JP2004141170A5 - - Google Patents
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- Publication number
- JP2004141170A5 JP2004141170A5 JP2003428482A JP2003428482A JP2004141170A5 JP 2004141170 A5 JP2004141170 A5 JP 2004141170A5 JP 2003428482 A JP2003428482 A JP 2003428482A JP 2003428482 A JP2003428482 A JP 2003428482A JP 2004141170 A5 JP2004141170 A5 JP 2004141170A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- region
- template
- acid molecule
- complementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 171
- 150000007523 nucleic acids Chemical class 0.000 claims 136
- 108020004707 nucleic acids Proteins 0.000 claims 122
- 102000039446 nucleic acids Human genes 0.000 claims 122
- 239000013615 primer Substances 0.000 claims 104
- 230000000295 complement effect Effects 0.000 claims 102
- 108091034117 Oligonucleotide Proteins 0.000 claims 69
- 238000006073 displacement reaction Methods 0.000 claims 41
- 239000002773 nucleotide Substances 0.000 claims 40
- 125000003729 nucleotide group Chemical group 0.000 claims 40
- 239000000523 sample Substances 0.000 claims 34
- 230000000694 effects Effects 0.000 claims 32
- 238000000137 annealing Methods 0.000 claims 28
- 108091093088 Amplicon Proteins 0.000 claims 26
- 230000003321 amplification Effects 0.000 claims 23
- 238000003199 nucleic acid amplification method Methods 0.000 claims 23
- 239000000155 melt Substances 0.000 claims 17
- 239000003607 modifier Substances 0.000 claims 17
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 16
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 16
- 229960003237 betaine Drugs 0.000 claims 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 230000037452 priming Effects 0.000 claims 14
- 238000006243 chemical reaction Methods 0.000 claims 11
- 238000006116 polymerization reaction Methods 0.000 claims 9
- 230000001419 dependent effect Effects 0.000 claims 8
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 230000001351 cycling effect Effects 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 238000003505 heat denaturation Methods 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 238000004925 denaturation Methods 0.000 claims 3
- 230000036425 denaturation Effects 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000379 polymerizing effect Effects 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- 239000003155 DNA primer Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000001668 nucleic acid synthesis Methods 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000005758 transcription activity Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/104,067 US6743605B1 (en) | 1998-06-24 | 1998-06-24 | Linear amplification of specific nucleic acid sequences |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11179056A Division JP2000037194A (ja) | 1998-06-24 | 1999-06-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005120409A Division JP4675141B2 (ja) | 1998-06-24 | 2005-04-18 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004141170A JP2004141170A (ja) | 2004-05-20 |
| JP2004141170A5 true JP2004141170A5 (https=) | 2005-08-25 |
| JP4493330B2 JP4493330B2 (ja) | 2010-06-30 |
Family
ID=22298492
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11179056A Withdrawn JP2000037194A (ja) | 1998-06-24 | 1999-06-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
| JP2003428482A Expired - Lifetime JP4493330B2 (ja) | 1998-06-24 | 2003-12-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
| JP2005120409A Expired - Lifetime JP4675141B2 (ja) | 1998-06-24 | 2005-04-18 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11179056A Withdrawn JP2000037194A (ja) | 1998-06-24 | 1999-06-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005120409A Expired - Lifetime JP4675141B2 (ja) | 1998-06-24 | 2005-04-18 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (11) | US6743605B1 (https=) |
| EP (1) | EP0971039B1 (https=) |
| JP (3) | JP2000037194A (https=) |
| CA (1) | CA2273064C (https=) |
| DE (1) | DE69943292D1 (https=) |
| IL (1) | IL130477A (https=) |
Families Citing this family (110)
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-
1998
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-
1999
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- 1999-06-15 CA CA002273064A patent/CA2273064C/en not_active Expired - Lifetime
- 1999-06-24 EP EP99112181A patent/EP0971039B1/en not_active Expired - Lifetime
- 1999-06-24 DE DE69943292T patent/DE69943292D1/de not_active Expired - Lifetime
- 1999-06-24 JP JP11179056A patent/JP2000037194A/ja not_active Withdrawn
- 1999-11-12 US US09/439,594 patent/US6764821B1/en not_active Expired - Lifetime
-
2002
- 2002-11-22 US US10/304,035 patent/US7485417B2/en not_active Expired - Fee Related
- 2002-11-22 US US10/303,152 patent/US20050260573A1/en not_active Abandoned
- 2002-11-22 US US10/302,362 patent/US7264930B2/en not_active Expired - Lifetime
- 2002-11-27 US US10/305,690 patent/US7468245B2/en not_active Expired - Fee Related
- 2002-11-27 US US10/305,664 patent/US7713691B2/en not_active Expired - Lifetime
- 2002-11-27 US US10/307,108 patent/US8133989B2/en not_active Expired - Fee Related
- 2002-11-29 US US10/306,990 patent/US20030165938A1/en not_active Abandoned
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2003
- 2003-12-24 JP JP2003428482A patent/JP4493330B2/ja not_active Expired - Lifetime
-
2005
- 2005-04-18 JP JP2005120409A patent/JP4675141B2/ja not_active Expired - Lifetime
-
2007
- 2007-10-26 US US11/925,556 patent/US8288092B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/925,730 patent/US8486633B2/en not_active Expired - Fee Related
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