|
US4486530A
(en)
|
1980-08-04 |
1984-12-04 |
Hybritech Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4514505A
(en)
|
1982-05-21 |
1985-04-30 |
The Trustees Of Columbia University In The City Of New York |
Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
|
|
ATE202801T1
(de)
|
1983-01-10 |
2001-07-15 |
Gen Probe Inc |
Verfahren zum nachweis, identifizieren und quantifizieren von organismen und viren
|
|
US4595661A
(en)
|
1983-11-18 |
1986-06-17 |
Beckman Instruments, Inc. |
Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
|
|
US4851334A
(en)
|
1984-01-03 |
1989-07-25 |
The New York Blood Center, Inc. |
Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fibrin I or human fibrin II
|
|
US4766062A
(en)
|
1984-05-07 |
1988-08-23 |
Allied Corporation |
Displacement polynucleotide assay method and polynucleotide complex reagent therefor
|
|
US6040166A
(en)
|
1985-03-28 |
2000-03-21 |
Roche Molecular Systems, Inc. |
Kits for amplifying and detecting nucleic acid sequences, including a probe
|
|
US6197563B1
(en)
|
1985-03-28 |
2001-03-06 |
Roche Molecular Systems, Inc. |
Kits for amplifying and detecting nucleic acid sequences
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5707559A
(en)
|
1986-07-17 |
1998-01-13 |
Tropix, Inc. |
Chemiluminescent 1,2-dioxetane compounds
|
|
US5616729A
(en)
|
1986-07-17 |
1997-04-01 |
Board Of Governors Of Wayne State University |
Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
|
|
US5004565A
(en)
|
1986-07-17 |
1991-04-02 |
The Board Of Governors Of Wayne State University |
Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
|
|
US5310652A
(en)
|
1986-08-22 |
1994-05-10 |
Hoffman-La Roche Inc. |
Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
|
|
US5322770A
(en)
|
1989-12-22 |
1994-06-21 |
Hoffman-Laroche Inc. |
Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
|
|
US4745181A
(en)
|
1986-10-06 |
1988-05-17 |
Ciba Corning Diagnostics Corp. |
Polysubstituted aryl acridinium esters
|
|
US5585481A
(en)
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US5283174A
(en)
|
1987-09-21 |
1994-02-01 |
Gen-Probe, Incorporated |
Homogenous protection assay
|
|
US5185439A
(en)
|
1987-10-05 |
1993-02-09 |
Gen-Probe Incorporated |
Acridinium ester labelling and purification of nucleotide probes
|
|
US5130238A
(en)
|
1988-06-24 |
1992-07-14 |
Cangene Corporation |
Enhanced nucleic acid amplification process
|
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
|
GB2233450B
(en)
|
1989-06-24 |
1993-06-30 |
Univ Wales Medicine |
Detecting or quantifing multiple analytes with luminescent reagents
|
|
CA2020958C
(en)
|
1989-07-11 |
2005-01-11 |
Daniel L. Kacian |
Nucleic acid sequence amplification methods
|
|
US5219727A
(en)
|
1989-08-21 |
1993-06-15 |
Hoffmann-Laroche Inc. |
Quantitation of nucleic acids using the polymerase chain reaction
|
|
US5427930A
(en)
|
1990-01-26 |
1995-06-27 |
Abbott Laboratories |
Amplification of target nucleic acids using gap filling ligase chain reaction
|
|
US5516663A
(en)
|
1990-01-26 |
1996-05-14 |
Abbott Laboratories |
Ligase chain reaction with endonuclease IV correction and contamination control
|
|
US5312921A
(en)
|
1990-03-14 |
1994-05-17 |
Regents Of The University Of California |
Dyes designed for high sensitivity detection of double-stranded DNA
|
|
US5200314A
(en)
|
1990-03-23 |
1993-04-06 |
Chiron Corporation |
Polynucleotide capture assay employing in vitro amplification
|
|
US5395752A
(en)
|
1993-03-19 |
1995-03-07 |
