HK1220737A1 - 短端粒丰度的量度 - Google Patents

短端粒丰度的量度

Info

Publication number
HK1220737A1
HK1220737A1 HK16108844.3A HK16108844A HK1220737A1 HK 1220737 A1 HK1220737 A1 HK 1220737A1 HK 16108844 A HK16108844 A HK 16108844A HK 1220737 A1 HK1220737 A1 HK 1220737A1
Authority
HK
Hong Kong
Prior art keywords
measures
short telomere
telomere abundance
abundance
short
Prior art date
Application number
HK16108844.3A
Other languages
English (en)
Inventor
Calvin Harley
Jue Lin
Yajing Hu
Original Assignee
Telomere Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telomere Diagnostics Inc filed Critical Telomere Diagnostics Inc
Publication of HK1220737A1 publication Critical patent/HK1220737A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16108844.3A 2013-05-22 2016-07-25 短端粒丰度的量度 HK1220737A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361826484P 2013-05-22 2013-05-22
PCT/US2014/039110 WO2014190138A2 (en) 2013-05-22 2014-05-22 Measures of short telomere abundance

Publications (1)

Publication Number Publication Date
HK1220737A1 true HK1220737A1 (zh) 2017-05-12

Family

ID=51934344

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108844.3A HK1220737A1 (zh) 2013-05-22 2016-07-25 短端粒丰度的量度

Country Status (10)

Country Link
US (2) US10316366B2 (zh)
EP (1) EP2999800B1 (zh)
JP (1) JP6546158B2 (zh)
CN (1) CN105283559A (zh)
AU (1) AU2014268510A1 (zh)
CA (1) CA2912216A1 (zh)
ES (1) ES2762860T3 (zh)
HK (1) HK1220737A1 (zh)
MX (1) MX2015015891A (zh)
WO (1) WO2014190138A2 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169516B2 (en) 2003-01-24 2015-10-27 University Of Utah Research Foundation Methods of predicting mortality risk by determining telomere length
US9689028B2 (en) 2008-12-22 2017-06-27 University Of Utah Foundation Monochrome multiplex quantitative PCR
MX2015015891A (es) 2013-05-22 2016-06-02 Telomere Diagnostics Inc Mediciones de abundancia de telomeros cortos.
BR112017014116A2 (pt) * 2014-12-30 2018-03-06 Telomere Diagnostics Inc pcr quantitativo multiplex
CN106480218A (zh) * 2016-12-13 2017-03-08 浙江指针基因科技有限公司 一种基于qPCR法检测白细胞端粒长度的方法
US10604794B2 (en) 2017-05-10 2020-03-31 The Board Of Regents Of The University Of Texas System Method to measure the shortest telomeres
CN107164365B (zh) * 2017-06-16 2020-11-27 广州普麦健康咨询有限公司 应用三代测序技术检测染色体端粒dna全长的方法
EP3674418A1 (en) * 2018-12-26 2020-07-01 Life Length S.L. Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases
CN112029841B (zh) * 2019-06-03 2024-02-09 香港中文大学 定量端粒长度和基因组基序的方法
US11227691B2 (en) 2019-09-03 2022-01-18 Kpn Innovations, Llc Systems and methods for selecting an intervention based on effective age
US11250337B2 (en) 2019-11-04 2022-02-15 Kpn Innovations Llc Systems and methods for classifying media according to user negative propensities
CN113862336A (zh) * 2021-11-03 2021-12-31 天津医科大学 一种基于单基因校正的高通量斑点杂交端粒长度检测方法
CN117248003B (zh) * 2023-11-13 2024-04-12 元码基因科技(北京)股份有限公司 用于完整端粒扩增子测序的组合物、预文库及其构建方法
CN117230171B (zh) * 2023-11-13 2024-04-12 元码基因科技(北京)股份有限公司 端粒扩增子测序用试剂盒及预文库构建方法
CN117230169B (zh) * 2023-11-13 2024-02-13 元码基因科技(北京)股份有限公司 用于长片段端粒序列测序的接头、预文库及其构建方法

