JP2019504057A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019504057A5 JP2019504057A5 JP2018534682A JP2018534682A JP2019504057A5 JP 2019504057 A5 JP2019504057 A5 JP 2019504057A5 JP 2018534682 A JP2018534682 A JP 2018534682A JP 2018534682 A JP2018534682 A JP 2018534682A JP 2019504057 A5 JP2019504057 A5 JP 2019504057A5
- Authority
- JP
- Japan
- Prior art keywords
- cys
- seq
- isolated peptide
- gln
- lys
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2015-0191082 | 2015-12-31 | ||
| KR20150191082 | 2015-12-31 | ||
| KR10-2016-0163737 | 2016-12-02 | ||
| KR20160163737 | 2016-12-02 | ||
| PCT/KR2016/015554 WO2017116204A1 (ko) | 2015-12-31 | 2016-12-30 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093904A Division JP7030894B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504057A JP2019504057A (ja) | 2019-02-14 |
| JP2019504057A5 true JP2019504057A5 (https=) | 2019-11-28 |
| JP6712323B2 JP6712323B2 (ja) | 2020-06-17 |
Family
ID=59225193
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534682A Active JP6712323B2 (ja) | 2015-12-31 | 2016-12-30 | グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
| JP2018534662A Active JP6712322B2 (ja) | 2015-12-31 | 2016-12-30 | グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2020093904A Active JP7030894B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
| JP2020093915A Active JP7526039B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2022109549A Pending JP2022130723A (ja) | 2015-12-31 | 2022-07-07 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534662A Active JP6712322B2 (ja) | 2015-12-31 | 2016-12-30 | グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2020093904A Active JP7030894B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
| JP2020093915A Active JP7526039B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2022109549A Pending JP2022130723A (ja) | 2015-12-31 | 2022-07-07 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US10370426B2 (https=) |
| EP (3) | EP3985017A1 (https=) |
| JP (5) | JP6712323B2 (https=) |
| KR (8) | KR20170080522A (https=) |
| CN (6) | CN116059389A (https=) |
| AU (4) | AU2016382394B2 (https=) |
| BR (1) | BR112018013530A2 (https=) |
| CA (2) | CA3010182A1 (https=) |
| CL (6) | CL2018001776A1 (https=) |
| CO (2) | CO2018006986A2 (https=) |
| CR (2) | CR20180381A (https=) |
| DK (1) | DK3398961T3 (https=) |
| DO (2) | DOP2018000157A (https=) |
| EA (2) | EA038524B1 (https=) |
| EC (2) | ECSP18053055A (https=) |
| ES (1) | ES2925098T3 (https=) |
| HK (1) | HK1258177A1 (https=) |
| HR (1) | HRP20220995T1 (https=) |
| HU (1) | HUE059737T2 (https=) |
| IL (2) | IL260310B2 (https=) |
| MX (2) | MX2018008128A (https=) |
| PE (2) | PE20250556A1 (https=) |
| PH (2) | PH12018501411B1 (https=) |
| PL (1) | PL3398961T3 (https=) |
| PT (1) | PT3398961T (https=) |
| RS (1) | RS63541B1 (https=) |
| SA (2) | SA518391891B1 (https=) |
| SG (2) | SG11201805586SA (https=) |
| TN (2) | TN2018000228A1 (https=) |
| TW (4) | TWI807580B (https=) |
| UA (1) | UA130717C2 (https=) |
| WO (2) | WO2017116205A1 (https=) |
| ZA (2) | ZA201804998B (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| MX387560B (es) * | 2014-03-31 | 2025-03-18 | Hanmi Pharmaceutical Co Ltd | Procedimiento para mejorar la solubilidad de proteínas y péptidos usando un enlace del fragmento fc de inmunoglobulina. |
