JP2017510244A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017510244A5 JP2017510244A5 JP2016539051A JP2016539051A JP2017510244A5 JP 2017510244 A5 JP2017510244 A5 JP 2017510244A5 JP 2016539051 A JP2016539051 A JP 2016539051A JP 2016539051 A JP2016539051 A JP 2016539051A JP 2017510244 A5 JP2017510244 A5 JP 2017510244A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- less
- polynucleotide
- item
- polynucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims description 99
- 102000040430 polynucleotide Human genes 0.000 claims description 99
- 239000002157 polynucleotide Substances 0.000 claims description 99
- 238000000034 method Methods 0.000 claims description 78
- 230000003321 amplification Effects 0.000 claims description 34
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 34
- 239000000523 sample Substances 0.000 claims description 32
- 238000012163 sequencing technique Methods 0.000 claims description 24
- 239000011541 reaction mixture Substances 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 108020004414 DNA Proteins 0.000 claims description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 4
- 108091035707 Consensus sequence Proteins 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000001124 body fluid Anatomy 0.000 claims description 3
- 239000010839 body fluid Substances 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 238000006073 displacement reaction Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 210000004881 tumor cell Anatomy 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 4
- 102000003960 Ligases Human genes 0.000 description 3
- 108090000364 Ligases Proteins 0.000 description 3
- 102000054767 gene variant Human genes 0.000 description 3
- 230000001364 causal effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012569 microbial contaminant Substances 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914907P | 2013-12-11 | 2013-12-11 | |
| US61/914,907 | 2013-12-11 | ||
| US201461987414P | 2014-05-01 | 2014-05-01 | |
| US61/987,414 | 2014-05-01 | ||
| US201462010975P | 2014-06-11 | 2014-06-11 | |
| US62/010,975 | 2014-06-11 | ||
| PCT/US2014/069848 WO2015089333A1 (en) | 2013-12-11 | 2014-12-11 | Compositions and methods for detecting rare sequence variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510244A JP2017510244A (ja) | 2017-04-13 |
| JP2017510244A5 true JP2017510244A5 (OSRAM) | 2018-01-25 |
| JP6435334B2 JP6435334B2 (ja) | 2018-12-05 |
Family
ID=53371852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539051A Active JP6435334B2 (ja) | 2013-12-11 | 2014-12-11 | 稀な配列変異体を検出するための組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10767222B2 (OSRAM) |
| EP (2) | EP3495506B1 (OSRAM) |
| JP (1) | JP6435334B2 (OSRAM) |
| KR (3) | KR102640585B1 (OSRAM) |
| CN (2) | CN104946737B (OSRAM) |
| AU (3) | AU2014362227B2 (OSRAM) |
| CA (1) | CA2933343A1 (OSRAM) |
| ES (2) | ES2707744T3 (OSRAM) |
| IL (3) | IL300974A (OSRAM) |
| MX (1) | MX376900B (OSRAM) |
| SG (2) | SG10201807532SA (OSRAM) |
| WO (1) | WO2015089333A1 (OSRAM) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| EP1984738A2 (en) | 2006-01-11 | 2008-10-29 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2047910B1 (en) | 2006-05-11 | 2012-01-11 | Raindance Technologies, Inc. | Microfluidic device and method |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| EP2315629B1 (en) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP2318552B1 (en) | 2008-09-05 | 2016-11-23 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| EP3415235B1 (en) | 2009-03-23 | 2025-11-12 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
| WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| JP5986572B2 (ja) | 2010-09-24 | 2016-09-06 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 固定化プライマーを使用した標的ｄｎａの直接的な捕捉、増幅、および配列決定 |
| EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| EP2673614B1 (en) | 2011-02-11 | 2018-08-01 | Raindance Technologies, Inc. | Method for forming mixed droplets |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US9556470B2 (en) | 2011-06-02 | 2017-01-31 | Raindance Technologies, Inc. | Enzyme quantification |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US10691775B2 (en) | 2013-01-17 | 2020-06-23 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
| US9679104B2 (en) | 2013-01-17 | 2017-06-13 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
| GB2523495A (en) | 2013-01-17 | 2015-08-26 | Edico Genome Corp | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
