JP2018536710A - 混合型脂質異常症の治療 - Google Patents

混合型脂質異常症の治療 Download PDF

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JP2018536710A
JP2018536710A JP2018543283A JP2018543283A JP2018536710A JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018543283 A JP2018543283 A JP 2018543283A JP 2018543283 A JP2018543283 A JP 2018543283A JP 2018536710 A JP2018536710 A JP 2018536710A
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Japan
Prior art keywords
gemcabene
subject
atorvastatin
daily dose
statin
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JP2018543283A
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Japanese (ja)
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JP2018536710A5 (https=
Inventor
チャールズ・エル・ビスゲイア
ダニエラ・カルメン・オニチュ
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Metavia
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Gemphire Therapeutics LLC
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JP2018543283A 2015-11-06 2016-11-07 混合型脂質異常症の治療 Pending JP2018536710A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562252195P 2015-11-06 2015-11-06
US201562252147P 2015-11-06 2015-11-06
US62/252,195 2015-11-06
US62/252,147 2015-11-06
PCT/US2016/060837 WO2017079748A1 (en) 2015-11-06 2016-11-07 Treatment of mixed dyslipidemia

Publications (2)

Publication Number Publication Date
JP2018536710A true JP2018536710A (ja) 2018-12-13
JP2018536710A5 JP2018536710A5 (https=) 2019-12-19

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JP2018543283A Pending JP2018536710A (ja) 2015-11-06 2016-11-07 混合型脂質異常症の治療
JP2018543079A Pending JP2018532808A (ja) 2015-11-06 2016-11-07 心血管疾患の処置のためのゲムカベンの組み合わせ

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JP2018543079A Pending JP2018532808A (ja) 2015-11-06 2016-11-07 心血管疾患の処置のためのゲムカベンの組み合わせ

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US (4) US9849104B2 (https=)
EP (2) EP3370713A4 (https=)
JP (2) JP2018536710A (https=)
KR (2) KR20180073597A (https=)
CN (2) CN108348491A (https=)
AU (2) AU2016348638A1 (https=)
BR (2) BR112018009238A8 (https=)
CA (2) CA3001627A1 (https=)
HK (2) HK1259458A1 (https=)
IL (2) IL258819A (https=)
MA (1) MA43190A (https=)
MX (2) MX2018005096A (https=)
PH (1) PH12018500972A1 (https=)
RU (2) RU2018120599A (https=)
SG (2) SG10201912754UA (https=)
WO (2) WO2017079755A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019043880A (ja) * 2017-09-01 2019-03-22 興和株式会社 医薬組成物

