JP2019501973A5 - - Google Patents
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- JP2019501973A5 JP2019501973A5 JP2018555314A JP2018555314A JP2019501973A5 JP 2019501973 A5 JP2019501973 A5 JP 2019501973A5 JP 2018555314 A JP2018555314 A JP 2018555314A JP 2018555314 A JP2018555314 A JP 2018555314A JP 2019501973 A5 JP2019501973 A5 JP 2019501973A5
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- 239000000203 mixture Substances 0.000 claims 35
- 108090001123 antibodies Proteins 0.000 claims 20
- 102000004965 antibodies Human genes 0.000 claims 20
- 210000004027 cells Anatomy 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 12
- 108091007172 antigens Proteins 0.000 claims 12
- 102000038129 antigens Human genes 0.000 claims 12
- 101710044433 SAG Proteins 0.000 claims 11
- 231100000617 Superantigen Toxicity 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 10
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 230000000091 immunopotentiator Effects 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 230000004913 activation Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 230000002708 enhancing Effects 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 231100000655 Enterotoxin Toxicity 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- 102000018358 Immunoglobulins Human genes 0.000 claims 2
- 108060003951 Immunoglobulins Proteins 0.000 claims 2
- 108010019706 Nivolumab Proteins 0.000 claims 2
- 108091008153 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010072668 atezolizumab Proteins 0.000 claims 2
- 229960003852 atezolizumab Drugs 0.000 claims 2
- 230000001900 immune effect Effects 0.000 claims 2
- 230000001404 mediated Effects 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 108010026276 pembrolizumab Proteins 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 1
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 102000000034 Programmed Cell Death 1 Receptor Human genes 0.000 claims 1
- 108010080196 Programmed Cell Death 1 Receptor Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Claims (34)
- 癌の治療を必要とする被験体において癌を治療するための医薬組成物であって、該組成物が、
(i) 被験体において癌性細胞により発現される第1の抗原に結合する標的化部分に共有結合するスーパー抗原を含むスーパー抗原コンジュゲート、および／または
(ii) 以下の活性(a) T細胞シグナル伝達の活性化の刺激、(b) 癌性細胞とT細胞の間のT細胞抑制性シグナル伝達の抑制、および/または(c) ヒトIgG4免疫グロブリン媒介性経路を介するT細胞の拡大、活性化および/または活性をもたらす抑制性シグナル伝達の抑制の1つ以上をなし得る免疫増強物質を含み、(i)と(ii)は組み合わせて使用され、それにより癌性細胞に対する被験体における免疫応答を強化して、癌が治療される、組成物。 - スーパー抗原が、免疫増強物質の前、同時または後に被験体に投与される、請求項１記載の組成物。
- スーパー抗原が、T細胞の表面上のT細胞受容体に結合する、請求項１または２記載の組成物。
- スーパー抗原が、ブドウ球菌エンテロトキシンAまたはその免疫学的バリアントおよび/または断片を含む、請求項１〜３いずれか一項記載の組成物。
- 第1の抗原が細胞表面抗原である、請求項１記載の組成物。
- 細胞表面抗原が5T4癌抗原である、請求項５記載の組成物。
- 標的化部分が抗体である、請求項１〜６いずれか一項記載の組成物。
- 抗体が抗5T4抗体である、請求項７記載の組成物。
- 抗5T4抗体が、5T4癌抗原に結合するFab断片を含む、請求項８記載の組成物。
- 抗5T4抗体が、配列番号：8のアミノ酸残基1〜458を含む重鎖、および配列番号：9のアミノ酸残基1〜214を含む軽鎖を含む、請求項８または９記載の組成物。
- スーパー抗原が、配列番号：7のアミノ酸残基226〜458またはその免疫学的に反応性のバリアントおよび/または断片を含む、請求項１〜１０いずれか一項記載の組成物。
- T細胞により発現されるプログラム細胞死-1タンパク質(PD-1)に結合するプログラム細胞死リガンド(PD-L)が、癌性細胞の表面に発現される、請求項１〜１１いずれか一項記載の組成物。
- 免疫増強物質が、T細胞の表面上に発現されるPD-1にPD-Lが結合することを防ぐ抗PD-1抗体である、請求項１２記載の組成物。