| US10068054B2 (en) | 2013-01-17 | 2018-09-04 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
| US10847251B2 (en) | 2013-01-17 | 2020-11-24 | Illumina, Inc. | Genomic infrastructure for on-site or cloud-based DNA and RNA processing and analysis |
| US9792405B2 (en) | 2013-01-17 | 2017-10-17 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| CN104946737B (zh) | 2013-12-11 | 2019-02-22 | 安可济控股有限公司 | 用于检测罕见序列变体的组合物和方法 |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| US9944977B2 (en) * | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| EP3795697B1 (en) | 2014-02-04 | 2024-09-18 | Jumpcode Genomics, Inc. | Genome fractioning |
| ES2935285T3 (es) | 2014-06-06 | 2023-03-03 | Univ Cornell | Método para identificación y enumeración de cambios en la secuencia de ácidos nucleicos, expresión, copia, o metilación de ADN, usando reacciones combinadas de nucleasa, ligasa, polimerasa y secuenciación |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| EP3224595A4 (en) | 2014-09-24 | 2018-06-13 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| US11987836B2 (en) * | 2014-09-30 | 2024-05-21 | Global Life Sciences Solutions Usa Llc | Method for nucleic acid analysis directly from an unpurified biological sample |
| HK1255431A1 (zh) | 2015-03-23 | 2019-08-16 | Edico Genome Corporation | 用於基因组可视化的方法和系统 |
| TWI728994B (zh) * | 2015-08-12 | 2021-06-01 | 香港中文大學 | 血漿ｄｎａ之單分子定序 |
| GB2541904B (en) * | 2015-09-02 | 2020-09-02 | Oxford Nanopore Tech Ltd | Method of identifying sequence variants using concatenation |
| CN108603190B (zh) | 2015-09-08 | 2023-05-23 | 美国冷泉港实验室 | 使用经破碎的核苷酸的高通量多重测序确定基因拷贝数 |
| AU2016334233B2 (en) | 2015-10-09 | 2023-01-05 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| EP3365335B1 (en) | 2015-10-23 | 2024-02-14 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
| EP3383994A4 (en) * | 2015-12-03 | 2019-08-28 | Accuragen Holdings Limited | METHOD AND COMPOSITIONS FOR FORMING LIGATION PRODUCTS |
| US20170270245A1 (en) | 2016-01-11 | 2017-09-21 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods for performing secondary and/or tertiary processing |
| US10068183B1 (en) | 2017-02-23 | 2018-09-04 | Edico Genome, Corp. | Bioinformatics systems, apparatuses, and methods executed on a quantum processing platform |
| WO2017136720A1 (en) * | 2016-02-05 | 2017-08-10 | Good Start Genetics, Inc. | Variant detection of sequencing assays |
| US9976181B2 (en) | 2016-03-25 | 2018-05-22 | Karius, Inc. | Synthetic nucleic acid spike-ins |
| WO2017190067A1 (en) | 2016-04-28 | 2017-11-02 | Impact Genomics, Inc. | Methods of assessing and monitoring tumor load |
| US10354747B1 (en) * | 2016-05-06 | 2019-07-16 | Verily Life Sciences Llc | Deep learning analysis pipeline for next generation sequencing |
| EP3458586B1 (en) | 2016-05-16 | 2022-12-28 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
| WO2017209891A1 (en) | 2016-05-31 | 2017-12-07 | Quantapore, Inc. | Two-color nanopore sequencing |
| AU2017277929A1 (en) * | 2016-06-10 | 2018-12-13 | Zinfandel Pharmaceuticals, Inc. | Methods for detecting structural variants in neurodegenerative disease |
| US11441169B2 (en) | 2016-06-17 | 2022-09-13 | Ludwig Institute For Cancer Research Ltd | Methods of small-RNA transcriptome sequencing and applications thereof |
| EP3475449B1 (en) * | 2016-06-23 | 2022-08-17 | Accuragen Holdings Limited | Uses of a cell-free nucleic acid standards |
| AU2017290237B2 (en) | 2016-06-30 | 2020-10-22 | GRAIL, Inc | Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library |
| CN107557355A (zh) * | 2016-07-01 | 2018-01-09 | Pgi股份有限公司 | 建构环状模板和检测dna分子的方法 |
| ES2875318T3 (es) | 2016-07-18 | 2021-11-10 | Hoffmann La Roche | Procedimiento para generar colecciones de ADN circular monocatenario para secuenciación de molécula única |
| US10626443B2 (en) * | 2016-08-10 | 2020-04-21 | Grail, Inc. | Methods of analyzing nucleic acid fragments |
| CN106282161B (zh) * | 2016-08-12 | 2020-10-30 | 成都诺恩基因科技有限公司 | 特异捕获并重复复制低频率dna碱基变异的方法及应用 |
| WO2018035170A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| JP6810559B2 (ja) * | 2016-09-09 | 2021-01-06 | 株式会社日立製作所 | 環状型一本鎖核酸、およびその調製方法と使用方法 |
| CN110023504B (zh) * | 2016-09-15 | 2023-05-09 | 阿谢尔德克斯有限责任公司 | 用于分析无细胞dna的核酸样品制备方法 |
| AU2017328950B2 (en) | 2016-09-15 | 2023-09-14 | Archerdx, Llc | Methods of nucleic acid sample preparation |
