|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
USRE28819E
(en)
|
1972-12-08 |
1976-05-18 |
Syntex (U.S.A.) Inc. |
Dialkylated glycol compositions and medicament preparations containing same
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
DE2352702A1
(de)
*
|
1973-10-20 |
1975-06-26 |
Hoechst Ag |
Basisch substituierte 1,4-dihydro-2hisochinolinderivate und verfahren zu ihrer herstellung
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4358603A
(en)
|
1981-04-16 |
1982-11-09 |
Syntex (U.S.A.) Inc. |
Acetal stabilized prostaglandin compositions
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
KR890002631B1
(ko)
|
1984-10-04 |
1989-07-21 |
몬산토 캄파니 |
생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US6010715A
(en)
|
1992-04-01 |
2000-01-04 |
Bertek, Inc. |
Transdermal patch incorporating a polymer film incorporated with an active agent
|
|
US6024975A
(en)
|
1992-04-08 |
2000-02-15 |
Americare International Diagnostics, Inc. |
Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
|
ATE456367T1
(de)
*
|
1993-12-23 |
2010-02-15 |
Lilly Co Eli |
Proteinkinase c inhibitoren
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
|
US5983134A
(en)
|
1995-04-23 |
1999-11-09 |
Electromagnetic Bracing Systems Inc. |
Electrophoretic cuff apparatus drug delivery system
|
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
|
DE69632684T2
(de)
|
1995-06-27 |
2005-06-09 |
Takeda Pharmaceutical Co. Ltd. |
Verfahren zur herstellung von zubereitungen mit verzögerter freisetzung
|
|
US6167301A
(en)
|
1995-08-29 |
2000-12-26 |
Flower; Ronald J. |
Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
US5985317A
(en)
|
1996-09-06 |
1999-11-16 |
Theratech, Inc. |
Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
|
|
US6139865A
(en)
|
1996-10-01 |
2000-10-31 |
Eurand America, Inc. |
Taste-masked microcapsule compositions and methods of manufacture
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
EP0839525B1
(en)
|
1996-10-31 |
2004-08-04 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
|
DK0946169T3
(da)
|
1996-12-20 |
2003-04-22 |
Takeda Chemical Industries Ltd |
Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
CA2226058C
(en)
*
|
1997-01-30 |
2008-01-29 |
F. Hoffmann-La Roche Ag |
8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives
|
|
US5860957A
(en)
|
1997-02-07 |
1999-01-19 |
Sarcos, Inc. |
Multipathway electronically-controlled drug delivery system
|
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
|
US5948433A
(en)
|
1997-08-21 |
1999-09-07 |
Bertek, Inc. |
Transdermal patch
|
|
EP0968711B9
(en)
|
1997-10-28 |
2008-05-28 |
Bando Chemical Industries, Ltd. |
Dermatological patch sheet and process for producing base sheet therefor
|
|
US6740634B1
(en)
|
1998-01-16 |
2004-05-25 |
Takeda Chemical Industries, Ltd. |
Sustained release compositions, process for producing the same and utilization thereof
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
JP2002526500A
(ja)
*
|
1998-09-18 |
2002-08-20 |
ビーエーエスエフ アクチェンゲゼルシャフト |
プロテインキナーゼ阻害剤としてのピロロピリミジン
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
|
US6256533B1
(en)
|
1999-06-09 |
2001-07-03 |
The Procter & Gamble Company |
Apparatus and method for using an intracutaneous microneedle array
|
|
HK1049004A1
(en)
*
|
2000-01-20 |
2003-04-25 |
Eisai Co., Ltd. |
Nitrogenous cyclic compounds and pharmaceutical compositions containing the same
|
|
JP3966693B2
(ja)
*
|
2000-01-20 |
2007-08-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
含窒素環化合物およびそれらを含んでなる医薬組成物
|
|
US6261595B1
(en)
|
2000-02-29 |
2001-07-17 |
Zars, Inc. |
Transdermal drug patch with attached pocket for controlled heating device
|
|
WO2001072751A1
(en)
*
|
2000-03-29 |
2001-10-04 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
|
DE60140708D1
(de)
*
|
2000-08-10 |
2010-01-14 |
Mitsubishi Tanabe Pharma Corp |
Prolinderivative und deren Verwendung als Medikamente
|
|
ES2323876T3
(es)
*
|
2001-04-18 |
2009-07-27 |
Euro-Celtique S.A. |
Derivados de 1-(4-piperidinil)-1,3-dihidro-2h-benzoxazol-2-ona y compuestos relacionados como analogos de la nociceptina y ligandos de orl1 para el tratamiento del dolor.
