JP7085999B2 - 分子プログラミングツール - Google Patents
分子プログラミングツール Download PDFInfo
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- JP7085999B2 JP7085999B2 JP2018543210A JP2018543210A JP7085999B2 JP 7085999 B2 JP7085999 B2 JP 7085999B2 JP 2018543210 A JP2018543210 A JP 2018543210A JP 2018543210 A JP2018543210 A JP 2018543210A JP 7085999 B2 JP7085999 B2 JP 7085999B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/127—DNAzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296310P | 2016-02-17 | 2016-02-17 | |
| US62/296,310 | 2016-02-17 | ||
| US201662299206P | 2016-02-24 | 2016-02-24 | |
| US62/299,206 | 2016-02-24 | ||
| US201662429149P | 2016-12-02 | 2016-12-02 | |
| US62/429,149 | 2016-12-02 | ||
| US201662432017P | 2016-12-09 | 2016-12-09 | |
| US62/432,017 | 2016-12-09 | ||
| PCT/US2017/018086 WO2017143006A1 (en) | 2016-02-17 | 2017-02-16 | Molecular programming tools |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506872A JP2019506872A (ja) | 2019-03-14 |
| JP2019506872A5 JP2019506872A5 (https=) | 2020-03-26 |
| JP7085999B2 true JP7085999B2 (ja) | 2022-06-17 |
Family
ID=59626272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543210A Active JP7085999B2 (ja) | 2016-02-17 | 2017-02-16 | 分子プログラミングツール |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11286517B2 (https=) |
| EP (4) | EP3417078B1 (https=) |
| JP (1) | JP7085999B2 (https=) |
| CN (2) | CN116949140A (https=) |
| WO (1) | WO2017143006A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011319755B2 (en) | 2010-10-27 | 2017-02-23 | President And Fellows Of Harvard College | Compositions of toehold primer duplexes and methods of use |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| ES2891085T3 (es) | 2015-01-30 | 2022-01-26 | Harvard College | Obtención de imágenes sin microscopio |
| CN116949140A (zh) * | 2016-02-17 | 2023-10-27 | 哈佛学院院长及董事 | 分子编程工具 |
| EP3448886A4 (en) | 2016-04-26 | 2019-12-11 | Ultivue, Inc. | SUPER-HIGH-RESOLUTION IMMUNOFLUORESCENCE WITH BINDING-LIMITED PREVIEW |
| AU2017259794B2 (en) | 2016-05-02 | 2023-04-13 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| US11208676B2 (en) | 2016-05-27 | 2021-12-28 | President And Fellows Of Harvard College | Conditional primer extension for single-molecule detection |
| WO2018017914A1 (en) | 2016-07-22 | 2018-01-25 | President And Fellows Of Harvard College | Methods and compositions for protein identification |
| CN109923213B (zh) | 2016-09-20 | 2023-02-28 | 哈佛学院院长及董事 | 分子验证系统 |
| EP3568492B1 (en) | 2017-01-10 | 2025-01-01 | President and Fellows of Harvard College | Multiplexed signal amplification |
| MX2020004559A (es) | 2017-10-31 | 2020-10-05 | Encodia Inc | Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. |
| CN111630179B (zh) * | 2018-01-26 | 2024-07-19 | 哈佛学院院长及董事 | 邻近检测方法和组合物 |
| CN112189055B (zh) | 2018-03-22 | 2024-07-19 | 哈佛学院院长及董事 | 用于分子认证的方法和组合物 |
| WO2019236841A1 (en) | 2018-06-08 | 2019-12-12 | Ultivue, Inc. | Multiplexed catalyzed reporter deposition |
| WO2020069386A2 (en) * | 2018-09-28 | 2020-04-02 | California Institute Of Technology | Efficient combinatorial bead barcoding |
| JP2022513739A (ja) | 2018-12-14 | 2022-02-09 | アルティヴュー, インク. | 標的を逐次検出するための方法及び組成物 |
| WO2020185312A2 (en) * | 2019-01-25 | 2020-09-17 | President And Fellows Of Harvard College | Compositions and method for synthesizing nucleic acids |
| EP3963070A4 (en) | 2019-04-30 | 2023-02-22 | Encodia, Inc. | METHODS OF PREPARATION OF ANALYTES AND RELATED KITS |
| US20220356509A1 (en) | 2019-07-05 | 2022-11-10 | Ultivue, Inc. | Improved Multiplexing Method |
| CN114641581A (zh) * | 2019-10-28 | 2022-06-17 | 深圳华大智造科技股份有限公司 | Dna接头寡核苷酸 |
