JP2019196400A5 - - Google Patents
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- Publication number
- JP2019196400A5 JP2019196400A5 JP2019137587A JP2019137587A JP2019196400A5 JP 2019196400 A5 JP2019196400 A5 JP 2019196400A5 JP 2019137587 A JP2019137587 A JP 2019137587A JP 2019137587 A JP2019137587 A JP 2019137587A JP 2019196400 A5 JP2019196400 A5 JP 2019196400A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- ros
- gene
- ros fusion
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 230000004927 fusion Effects 0.000 claims 16
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 101150042287 ros gene Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 238000003556 assay Methods 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 101150016193 fig gene Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000002853 nucleic acid probe Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 238000002944 PCR assay Methods 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20748409P | 2009-02-12 | 2009-02-12 | |
| US61/207,484 | 2009-02-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113248A Division JP6564500B2 (ja) | 2009-02-12 | 2018-06-14 | ヒト癌における変異ｒｏｓ発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019196400A JP2019196400A (ja) | 2019-11-14 |
| JP2019196400A5 true JP2019196400A5 (OSRAM) | 2020-01-23 |
| JP6797977B2 JP6797977B2 (ja) | 2020-12-09 |
Family
ID=42562298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550275A Active JP5979877B2 (ja) | 2009-02-12 | 2010-02-12 | ヒト癌における変異ｒｏｓ発現 |
| JP2015226709A Active JP6356654B2 (ja) | 2009-02-12 | 2015-11-19 | ヒト癌における変異ｒｏｓ発現 |
| JP2018113248A Active JP6564500B2 (ja) | 2009-02-12 | 2018-06-14 | ヒト癌における変異ｒｏｓ発現 |
| JP2019137587A Active JP6797977B2 (ja) | 2009-02-12 | 2019-07-26 | ヒト癌における変異ｒｏｓ発現 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550275A Active JP5979877B2 (ja) | 2009-02-12 | 2010-02-12 | ヒト癌における変異ｒｏｓ発現 |
| JP2015226709A Active JP6356654B2 (ja) | 2009-02-12 | 2015-11-19 | ヒト癌における変異ｒｏｓ発現 |
| JP2018113248A Active JP6564500B2 (ja) | 2009-02-12 | 2018-06-14 | ヒト癌における変異ｒｏｓ発現 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9364477B2 (OSRAM) |
| EP (3) | EP3266795A1 (OSRAM) |
| JP (4) | JP5979877B2 (OSRAM) |
| AU (1) | AU2010213578B2 (OSRAM) |
| CA (1) | CA2744236C (OSRAM) |
| DK (1) | DK2881402T3 (OSRAM) |
| ES (1) | ES2637174T3 (OSRAM) |
| HK (1) | HK1248259A1 (OSRAM) |
| HU (1) | HUE035769T2 (OSRAM) |
| PL (1) | PL2881402T3 (OSRAM) |
| PT (1) | PT2881402T (OSRAM) |
| SI (1) | SI2881402T1 (OSRAM) |
| WO (1) | WO2010093928A2 (OSRAM) |
Families Citing this family (31)
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| CN105693720B (zh) | 2010-05-20 | 2019-01-18 | 阵列生物制药公司 | 作为trk激酶抑制剂的大环化合物 |
| US20130288240A1 (en) * | 2010-05-21 | 2013-10-31 | Cell Signaling Technology, Inc. | Alk and ros kinase in cancer |
| EP2586862B9 (en) | 2010-06-22 | 2016-07-13 | LSI Medience Corporation | Detection method for novel ros1 fusion product |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
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| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| CA2872645A1 (en) | 2012-05-30 | 2013-12-05 | Nippon Shinyaku Co., Ltd. | Aromatic heterocyclic derivative and pharmaceutical |
| AU2013307383A1 (en) * | 2012-08-27 | 2015-03-26 | Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh | Aminoheteroaryl compounds as MTH1 inhibitors |
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| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| EP3134084B1 (en) | 2014-04-25 | 2021-03-17 | Exelixis, Inc. | Method of treating lung adenocarcinoma |
| TWI746426B (zh) | 2014-11-16 | 2021-11-21 | 美商亞雷生物製藥股份有限公司 | (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型 |
| TN2018000138A1 (en) | 2015-10-26 | 2019-10-04 | Array Biopharma Inc | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| AU2016349644B2 (en) * | 2015-11-06 | 2022-11-24 | Ventana Medical Systems, Inc. | Representative diagnostics |
| HUE068971T2 (hu) | 2016-04-04 | 2025-02-28 | Loxo Oncology Inc | (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid folyékony készítményei |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| SI3458456T1 (sl) | 2016-05-18 | 2021-04-30 | Loxo Oncology, Inc. | Priprava (S)-N-(5-((R)-2-(2,5-difluorofenil) pirolidin-1-il) pirazolo (1,5-A) pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US12159700B2 (en) | 2020-04-22 | 2024-12-03 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
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-
2010
- 2010-02-12 DK DK14184691.5T patent/DK2881402T3/en active
- 2010-02-12 US US13/146,705 patent/US9364477B2/en active Active
- 2010-02-12 HU HUE14184691A patent/HUE035769T2/en unknown
- 2010-02-12 JP JP2011550275A patent/JP5979877B2/ja active Active
- 2010-02-12 CA CA2744236A patent/CA2744236C/en active Active
- 2010-02-12 EP EP17169877.2A patent/EP3266795A1/en not_active Withdrawn
- 2010-02-12 SI SI201031519T patent/SI2881402T1/sl unknown
- 2010-02-12 PL PL14184691T patent/PL2881402T3/pl unknown
- 2010-02-12 EP EP14184691.5A patent/EP2881402B1/en active Active
- 2010-02-12 EP EP10741807.1A patent/EP2396342B1/en active Active
- 2010-02-12 PT PT141846915T patent/PT2881402T/pt unknown
- 2010-02-12 WO PCT/US2010/024109 patent/WO2010093928A2/en not_active Ceased
- 2010-02-12 AU AU2010213578A patent/AU2010213578B2/en active Active
- 2010-02-12 ES ES14184691.5T patent/ES2637174T3/es active Active
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2014
- 2014-09-11 US US14/483,681 patent/US9539254B2/en active Active
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2015
- 2015-11-19 JP JP2015226709A patent/JP6356654B2/ja active Active
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2016
- 2016-11-30 US US15/364,870 patent/US20170071941A1/en not_active Abandoned
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2018
- 2018-06-14 JP JP2018113248A patent/JP6564500B2/ja active Active
- 2018-06-15 HK HK18107825.6A patent/HK1248259A1/en unknown
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2019
- 2019-07-26 JP JP2019137587A patent/JP6797977B2/ja active Active
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