KR102428569B1 - 방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 - Google Patents

방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 Download PDF

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KR102428569B1
KR102428569B1 KR1020207023105A KR20207023105A KR102428569B1 KR 102428569 B1 KR102428569 B1 KR 102428569B1 KR 1020207023105 A KR1020207023105 A KR 1020207023105A KR 20207023105 A KR20207023105 A KR 20207023105A KR 102428569 B1 KR102428569 B1 KR 102428569B1
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tau
radionuclide
amyloid
imaging
compound
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KR20200109335A (ko
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빈 지
마코토 히구치
테츠야 스하라
춘-젠 첸
오스케 후지모토
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상하이 차트웰 메디컬 사이언스 앤 테크놀로지 컴퍼니 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020207023105A 2018-01-12 2019-01-11 방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 Active KR102428569B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018003564A JP6831802B2 (ja) 2018-01-12 2018-01-12 放射性核種標識化合物及びこれを含有するイメージング剤
JPJP-P-2018-003564 2018-01-12
PCT/IB2019/000060 WO2019138296A2 (ja) 2018-01-12 2019-01-11 放射性核種標識化合物及びこれを含有するイメージング剤

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KR20200109335A KR20200109335A (ko) 2020-09-22
KR102428569B1 true KR102428569B1 (ko) 2022-08-03

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JP (1) JP6831802B2 (enExample)
KR (1) KR102428569B1 (enExample)
CN (1) CN111556868B (enExample)
TW (1) TWI818946B (enExample)
WO (1) WO2019138296A2 (enExample)

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Publication number Priority date Publication date Assignee Title
CN115989029B (zh) * 2020-08-25 2025-07-22 国立研究开发法人量子科学技术研究开发机构 化合物、α突触核蛋白凝集体结合剂及其利用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009007348A (ja) * 2007-05-30 2009-01-15 Fujifilm Ri Pharma Co Ltd アミロイドの凝集及び／又は沈着に起因する疾患のイメージング薬及び治療薬

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
EP1381604B1 (en) * 2001-04-23 2006-12-27 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
AU2003304416A1 (en) * 2003-08-13 2005-03-07 Bf Research Institute, Inc. Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change
WO2005016888A1 (ja) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
CN101466711A (zh) * 2006-05-19 2009-06-24 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
WO2008078424A1 (ja) * 2006-12-25 2008-07-03 Tohoku University ベンゾキサゾール誘導体
JP2011524864A (ja) * 2008-05-30 2011-09-08 メルク・シャープ・エンド・ドーム・コーポレイション 新規な置換されたアザベンゾオキサゾール
AU2012259929B2 (en) * 2011-05-20 2016-08-04 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
JP5167436B2 (ja) * 2011-06-24 2013-03-21 日本メジフィジックス株式会社 新規アミロイド親和性化合物
AU2012397435B2 (en) * 2012-12-21 2017-03-30 National Institutes For Quantum And Radiological Science And Technology Novel compound for imaging TAU protein accumulated in the brain
JP6130055B2 (ja) * 2013-05-23 2017-05-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 造影剤としての２−フェニルイミダゾ［１．２−ａ］ピリミジン

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009007348A (ja) * 2007-05-30 2009-01-15 Fujifilm Ri Pharma Co Ltd アミロイドの凝集及び／又は沈着に起因する疾患のイメージング薬及び治療薬

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TW201929909A (zh) 2019-08-01
CN111556868A (zh) 2020-08-18
JP6831802B2 (ja) 2021-02-17
TWI818946B (zh) 2023-10-21
JP2019123675A (ja) 2019-07-25
WO2019138296A2 (ja) 2019-07-18
WO2019138296A3 (ja) 2019-10-03
CN111556868B (zh) 2023-03-28
KR20200109335A (ko) 2020-09-22

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