| WO2021138312A1 (en) | 2019-12-30 | 2021-07-08 | Ultivue, Inc. | Methods for reducing nonspecific interactions on biological samples |
| US12275984B2 (en) | 2021-03-02 | 2025-04-15 | 10X Genomics, Inc. | Sequential hybridization and quenching |
| CN113156122B (zh) * | 2021-04-29 | 2023-07-04 | 重庆医科大学 | 一种检测外泌体pd-l1的荧光传感器及其制备与应用 |
| US20220380838A1 (en) | 2021-06-01 | 2022-12-01 | 10X Genomics, Inc. | Methods and compositions for analyte detection and probe resolution |
| WO2022256422A1 (en) | 2021-06-02 | 2022-12-08 | 10X Genomics, Inc. | Sample analysis using asymmetric circularizable probes |
| WO2023283442A1 (en) | 2021-07-09 | 2023-01-12 | 10X Genomics, Inc. | Methods for detecting analytes using sparse labelling |
| CN117651855A (zh) | 2021-07-13 | 2024-03-05 | 10X基因组学有限公司 | 用于制备具有可控厚度的聚合基质的方法 |
| CA3224093A1 (en) | 2021-07-30 | 2023-02-02 | Jorge Ivan Hernandez Neuta | Methods and compositions for synchronizing reactions in situ |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| US12529096B2 (en) | 2021-08-03 | 2026-01-20 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid structures |
| US12435364B2 (en) | 2021-08-16 | 2025-10-07 | 10X Genomics, Inc. | Probes comprising a split barcode region and methods of use |
| WO2023108139A2 (en) | 2021-12-10 | 2023-06-15 | 10X Genomics, Inc. | Multi-resolution in situ decoding |
| WO2023129898A2 (en) | 2021-12-27 | 2023-07-06 | 10X Genomics, Inc. | Methods and compositions for rolling circle amplification |
| CN114438079B (zh) * | 2021-12-31 | 2023-08-08 | 上海交通大学医学院附属仁济医院 | 一种仿病毒dna多面体框架结构及其制备方法与应用 |
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| WO2023215612A1 (en) | 2022-05-06 | 2023-11-09 | 10X Genomics, Inc. | Analysis of antigen and antigen receptor interactions |
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| WO2023245190A1 (en) | 2022-06-17 | 2023-12-21 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| CA3261351A1 (en) | 2022-07-12 | 2024-01-18 | Abrus Bio, Inc. | DETERMINATION OF PROTEIN INFORMATION BY RECODED AMINO ACID POLYMERS INTO DNA POLYMERS |
| CN115948605A (zh) * | 2022-07-13 | 2023-04-11 | 宁波华岳生物科技有限公司 | 一种基于dna链置换反应与per扩增的病毒检测试剂盒 |
| EP4558647A2 (en) | 2022-07-19 | 2025-05-28 | Digital Biology Inc. | Barcode diffusion-based spatial omics |
| WO2024040236A2 (en) | 2022-08-19 | 2024-02-22 | Abrus Bio, Inc. | Determination of protein information by recoding amino acid polymers into dna polymers |
| EP4602344A1 (en) | 2022-10-14 | 2025-08-20 | 10X Genomics, Inc. | Methods for analysis of biological samples |
| US12372771B2 (en) | 2022-11-18 | 2025-07-29 | 10X Genomics, Inc. | Systems and methods for actively mitigating vibrations |
| US12581050B2 (en) | 2022-11-23 | 2026-03-17 | 10X Genomics, Inc. | Optical assemblies for machine vision calibration |
| CN116334185A (zh) * | 2023-04-10 | 2023-06-27 | 江苏甬泽生物科技有限公司 | 一种基于PER-Cas12a的核酸检测试剂盒 |
| EP4720336A1 (en) * | 2023-06-01 | 2026-04-08 | Sherlock Biosciences, Inc. | Condensed loop-mediated isothermal amplification |
| WO2025014758A1 (en) | 2023-07-07 | 2025-01-16 | 10X Genomics, Inc. | Systems and methods for tissue bounds detection |
| WO2025038914A1 (en) | 2023-08-16 | 2025-02-20 | 10X Genomics, Inc. | Systems and methods for image segmentation |
| WO2025076421A1 (en) | 2023-10-06 | 2025-04-10 | 10X Genomics, Inc. | Feature pyramiding for in situ data visualizations |
| US20250188524A1 (en) | 2023-12-07 | 2025-06-12 | 10X Genomics, Inc. | Graphical user interface and method of estimating an instrument run completion time |