| WO2018077847A1 (en) * | 2016-10-31 | 2018-05-03 | F. Hoffmann-La Roche Ag | Barcoded circular library construction for identification of chimeric products |
| EP3612642B1 (en) * | 2017-04-17 | 2025-07-09 | GeneFirst Limited | Methods and kits for preparing nucleic acid libraries |
| EP3643787A4 (en) * | 2017-06-20 | 2021-01-06 | MGI Tech Co., Ltd. | PCR PRIMER PAIR AND USE OF IT |
| EP3662480A4 (en) * | 2017-08-04 | 2021-05-19 | BillionToOne, Inc. | MOLECULES ASSOCIATED WITH A TARGET FOR A CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS |
| AU2018342007B2 (en) * | 2017-08-07 | 2025-07-17 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
| US10350307B2 (en) * | 2017-09-18 | 2019-07-16 | General Electric Company | In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides |
| WO2019060722A2 (en) | 2017-09-22 | 2019-03-28 | X Gen Us Co. | METHODS AND COMPOSITIONS FOR USE IN PREPARING POLYNUCLEOTIDES |
| JP7067896B2 (ja) * | 2017-10-27 | 2022-05-16 | シスメックス株式会社 | 品質評価方法、品質評価装置、プログラム、および記録媒体 |
| WO2019086531A1 (en) * | 2017-11-03 | 2019-05-09 | F. Hoffmann-La Roche Ag | Linear consensus sequencing |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| WO2019191900A1 (en) | 2018-04-03 | 2019-10-10 | Burning Rock Biotech | Compositions and methods for preparing nucleic acid libraries |
| CN113383083B (zh) | 2018-04-27 | 2024-12-10 | 赛纳生物科技(北京)有限公司 | 用于制备多核苷酸的方法和组合物 |
| CN112534063A (zh) | 2018-05-22 | 2021-03-19 | 安序源有限公司 | 用于核酸测序的方法、系统和组合物 |
| WO2019241290A1 (en) * | 2018-06-12 | 2019-12-19 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| CN112654713A (zh) * | 2018-07-05 | 2021-04-13 | 安可济控股有限公司 | 用于数字聚合酶链反应的组合物和方法 |
| SG11202100564PA (en) * | 2018-07-23 | 2021-02-25 | Univ Hong Kong Chinese | Cell-free dna damage analysis and its clinical applications |
| CN110872632A (zh) * | 2018-08-30 | 2020-03-10 | 深圳华大生命科学研究院 | 咽颊炎链球菌的特异基因序列、其检测引物及其应用 |
| CA3118990A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| WO2020131923A1 (en) * | 2018-12-17 | 2020-06-25 | uBiome, Inc. | Automatic standardization pipeline for data analysis |
| EP3898626A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| EP3898615A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| CN113728116A (zh) * | 2019-02-22 | 2021-11-30 | 安可济控股有限公司 | 用于早期癌症检测的方法和组合物 |
| US11512346B2 (en) * | 2019-03-14 | 2022-11-29 | Genome Research Limited | Method for sequencing a direct repeat |
| EP4017620B1 (en) * | 2019-08-21 | 2024-05-01 | Life Technologies Corporation | System and method for sequencing |
| CA3154235A1 (en) * | 2019-09-13 | 2021-03-18 | University Health Network | Detection of circulating tumor dna using double stranded hybrid capture |
| EP3798319A1 (en) | 2019-09-30 | 2021-03-31 | Diagenode S.A. | An improved diagnostic and/or sequencing method and kit |
| EP3828283A1 (en) * | 2019-11-28 | 2021-06-02 | Diagenode S.A. | An improved sequencing method and kit |
| CA3158739A1 (en) * | 2019-11-19 | 2021-05-27 | Xiao Bing Wang | Method for identifying gene fusions by circle cdna amplification |
| US20240279735A1 (en) * | 2019-12-20 | 2024-08-22 | Korea University Research And Business Foundation | Primers for detecting trace amount of rare single- nucleotide variant and method for specifically and sensitively detecting trace amount of rare single-nucleotide variant by using same |
| US20230115945A1 (en) | 2019-12-30 | 2023-04-13 | Tyra Biosciences, Inc. | Aminopyrimidine compounds |
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
| AU2020423361B2 (en) * | 2020-01-17 | 2024-08-29 | Mgi Tech Co., Ltd. | Method for synchronously sequencing sense strand and antisense strand of DNA |
| CA3182741A1 (en) * | 2020-06-15 | 2021-12-23 | Aziz AL'KHAFAJI | Chimeric amplicon array sequencing |
| WO2022018055A1 (en) * | 2020-07-20 | 2022-01-27 | Westfälische Wilhelms-Universität Münster | Circulation method to sequence immune repertoires of individual cells |
| WO2022087485A1 (en) * | 2020-10-22 | 2022-04-28 | Singular Genomics Systems, Inc. | Nucleic acid circularization and amplification on a surface |
| MX2023007793A (es) | 2020-12-30 | 2023-09-22 | Tyra Biosciences Inc | Compuestos de indazol como inhibidores de cinasas. |
| CN115956129A (zh) * | 2021-02-03 | 2023-04-11 | 国立大学法人东北大学 | 遗传信息分析系统和遗传信息分析方法 |
| EP4047100A1 (en) * | 2021-02-18 | 2022-08-24 | Miltenyi Biotec B.V. & Co. KG | Ngs targeted dna panel using multiplex selective rca |
| MX2023009954A (es) | 2021-02-26 | 2023-11-09 | Tyra Biosciences Inc | Compuestos de aminopirimidina y métodos de uso de estos. |