- 抗PD-1抗体が、ヒトIgG4アイソタイプを有するかまたはヒトIgG4アイソタイプに基づく、請求項１３記載の組成物。
- 抗PD-1抗体が、ニボルマブおよびペンブロリズマブからなる群より選択される、請求項１３または１４記載の組成物。
- 免疫増強物質が、抗PD-L1抗体である、請求項１２記載の組成物。
- 抗PD-L1抗体が、アテゾリズマブおよびMEDI4736からなる群より選択される、請求項１６記載の組成物。
- 癌が、黒色腫、乳癌、子宮頸癌、結腸直腸癌、胃癌、非小細胞肺癌、卵巣癌、膵臓癌、前立腺癌、腎臓細胞癌および皮膚癌からなる群より選択される、請求項１〜１７いずれか一項記載の組成物。
- 被験体において癌性細胞により発現される第1の抗原に結合する標的化部分に共有結合するスーパー抗原を含むスーパー抗原コンジュゲートの有効量、被験体において以下の活性(a) T細胞シグナル伝達の活性化の刺激、(b) 癌性細胞とT細胞の間のT細胞抑制性シグナル伝達の抑制、および/または(c)ヒトIgG4免疫グロブリン媒介性経路を介するT細胞の拡大、活性化および/または活性をもたらす抑制性シグナル伝達の抑制の1つ以上をなし得る免疫増強物質の有効量、ならびに薬学的に許容され得る賦形剤を含む、医薬組成物。
- スーパー抗原がT細胞の細胞表面に発現されるT細胞受容体に結合する、請求項１９記載の組成物。
- スーパー抗原が、ブドウ球菌エンテロトキシンAまたはその免疫学的バリアントおよび/または断片を含む、請求項１９または２０記載の組成物。
- 第1の抗原が細胞表面抗原である、請求項１９〜２１いずれか一項記載の組成物。
- 該抗原が5T4癌抗原である、請求項１９〜２２いずれか一項記載の組成物。
- 標的化部分が抗体である、請求項１９〜２３いずれか一項記載の組成物。
- 該抗体が抗5T4抗体である、請求項２４記載の組成物。
- 該抗体が5T4抗原に結合するFab断片を含む、請求項２５記載の組成物。
- 抗5T4抗体が、配列番号：8のアミノ酸残基1〜458を含む重鎖、および配列番号：9のアミノ酸残基1〜214を含む軽鎖を含む、請求項２５または２６記載の組成物。
- スーパー抗原が、配列番号：7のアミノ酸残基226〜458またはその免疫学的に反応性のバリアントおよび/または断片を含む、請求項１９〜２７いずれか一項記載の組成物。
- 免疫増強物質が、癌性細胞において発現されるPD-LがT細胞により発現されるPD-1に結合することを防ぐ、請求項１９〜２８いずれか一項記載の組成物。
- 免疫増強物質が、抗PD-1抗体である、請求項２９記載の組成物。
- 該抗体が、ヒトIgG4アイソタイプを有するかまたはヒトIgG4アイソタイプに基づく、請求項３０記載の組成物。
- 抗PD-1抗体が、ニボルマブおよびペンブロリズマブからなる群より選択される、請求項３０または３１記載の組成物。
- 免疫増強物質が、抗PD-L1抗体である、請求項２９記載の組成物。
- 抗PD-L1抗体が、アテゾリズマブおよびMEDI4736からなる群より選択される、請求項３３記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276955P | 2016-01-10 | 2016-01-10 | |
| US62/276,955 | 2016-01-10 | ||
| PCT/IB2017/000511 WO2017122098A2 (en) | 2016-01-10 | 2017-01-10 | Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501973A JP2019501973A (ja) | 2019-01-24 |
| JP2019501973A5 true JP2019501973A5 (ja) | 2020-02-20 |
| JP7161938B2 JP7161938B2 (ja) | 2022-10-27 |
Family
ID=58737690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555314A Active JP7161938B2 (ja) | 2016-01-10 | 2017-01-10 | スーパー抗原媒介性癌免疫療法の能力を増強するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10314910B2 (ja) |
| EP (1) | EP3411409A2 (ja) |
| JP (1) | JP7161938B2 (ja) |
| KR (1) | KR20180100412A (ja) |
| CN (2) | CN109195988B (ja) |
| AU (1) | AU2017206656B2 (ja) |
| CA (1) | CA3010678A1 (ja) |
| EA (1) | EA201891601A1 (ja) |
| IL (1) | IL260423B2 (ja) |
| MX (1) | MX2018008383A (ja) |
| WO (1) | WO2017122098A2 (ja) |
| ZA (1) | ZA201804565B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10314910B2 (en) * | 2016-01-10 | 2019-06-11 | Neotx Therapeutics Ltd. | Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy |
| US20210214442A1 (en) * | 2018-05-16 | 2021-07-15 | Duke University | Neoadjuvant cancer treatment with immunotoxin and checkpoint inhibitor combination |
| CN108840923B (zh) * | 2018-06-22 | 2021-08-03 | 上海交通大学医学院附属仁济医院 | 一种靶向pd-l1的多肽及其应用 |
| KR20220009428A (ko) * | 2019-05-15 | 2022-01-24 | 네오티엑스 테라퓨틱스 엘티디. | 암 치료 |
| CN115484978A (zh) * | 2020-03-05 | 2022-12-16 | 尼奥克斯医疗有限公司 | 使用免疫细胞治疗癌症的方法和组合物 |
| US20230285588A1 (en) * | 2020-07-20 | 2023-09-14 | Neotx Therapeutics Ltd. | Superantigen conjugate for use in methods and compositions for treating cancer |
| JP2023545893A (ja) * | 2020-08-19 | 2023-11-01 | ▲蘇▼州易慕峰生物科技有限公司 | ヒト化抗体、キメラ抗原受容体、核酸、ベクター、細胞及び応用 |
