JP2016521548A5 - - Google Patents

Info

Publication number

JP2016521548A5

JP2016521548A5 JP2016515077A JP2016515077A JP2016521548A5 JP 2016521548 A5 JP2016521548 A5 JP 2016521548A5 JP 2016515077 A JP2016515077 A JP 2016515077A JP 2016515077 A JP2016515077 A JP 2016515077A JP 2016521548 A5 JP2016521548 A5 JP 2016521548A5

Authority

JP

Japan

Prior art keywords

sequence

abundance

primer

telomere

short

Prior art date

2014-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 36
• 108091035539 telomere Proteins 0.000 claims 27
• 102000055501 telomere Human genes 0.000 claims 27
• 210000003411 telomere Anatomy 0.000 claims 27
• 108091081400 Subtelomere Proteins 0.000 claims 9
• 230000003321 amplification Effects 0.000 claims 9
• 239000013611 chromosomal DNA Substances 0.000 claims 9
• 201000010099 disease Diseases 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
• 238000003199 nucleic acid amplification method Methods 0.000 claims 9
• 238000000137 annealing Methods 0.000 claims 7
• 239000000523 sample Substances 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 4
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 210000000349 chromosome Anatomy 0.000 claims 3
• 238000005259 measurement Methods 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 238000011529 RT qPCR Methods 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 108091023043 Alu Element Proteins 0.000 claims 1
• 101000899111 Homo sapiens Hemoglobin subunit beta Proteins 0.000 claims 1
• 238000002105 Southern blotting Methods 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 230000002759 chromosomal effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 239000013068 control sample Substances 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 238000007847 digital PCR Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 238000004393 prognosis Methods 0.000 claims 1
• 238000011002 quantification Methods 0.000 claims 1
• 239000013074 reference sample Substances 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 102000053632 repetitive DNA sequence Human genes 0.000 claims 1
• 108091035233 repetitive DNA sequence Proteins 0.000 claims 1
• 230000004043 responsiveness Effects 0.000 claims 1
• 238000012163 sequencing technique Methods 0.000 claims 1