| US20250188505A1 (en) * | 2021-03-26 | 2025-06-12 | Flagship Pioneering Innovations Vii, Llc | Production of circular polyribonucleotides in a prokaryotic system |
| EP4314281A1 (en) * | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Production of circular polyribonucleotides in a eukaryotic system |
| AR125217A1 (es) * | 2021-03-26 | 2023-06-28 | Flagship Pioneering Innovations Vii Llc | Producción de polirribonucleótidos circulares en un sistema procariota |
| EP4314325A4 (en) * | 2021-03-31 | 2025-03-05 | Jumpcode Genomics, Inc. | Methods for targeted nucleic acid sequencing |
| CN113549674B (zh) * | 2021-04-22 | 2023-11-03 | 福建和瑞基因科技有限公司 | 一种检测样本中目标序列整合和突变的方法及其引物的设计方法和试剂盒 |
| WO2023055752A2 (en) | 2021-09-28 | 2023-04-06 | Axbio Inc. | Methods for processing a nucleic acid sample and compositions thereof |
| US12431218B2 (en) | 2022-03-08 | 2025-09-30 | Illumina, Inc. | Multi-pass software-accelerated genomic read mapping engine |
| WO2024006897A1 (en) | 2022-06-29 | 2024-01-04 | Tyra Biosciences, Inc. | Indazole compounds |
| EP4547670A1 (en) | 2022-06-29 | 2025-05-07 | Tyra Biosciences, Inc. | Polymorphic compounds and uses thereof |
| US20240068010A1 (en) * | 2022-08-31 | 2024-02-29 | Genomill Health Oy | Highly sensitive methods for accurate parallel quantification of variant nucleic acids |
| WO2024138112A1 (en) | 2022-12-22 | 2024-06-27 | Tyra Biosciences, Inc. | Indazole compounds |
| WO2025129014A1 (en) | 2023-12-15 | 2025-06-19 | Tyra Biosciences, Inc. | Indazole compounds for the treatment of cancer |
| WO2025132779A2 (en) | 2023-12-22 | 2025-06-26 | F. Hoffmann-La Roche Ag | Methods and compositions for nucleic acid library and template preparation for duplexed sequencing by expansion |
| WO2025222097A1 (en) | 2024-04-19 | 2025-10-23 | Tyra Biosciences, Inc. | Indazole-based protac degraders and their anticancer activity |
Family Cites Families (167)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US5310652A (en) | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| US6677312B1 (en) | 1989-03-29 | 2004-01-13 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5362623A (en) | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| DE69032864T3 (de) | 1989-03-29 | 2013-01-31 | The Johns Hopkins University | Nachweis des Ausfalls des Wildtyps des p53-Gens |
| US6800617B1 (en) | 1989-03-29 | 2004-10-05 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| DE69028257T2 (de) | 1989-07-11 | 1997-01-09 | Gen Probe Inc | Verfahren zur Vervielfältigung von Nukleinsäuresequenzen |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5527670A (en) | 1990-09-12 | 1996-06-18 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
| CA2100472C (en) | 1991-01-16 | 2009-04-07 | Kenneth W. Kinzler | Inherited and somatic mutations of apc gene in colerectal cancer of humans |
| US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5330892A (en) | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US7326778B1 (en) | 1993-05-05 | 2008-02-05 | The John Hopkins University | Mutator gene and hereditary non-polyposis colorectal cancer |
| US5492808A (en) | 1993-05-05 | 1996-02-20 | The Johns Hopkins University | Means for detecting familial colon cancer (FCC) |
| US5591826A (en) | 1993-05-05 | 1997-01-07 | The Johns Hopkins University | Human MSH2 protein |
| EP0702728B1 (en) | 1993-06-09 | 1998-04-15 | Gamera Bioscience Corporation | Magnetic cycle reaction |
| WO1995013375A1 (en) | 1993-11-10 | 1995-05-18 | The Johns Hopkins University | Tumor suppressor waf1 |
| WO1995015381A2 (en) | 1993-12-02 | 1995-06-08 | The Johns Hopkins University | HUMAN MUTATOR GENE hMSH2 AND HEREDITARY NON POLYPOSIS COLORECTAL CANCER |
| US6482606B1 (en) | 1994-01-27 | 2002-11-19 | Human Genome Sciences, Inc. | Human DNA mismatch repair polynucleotides |
| US6380369B1 (en) | 1994-01-27 | 2002-04-30 | Human Genome Sciences, Inc. | Human DNA mismatch repair proteins |
| EP0749496A4 (en) | 1994-01-27 | 1999-03-03 | Human Genome Sciences Inc | HUMAN DNA MALFUNCTION REPAIR PROTEINS |
| JPH09510107A (ja) | 1994-03-15 | 1997-10-14 | サイエンティフィック ジェネリクス リミテッド | 二本鎖核酸の電気化学的変性 |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| US6593086B2 (en) | 1996-05-20 | 2003-07-15 | Mount Sinai School Of Medicine Of New York University | Nucleic acid amplification methods |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5705628A (en) | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| US5648245A (en) | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