| PE20171154A1 (es) | 2014-12-30 | 2017-08-16 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon con estabilidad mejorada |
| EP4523705A3 (en) | 2015-06-30 | 2025-06-11 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
| SG11201805586SA (en) | 2015-12-31 | 2018-07-30 | Hanmi Pharmaceutical Co Ltd | Triple glucagon/glp-1/gip receptor agonist |
| EP3479841A4 (en) | 2016-06-29 | 2020-03-04 | Hanmi Pharm. Co., Ltd. | GLUCAGON DERIVATIVE, CONJUGATE THEREOF, COMPOSITION THEREOF AND THERAPEUTIC USE THEREOF |
| CN110545849A (zh) | 2017-02-03 | 2019-12-06 | 韩美药品株式会社 | 具有增加的持续性的生理活性物质的缀合物及其应用 |
| KR20180091773A (ko) | 2017-02-07 | 2018-08-16 | 한미약품 주식회사 | 비펩티드성 중합체 링커 화합물, 그 링커 화합물을 포함하는 결합체, 및 이들의 제조방법 |
| PE20191716A1 (es) | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
| JOP20190211A1 (ar) | 2017-03-31 | 2019-09-15 | Takeda Pharmaceuticals Co | ببتيد منشط لمستقبل gip |
| TWI767095B (zh) | 2017-12-21 | 2022-06-11 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| AR113486A1 (es) | 2017-12-21 | 2020-05-06 | Lilly Co Eli | Análogos de incretina y sus usos |
| CN109239346B (zh) * | 2018-10-31 | 2019-10-11 | 中国药科大学 | 一组代谢标志物在代谢综合征早期诊断方面的应用 |
| CN113453703A (zh) * | 2018-12-21 | 2021-09-28 | 韩美药品株式会社 | 包括胰岛素和对胰高血糖素和glp-1和gip受体均具有活性的三重激动剂的药物组合物 |
| EP3939990A4 (en) * | 2019-02-15 | 2023-05-24 | Hanmi Fine Chemical Co., Ltd. | NOVEL INTERMEDIATE FOR BIOLOGICALLY ACTIVE POLYPEPTIDE AND PROCESS FOR THE PRODUCTION THEREOF |
| WO2020214013A1 (ko) * | 2019-04-19 | 2020-10-22 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체의 고지혈증에 대한 치료적 용도 |
| WO2020214012A1 (ko) * | 2019-04-19 | 2020-10-22 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체를 포함하는 고지혈증 예방 또는 치료용 약학적 조성물 및 예방 또는 치료 방법 |
| CN111944055B (zh) * | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| DK3936142T3 (da) * | 2019-06-28 | 2024-03-25 | Hanmi Pharmaceutical Co Ltd | Tredobbelt agonist med aktivitet med hensyn til alle glucagon-, GLP-1- og GLP-receptorer til behandling af leversygdom |
| KR102812908B1 (ko) | 2019-08-19 | 2025-05-28 | 일라이 릴리 앤드 캄파니 | 인크레틴 유사체의 제조 방법 |
| KR20210040818A (ko) * | 2019-10-04 | 2021-04-14 | 한미약품 주식회사 | 글루카곤, 및 glp-1 수용체 및 gip 수용체 이중 작용제를 포함하는 조성물 및 이의 치료학적 용도 |
| CR20220206A (es) | 2019-11-11 | 2022-06-16 | Boehringer Ingelheim Int | Agonistas del receptor npy2 |
| AR120714A1 (es) | 2019-12-18 | 2022-03-09 | Lilly Co Eli | Análogos de incretina y sus usos |
| CN111040022B (zh) * | 2019-12-23 | 2021-12-14 | 万新医药科技(苏州)有限公司 | 针对胰高血糖素样肽-1受体、胰高血糖素受体、以及抑胃肽受体的三重激动剂 |
| EP4085077A4 (en) | 2019-12-31 | 2024-01-17 | Beijing QL Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| MX2022008646A (es) * | 2020-01-13 | 2022-08-10 | Hanmi Pharm Ind Co Ltd | Uso terapeutico de un conjugado de accion prolongada de un triple agonista que tiene actividad en todos los receptores de glucagon/glp-1/gip para enfermedades pulmonares. |
| HRP20241159T1 (hr) | 2020-02-07 | 2024-12-06 | Gasherbrum Bio, Inc. | Heterociklički agonisti za glp-1 |
| EP4140496A4 (en) * | 2020-04-20 | 2024-05-22 | Hanmi Pharm. Co., Ltd. | Preventive or therapeutic pharmaceutical composition for hyperlipidemia comprising triple agonist acting on all of glucagon, glp-1 and gip receptors, or conjugate thereof, and preventive or therapeutic method |