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608745B2 (ja) 1978-02-14 1985-03-05 三洋化成工業株式会社 免疫活性物質−つや消しガラス複合体,その製造法及び該複合体を含有してなる測定試薬
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
EP0155747A1 (en) 1984-03-19 1985-09-25 Kidde, Inc. Tube culture system
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US5512441A (en) 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5741677A (en) 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5856096A (en) 1995-09-20 1999-01-05 Ctrc Research Foundation Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities
WO1997012681A1 (en) 1995-10-02 1997-04-10 Analyte Diagnostics, Inc. Sample collection, recovery and dispensing device for saliva
DE69637086T2 (de) 1995-10-12 2008-01-10 Lansdorp, Peter M., Vancouver Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
IN182876B (zh) 1995-11-22 1999-07-31 Abion Ohg
JP3718892B2 (ja) 1996-02-05 2005-11-24 三菱化学株式会社 ヒト・テロメラーゼ活性の測定方法
US5945319A (en) 1996-04-25 1999-08-31 Medtronic, Inc. Periodate oxidative method for attachment of biomolecules to medical device surfaces
US5928916A (en) 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
US5910122A (en) 1996-06-04 1999-06-08 Americare Health Scan Inc. Saliva collector with an aspirating pipette
HUP9902721A2 (hu) 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
JP4013333B2 (ja) 1998-06-05 2007-11-28 株式会社B&Cラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US6022326A (en) 1998-10-30 2000-02-08 Lifepoint, Inc. Device and method for automatic collection of whole saliva
AU764964B2 (en) 1998-11-23 2003-09-04 Usamriid Purification method and apparatus
US6436677B1 (en) 2000-03-02 2002-08-20 Promega Corporation Method of reverse transcription
JP2004533801A (ja) 2000-03-07 2004-11-11 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 単一および多重標的dnaのためのインターカレーション色素を用いる実時間定量pcr
EP1399591A2 (en) 2001-06-23 2004-03-24 University of Wales College of Medicine Method for the determination of telomere length
JP2005512578A (ja) 2001-12-19 2005-05-12 ロシュ ダイアグノスティックス コーポレーション Pcrをベースとする高効率のポリペプチドスクリーニング
EP1476561B1 (en) 2002-01-31 2011-11-23 University of Utah Amplifying repetitive nucleic acid sequences
US20100311954A1 (en) 2002-03-01 2010-12-09 Xencor, Inc. Optimized Proteins that Target Ep-CAM
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
GB2391813B (en) 2002-08-14 2006-03-29 Cozart Bioscience Ltd An oral fluid collection, transfer and transportation device and method
AU2003298706A1 (en) 2002-12-04 2004-06-23 Applera Corporation Multiplex amplification of polynucleotides
US9169516B2 (en) 2003-01-24 2015-10-27 University Of Utah Research Foundation Methods of predicting mortality risk by determining telomere length
US20050009097A1 (en) 2003-03-31 2005-01-13 Better Marc D. Human engineered antibodies to Ep-CAM
JP4228041B2 (ja) 2003-07-08 2009-02-25 東洋紡績株式会社 塩基多型の検出方法
US20050180979A1 (en) 2004-02-13 2005-08-18 Micromet Ag Anti-EpCAM immunoglobulins
US20060141492A1 (en) 2004-07-27 2006-06-29 Sowers Kevin R Gene probes for the selective detection of microorganisms that reductively dechlorinate polychlorinated biphenyl compounds
US20080182252A1 (en) 2005-04-08 2008-07-31 Linkage Biosciences, Inc. Genotyping Hla Loci
EP1876893B1 (en) 2005-04-15 2012-04-11 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
WO2007008943A2 (en) 2005-07-08 2007-01-18 Xencor, Inc. Optimized anti-ep-cam antibodies
US20070059716A1 (en) 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
CA2632614C (en) 2005-12-09 2014-04-01 Dna Genotek Inc. Container system for releasably storing a substance
US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
WO2008143679A2 (en) 2006-06-01 2008-11-27 Verenium Corporation Nucleic acids and proteins and methods for making and using them
US20080063628A1 (en) 2006-09-11 2008-03-13 Davis Janet E Methods to promote cell differentiation
KR101683884B1 (ko) 2007-04-04 2016-12-07 시구마-토우인더스트리에파아마슈우티히리유니트에스.피이.에이. 항-EpCAM 항체 및 이의 용도
US20090142408A1 (en) 2007-07-23 2009-06-04 Telomolecular Corporation Telomerase delivery by biodegradable Nanoparticle
EP2191013A1 (en) * 2007-08-10 2010-06-02 Tina Holding APS Method for estimating telomere length
CN201188066Y (zh) 2008-02-03 2009-01-28 上海邃志生物科技有限公司 一种能储存试剂的唾液采集装置
US9079181B2 (en) 2008-08-21 2015-07-14 Dna Genotek Inc. Sample receiving device
JP5519511B2 (ja) 2008-09-08 2014-06-11 アークレイ株式会社 試料採取用具
US9689028B2 (en) 2008-12-22 2017-06-27 University Of Utah Foundation Monochrome multiplex quantitative PCR
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
WO2010115156A2 (en) 2009-04-03 2010-10-07 Synthetic Genomics, Inc. Endophytic fungus and uses therefor
EP2280080A1 (en) 2009-07-31 2011-02-02 Qiagen GmbH Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides
US20110207128A1 (en) 2010-02-16 2011-08-25 Cawthon Richard M Methods and kits for determining biological age and longevity based on gene expression profiles
US20130011918A1 (en) 2010-02-17 2013-01-10 Biotime Inc. Methods for telomere length and genomic dna quality control and analysis in pluripotent stem cells
CA2830673C (en) 2011-03-28 2019-11-12 Hui Wang Telomere length measurement in formalin-fixed, paraffin embedded (ffpe) samples by quantitative pcr
WO2013102116A1 (en) 2011-12-31 2013-07-04 Telome Health, Inc. Saliva-derived measures of telomere abundance and sample collection device
US10093970B2 (en) 2013-03-15 2018-10-09 New York University Method for single cell analysis of telomere length using pre-amplification and multiple-copy reference sequence
MX2015015891A (es) 2013-05-22 2016-06-02 Telomere Diagnostics Inc Mediciones de abundancia de telomeros cortos.
BR112017014116A2 (pt) 2014-12-30 2018-03-06 Telomere Diagnostics Inc pcr quantitativo multiplex

Also Published As

Publication number Publication date
CA2912216A1 (en) 2014-11-27
WO2014190138A3 (en) 2015-02-26
US10316366B2 (en) 2019-06-11
JP6546158B2 (ja) 2019-07-17
EP2999800A4 (en) 2017-01-04
US20190382841A1 (en) 2019-12-19
CN105283559A (zh) 2016-01-27
ES2762860T3 (es) 2020-05-26
US20160090630A1 (en) 2016-03-31
MX2015015891A (es) 2016-06-02
EP2999800A2 (en) 2016-03-30
JP2016521548A (ja) 2016-07-25
EP2999800B1 (en) 2019-09-25
WO2014190138A2 (en) 2014-11-27
AU2014268510A1 (en) 2015-11-26

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