| WO2025160489A1 (en) | 2024-01-25 | 2025-07-31 | 10X Genomics, Inc. | Systems and methods for image segmentation using multiple stain indicators |
| WO2025189080A1 (en) | 2024-03-08 | 2025-09-12 | 10X Genomics, Inc. | Multi-focus image fusion with background removal |
| US20250288988A1 (en) | 2024-03-15 | 2025-09-18 | 10X Genomics, Inc. | Systems and methods for covering and sealing an open well |
| WO2026009634A1 (ja) * | 2024-07-03 | 2026-01-08 | パナソニックIpマネジメント株式会社 | 情報処理方法、情報処理システム、および情報処理プログラム |
| WO2026076066A1 (en) | 2024-10-01 | 2026-04-09 | 10X Genomics, Inc. | Systems and methods for illumination of a sample |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008017853A (ja) | 2001-06-30 | 2008-01-31 | Enzo Life Sciences Inc | 分析物の検出、定量及び増幅のための新規な組成物および方法 |
| JP2013540451A (ja) | 2010-10-27 | 2013-11-07 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | トーホールドプライマーデュプレックスの組成物およびその使用方法 |
| JP2014504153A (ja) | 2010-11-12 | 2014-02-20 | ジェン9・インコーポレイテッド | 核酸合成のための方法およびデバイス |
| WO2015114469A2 (en) | 2014-01-15 | 2015-08-06 | Abbott Japan Co., Ltd | Covered sequence conversion dna and detection methods |
| JP2015523864A (ja) | 2012-06-18 | 2015-08-20 | スピードックス・プロプライエタリー・リミテッドSpeeDx PtyLtd | 標的検出およびシグナル増幅 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030566A (en) | 1989-01-04 | 1991-07-09 | Board Of Regents, The University Of Texas System | Concatemeric DNA length standards |
| US5543507A (en) | 1992-03-05 | 1996-08-06 | Isis Pharmaceuticals, Inc. | Covalently cross-linked oligonucleotides |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| WO2000034527A2 (en) | 1998-12-11 | 2000-06-15 | The Regents Of The University Of California | Targeted molecular bar codes |
| ES2546450T3 (es) * | 2000-04-07 | 2015-09-23 | Eiken Kagaku Kabushiki Kaisha | Método para amplificar y detectar un ácido nucleico usando ácido nucleico bicatenario como molde |
| AU2002367750A1 (en) | 2001-08-14 | 2003-11-03 | Discovery, Inc. | Isothermal amplification in nucleic acid analysis |
| US20030148335A1 (en) | 2001-10-10 | 2003-08-07 | Li Shen | Detecting targets by unique identifier nucleotide tags |
| ATE352594T1 (de) | 2001-11-02 | 2007-02-15 | November Ag Molekulare Medizin | Markierungslösung zur fälschungssicheren kennzeichnung eines wertgegenstands, aus der markierungslösung hergestellte markierung sowie verfahren zur markierung eines wertgegenstands |
| WO2004046321A2 (en) | 2002-11-15 | 2004-06-03 | Trustees Of Boston University | Cis/trans riboregulators |
| US20040166520A1 (en) | 2003-01-03 | 2004-08-26 | Connolly D. Michael | Identifying items with nucleic acid taggants |
| US20070048761A1 (en) | 2005-05-20 | 2007-03-01 | Applied Dna Sciences, Inc. | System and method for authenticating multiple components associated with a particular product |
| US20050112610A1 (en) | 2003-04-16 | 2005-05-26 | Applied Dna Sciences, Inc. | System and method for marking textiles with nucleic acids |
| US8415164B2 (en) | 2003-04-16 | 2013-04-09 | Apdn (B.V.I.) Inc. | System and method for secure document printing and detection |
| US8426216B2 (en) | 2003-04-16 | 2013-04-23 | APDN (B.V.I.), Inc. | Methods for authenticating articles with optical reporters |
| AU2004232976B2 (en) | 2003-04-18 | 2011-02-10 | Becton, Dickinson And Company | Immuno-amplification |
| NZ544959A (en) | 2003-07-07 | 2009-02-28 | One Cell Systems Inc | Hairpin-labeled probes and methods of use |
| US20050064435A1 (en) | 2003-09-24 | 2005-03-24 | Xing Su | Programmable molecular barcodes |
| CN101048505A (zh) | 2004-10-25 | 2007-10-03 | 德福根有限公司 | 用于递送双链rna至有害生物的包含至少一个适配子的多结构域rna分子 |