| WO2022224041A1 (en) * | 2021-04-22 | 2022-10-27 | Neotx Therapeutics Ltd. | Methods and compositions for treating glioblastoma |
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| CN116284448A (zh) * | 2023-02-14 | 2023-06-23 | 浙江大学 | 一种超抗原参与的三功能t细胞衔接器及其应用 |
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| PL208712B1 (pl) | 2001-08-31 | 2011-05-31 | Avidex Ltd | Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd |
| EP1478381A4 (en) | 2002-01-10 | 2006-11-29 | Nat Jewish Med & Res Center | USE OF SOLUBLE GAMMA DELTA T CELL RECEPTORS TO REGULATE THE FUNCTION OF T CELLS |
| AU2003281200A1 (en) | 2002-07-03 | 2004-01-23 | Tasuku Honjo | Immunopotentiating compositions |
| US6926694B2 (en) | 2003-05-09 | 2005-08-09 | Medsolve Technologies, Llc | Apparatus and method for delivery of therapeutic and/or diagnostic agents |
| CA2572433A1 (en) | 2004-06-30 | 2006-01-12 | Fiberstars Incorporated | Adjustable-aim light pipe fixture |
| SE0402025D0 (sv) * | 2004-08-13 | 2004-08-13 | Active Biotech Ab | Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| DK2170959T3 (da) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | Antistoffer mod human programmeret dødsreceptor pd-1 |
| EP2869845B1 (en) * | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
| CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| AU2013347838A1 (en) * | 2012-11-26 | 2015-06-11 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarker compositions and methods |
| US20170002060A1 (en) * | 2014-01-08 | 2017-01-05 | Moderna Therapeutics, Inc. | Polynucleotides for the in vivo production of antibodies |
| SI3789402T1 (sl) * | 2014-11-20 | 2022-10-28 | F. Hoffmann-La Roche Ag | Kombinirano zdravljenje z bispecifičnimi molekulami, ki vežejo antigen in aktivirajo celice T, ter antagonisti za vezavo osi PD-1 |
| US10314910B2 (en) * | 2016-01-10 | 2019-06-11 | Neotx Therapeutics Ltd. | Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy |
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2017
- 2017-01-10 US US15/402,888 patent/US10314910B2/en active Active
- 2017-01-10 CN CN201780016492.5A patent/CN109195988B/zh active Active
- 2017-01-10 AU AU2017206656A patent/AU2017206656B2/en active Active
- 2017-01-10 JP JP2018555314A patent/JP7161938B2/ja active Active
- 2017-01-10 CA CA3010678A patent/CA3010678A1/en active Pending
- 2017-01-10 MX MX2018008383A patent/MX2018008383A/es unknown
- 2017-01-10 WO PCT/IB2017/000511 patent/WO2017122098A2/en active Application Filing
- 2017-01-10 EP EP17724437.3A patent/EP3411409A2/en active Pending
- 2017-01-10 CN CN202311526574.8A patent/CN117679499A/zh active Pending
- 2017-01-10 KR KR1020187022673A patent/KR20180100412A/ko active Search and Examination
- 2017-01-10 EA EA201891601A patent/EA201891601A1/ru unknown
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2018
- 2018-07-04 IL IL260423A patent/IL260423B2/en unknown
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2019
- 2019-05-14 US US16/411,276 patent/US11202829B2/en active Active
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