JP2019501139A5 - - Google Patents
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- JP2019501139A5 JP2019501139A5 JP2018527232A JP2018527232A JP2019501139A5 JP 2019501139 A5 JP2019501139 A5 JP 2019501139A5 JP 2018527232 A JP2018527232 A JP 2018527232A JP 2018527232 A JP2018527232 A JP 2018527232A JP 2019501139 A5 JP2019501139 A5 JP 2019501139A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- antibody
- variable region
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 101
- 239000000203 mixture Substances 0.000 claims description 68
- 230000002209 hydrophobic effect Effects 0.000 claims description 30
- 239000013011 aqueous formulation Substances 0.000 claims description 24
- 239000007864 aqueous solution Substances 0.000 claims description 22
- 238000009472 formulation Methods 0.000 claims description 21
- 229940049706 benzodiazepine Drugs 0.000 claims description 20
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 19
- 230000002441 reversible effect Effects 0.000 claims description 19
- 229940074404 sodium succinate Drugs 0.000 claims description 14
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 7
- 229940074410 trehalose Drugs 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 5
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 5
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 3
- 229940068977 polysorbate 20 Drugs 0.000 claims description 3
- DPVHGFAJLZWDOC-PVXXTIHASA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate Chemical compound O.O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DPVHGFAJLZWDOC-PVXXTIHASA-N 0.000 claims description 2
- 229940074409 trehalose dihydrate Drugs 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 2
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 1
- DOKWDOLZCMETIJ-ZAQUEYBZSA-N (12as)-9-[[3-[[(12as)-8-methoxy-6-oxo-11,12,12a,13-tetrahydroindolo[2,1-c][1,4]benzodiazepin-9-yl]oxymethyl]-5-[2-[2-(2-methoxyethoxy)ethoxy]ethyl-(2-methyl-2-sulfanylpropyl)amino]phenyl]methoxy]-8-methoxy-12a,13-dihydroindolo[2,1-c][1,4]benzodiazepin-6-o Chemical compound N1=C[C@@H]2CC3=CC=CC=C3N2C(=O)C(C=C2OC)=C1C=C2OCC1=CC(N(CC(C)(C)S)CCOCCOCCOC)=CC(COC=2C(=CC=3C(=O)N4C5=CC=CC=C5C[C@H]4CNC=3C=2)OC)=C1 DOKWDOLZCMETIJ-ZAQUEYBZSA-N 0.000 description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical group C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
- 229960000310 isoleucine Drugs 0.000 description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 3
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021075689A JP7157204B2 (ja) | 2015-11-25 | 2021-04-28 | 医薬製剤及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260104P | 2015-11-25 | 2015-11-25 | |
| US62/260,104 | 2015-11-25 | ||
| US201662368156P | 2016-07-28 | 2016-07-28 | |
| US62/368,156 | 2016-07-28 | ||
| PCT/US2016/063624 WO2017091745A1 (en) | 2015-11-25 | 2016-11-23 | Pharmaceutical formulations and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021075689A Division JP7157204B2 (ja) | 2015-11-25 | 2021-04-28 | 医薬製剤及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019501139A JP2019501139A (ja) | 2019-01-17 |
| JP2019501139A5 true JP2019501139A5 (enExample) | 2020-01-09 |
Family
ID=58763708
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527232A Pending JP2019501139A (ja) | 2015-11-25 | 2016-11-23 | 医薬製剤及びその使用 |
| JP2021075689A Active JP7157204B2 (ja) | 2015-11-25 | 2021-04-28 | 医薬製剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021075689A Active JP7157204B2 (ja) | 2015-11-25 | 2021-04-28 | 医薬製剤及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20170189548A1 (enExample) |
| EP (2) | EP3380525B1 (enExample) |
| JP (2) | JP2019501139A (enExample) |
| DK (1) | DK3380525T3 (enExample) |
| ES (1) | ES2970186T3 (enExample) |
| FI (1) | FI3380525T3 (enExample) |
| PT (1) | PT3380525T (enExample) |
| RS (1) | RS65120B1 (enExample) |
| WO (1) | WO2017091745A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017027254A2 (pt) | 2015-06-29 | 2019-05-14 | Immunogen, Inc. | anticorpos anti-cd123 e conjugados e derivados dos mesmos |
| KR20180038460A (ko) * | 2015-07-21 | 2018-04-16 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체의 제조 방법 |
| EP4374850A2 (en) * | 2017-09-22 | 2024-05-29 | ImmunoGen, Inc. | Methods of preventing methionine oxidation in immunoconjugates |
| SG11202104423XA (en) * | 2018-11-12 | 2021-05-28 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN112996792B (zh) * | 2018-11-12 | 2024-04-26 | 伊缪诺金公司 | 制备细胞毒性苯并二氮杂卓衍生物的方法 |
| CN113853217A (zh) | 2019-04-29 | 2021-12-28 | 伊缪诺金公司 | 包含抗cd123免疫缀合物的治疗组合 |
| US20210077632A1 (en) * | 2019-08-15 | 2021-03-18 | Silverback Therapeutics, Inc. | Formulations of Benzazepine Conjugates and Uses Thereof |
| US11179473B2 (en) | 2020-02-21 | 2021-11-23 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| CN116209678A (zh) | 2020-07-01 | 2023-06-02 | 安尔士制药公司 | 抗asgr1抗体缀合物及其用途 |
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| RU2733740C2 (ru) * | 2015-06-29 | 2020-10-06 | Иммуноджен, Инк. | Конъюгаты сконструированных антител с цистеиновыми заменами |
-
2016
- 2016-11-23 DK DK16869289.5T patent/DK3380525T3/da active
- 2016-11-23 PT PT168692895T patent/PT3380525T/pt unknown
- 2016-11-23 EP EP16869289.5A patent/EP3380525B1/en active Active
- 2016-11-23 ES ES16869289T patent/ES2970186T3/es active Active
- 2016-11-23 WO PCT/US2016/063624 patent/WO2017091745A1/en not_active Ceased
- 2016-11-23 US US15/360,689 patent/US20170189548A1/en not_active Abandoned
- 2016-11-23 JP JP2018527232A patent/JP2019501139A/ja active Pending
- 2016-11-23 RS RS20240036A patent/RS65120B1/sr unknown
- 2016-11-23 EP EP23200032.3A patent/EP4335851A3/en not_active Withdrawn
- 2016-11-23 FI FIEP16869289.5T patent/FI3380525T3/fi active
-
2017
- 2017-08-16 US US15/678,421 patent/US20170348427A1/en not_active Abandoned
-
2019
- 2019-11-12 US US16/680,930 patent/US11278628B2/en active Active
-
2021
- 2021-04-28 JP JP2021075689A patent/JP7157204B2/ja active Active
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