BR112017014116A2 - pcr quantitativo multiplex - Google Patents
pcr quantitativo multiplexInfo
- Publication number
- BR112017014116A2 BR112017014116A2 BR112017014116A BR112017014116A BR112017014116A2 BR 112017014116 A2 BR112017014116 A2 BR 112017014116A2 BR 112017014116 A BR112017014116 A BR 112017014116A BR 112017014116 A BR112017014116 A BR 112017014116A BR 112017014116 A2 BR112017014116 A2 BR 112017014116A2
- Authority
- BR
- Brazil
- Prior art keywords
- target nucleic
- nucleic acid
- average
- compositions
- abundance
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
são descritos métodos e composições para determinar o comprimento ou a abundância média de um primeiro nucleico alvo calculando-se a abundância de um primeiro ácido nucleico alvo (t) em relação à abundância média (s) de um segundo e um terceiro ácido nucleico alvo, em um único poço, utilizando-se uma etiqueta de detecção separada para cada ácido nucleico alvo. em vários aspectos, o primeiro ácido nucleico alvo é um telômero. em aspectos exemplificativos, os métodos e composições divulgados podem ser utilizados para determinar o comprimento médio de telômero em uma amostra biológica. o comprimento médio de telômero determinado utilizando os métodos e composições divulgados pode ser correlacionado com uma variedade de condições e índices clinicamente importantes. este resumo é concebido como uma ferramenta de verificação para fins de pesquisa na técnica específica e não é destinado a ser um fator limitante da presente invenção.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462098057P | 2014-12-30 | 2014-12-30 | |
US201562163434P | 2015-05-19 | 2015-05-19 | |
PCT/US2015/036991 WO2016108954A1 (en) | 2014-12-30 | 2015-06-22 | Multiplex quantitative pcr |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017014116A2 true BR112017014116A2 (pt) | 2018-03-06 |
Family
ID=56163505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017014116A BR112017014116A2 (pt) | 2014-12-30 | 2015-06-22 | pcr quantitativo multiplex |
Country Status (9)
Country | Link |
---|---|
US (2) | US9944978B2 (pt) |
EP (1) | EP3240910B1 (pt) |
JP (1) | JP2018501799A (pt) |
CN (1) | CN107208145A (pt) |
AU (1) | AU2015372584A1 (pt) |
BR (1) | BR112017014116A2 (pt) |
CA (1) | CA2971169A1 (pt) |
MX (1) | MX2017008553A (pt) |
WO (1) | WO2016108954A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1585974B1 (en) | 2003-01-24 | 2013-02-27 | University of Utah | Methods of predicting mortality risk by determining telomere length |
CN107083444B (zh) | 2008-12-22 | 2023-03-14 | 犹他大学研究基金会 | 单色多重定量pcr |
ES2762860T3 (es) | 2013-05-22 | 2020-05-26 | Telomere Diagnostics Inc | Medidas de abundancia de telómeros cortos |
US10580077B1 (en) * | 2015-03-02 | 2020-03-03 | Longevity Quest, Inc. | System and method for providing a lifespan expectation to an insurance applicant |
CN107022607B (zh) * | 2017-03-16 | 2019-01-22 | 北京博奥晶典生物技术有限公司 | 通过碱基错配解决多重pcr时等位基因扩增不平衡的方法 |
EP3728645A4 (en) * | 2017-12-22 | 2021-09-08 | Gutfeeling Labs AB | HEALTH STATE ANALYSIS PROCESS |
CA3088250A1 (en) * | 2018-01-22 | 2019-07-25 | Luminex Corporation | Methods and compositions for discrete melt analysis |
CN112029841B (zh) | 2019-06-03 | 2024-02-09 | 香港中文大学 | 定量端粒长度和基因组基序的方法 |
CN111041073B (zh) * | 2019-12-31 | 2023-04-11 | 南昌五元生物科技有限公司 | 一种端粒长度的高通量检测方法 |
CN111705114B (zh) * | 2020-06-11 | 2023-08-15 | 湖南圣洲生物科技有限公司 | 基于实时数字pcr检测人端粒绝对长度的方法及试剂盒 |
CN111996242A (zh) * | 2020-08-21 | 2020-11-27 | 山东端泉健康科技有限公司 | 精子端粒长度测量试剂盒与应用 |
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-
2015
- 2015-06-22 JP JP2017534714A patent/JP2018501799A/ja active Pending
- 2015-06-22 MX MX2017008553A patent/MX2017008553A/es unknown
- 2015-06-22 CN CN201580073932.1A patent/CN107208145A/zh active Pending
- 2015-06-22 CA CA2971169A patent/CA2971169A1/en not_active Abandoned
- 2015-06-22 BR BR112017014116A patent/BR112017014116A2/pt not_active IP Right Cessation
- 2015-06-22 US US14/746,437 patent/US9944978B2/en not_active Expired - Fee Related
- 2015-06-22 WO PCT/US2015/036991 patent/WO2016108954A1/en active Application Filing
- 2015-06-22 AU AU2015372584A patent/AU2015372584A1/en not_active Abandoned
- 2015-06-22 EP EP15875839.1A patent/EP3240910B1/en active Active
-
2018
- 2018-04-16 US US15/954,441 patent/US20180237843A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2017008553A (es) | 2018-03-14 |
CA2971169A1 (en) | 2016-07-07 |
EP3240910A4 (en) | 2018-06-06 |
WO2016108954A1 (en) | 2016-07-07 |
US20160186250A1 (en) | 2016-06-30 |
US9944978B2 (en) | 2018-04-17 |
US20180237843A1 (en) | 2018-08-23 |
CN107208145A (zh) | 2017-09-26 |
AU2015372584A1 (en) | 2017-06-29 |
EP3240910A1 (en) | 2017-11-08 |
EP3240910B1 (en) | 2020-11-18 |
JP2018501799A (ja) | 2018-01-25 |
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