21171977.8A patent/EP3916107B1/en active Active
- 2017-02-16 EP EP25223351.5A patent/EP4726056A2/en active Pending
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2022
- 2022-02-03 US US17/592,435 patent/US12227795B2/en active Active
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2025
- 2025-01-07 US US19/012,181 patent/US20250250611A1/en active Pending
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