JP2019038820A5 - - Google Patents
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- Publication number
- JP2019038820A5 JP2019038820A5 JP2018196401A JP2018196401A JP2019038820A5 JP 2019038820 A5 JP2019038820 A5 JP 2019038820A5 JP 2018196401 A JP2018196401 A JP 2018196401A JP 2018196401 A JP2018196401 A JP 2018196401A JP 2019038820 A5 JP2019038820 A5 JP 2019038820A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dimethylcyclohex
- piperazin
- pyrrolo
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 4-{[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl Chemical group 0.000 claims 85
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 46
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
- 208000005777 Lupus Nephritis Diseases 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 3
- 206010041067 Small cell lung cancer Diseases 0.000 claims 3
- 208000000277 Splenic Neoplasms Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 201000006491 bone marrow cancer Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 201000004101 esophageal cancer Diseases 0.000 claims 3
- 201000003444 follicular lymphoma Diseases 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
- 208000003747 lymphoid leukemia Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000025113 myeloid leukemia Diseases 0.000 claims 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 3
- 201000002471 spleen cancer Diseases 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- TYERRNIXCPPQQD-UHFFFAOYSA-N N-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide Chemical compound C(C1=CC=CC=C1)(=O)NOC=1C=C2C(=NC=1)NC=C2 TYERRNIXCPPQQD-UHFFFAOYSA-N 0.000 claims 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000005443 oral cavity cancer Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781070P | 2013-03-14 | 2013-03-14 | |
| US61/781,070 | 2013-03-14 | ||
| US14/176,506 | 2014-02-10 | ||
| US14/176,506 US20140275082A1 (en) | 2013-03-14 | 2014-02-10 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500337A Division JP6449222B2 (ja) | 2013-03-14 | 2014-02-21 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020118278A Division JP2020180145A (ja) | 2013-03-14 | 2020-07-09 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019038820A JP2019038820A (ja) | 2019-03-14 |
| JP2019038820A5 true JP2019038820A5 (OSRAM) | 2019-06-13 |
Family
ID=51529947
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500337A Active JP6449222B2 (ja) | 2013-03-14 | 2014-02-21 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2018196401A Pending JP2019038820A (ja) | 2013-03-14 | 2018-10-18 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2020118278A Pending JP2020180145A (ja) | 2013-03-14 | 2020-07-09 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2021109903A Pending JP2021167330A (ja) | 2013-03-14 | 2021-07-01 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500337A Active JP6449222B2 (ja) | 2013-03-14 | 2014-02-21 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020118278A Pending JP2020180145A (ja) | 2013-03-14 | 2020-07-09 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2021109903A Pending JP2021167330A (ja) | 2013-03-14 | 2021-07-01 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Country Status (35)
| Country | Link |
|---|---|
| US (6) | US20140275082A1 (OSRAM) |
| EP (2) | EP3415514A1 (OSRAM) |
| JP (4) | JP6449222B2 (OSRAM) |
| KR (2) | KR20210021613A (OSRAM) |
| CN (2) | CN107987075B (OSRAM) |
| AR (2) | AR095263A1 (OSRAM) |
| AU (2) | AU2014242104B2 (OSRAM) |
| BR (1) | BR112015021115B1 (OSRAM) |
| CA (2) | CA2899041A1 (OSRAM) |
| CL (2) | CL2015002640A1 (OSRAM) |
| CR (1) | CR20150510A (OSRAM) |
| CY (1) | CY1120862T1 (OSRAM) |
| DK (1) | DK2970257T3 (OSRAM) |
| DO (1) | DOP2018000026A (OSRAM) |
| ES (1) | ES2689679T3 (OSRAM) |
| GT (1) | GT201500248A (OSRAM) |
| HR (1) | HRP20181403T8 (OSRAM) |
| HU (1) | HUE038983T2 (OSRAM) |
| IL (3) | IL240010B (OSRAM) |
| LT (1) | LT2970257T (OSRAM) |
| MX (2) | MX360541B (OSRAM) |
| MY (1) | MY178821A (OSRAM) |
| NZ (1) | NZ631701A (OSRAM) |
| PE (2) | PE20151555A1 (OSRAM) |
| PL (1) | PL2970257T4 (OSRAM) |
| PT (1) | PT2970257T (OSRAM) |
| RS (1) | RS57750B1 (OSRAM) |
| RU (2) | RU2018127315A (OSRAM) |
| SG (2) | SG10201908388UA (OSRAM) |
| SI (1) | SI2970257T1 (OSRAM) |
| TW (2) | TWI717662B (OSRAM) |
| UA (1) | UA120035C2 (OSRAM) |
| UY (1) | UY35406A (OSRAM) |
| WO (1) | WO2014158528A1 (OSRAM) |
| ZA (1) | ZA201505203B (OSRAM) |
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| US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
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| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| WO2017147475A1 (en) * | 2016-02-27 | 2017-08-31 | Hpvvax, Llc | Method and composition for treating cancer or skin lesion using a vaccine |
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| CN109641897B (zh) * | 2016-09-01 | 2021-12-07 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| CN110177788B (zh) * | 2017-01-07 | 2023-03-24 | 重庆复创医药研究有限公司 | 作为bcl-2选择性凋亡诱导剂的化合物 |
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| CN110577525A (zh) * | 2018-06-11 | 2019-12-17 | 北京万全德众医药生物技术有限公司 | 一种维奈妥拉中间体的制备方法 |
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