| US5705365A (en) | 1995-06-07 | 1998-01-06 | Gen-Probe Incorporated | Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5710029A (en) | 1995-06-07 | 1998-01-20 | Gen-Probe Incorporated | Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| DE69612013T2 (de) | 1995-11-21 | 2001-08-02 | Yale University, New Haven | Unimolekulare segmentamplifikation und bestimmung |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6156504A (en) | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
| US8048629B2 (en) | 1996-03-15 | 2011-11-01 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum |
| US6511805B1 (en) | 1996-03-15 | 2003-01-28 | The Penn State Research Foundation | Methods for detecting papillomavirus DNA in blood plasma and serum |
| PT938320E (pt) | 1996-03-26 | 2010-09-22 | Michael S Kopreski | Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro |
| US5939291A (en) | 1996-06-14 | 1999-08-17 | Sarnoff Corporation | Microfluidic method for nucleic acid amplification |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| WO1998044151A1 (en) | 1997-04-01 | 1998-10-08 | Glaxo Group Limited | Method of nucleic acid amplification |
| GB9706654D0 (en) | 1997-04-02 | 1997-05-21 | Scient Generics Ltd | Disassociation of interacting molecules |
| EP0917590A1 (en) | 1997-04-04 | 1999-05-26 | Innogenetics N.V. | Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions |
| WO1999053102A1 (en) | 1998-04-16 | 1999-10-21 | Packard Bioscience Company | Analysis of polynucleotide sequence |
| DE69940623D1 (de) | 1998-11-09 | 2009-04-30 | Eiken Chemical | Prozess zur Synthetisierung von Nukleinsäure |
| GB9903906D0 (en) | 1999-02-19 | 1999-04-14 | Microbiological Res Authority | Method and apparatus for nucleic acid strand separation |
| WO2000055369A1 (en) | 1999-03-17 | 2000-09-21 | The Board Of Trustees Of The Leland Stanford Junior University | Mismatch repair detection |
| JP2002541799A (ja) * | 1999-04-12 | 2002-12-10 | ジェネンテック・インコーポレーテッド | Ｐｃｒによるクローニング方法 |
| US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| WO2001018230A1 (en) | 1999-09-08 | 2001-03-15 | University Of Victoria Innovation & Development Corporation | Use of psychrotrophic bacterium in biotechnology applications |
| NZ517121A (en) | 1999-09-13 | 2004-05-28 | Nugen Technologies Inc | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| AU783841B2 (en) * | 1999-11-26 | 2005-12-15 | 454 Life Sciences Corporation | Nucleic acid probe arrays |
| US6653079B2 (en) | 2000-03-13 | 2003-11-25 | Freshgene, Inc. | Methods for detection of differences in nucleic acids |
| US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
| US6626906B1 (en) | 2000-10-23 | 2003-09-30 | Sdgi Holdings, Inc. | Multi-planar adjustable connector |
| US7001724B1 (en) | 2000-11-28 | 2006-02-21 | Applera Corporation | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases |
| US20040067511A1 (en) | 2001-02-27 | 2004-04-08 | Thomas David C. | Circular probe amplification (cpa) using energy-transfer primers |
| BR0205268A (pt) | 2001-03-09 | 2004-11-30 | Nugen Technologies Inc | Processos e composições para a mplificação de sequências de rna |
| US7122715B2 (en) | 2001-09-20 | 2006-10-17 | Monsanto Technology Llc | In vitro method to create circular molecules for use in transformation |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US20110151438A9 (en) | 2001-11-19 | 2011-06-23 | Affymetrix, Inc. | Methods of Analysis of Methylation |
| US7553619B2 (en) | 2002-02-08 | 2009-06-30 | Qiagen Gmbh | Detection method using dissociated rolling circle amplification |
| US6815167B2 (en) | 2002-04-25 | 2004-11-09 | Geneohm Sciences | Amplification of DNA to produce single-stranded product of defined sequence and length |
| WO2004027025A2 (en) | 2002-09-20 | 2004-04-01 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| CA2505472A1 (en) | 2002-11-11 | 2004-05-27 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| US7309571B2 (en) | 2003-02-03 | 2007-12-18 | Ge Healthcare Bio-Sciences Corp. | Amplification of self-ligated, circularized cDNA for expression profiling |
| WO2005059157A2 (en) | 2003-12-11 | 2005-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | METHODS AND COMPOSITIONS FOR USE IN PREPARING HAIRPIN RNAs |
| JP2007525571A (ja) | 2004-01-07 | 2007-09-06 | ソレクサ リミテッド | 修飾分子アレイ |
| JP2007526772A (ja) | 2004-02-27 | 2007-09-20 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | インサイチュー配列決定用ポロニー蛍光ビーズ |