| TW202206429A (zh) | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| WO2021235915A1 (ko) * | 2020-05-22 | 2021-11-25 | 한미약품 주식회사 | 액상 제제 |
| BR112022023609A2 (pt) * | 2020-05-22 | 2023-02-07 | Hanmi Pharm Ind Co Ltd | Formulação líquida de conjugado de ação prolongada de agonista trigonal de glucagon, glp-1 e gip |
| JP2023535382A (ja) * | 2020-07-17 | 2023-08-17 | ハンミ ファーマシューティカル カンパニー リミテッド | 三重作用性持続型結合体又は三重作用剤を含む組合せ物の治療学的用途 |
| JP2023537501A (ja) | 2020-08-06 | 2023-09-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| JP7661478B2 (ja) | 2020-08-07 | 2025-04-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性ｎｐｙ２受容体アゴニスト |
| EP4197560A4 (en) * | 2020-08-14 | 2025-11-26 | Hanmi Pharmaceutical Co Ltd | Pharmaceutical composition comprising a persistent triple activator conjugate used as the active ingredient. |
| EP4197550A4 (en) * | 2020-08-14 | 2025-10-08 | Hanmi Pharmaceutical Co Ltd | PHARMACEUTICAL COMPOSITION WITH HYPOTENSIVE EFFECT COMPRISING A TRIPLE ACTIVATOR WITH ACTIVITY FOR ALL GLUCAGON, GLP-1, AND GIP RECEPTORS |
| EP4257144A4 (en) * | 2020-09-25 | 2024-11-20 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF BONE DISEASES, COMPRISING A TRIPLE AGONIST OR A RELATED CONJUGATE HAVING ACTIVITY WITH RESPECT TO ALL GLUCAGON, GLP-1 AND GLP RECEPTORS |
| JP2023543043A (ja) * | 2020-09-25 | 2023-10-12 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体の持続型結合体の多発性硬化症の治療用途 |
| JP2023543036A (ja) * | 2020-09-25 | 2023-10-12 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体またはその結合体の神経退行性疾患の治療用途 |
| CN114729060B (zh) | 2020-09-30 | 2022-11-25 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| WO2022080987A1 (ko) * | 2020-10-16 | 2022-04-21 | 한미약품 주식회사 | 글루카곤/glp-1/gip 삼중작용제 또는 이의 지속형 결합체를 포함하는 혈관염 예방 또는 치료용 약학적 조성물 |
| TW202233226A (zh) * | 2020-10-16 | 2022-09-01 | 南韓商韓美藥品股份有限公司 | 用於治療呼吸感染後遺症的三重升糖素／ｇｌｐ－１／ｇｉｐ受體促效劑 |
| JP2023546089A (ja) * | 2020-10-16 | 2023-11-01 | ハンミ ファーマシューティカルズ カンパニー リミテッド | Ｇｉｐ誘導体またはその持続型結合体を含むループス関連疾患の予防用または治療用の薬学的組成物 |
| US20230381281A1 (en) * | 2020-10-16 | 2023-11-30 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition comprising glucagon/glp-1/gip triple agonist or long-acting conjugate thereof for preventing or treating lupus-related diseases |
| EP4230639A4 (en) * | 2020-10-16 | 2025-01-15 | Hanmi Pharm. Co., Ltd. | GIP DERIVATIVE, LONG-ACTING CONJUGATE THEREOF AND PHARMACEUTICAL COMPOSITION THEREOF |
| US20230391845A1 (en) | 2020-10-30 | 2023-12-07 | Novo Nordisk A/S | Glp-1, gip and glucagon receptor triple agonists |
| MX2023006419A (es) * | 2020-12-02 | 2023-08-15 | Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd | Compuestos polipéptidos modificados con lactama. |
| KR20220092442A (ko) * | 2020-12-24 | 2022-07-01 | 한미약품 주식회사 | 신규한 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중활성체 및 이의 용도 |
| CA3204051A1 (en) | 2021-01-20 | 2022-07-28 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
| CN116847868A (zh) * | 2021-01-29 | 2023-10-03 | 韩美药品株式会社 | 用于预防或治疗肺部疾病的包括gip衍生物或其长效共轭物的药学组合物 |
| WO2022247701A1 (zh) | 2021-05-26 | 2022-12-01 | 联邦生物科技(珠海横琴)有限公司 | 多激动剂及其应用 |
| KR20230004135A (ko) * | 2021-06-30 | 2023-01-06 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체를 포함하는 조합물의 치료학적 용도 |