Ciba Corning Diagnostics Corp. |
Long emission wavelength chemiluminescent compounds and their use in test assays
|
|
AU687363B2
(en)
|
1993-03-19 |
1998-02-26 |
Ciba Corning Diagnostics Corp. |
Luminometer
|
|
US5876978A
(en)
|
1993-04-06 |
1999-03-02 |
Medical College Of Ohio |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5422252A
(en)
|
1993-06-04 |
1995-06-06 |
Becton, Dickinson And Company |
Simultaneous amplification of multiple targets
|
|
WO1995003430A1
(en)
|
1993-07-23 |
1995-02-02 |
Gen-Probe Incorporated |
Methods for enhancing nucleic acid amplification
|
|
US6156501A
(en)
|
1993-10-26 |
2000-12-05 |
Affymetrix, Inc. |
Arrays of modified nucleic acid probes and methods of use
|
|
US5925517A
(en)
|
1993-11-12 |
1999-07-20 |
The Public Health Research Institute Of The City Of New York, Inc. |
Detectably labeled dual conformation oligonucleotide probes, assays and kits
|
|
GB9326238D0
(en)
|
1993-12-23 |
1994-02-23 |
Sinvent As |
Method of assay
|
|
US5648211A
(en)
|
1994-04-18 |
1997-07-15 |
Becton, Dickinson And Company |
Strand displacement amplification using thermophilic enzymes
|
|
US5547861A
(en)
|
1994-04-18 |
1996-08-20 |
Becton, Dickinson And Company |
Detection of nucleic acid amplification
|
|
US5514551A
(en)
|
1994-10-14 |
1996-05-07 |
Gen-Probe Incorporated |
Compositions for the detection of Chlamydia trachomatis
|
|
DE69535240T2
(de)
|
1994-10-28 |
2007-06-06 |
Gen-Probe Inc., San Diego |
Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
|
|
JP3189000B2
(ja)
|
1994-12-01 |
2001-07-16 |
東ソー株式会社 |
特定核酸配列の検出方法
|
|
US5830645A
(en)
|
1994-12-09 |
1998-11-03 |
The Regents Of The University Of California |
Comparative fluorescence hybridization to nucleic acid arrays
|
|
US6312894B1
(en)
|
1995-04-03 |
2001-11-06 |
Epoch Pharmaceuticals, Inc. |
Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
|
|
US5648245A
(en)
|
1995-05-09 |
1997-07-15 |
Carnegie Institution Of Washington |
Method for constructing an oligonucleotide concatamer library by rolling circle replication
|
|
US5514505A
(en)
*
|
1995-05-15 |
1996-05-07 |
Xerox Corporation |
Method for obtaining improved image contrast in migration imaging members
|
|
ATE215993T1
(de)
|
1995-05-19 |
2002-04-15 |
Abbott Lab |
Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihen
|
|
US5710029A
(en)
|
1995-06-07 |
1998-01-20 |
Gen-Probe Incorporated |
Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
|
|
US5705365A
(en)
|
1995-06-07 |
1998-01-06 |
Gen-Probe Incorporated |
Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
US5741650A
(en)
|
1996-01-30 |
1998-04-21 |
Exact Laboratories, Inc. |
Methods for detecting colon cancer from stool samples
|
|
JP4540754B2
(ja)
|
1996-06-04 |
2010-09-08 |
ユニバーシティ オブ ユタ リサーチ ファウンデーション |
Ｐｃｒ中のハイブリダイゼーションのモニタリング
|
|
US20020042048A1
(en)
|
1997-01-16 |
2002-04-11 |
Radoje Drmanac |
Methods and compositions for detection or quantification of nucleic acid species
|
|
JP3968810B2
(ja)
|
1997-01-24 |
2007-08-29 |
東ソー株式会社 |
核酸配列分析方法
|
|
US6143496A
(en)
|
1997-04-17 |
2000-11-07 |
Cytonix Corporation |
Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
|
|
US6165800A
(en)
|
1997-05-30 |
2000-12-26 |
Bayer Corporation |
Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
|
|
DE69833758T2
(de)
|
1997-06-13 |
2006-08-31 |
Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara |
Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips
|
|
US6566101B1
(en)
|
1997-06-16 |
2003-05-20 |
Anthony P. Shuber |