| WO2005095654A1 (en) | 2004-03-25 | 2005-10-13 | Biohelix Corporation | Helicase-dependent amplification of circular nucleic acids |
| WO2005113824A2 (en) | 2004-05-14 | 2005-12-01 | Zhenghe Wang | Protein tyrosine phosphatase mutations in cancers |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| US8916351B2 (en) | 2005-01-04 | 2014-12-23 | Hitachi Chemical Co., Ltd. | Primer generation rolling circle amplification |
| WO2006084051A2 (en) | 2005-02-01 | 2006-08-10 | John Wayne Cancer Institute | Use of id4 for diagnosis and treatment of cancer |
| WO2006087574A2 (en) | 2005-02-19 | 2006-08-24 | Geneform Technologies Limited | Isothermal nucleic acid amplification |
| EP1712639B1 (en) | 2005-04-06 | 2008-08-27 | Maurice Stroun | Method for the diagnosis of cancer by detecting circulating DNA and RNA |
| US9139849B2 (en) | 2005-04-08 | 2015-09-22 | The United States of America as Represented by the Government of the Department of Health and Human Services | Rapid generation of long synthetic centromeric tandem repeats for mammalian artificial chromosome formation |
| CA2604095A1 (en) * | 2005-04-12 | 2006-10-19 | 454 Life Sciences Corporation | Methods for determining sequence variants using ultra-deep sequencing |
| US20060228721A1 (en) * | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| JP5331476B2 (ja) | 2005-06-15 | 2013-10-30 | カリダ・ジェノミックス・インコーポレイテッド | 遺伝子解析および化学解析用の単分子アレイ |
| WO2007024653A2 (en) | 2005-08-19 | 2007-03-01 | Bioventures, Inc. | Method and substances for isolating micro rnas |
| AU2007249635B2 (en) * | 2005-10-07 | 2012-05-31 | Complete Genomics, Inc. | High throughput genome sequencing on DNA arrays |
| AU2006320739B2 (en) | 2005-11-28 | 2012-03-29 | Pacific Biosciences Of California, Inc. | Uniform surfaces for hybrid material substrates and methods for making and using same |
| US7537897B2 (en) | 2006-01-23 | 2009-05-26 | Population Genetics Technologies, Ltd. | Molecular counting |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| WO2007117832A2 (en) | 2006-03-12 | 2007-10-18 | Applera Corporation | Methods of detecting target nucleic acids |
| WO2007133703A2 (en) | 2006-05-10 | 2007-11-22 | Dxterity Diagnostics | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
| US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| EP3617321B1 (en) | 2006-05-31 | 2024-10-23 | Sequenom, Inc. | Kit for the extraction and amplification of nucleic acid from a sample |
| US7910354B2 (en) | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
| AU2007203390B2 (en) | 2007-04-26 | 2012-10-04 | Yew Jin Fong | Improved lace fastener |
| FR2924440B1 (fr) | 2007-12-04 | 2015-01-09 | Pf Medicament | Nouveau procede de generation et de criblage d'une banque d'anticorps |
| ES2805347T3 (es) * | 2009-02-11 | 2021-02-11 | Caris Mpi Inc | Perfilado molecular de tumores |
| CA2751470C (en) | 2009-02-16 | 2016-07-26 | Epicentre Technologies Corporation | Template-independent ligation of single-stranded dna |
| WO2010117817A2 (en) | 2009-03-30 | 2010-10-14 | Life Technologies Corporation | Methods for generating target specific probes for solution based capture |
| WO2010115100A1 (en) * | 2009-04-03 | 2010-10-07 | L&C Diagment, Inc. | Multiplex nucleic acid detection methods and systems |
| US8962253B2 (en) * | 2009-04-13 | 2015-02-24 | Somagenics Inc. | Methods and compositions for detection of small RNAs |
| GB0910302D0 (en) | 2009-06-15 | 2009-07-29 | Lumora Ltd | Nucleic acid amplification |
| US20110237444A1 (en) | 2009-11-20 | 2011-09-29 | Life Technologies Corporation | Methods of mapping genomic methylation patterns |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9315857B2 (en) * | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8801578B2 (en) | 2009-12-21 | 2014-08-12 | Core Industries, Llc | Instructional displays and methods for exercise machine |
| MX2012007305A (es) * | 2009-12-22 | 2012-07-04 | Procter & Gamble | Composicion liquida de limpieza y/o lavado. |
| WO2011120046A2 (en) | 2010-03-26 | 2011-09-29 | Swift Biosciences, Inc. | Methods and compositions for isolating polynucleotides |
| CN101935697B (zh) * | 2010-04-16 | 2015-11-25 | 中生方政生物技术有限公司 | 用于核酸序列检测的方法和试剂盒 |
| EP2585593B1 (en) | 2010-06-24 | 2017-03-01 | Population Genetics Technologies Ltd. | Methods for polynucleotide library production, immortalization and region of interest extraction |