| WO2023005841A1 (zh) * | 2021-07-30 | 2023-02-02 | 南京明德新药研发有限公司 | 含内酰胺桥的多肽化合物 |
| JP7642830B2 (ja) | 2021-09-15 | 2025-03-10 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| KR20230095665A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 약물 및 이의 용도 |
| JP2025509281A (ja) | 2022-03-09 | 2025-04-11 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| US20250206757A1 (en) | 2022-03-21 | 2025-06-26 | Gasherbrum Bio, Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| US20250250269A1 (en) | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| GB2634433A (en) * | 2022-05-27 | 2025-04-09 | D&D Pharmatech Inc | Peptide compositions and methods of use thereof |
| IL321555B1 (en) * | 2022-12-23 | 2026-01-01 | Hanmi Pharmaceutical Co Ltd | A novel triple agonist for glp-1/gip/glucagon and a pharmaceutical preparation containing it for the prevention or treatment of obesity |
| US20240270821A1 (en) | 2023-01-31 | 2024-08-15 | Eli Lilly And Company | Gip/glp1/gcg tri-receptor agonists and uses thereof |
| KR20260022948A (ko) | 2023-06-09 | 2026-02-20 | 썬 파마슈티컬 인더스트리스 리미티드 | Glp-1/gip 이중 수용체 작용제, glp-1/gcg 이중 수용체 작용제, 및 glp-1/gip/gcg 삼중 수용체 작용제 |
| WO2025259062A1 (ko) * | 2024-06-13 | 2025-12-18 | 한미약품 주식회사 | Glp-1, gip, 및 글루카곤 수용체 모두에 활성을 갖는 삼중 활성체 및 이를 포함하는 신장 질환의 예방 또는 치료용 약학적 조성물 |
| WO2025259064A1 (ko) * | 2024-06-13 | 2025-12-18 | 한미약품 주식회사 | Glp-1, gip, 및 글루카곤 수용체 모두에 활성을 갖는 삼중 활성체 및 이를 포함하는 심혈관계 질환 예방 또는 치료용 약학적 조성물 |
| KR20250177375A (ko) * | 2024-06-13 | 2025-12-23 | 한미약품 주식회사 | Glp-1, gip, 및 글루카곤 수용체 모두에 활성을 갖는 삼중 활성체 및 이를 포함하는 지질 대사 질환 예방 또는 치료용 약학적 조성물 |
| KR20250177377A (ko) * | 2024-06-13 | 2025-12-23 | 한미약품 주식회사 | Glp-1, gip, 및 글루카곤 수용체 모두에 활성을 갖는 삼중 활성체 및 이를 포함하는 당뇨 예방 또는 치료용 약학적 조성물 |
| CN120189527B (zh) * | 2025-05-27 | 2026-04-03 | 广州富肽生物有限公司 | 一种多肽与抗体Fc片段的偶联物、药物组合物及其用途 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5476304A (en) | 1977-11-29 | 1979-06-18 | Tokyo Printing Ink Mfg Co Ltd | Ink |
| US5408037A (en) | 1991-01-17 | 1995-04-18 | Zymogenetics, Inc. | Methods for detecting glucagon antagonists |
| GB9423277D0 (en) | 1994-11-18 | 1995-01-11 | Univ Nottingham | Pulsed laser deposition of coatings |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| ES2278589T3 (es) * | 1999-01-14 | 2007-08-16 | Amylin Pharmaceuticals, Inc. | Excendinas destinadas a la inhibicion de glucagon. |
| US6677136B2 (en) | 2000-05-03 | 2004-01-13 | Amgen Inc. | Glucagon antagonists |
| JP4716641B2 (ja) * | 2000-06-16 | 2011-07-06 | イーライ リリー アンド カンパニー | グルカゴン様ペプチド−１類似体 |
| ATE408414T1 (de) * | 2001-07-31 | 2008-10-15 | Us Gov Health & Human Serv | Glp 1 exendin 4 peptidanaloga und deren verwendungen |
| JP2006520818A (ja) * | 2003-03-19 | 2006-09-14 | イーライ リリー アンド カンパニー | ポリエチレングリコール結合ｇｌｐ−１化合物 |
| EP1667724A2 (en) * | 2003-09-19 | 2006-06-14 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
| ES2383300T3 (es) | 2003-11-13 | 2012-06-20 | Hanmi Holdings Co., Ltd | Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación |
| US8263084B2 (en) | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
| JP2009534423A (ja) * | 2006-04-20 | 2009-09-24 | アムジェン インコーポレイテッド | Ｇｌｐ−１化合物 |
| US20080027072A1 (en) * | 2006-04-20 | 2008-01-31 | Ampla Pharmaceuticals, Inc. | Potentiation of MC4 receptor activity |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| RU2477286C2 (ru) | 2007-01-05 | 2013-03-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH |
| CA2677932A1 (en) | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
| EP2158214B1 (en) | 2007-06-15 | 2011-08-17 | Zealand Pharma A/S | Glucagon analogues |
| KR20100049032A (ko) | 2007-06-19 | 2010-05-11 | 오츠카 가가쿠 가부시키가이샤 | 당사슬 부가 ｇｌｐ―１ 펩티드 |
| EP2190872B1 (en) | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| EP2249853A4 (en) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| AR072160A1 (es) * | 2008-06-17 | 2010-08-11 | Univ Indiana Res & Tech Corp | Co-agonistas del receptor de glucagon/glp-1 |
| US8450270B2 (en) | 2008-06-17 | 2013-05-28 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers |
| CN102105159B (zh) | 2008-06-17 | 2015-07-08 | 印第安纳大学研究及科技有限公司 | 基于gip的混合激动剂用于治疗代谢紊乱和肥胖症 |
| WO2010096052A1 (en) | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Oxyntomodulin analogs |
| EP2443146B1 (en) | 2009-06-16 | 2016-10-05 | Indiana University Research And Technology Corporation | Gip receptor-active glucagon compounds |
| AU2010272944B2 (en) | 2009-07-13 | 2015-11-19 | Zealand Pharma A/S | Acylated glucagon analogues |
| GB0917072D0 (en) | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
| US8703701B2 (en) * | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| US20130157953A1 (en) | 2010-01-20 | 2013-06-20 | Zealand Pharma A/S | Treatment of cardiac conditions |
| KR20120123443A (ko) * | 2010-01-27 | 2012-11-08 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 대사 장애 및 비만 치료용 글루카곤 길항제-ｇｉｐ 항진제 콘쥬게이트 |
| JP5812627B2 (ja) * | 2010-03-10 | 2015-11-17 | 公益財団法人相模中央化学研究所 | 改良Ｆｃ受容体およびその製造方法 |
| EP2552951A1 (en) | 2010-03-26 | 2013-02-06 | Novo Nordisk A/S | Novel glucagon analogues |
| JP6050746B2 (ja) | 2010-05-13 | 2016-12-21 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | Ｇタンパク質共役受容体活性を示すグルカゴンスーパーファミリーのペプチド |
| KR101382593B1 (ko) | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
| US8507428B2 (en) * | 2010-12-22 | 2013-08-13 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting GIP receptor activity |
| WO2012150503A2 (en) | 2011-05-03 | 2012-11-08 | Zealand Pharma A/S | Glu-glp-1 dual agonist signaling-selective compounds |
| DK2710031T3 (en) | 2011-05-18 | 2018-01-02 | Mederis Diabetes Llc | IMPROVED PEPTID MEDICINALS FOR INSULIN RESISTANCE |
| UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
| UA126465C2 (uk) | 2011-06-10 | 2022-10-12 | Ханмі Сайенс Ко., Лтд. | Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить |
| RU2607365C2 (ru) | 2011-06-17 | 2017-01-10 | Ханми Сайенс Ко., Лтд. | Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение |
| KR20140043793A (ko) * | 2011-06-22 | 2014-04-10 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/glp-1 수용체 공동-작용물질 |
| RS56173B1 (sr) * | 2011-06-22 | 2017-11-30 | Univ Indiana Res & Tech Corp | Koagonisti receptora za glukagon/glp-1 receptora |
| WO2013004983A1 (en) | 2011-07-04 | 2013-01-10 | Imperial Innovations Limited | Novel compounds and their effects on feeding behaviour |
| JP6324315B2 (ja) | 2011-11-17 | 2018-05-16 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | グルココルチコイド受容体の活性を示すグルカゴンスーパーファミリーのペプチド |
| EP2851429B1 (en) | 2012-05-18 | 2019-07-24 | Adda Biotech Inc. | Protein and protein conjugate for diabetes treatment, and applications thereof |