Primer extension methods for detecting nucleic acids
|
|
ATE478090T1
(de)
|
1997-10-27 |
2010-09-15 |
Boston Probes Inc |
SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN
|
|
WO1999023256A1
(en)
|
1997-10-30 |
1999-05-14 |
Cold Spring Harbor Laboratory |
Probe arrays and methods of using probe arrays for distinguishing dna
|
|
US6180340B1
(en)
|
1997-10-31 |
2001-01-30 |
Gen-Probe Incorporated |
Extended dynamic range assays
|
|
US5989823A
(en)
|
1998-09-18 |
1999-11-23 |
Nexstar Pharmaceuticals, Inc. |
Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
|
|
AU3909199A
(en)
|
1997-12-15 |
1999-07-05 |
Nexstar Pharmaceuticals, Inc. |
Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
|
|
US6238869B1
(en)
|
1997-12-19 |
2001-05-29 |
High Throughput Genomics, Inc. |
High throughput assay system
|
|
US6268146B1
(en)
|
1998-03-13 |
2001-07-31 |
Promega Corporation |
Analytical methods and materials for nucleic acid detection
|
|
WO1999049293A2
(en)
|
1998-03-24 |
1999-09-30 |
Boston Probes, Inc. |
Methods, kits and compositions pertaining to detection complexes
|
|
WO1999058640A2
(en)
|
1998-05-11 |
1999-11-18 |
Philadelphia Health And Education Corporation |
Mct-1, a human oncogene
|
|
US6066458A
(en)
|
1998-05-18 |
2000-05-23 |
Becton, Dickinson And Company |
Methods, apparatus and computer program products for determining quantities of nucleic acid sequences in samples using standard curves and amplification ratio estimates
|
|
AU762728B2
(en)
|
1998-07-02 |
2003-07-03 |
Gen-Probe Incorporated |
Molecular torches
|
|
US6037130A
(en)
|
1998-07-28 |
2000-03-14 |
The Public Health Institute Of The City Of New York, Inc. |
Wavelength-shifting probes and primers and their use in assays and kits
|
|
US20020001800A1
(en)
|
1998-08-14 |
2002-01-03 |
Stanley N. Lapidus |
Diagnostic methods using serial testing of polymorphic loci
|
|
US6245517B1
(en)
|
1998-09-29 |
2001-06-12 |
The United States Of America As Represented By The Department Of Health And Human Services |
Ratio-based decisions and the quantitative analysis of cDNA micro-array images
|
|
WO2000020643A1
(en)
|
1998-10-05 |
2000-04-13 |
Mosaic Technologies |
Reverse displacement assay for detection of nucleic acid sequences
|
|
WO2000034521A1
(en)
|
1998-12-08 |
2000-06-15 |
Boston Probes, Inc. |
Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
|
|
WO2000043552A2
(en)
|
1999-01-25 |
2000-07-27 |
Ut-Battelle, Llc |
Multifunctional and multispectral biosensor devices and methods of use
|
|
US6245511B1
(en)
|
1999-02-22 |
2001-06-12 |
Vialogy Corp |
Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements
|
|
WO2000060126A2
(en)
|
1999-04-08 |
2000-10-12 |
Sir Mortimer B. Davis Jewish General Hospital |
Quantitative assay for expression of genes in microarray
|
|
US6235479B1
(en)
|
1999-04-13 |
2001-05-22 |
Bio Merieux, Inc. |
Methods and devices for performing analysis of a nucleic acid sample
|
|
EP1046717B1
(en)
|
1999-04-20 |
2010-10-06 |
National Institute of Advanced Industrial Science and Technology |
Method and probes for determining a concentration of target nucleic acid molecules and method for analyzing data obtained by the method
|
|
ES2459745T3
(es)
|
1999-05-14 |
2014-05-12 |
Brandeis University |
Detección basada en aptámero
|
|
DE60014762T2
(de)
|
1999-05-24 |
2005-10-13 |
Tosoh Corp., Shinnanyo |
Methode zum Nachweis von Ribonukleinsäuren
|
|
AU5733900A
(en)
|
1999-06-09 |
2000-12-28 |
Biosearch Technologies, Inc. |