| AU2006204087B2 (en) | 2005-01-03 | 2010-09-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Primer for nucleic acid detection |
| US20060286569A1 (en) | 2005-03-10 | 2006-12-21 | Bar-Or Yuval A | Method, apparatus, and system for authentication using labels containing nucleotide sequences |
| EP1896617B1 (en) | 2005-05-31 | 2013-01-02 | Life Technologies Corporation | Multiplex amplification of short nucleic acids |
| US20070048759A1 (en) | 2005-06-10 | 2007-03-01 | Dan Luo | Detection of target molecules with labeled nucleic acid detection molecules |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| US8458475B2 (en) | 2005-06-20 | 2013-06-04 | Authentiform Technologies, L.L.C. | Systems and methods for product authentication |
| US20070026430A1 (en) | 2005-06-30 | 2007-02-01 | Applera Corporation | Proximity probing of target proteins comprising restriction and/or extension |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| EP2522751B1 (en) | 2006-06-01 | 2018-11-21 | Third Wave Technologies, Inc. | Detection of nucleic acids by an improved INVADER assay |
| DE102006031015A1 (de) | 2006-07-03 | 2008-01-10 | Identif Gmbh | Verfahren und Vorrichtung zur Authentifizierung von mit einer Markierung versehenen Gegenständen |
| US20100216978A1 (en) | 2007-04-17 | 2010-08-26 | Dsna-Farber Cancer Institute Inc. | Wireframe nanostructures |
| US20080287668A1 (en) | 2007-05-14 | 2008-11-20 | Tihamer Thomas Toth-Fejel | Nanostructures and methods of making |
| WO2008144562A1 (en) | 2007-05-16 | 2008-11-27 | California Institute Of Technology | A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
| US9340416B2 (en) | 2008-08-13 | 2016-05-17 | California Institute Of Technology | Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems |
| US20110294116A1 (en) | 2008-12-11 | 2011-12-01 | The Regents of the Unicersity of California | Methods and systems for direct sequencing of single dna molecules |
| GB0910302D0 (en) | 2009-06-15 | 2009-07-29 | Lumora Ltd | Nucleic acid amplification |
| WO2011066330A2 (en) | 2009-11-24 | 2011-06-03 | Life Technologies Corporation | Selective amplification of polynucleotide sequences |
| US9238832B2 (en) * | 2009-12-11 | 2016-01-19 | Roche Molecular Systems, Inc. | Allele-specific amplification of nucleic acids |
| EP2524056A4 (en) | 2010-01-15 | 2013-08-14 | Univ British Columbia | MULTIPLEX REINFORCEMENT FOR DETECTING NUCLEIC ACID VARIATIONS |
| EP2576839B1 (en) | 2010-06-07 | 2017-05-10 | Firefly Bioworks, Inc. | Nucleic acid detection and quantification by post-hybridization labeling and universal encoding |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| EP2633081B1 (en) | 2010-10-29 | 2017-01-11 | Olink Bioscience AB | Proximity ligation technology for western blot applications |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| US20130123121A1 (en) | 2010-11-22 | 2013-05-16 | The University Of Chicago | Methods and/or Use of Oligonucleotide-Bead Conjugates for Assays and Detections |
| US20120178081A1 (en) | 2010-12-31 | 2012-07-12 | Affymetrix. Inc. | Methods of Labeling Cells, Labeled Cells, and uses Thereof |
| KR101350919B1 (ko) | 2011-03-14 | 2014-01-14 | (주)바이오니아 | 핵산을 포함하는 물체의 식별 방법 |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| WO2013012434A1 (en) | 2011-07-15 | 2013-01-24 | University Of Miami | Bioluminescent stem-loop probes, compositions containing the same and methods utilizing the same |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| WO2013138300A1 (en) | 2012-03-13 | 2013-09-19 | Authentiform Technologies, Llc | Nucleic acid-based authentication codes |