| CN104583232B (zh) * | 2012-06-21 | 2018-04-13 | 印第安纳大学研究及科技有限公司 | 展现gip受体活性的胰高血糖素类似物 |
| HK1209034A1 (en) * | 2012-06-21 | 2016-03-24 | Indiana University Research And Technology Corporation | Incretin receptor ligand polypeptide fc-region fusion polypeptides and conjugates with altered fc-effector function |
| PE20150863A1 (es) * | 2012-06-21 | 2015-06-11 | Univ Indiana Res & Tech Corp | Analogos de glucagon que exhiben actividad de receptor de gip |
| AR094821A1 (es) | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| AR092873A1 (es) * | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| WO2014073842A1 (en) | 2012-11-06 | 2014-05-15 | Hanmi Pharm. Co., Ltd. | Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment |
| KR101993393B1 (ko) | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| ES2906975T3 (es) * | 2012-11-20 | 2022-04-21 | Eumederis Pharmaceuticals Inc | Productos farmacéuticos de péptidos mejorados |
| MX360816B (es) | 2012-11-20 | 2018-11-15 | Mederis Diabetes Llc | Productos farmacéuticos peptídicos mejorados para la resistencia a la insulina. |
| AU2013366692B2 (en) * | 2012-12-21 | 2017-11-23 | Sanofi | Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists |
| JP2016521253A (ja) * | 2013-03-15 | 2016-07-21 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | 持続性作用を有するプロドラッグ |
| EP2986313B1 (en) | 2013-04-18 | 2019-06-12 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| US20160185837A1 (en) | 2013-08-16 | 2016-06-30 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
| TWI802396B (zh) | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| CN108271356A (zh) * | 2014-09-24 | 2018-07-10 | 印第安纳大学研究及科技有限公司 | 肠降血糖素-胰岛素缀合物 |
| KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| PE20171154A1 (es) | 2014-12-30 | 2017-08-16 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon con estabilidad mejorada |
| EP4523705A3 (en) | 2015-06-30 | 2025-06-11 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
| TW201718629A (zh) | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物 |
| EP3384935A4 (en) | 2015-12-02 | 2019-08-21 | Hanmi Pharm. Co., Ltd. | PROTEIN COMPLEX WITH FATTY ACID DERIVATIVE AND MANUFACTURING METHOD THEREFOR |
| SG11201805586SA (en) * | 2015-12-31 | 2018-07-30 | Hanmi Pharmaceutical Co Ltd | Triple glucagon/glp-1/gip receptor agonist |
-
2016
- 2016-12-30 SG SG11201805586SA patent/SG11201805586SA/en unknown
- 2016-12-30 CN CN202211287482.4A patent/CN116059389A/zh active Pending
- 2016-12-30 PE PE2023002166A patent/PE20250556A1/es unknown
- 2016-12-30 HK HK19100534.2A patent/HK1258177A1/en unknown
- 2016-12-30 AU AU2016382394A patent/AU2016382394B2/en active Active
- 2016-12-30 CR CR20180381A patent/CR20180381A/es unknown
- 2016-12-30 EA EA201891359A patent/EA038524B1/ru unknown
- 2016-12-30 EP EP21201279.3A patent/EP3985017A1/en active Pending
- 2016-12-30 SG SG11201805573RA patent/SG11201805573RA/en unknown
- 2016-12-30 EP EP16882156.9A patent/EP3398961B1/en active Active
- 2016-12-30 PH PH1/2018/501411A patent/PH12018501411B1/en unknown
- 2016-12-30 TW TW111101118A patent/TWI807580B/zh active
- 2016-12-30 WO PCT/KR2016/015555 patent/WO2017116205A1/ko not_active Ceased
- 2016-12-30 CR CR20180380A patent/CR20180380A/es unknown