| WO2012006291A2 (en) | 2010-07-06 | 2012-01-12 | Life Technologies Corporation | Systems and methods to detect copy number variation |
| CN102971434B (zh) | 2010-08-11 | 2014-04-09 | 中国科学院心理研究所 | 一种甲基化dna的高通量测序方法及其应用 |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| CN101985654A (zh) * | 2010-10-21 | 2011-03-16 | 徐州医学院 | 检测多样本多位点snp的检测方法 |
| US9260753B2 (en) * | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| CN110016499B (zh) | 2011-04-15 | 2023-11-14 | 约翰·霍普金斯大学 | 安全测序系统 |
| US9670527B2 (en) | 2011-06-29 | 2017-06-06 | The Johns Hopkins University | Enrichment of nucleic acids by complimentary capture |
| EP2740804A4 (en) | 2011-08-05 | 2015-06-24 | Toshiba Kk | PROCESS FOR NUCLEIC ACID ANALYSIS |
| US9586987B2 (en) | 2011-09-08 | 2017-03-07 | Kabushiki Kaisha Dnaform | Primer set for isothermal amplication of a target nucleic acid sequence |
| WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
| WO2013074632A1 (en) | 2011-11-14 | 2013-05-23 | Rose Floyd D | Mismatch nucleotide purification and identification |
| US20130217023A1 (en) * | 2012-02-22 | 2013-08-22 | 454 Life Sciences Corporation | System And Method For Generation And Use Of Compact Clonally Amplified Products |
| PT2828218T (pt) | 2012-03-20 | 2020-11-11 | Univ Washington Through Its Center For Commercialization | Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| EP2855707B1 (en) | 2012-05-31 | 2017-07-12 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of dna |
| US10538807B2 (en) | 2012-06-01 | 2020-01-21 | Fred Hutchinson Cancer Research Center | Compositions and methods for detecting rare nucleic acid molecule mutations |
| CA2875666A1 (en) | 2012-06-14 | 2013-12-19 | Fred Hutchinson Cancer Research Center | Compositions and methods for sensitive mutation detection in nucleic acid molecules |
| US9540687B2 (en) | 2012-07-11 | 2017-01-10 | Berry Genomics Co., Ltd. | DNA fragment detection method, DNA fragment detection kit and the use thereof |
| US9092401B2 (en) | 2012-10-31 | 2015-07-28 | Counsyl, Inc. | System and methods for detecting genetic variation |
| AU2013292610B2 (en) | 2012-07-17 | 2018-05-17 | Myriad Women's Health, Inc. | System and methods for detecting genetic variation |
| EP2877594B1 (en) | 2012-07-20 | 2019-12-04 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
| US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP2914753A4 (en) | 2012-10-31 | 2016-06-08 | Becton Dickinson Co | SELECTIVE AMPLIFICATION AND REAL-TIME PCR DETECTION OF RARE MUTATIONS |
| US10980804B2 (en) | 2013-01-18 | 2021-04-20 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| EP3550033B1 (en) | 2013-02-20 | 2021-10-20 | Emory University | Compositions for sequencing nucleic acids in mixtures |
| EP2971097B1 (en) | 2013-03-15 | 2018-08-01 | Verinata Health, Inc | Generating cell-free dna libraries directly from blood |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| CN105518151B (zh) | 2013-03-15 | 2021-05-25 | 莱兰斯坦福初级大学评议会 | 循环核酸肿瘤标志物的鉴别和用途 |
| US10081825B2 (en) | 2013-03-15 | 2018-09-25 | Aegea Biotechnologies, Inc. | Methods for amplification of nucleic acids utilizing a circularized template prepared from a target nucleic acid |
| US20150033372A1 (en) | 2013-05-01 | 2015-01-29 | Kymab Limited | Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates |
| US9644232B2 (en) | 2013-07-26 | 2017-05-09 | General Electric Company | Method and device for collection and amplification of circulating nucleic acids |
| US9217167B2 (en) | 2013-07-26 | 2015-12-22 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| WO2015048535A1 (en) | 2013-09-27 | 2015-04-02 | Natera, Inc. | Prenatal diagnostic resting standards |
| EP3760733A1 (en) | 2013-10-17 | 2021-01-06 | Takara Bio USA, Inc. | Methods for adding adapters to nucleic acids and compositions for practicing the same |
| KR20240038168A (ko) | 2013-11-07 | 2024-03-22 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 |
| GB201321123D0 (en) | 2013-11-29 | 2014-01-15 | Linea Ab Q | Amplification of circular molecules |
| US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| CN104946737B (zh) | 2013-12-11 | 2019-02-22 | 安可济控股有限公司 | 用于检测罕见序列变体的组合物和方法 |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| CN111534580B (zh) | 2013-12-28 | 2024-06-04 | 夸登特健康公司 | 用于检测遗传变异的方法和系统 |
| CN104745679B (zh) | 2013-12-31 | 2018-06-15 | 杭州贝瑞和康基因诊断技术有限公司 | 一种无创检测egfr基因突变的方法及试剂盒 |
| EP3099796B1 (en) | 2014-01-31 | 2018-08-29 | Swift Biosciences, Inc. | Improved methods for processing dna substrates |