| CA2867916C (en) | 2012-03-22 | 2020-05-26 | Lgc Genomics Limited | Polymerase chain reaction detection system using oligonucleotides comprising a phosphorothioate group |
| SG11201501820TA (en) | 2012-09-11 | 2015-04-29 | Theranos Inc | Information management systems and methods using a biological signature |
| US20140272097A1 (en) | 2013-03-12 | 2014-09-18 | Applied Dna Sciences, Inc. | Dna marking of previously undistinguished items for traceability |
| EP3216870A1 (en) | 2012-11-06 | 2017-09-13 | President and Fellows of Harvard College | Riboregulator compositions and methods of use |
| US9243283B2 (en) | 2012-11-19 | 2016-01-26 | Src, Inc. | System and method for authentication and tamper detection using nucleic acid taggants |
| CN103014168A (zh) | 2012-12-28 | 2013-04-03 | 北京大学 | 基于DNA hairpin和RCA的核酸检测方法 |
| CN106062211A (zh) * | 2013-12-15 | 2016-10-26 | 哈佛学院院长等 | 与光学超分辨率图案化相关的方法和组合物 |
| WO2015095633A1 (en) | 2013-12-20 | 2015-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions related to nucleic acid circuits and signal transducers |
| WO2015178978A2 (en) * | 2014-02-14 | 2015-11-26 | The Board Of Regents Of The University Of Texas System | Strand exchange hairpin primers that give high allelic discrimination |
| CN104164488B (zh) | 2014-07-09 | 2016-11-02 | 青岛艾菲生物技术有限公司 | 一种单引物引发的核酸恒温扩增方法 |
| WO2016011089A1 (en) | 2014-07-14 | 2016-01-21 | President And Fellows Of Harvard College | Compositions comprising riboregulators and methods of use thereof |
| US20160024558A1 (en) | 2014-07-23 | 2016-01-28 | 10X Genomics, Inc. | Nucleic acid binding proteins and uses thereof |
| WO2016140726A2 (en) | 2014-12-16 | 2016-09-09 | President And Fellows Of Harvard College | Triggered assembly of metafluorophores |
| ES2891085T3 (es) | 2015-01-30 | 2022-01-26 | Harvard College | Obtención de imágenes sin microscopio |
| CN116949140A (zh) * | 2016-02-17 | 2023-10-27 | 哈佛学院院长及董事 | 分子编程工具 |
| CN109923213B (zh) | 2016-09-20 | 2023-02-28 | 哈佛学院院长及董事 | 分子验证系统 |
| EP3568492B1 (en) | 2017-01-10 | 2025-01-01 | President and Fellows of Harvard College | Multiplexed signal amplification |
| CN111630179B (zh) | 2018-01-26 | 2024-07-19 | 哈佛学院院长及董事 | 邻近检测方法和组合物 |
| CN112189055B (zh) | 2018-03-22 | 2024-07-19 | 哈佛学院院长及董事 | 用于分子认证的方法和组合物 |
-
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- 2017-02-16 EP EP17753794.1A patent/EP3417078B1/en active Active
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- 2025-01-07 US US19/012,181 patent/US20250250611A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008017853A (ja) | 2001-06-30 | 2008-01-31 | Enzo Life Sciences Inc | 分析物の検出、定量及び増幅のための新規な組成物および方法 |
| JP2013540451A (ja) | 2010-10-27 | 2013-11-07 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | トーホールドプライマーデュプレックスの組成物およびその使用方法 |
| JP2014504153A (ja) | 2010-11-12 | 2014-02-20 | ジェン9・インコーポレイテッド | 核酸合成のための方法およびデバイス |
| JP2015523864A (ja) | 2012-06-18 | 2015-08-20 | スピードックス・プロプライエタリー・リミテッドSpeeDx PtyLtd | 標的検出およびシグナル増幅 |
| WO2015114469A2 (en) | 2014-01-15 | 2015-08-06 | Abbott Japan Co., Ltd | Covered sequence conversion dna and detection methods |
Non-Patent Citations (1)
| Title |
|---|
| Biosensors and Bioelectronics, 2014, Vol.59, pp.276-281 |
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| CN108779486B (zh) | 2023-02-28 |
| US12227795B2 (en) | 2025-02-18 |
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| EP3417078B1 (en) | 2021-05-05 |
| CN116949140A (zh) | 2023-10-27 |
| WO2017143006A1 (en) | 2017-08-24 |
| EP4239079A2 (en) | 2023-09-06 |
| CN108779486A (zh) | 2018-11-09 |
| US20190106733A1 (en) | 2019-04-11 |
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