- 2016-12-30 PL PL16882156.9T patent/PL3398961T3/pl unknown
- 2016-12-30 JP JP2018534682A patent/JP6712323B2/ja active Active
- 2016-12-30 EA EA201891360A patent/EA038544B1/ru unknown
- 2016-12-30 HU HUE16882156A patent/HUE059737T2/hu unknown
- 2016-12-30 PE PE2018001233A patent/PE20181494A1/es unknown
- 2016-12-30 MX MX2018008128A patent/MX2018008128A/es unknown
- 2016-12-30 UA UAA201807309A patent/UA130717C2/uk unknown
- 2016-12-30 TN TNP/2018/000228A patent/TN2018000228A1/en unknown
- 2016-12-30 CA CA3010182A patent/CA3010182A1/en active Pending
- 2016-12-30 DK DK16882156.9T patent/DK3398961T3/da active
- 2016-12-30 CN CN202211656375.4A patent/CN115920077B/zh active Active
- 2016-12-30 ES ES16882156T patent/ES2925098T3/es active Active
- 2016-12-30 BR BR112018013530-5A patent/BR112018013530A2/pt active Search and Examination
- 2016-12-30 EP EP16882157.7A patent/EP3398962A4/en active Pending
- 2016-12-30 MX MX2018008027A patent/MX2018008027A/es unknown
- 2016-12-30 TW TW105144155A patent/TWI800478B/zh active
- 2016-12-30 JP JP2018534662A patent/JP6712322B2/ja active Active
- 2016-12-30 CN CN202211234594.3A patent/CN116063454A/zh active Pending
- 2016-12-30 HR HRP20220995TT patent/HRP20220995T1/hr unknown
- 2016-12-30 RS RS20220774A patent/RS63541B1/sr unknown
- 2016-12-30 TW TW105144154A patent/TWI731015B/zh active
- 2016-12-30 CN CN201680082339.8A patent/CN109071624B/zh active Active
- 2016-12-30 WO PCT/KR2016/015554 patent/WO2017116204A1/ko not_active Ceased
- 2016-12-30 CN CN202211234307.9A patent/CN116063453A/zh active Pending
- 2016-12-30 AU AU2016382393A patent/AU2016382393B2/en active Active
- 2016-12-30 KR KR1020160183500A patent/KR20170080522A/ko not_active Ceased
- 2016-12-30 TN TNP/2018/000231A patent/TN2018000231A1/en unknown
- 2016-12-30 PT PT168821569T patent/PT3398961T/pt unknown
- 2016-12-30 KR KR1020160183499A patent/KR20170080521A/ko not_active Ceased
- 2016-12-30 IL IL260310A patent/IL260310B2/en unknown
- 2016-12-30 CA CA3010265A patent/CA3010265C/en active Active
- 2016-12-30 IL IL260318A patent/IL260318B2/en unknown
- 2016-12-30 TW TW112108994A patent/TWI877582B/zh active
- 2016-12-30 PH PH1/2018/501409A patent/PH12018501409B1/en unknown
- 2016-12-30 CN CN201680082352.3A patent/CN108699125B/zh active Active
-
2018
- 2018-06-25 SA SA518391891A patent/SA518391891B1/ar unknown
- 2018-06-26 SA SA518391903A patent/SA518391903B1/ar unknown
- 2018-06-28 CL CL2018001776A patent/CL2018001776A1/es unknown
- 2018-06-28 DO DO2018000157A patent/DOP2018000157A/es unknown
- 2018-06-29 US US16/023,994 patent/US10370426B2/en active Active
- 2018-06-29 DO DO2018000159A patent/DOP2018000159A/es unknown
- 2018-06-29 CL CL2018001795A patent/CL2018001795A1/es unknown
- 2018-06-29 US US16/024,014 patent/US10400020B2/en active Active
- 2018-07-04 CO CONC2018/0006986A patent/CO2018006986A2/es unknown
- 2018-07-04 CO CONC2018/0006982A patent/CO2018006982A2/es unknown
- 2018-07-13 EC ECSENADI201853055A patent/ECSP18053055A/es unknown
- 2018-07-13 EC ECSENADI201853053A patent/ECSP18053053A/es unknown
- 2018-07-25 ZA ZA2018/04998A patent/ZA201804998B/en unknown
- 2018-07-25 ZA ZA2018/04997A patent/ZA201804997B/en unknown
-
2019
- 2019-01-31 US US16/263,469 patent/US10981967B2/en active Active
