JP2019123675A5 - - Google Patents
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- Publication number
- JP2019123675A5 JP2019123675A5 JP2018003564A JP2018003564A JP2019123675A5 JP 2019123675 A5 JP2019123675 A5 JP 2019123675A5 JP 2018003564 A JP2018003564 A JP 2018003564A JP 2018003564 A JP2018003564 A JP 2018003564A JP 2019123675 A5 JP2019123675 A5 JP 2019123675A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- radionuclide
- labeled compound
- formula
- imaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 4
- 238000003384 imaging method Methods 0.000 claims 3
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000012216 imaging agent Substances 0.000 claims 2
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical group [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018003564A JP6831802B2 (ja) | 2018-01-12 | 2018-01-12 | 放射性核種標識化合物及びこれを含有するイメージング剤 |
| TW108101192A TWI818946B (zh) | 2018-01-12 | 2019-01-11 | 放射性核種標識化合物及含有其之成像劑 |
| CN201980007415.2A CN111556868B (zh) | 2018-01-12 | 2019-01-11 | 放射性核素标记化合物和含有该化合物的显影剂 |
| KR1020207023105A KR102428569B1 (ko) | 2018-01-12 | 2019-01-11 | 방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 |
| PCT/IB2019/000060 WO2019138296A2 (ja) | 2018-01-12 | 2019-01-11 | 放射性核種標識化合物及びこれを含有するイメージング剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018003564A JP6831802B2 (ja) | 2018-01-12 | 2018-01-12 | 放射性核種標識化合物及びこれを含有するイメージング剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019123675A JP2019123675A (ja) | 2019-07-25 |
| JP2019123675A5 true JP2019123675A5 (enExample) | 2020-09-17 |
| JP6831802B2 JP6831802B2 (ja) | 2021-02-17 |
Family
ID=67218458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018003564A Active JP6831802B2 (ja) | 2018-01-12 | 2018-01-12 | 放射性核種標識化合物及びこれを含有するイメージング剤 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6831802B2 (enExample) |
| KR (1) | KR102428569B1 (enExample) |
| CN (1) | CN111556868B (enExample) |
| TW (1) | TWI818946B (enExample) |
| WO (1) | WO2019138296A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115989029B (zh) * | 2020-08-25 | 2025-07-22 | 国立研究开发法人量子科学技术研究开发机构 | 化合物、α突触核蛋白凝集体结合剂及其利用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1381604B1 (en) * | 2001-04-23 | 2006-12-27 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| AU2003304416A1 (en) * | 2003-08-13 | 2005-03-07 | Bf Research Institute, Inc. | Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change |
| WO2005016888A1 (ja) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤 |
| US8022075B2 (en) * | 2005-11-30 | 2011-09-20 | Fujifilm Ri Pharma Co., Ltd. | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition |
| CN101466711A (zh) * | 2006-05-19 | 2009-06-24 | 日本医事物理股份有限公司 | 对淀粉状蛋白具有亲和性的新化合物 |
| WO2008078424A1 (ja) * | 2006-12-25 | 2008-07-03 | Tohoku University | ベンゾキサゾール誘導体 |
| JP4738443B2 (ja) * | 2007-05-30 | 2011-08-03 | 富士フイルムＲｉファーマ株式会社 | アミロイドの凝集及び／又は沈着に起因する疾患のイメージング薬及び治療薬 |
| JP2011524864A (ja) * | 2008-05-30 | 2011-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な置換されたアザベンゾオキサゾール |
| AU2012259929B2 (en) * | 2011-05-20 | 2016-08-04 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| JP5167436B2 (ja) * | 2011-06-24 | 2013-03-21 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
| AU2012397435B2 (en) * | 2012-12-21 | 2017-03-30 | National Institutes For Quantum And Radiological Science And Technology | Novel compound for imaging TAU protein accumulated in the brain |
| JP6130055B2 (ja) * | 2013-05-23 | 2017-05-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 造影剤としての２−フェニルイミダゾ［１．２−ａ］ピリミジン |
-
2018
- 2018-01-12 JP JP2018003564A patent/JP6831802B2/ja active Active
-
2019
- 2019-01-11 TW TW108101192A patent/TWI818946B/zh active
- 2019-01-11 KR KR1020207023105A patent/KR102428569B1/ko active Active
- 2019-01-11 WO PCT/IB2019/000060 patent/WO2019138296A2/ja not_active Ceased
- 2019-01-11 CN CN201980007415.2A patent/CN111556868B/zh active Active
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