|
|
WO2003064425A1
(en)
*
|
2002-01-28 |
2003-08-07 |
Pfizer Japan Inc. |
N-substituted spiropiperidine compounds as ligands for orl-1 receptor
|
|
AU2003235912A1
(en)
*
|
2002-05-10 |
2003-11-11 |
Taisho Pharmaceutical Co., Ltd. |
Spiro-ring compound
|
|
EA009369B1
(ru)
*
|
2002-09-09 |
2007-12-28 |
Янссен Фармацевтика, Н.В. |
Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором
|
|
US7045527B2
(en)
*
|
2002-09-24 |
2006-05-16 |
Amgen Inc. |
Piperidine derivatives
|
|
UA80171C2
(en)
*
|
2002-12-19 |
2007-08-27 |
Pfizer Prod Inc |
Pyrrolopyrimidine derivatives
|
|
WO2005016913A1
(en)
|
2003-08-19 |
2005-02-24 |
Pfizer Japan, Inc. |
Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
|
|
JP2007505136A
(ja)
|
2003-09-10 |
2007-03-08 |
マツプ・フアーマシユーテイカルズ・インコーポレーテツド |
ジヒドロエルゴタミンを肺吸入により体循環に送達するためのエアゾール製剤
|
|
AR046756A1
(es)
|
2003-12-12 |
2005-12-21 |
Solvay Pharm Gmbh |
Derivados de hidronopol como agonistas de receptores orl-1 humanos.
|
|
US20050228023A1
(en)
|
2003-12-19 |
2005-10-13 |
Sri International |
Agonist and antagonist ligands of the nociceptin receptor
|
|
BRPI0509377A
(pt)
*
|
2004-03-29 |
2007-09-11 |
Pfizer |
compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1
|
|
WO2006130416A2
(en)
*
|
2005-06-02 |
2006-12-07 |
Janssen Pharmaceutica, N.V. |
Novel 3-spirocyclic indolyl derivatives useful as orl-1 receptor modulators
|
|
CN101534824A
(zh)
*
|
2006-11-17 |
2009-09-16 |
艾博特公司 |
作为化学活素受体拮抗剂的氨基吡咯烷
|
|
CN101679430B
(zh)
*
|
2007-04-09 |
2013-12-25 |
詹森药业有限公司 |
用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
|
|
EP2141163A1
(de)
*
|
2008-07-02 |
2010-01-06 |
Bayer Schering Pharma AG |
Substituierte Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
|
|
EA201200471A1
(ru)
*
|
2009-09-10 |
2012-10-30 |
Новартис Аг |
Простые эфирные производные бициклических гетероарилов
|
|
UY33227A
(es)
*
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
TW201211028A
(en)
*
|
2010-08-10 |
2012-03-16 |
Dainippon Sumitomo Pharma Co |
Fused ring pyrrolidine derivatives
|
|
TW201348231A
(zh)
|
2012-02-29 |
2013-12-01 |
Amgen Inc |
雜雙環化合物
|
|
JP6327713B2
(ja)
*
|
2012-07-27 |
2018-05-23 |
国立研究開発法人理化学研究所 |
急性骨髄性白血病の治療又は再発抑制剤
|
|
US9963458B2
(en)
*
|
2012-12-27 |
2018-05-08 |
Purdue Pharma L.P. |
Indole and indoline-type piperidine compounds and uses thereof
|
|
WO2014106238A1
(en)
|
2012-12-31 |
2014-07-03 |
Fang, Qun, Kevin |
Heterocyclic compounds and methods of use thereof
|
|
JP2016113366A
(ja)
*
|
2013-03-29 |
2016-06-23 |
大鵬薬品工業株式会社 |
アセトアミド基を有する１，２，４−トリアジン−６−カルボキサミド誘導体
|
|
TWI663166B
(zh)
*
|
2013-04-24 |
2019-06-21 |
健生藥品公司 |
新化合物
|
|
WO2014184069A1
(en)
*
|
2013-05-14 |
2014-11-20 |
Nerviano Medical Sciences S.R.L. |
Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
|
|
TWI627173B
(zh)
*
|
2013-09-26 |
2018-06-21 |
比利時商健生藥品公司 |
作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
|
|
CA2960335C
(en)
*
|
2014-10-23 |
2023-09-19 |
Janssen Pharmaceutica Nv |
New pyrazole derivatives as nik inhibitors
|
|
MX371151B
(es)
*
|
2014-10-23 |
2020-01-20 |
Janssen Pharmaceutica Nv |
NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK).
|
|
EP4455145A3
(en)
*
|
2015-12-02 |
2025-03-12 |
Astraea Therapeutics, LLC |
Piperidinyl nociceptin receptor compounds
|