- 2019-03-29 US US16/370,057 patent/US11332508B2/en active Active
- 2019-05-27 KR KR1020190061853A patent/KR102401869B1/ko active Active
- 2019-05-27 KR KR1020190061852A patent/KR102367997B1/ko active Active
- 2019-06-04 AU AU2019203888A patent/AU2019203888B2/en active Active
- 2019-06-04 AU AU2019203891A patent/AU2019203891B2/en active Active
- 2019-08-29 KR KR1020190106690A patent/KR102179391B1/ko active Active
- 2019-08-29 KR KR1020190106691A patent/KR102179392B1/ko active Active
-
2020
- 2020-05-29 JP JP2020093904A patent/JP7030894B2/ja active Active
- 2020-05-29 JP JP2020093915A patent/JP7526039B2/ja active Active
- 2020-07-27 KR KR1020200093190A patent/KR102285378B1/ko active Active
- 2020-07-27 KR KR1020200093189A patent/KR102285377B1/ko active Active
- 2020-08-05 CL CL2020002034A patent/CL2020002034A1/es unknown
- 2020-08-05 CL CL2020002033A patent/CL2020002033A1/es unknown
-
2021
- 2021-02-26 US US17/187,098 patent/US20210188937A1/en not_active Abandoned
-
2022
- 2022-03-07 CL CL2022000557A patent/CL2022000557A1/es unknown
- 2022-03-07 CL CL2022000558A patent/CL2022000558A1/es unknown
- 2022-03-21 US US17/700,055 patent/US20220213164A1/en active Pending
- 2022-07-07 JP JP2022109549A patent/JP2022130723A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019504057A5 (https=) | ||
| JP2019504055A5 (https=) | ||
| PE20231309A1 (es) | Agonistas duales glp-1/gip | |
| JP7554928B2 (ja) | Ｇｌｐ－１およびアミリン受容体の共作動薬 | |
| ES2514615T3 (es) | Proteínas de dominio Kunitz inhibidores de calicreína y ácidos nucleicos que codifican las mismas | |
| JP7030894B2 (ja) | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 | |
| ES2646614T3 (es) | Uso de un compuesto de FGF 21 y un compuesto de GLP 1 para el tratamiento de la obesidad | |
| RU2207874C9 (ru) | Производное инсулина или его физиологически приемлемая соль, предшественник производного инсулина, днк-последовательность, кодирующая предшественник, вектор экспрессии, содержащий упомянутую днк-последовательность, субстрат, трансформированный упомянутым вектором экспрессии, фармацевтическая композиция с понижающей, соответственно регулирующей уровень глюкозы в крови эффективностью | |
| PE20230861A1 (es) | Agonistas dobles de glp-1/gip de accion prolongada | |
| RU2015101697A (ru) | Аналоги глюкагона, обладающие активностью рецептора gip | |
| US10822386B2 (en) | Insulin analogues with enhanced stability and reduced mitogenicity | |
| JP2023521491A5 (https=) | ||
| JP2013542715A5 (https=) | ||
| JP2021521230A5 (https=) | ||
| AR031701A1 (es) | COMPUESTOS ANA LOGOS DEL (GLP-1)-PEPTIDO-1 ANALOGO DEL GLUCAGoN, METODO PARA ESTIMULAR LOS RECEPTORES GLP-1 UTILIZANDO DICHOS COMPUESTOS Y USO DE DICHOS COMPUESTOS EN LA PREPARACION DE MEDICAMENTOS PARA ESTIMULAR LA SECRECION DE INSULINA | |
| JP2013501818A5 (https=) | ||
| WO2016045400A1 (zh) | 胃泌酸调节素类似物 | |
| JP2012518035A5 (https=) | ||
| JP2018515088A5 (https=) | ||
| PE20030820A1 (es) | Analogos extendidos de peptido 1 de tipo glucagon | |
| CN105324397A (zh) | 胰岛素-肠促胰岛素缀合物 | |
| JP2015180647A (ja) | ハロゲン安定化インスリン | |
| EP2804621A1 (en) | Glutamic acid-stabilized insulin analogues | |
| JP2014504588A5 (https=) | ||
| RU2012151296A (ru) | Пептид для улучшения биостабильности биоактивного вещества и биоактивное вещество, имеющее повышенную биостабильность |