| ES2935285T3 (es) | 2014-06-06 | 2023-03-03 | Univ Cornell | Método para identificación y enumeración de cambios en la secuencia de ácidos nucleicos, expresión, copia, o metilación de ADN, usando reacciones combinadas de nucleasa, ligasa, polimerasa y secuenciación |
| CA3172086A1 (en) | 2014-06-13 | 2015-12-17 | Illumina Cambridge Limited | Methods and compositions for preparing sequencing libraries |
| US10364458B2 (en) | 2014-07-16 | 2019-07-30 | Tangen Biosciences, Inc. | Isothermal methods for amplifying nucleic acid samples |
| US11987836B2 (en) | 2014-09-30 | 2024-05-21 | Global Life Sciences Solutions Usa Llc | Method for nucleic acid analysis directly from an unpurified biological sample |
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| AU2016334233B2 (en) | 2015-10-09 | 2023-01-05 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| EP3383994A4 (en) | 2015-12-03 | 2019-08-28 | Accuragen Holdings Limited | METHOD AND COMPOSITIONS FOR FORMING LIGATION PRODUCTS |
| EP3458586B1 (en) | 2016-05-16 | 2022-12-28 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
| US10370701B2 (en) | 2016-06-17 | 2019-08-06 | Pacific Biosciences Of California, Inc. | Methods and compositions for generating asymmetrically-tagged nucleic acid fragments |
| EP3475449B1 (en) | 2016-06-23 | 2022-08-17 | Accuragen Holdings Limited | Uses of a cell-free nucleic acid standards |
| WO2018035170A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
-
2014
- 2014-12-11 CN CN201410765164.3A patent/CN104946737B/zh not_active Expired - Fee Related
- 2014-12-11 JP JP2016539051A patent/JP6435334B2/ja active Active
- 2014-12-11 CA CA2933343A patent/CA2933343A1/en active Pending
- 2014-12-11 ES ES14868836T patent/ES2707744T3/es active Active
- 2014-12-11 EP EP18202891.0A patent/EP3495506B1/en active Active
- 2014-12-11 IL IL300974A patent/IL300974A/en unknown
- 2014-12-11 KR KR1020227009793A patent/KR102640585B1/ko active Active
- 2014-12-11 AU AU2014362227A patent/AU2014362227B2/en not_active Ceased
- 2014-12-11 US US15/102,241 patent/US10767222B2/en active Active
- 2014-12-11 SG SG10201807532SA patent/SG10201807532SA/en unknown
- 2014-12-11 SG SG11201604737VA patent/SG11201604737VA/en unknown
- 2014-12-11 IL IL274464A patent/IL274464B2/en unknown
- 2014-12-11 WO PCT/US2014/069848 patent/WO2015089333A1/en not_active Ceased
- 2014-12-11 ES ES18202891T patent/ES2960338T3/es active Active
- 2014-12-11 MX MX2016007605A patent/MX376900B/es active IP Right Grant
- 2014-12-11 KR KR1020247005806A patent/KR20240025725A/ko active Pending
- 2014-12-11 CN CN201910068812.2A patent/CN109706222A/zh active Pending
- 2014-12-11 KR KR1020167018274A patent/KR102379877B1/ko active Active
- 2014-12-11 EP EP14868836.9A patent/EP3080298B1/en active Active
-
2016
- 2016-06-05 IL IL246021A patent/IL246021B/en active IP Right Grant
-
2020
- 2020-07-31 US US16/945,553 patent/US11597973B2/en active Active
-
2021
- 2021-07-22 AU AU2021206868A patent/AU2021206868B2/en not_active Ceased
-
2023
- 2023-02-03 US US18/164,439 patent/US12234512B2/en active Active
-
2024
- 2024-02-22 AU AU2024201195A patent/AU2024201195A1/en not_active Abandoned
-
2025
- 2025-01-16 US US19/026,027 patent/US20250290136A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017510244A5 (OSRAM) | ||
| US20240229105A1 (en) | Attenuators | |
| US11293048B2 (en) | Attenuators | |
| JP2019196400A5 (OSRAM) | ||
| US20200354773A1 (en) | High multiplex pcr with molecular barcoding | |
| JP6525473B2 (ja) | 複製物配列決定リードを同定するための組成物および方法 | |
| JP2018524993A5 (OSRAM) | ||
| JP2017526353A (ja) | 標的化されたシークエンシングからのデジタル測定値 | |
| JP7539770B2 (ja) | ゲノム再編成検出のための配列決定方法 | |
| CN107075566B (zh) | 用于制备核酸的等温方法及相关组合物 | |
| JP2016521548A5 (OSRAM) | ||
| JP2012514451A5 (OSRAM) | ||
| WO2013021841A1 (ja) | 核酸解析法 | |
| JP2015500012A (ja) | 組成物中のｒｎａを特徴づける方法およびキット | |
| US10801056B2 (en) | Kit and method for detection of microRNA | |
| JP2018507706A (ja) | Ｐｃｒ方法 | |
| JP7134186B2 (ja) | Ｒｎａおよびｄｎａからの核酸ライブラリーの作製 | |
| EP4010493B1 (en) | Methods for the multiplexed isothermal amplification of nucleic acid sequences | |
| JP6837073B2 (ja) | プライマー伸長中のプライマー−プライマー相互作用の排除 | |
| CN107109478B (zh) | 获得配对末端测序信息的方法 | |
| EP4092136B1 (en) | Capture probes and uses thereof | |
| JP2014516545A5 (OSRAM) | ||
| CN110846395A (zh) | 一种检测肺动脉高压病的kcnk3基因探针组及其应用 | |
| WO2025109116A1 (en) | Method for the generation of a cdna library from an rna sample | |
| JP2025003961A (ja) | マウス腫瘍モデルにおける免疫応答を評価するための方法および組成物 |