Fluorescence energy transfer probes with stabilized conformations
|
|
AU781570B2
(en)
|
1999-07-23 |
2005-06-02 |
Gen-Probe Incorporated |
Polynucleotide amplification method
|
|
DE60030145T2
(de)
|
1999-10-22 |
2008-01-10 |
PHRI Properties, Inc., Newark |
Nachweisverfahren für kurze sequenzvarianten
|
|
EP1096024A1
(en)
|
1999-10-28 |
2001-05-02 |
Remacle, José |
Method and kit for the screening and/or the quantification of multiple homologous nucleic acid sequences on arrays
|
|
GB2359625B
(en)
|
1999-12-10 |
2004-10-20 |
Molecular Light Tech Res Ltd |
Monitoring oligonucleotide binding process using chemiluminescence quenching
|
|
US20040121364A1
(en)
*
|
2000-02-07 |
2004-06-24 |
Mark Chee |
Multiplex nucleic acid reactions
|
|
DE10045521A1
(de)
|
2000-03-31 |
2001-10-04 |
Roche Diagnostics Gmbh |
Nukleinsäureamplifikationen
|
|
WO2001094625A2
(en)
|
2000-06-06 |
2001-12-13 |
Tm Bioscience Corporation |
Capture moieties for nucleic acids and uses thereof
|
|
CA2383939C
(en)
|
2000-06-27 |
2009-12-01 |
National Institute Of Advanced Industrial Science And Technology |
Novel nucleic acid probes, method for determining nucleic acids by using the probes, and method for analyzing data obtained by the method
|
|
EP1440311B1
(en)
|
2001-08-31 |
2009-01-07 |
Gen-Probe Incorporated |
Affinity-shifted probes for quantifying analyte polynucleotides
|
|
AU2002346660A1
(en)
|
2001-11-30 |
2003-06-17 |
University Of Rochester |
Multiplex real-time quantitative pcr
|
|
US7198897B2
(en)
|
2001-12-19 |
2007-04-03 |
Brandeis University |
Late-PCR
|
|
ATE519861T1
(de)
|
2002-06-14 |
2011-08-15 |
Gen Probe Inc |
Zusammensetzungen zum nachweis von hepatitis-b- virus
|
|
US7662594B2
(en)
|
2002-09-20 |
2010-02-16 |
New England Biolabs, Inc. |
Helicase-dependent amplification of RNA
|
|
CA2498764C
(en)
|
2002-09-20 |
2015-11-10 |
New England Biolabs, Inc. |
Helicase dependent amplification of nucleic acids
|
|
WO2004102149A2
(en)
*
|
2003-04-11 |
2004-11-25 |
Stratagene California |
Methods and compositions for the detection of bacterial species
|
|
GB0320236D0
(en)
|
2003-08-29 |
2003-10-01 |
Molecular Light Tech Res Ltd |
Chemiluminescent compounds
|
|
US20060057611A1
(en)
|
2004-06-30 |
2006-03-16 |
Applera Corporation |
Log-linear amplification
|
|
WO2006004949A1
(en)
|
2004-06-30 |
2006-01-12 |
Applera Corporation |
Compositions and methods for detecting and quantitating polynucleotide sequences
|
|
CA2957197C
(en)
|
2004-08-27 |
2017-12-12 |
Gen-Probe Incorporated |
Single-primer nucleic acid amplification methods
|
|
AU2005286876A1
(en)
*
|
2004-09-20 |
2006-03-30 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Multiple mode multiplex reaction quenching method
|
|
CA2584741A1
(en)
*
|
2004-10-22 |
2006-05-04 |
Marijo Kent-First |
Methods and kits for detecting germ cell genomic instability
|
|
EP1838880A2
(en)
|
2005-01-21 |
2007-10-03 |
Third Wave Technologies, Inc. |
Methods and compositions for increased dynamic range detection of nucleic acid molecules
|
|
DE102006007778B3
(de)
*
|
2006-02-20 |
2007-11-08 |
Biotype Ag |
Verfahren zur Analyse von Multiplex-Gemischen bestehend aus Nukleinsäure-Amplifikationsprodukten mit überlappenden Detektionsbereichen
|
|
US20080131875A1
(en)
|
2006-06-07 |
2008-06-05 |
Third Wave Technologies, Inc. |
Multiplex assays
|
|
US20090181389A1
(en)
*
|
2008-01-11 |
2009-07-16 |
Signosis, Inc., A California Corporation |
Quantitative measurement of nucleic acid via ligation-based linear amplification
|