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
WO2016077832A2 (en) 2014-11-14 2016-05-19 Gemphire Therapeutics Inc. PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS
AU2016348638A1 (en) * 2015-11-06 2018-06-07 Gemphire Therapeutics Inc. Gemcabene combinations for the treatment of cardiovascular disease
ES2929758T3 (es) 2016-05-05 2022-12-01 Childrens Hospital Med Ct Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo
AU2017292184A1 (en) 2016-07-08 2019-02-07 Staten Biotechnology B.V. Anti-Apoc3 antibodies and methods of use thereof
EP3518918A4 (en) 2016-09-28 2020-04-22 Eiger Biopharmaceuticals, Inc. METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS
KR102729404B1 (ko) 2016-11-04 2024-11-14 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
JP7068305B2 (ja) 2016-12-05 2022-05-16 チルドレンズ ホスピタル メディカル センター 結腸オルガノイドならびにその作製方法および使用方法
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3612171A4 (en) 2017-04-18 2020-10-21 Gemphire Therapeutics Inc. GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND PROCEDURES FOR THE USE OF THE SAME
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
US20180338922A1 (en) * 2017-05-26 2018-11-29 Esperion Therapeutics, Inc. Fixed dose formulations
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
KR20200074975A (ko) 2017-10-31 2020-06-25 스태튼 바이오테크놀로지 비.브이. 항-ApoC3 항체 및 이의 사용 방법
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
EP3716975A4 (en) * 2017-11-28 2022-01-12 Eiger Biopharmaceuticals, Inc. METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
MX2021003156A (es) 2018-09-18 2021-05-14 1 Globe Biomedical Co Ltd Tratamiento para la enfermedad del higado graso no alcoholico.
WO2020077186A1 (en) * 2018-10-12 2020-04-16 Icahn School Of Medicine At Mount Sinai Azd3355 (lesogaberan) for treatment and prevention of nonalcoholic steatohepatitis (nash), liver fibrosis, and other liver conditions
WO2020081837A1 (en) * 2018-10-18 2020-04-23 Gemphire Therapeutics Inc. Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor
AU2020209216A1 (en) 2019-01-18 2021-08-26 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CN112851660B (zh) * 2019-11-12 2022-03-18 广东药科大学 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途
CN114957119B (zh) * 2022-05-05 2023-06-16 武汉大学中南医院 一种四氢喹啉螺1,3-茚二酮类衍生物及其制备方法与应用
WO2025186785A1 (en) * 2024-03-08 2025-09-12 TECNIMEDE - Sociedade Técnico-medicinal, SA Oral pharmaceutical composition of pitavastatin, method and uses thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508320A (ja) * 1997-12-12 2002-03-19 ワーナー−ランバート・カンパニー スタチン−カルボキシアルキルエーテル配合物
JP2005527553A (ja) * 2002-03-29 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 自己免疫疾患の治療におけるスタチン類および他の自己免疫調節剤の利用
JP2005538104A (ja) * 2002-07-26 2005-12-15 メルク　シャープ　エンド　ドーム　リミテッド コレステロール吸収阻害剤、ＨＭＧ−ＣｏＡレダクターゼ阻害剤および安定化剤を含有する組成物
JP2006508973A (ja) * 2002-11-15 2006-03-16 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー Ｃｒｐを低下させ、かつ全身性炎症を軽減する方法
JP2006131559A (ja) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
JP2008533029A (ja) * 2005-03-08 2008-08-21 レリアント ファーマスーティカルズ インコーポレイテッド スタチン及びω−３脂肪酸による治療方法、並びにそれらの複合生成物
JP2009521452A (ja) * 2005-12-21 2009-06-04 シェーリング コーポレイション コレステロール降下剤およびｈ３受容体アンタゴニスト／逆アゴニストを使用する非アルコール性脂肪性肝疾患の処置
JPWO2009151116A1 (ja) * 2008-06-13 2011-11-17 持田製薬株式会社 非アルコール性脂肪肝炎の予防／改善・治療薬
JP2013516489A (ja) * 2010-01-08 2013-05-13 アイシス ファーマシューティカルズ， インコーポレーテッド アンジオポエチン様３発現の調節
JP2014509305A (ja) * 2010-12-27 2014-04-17 ミシガン ライフ セラピューティクス リミティッド ライアビリティ カンパニー 膵炎を治療するためのゲムカベンおよび誘導体
JP2015503588A (ja) * 2012-01-06 2015-02-02 ミシガン ライフ セラピューティクス リミティッド ライアビリティ カンパニーＭｉｃｈｉｇａｎ Ｌｉｆｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｌｃ 心血管疾患のリスクを低減する方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT381664B (de) 1984-02-07 1986-11-10 Steyr Daimler Puch Ag Einrichtung zur ueberwachung elektrischer, von einer gesteuerten wechselstromquelle gespeister widerstandsschweissvorgaenge, insbesondere punktschweissungen
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
CA2039763A1 (en) 1990-04-30 1991-10-31 Henry Y. Pan Combination of pravastatin and a fibric acid derivative, and method for treating dyslipidemia using such combination
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
US5798375A (en) 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
WO1997016187A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine antagonists
AU7669496A (en) 1995-11-03 1997-05-22 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
DK1017390T3 (da) * 1997-07-31 2007-06-11 Kos Life Sciences Inc Coated tablet, der omfatter nikotinsyre eller en forbindelse, der metaboliseres til nikotinsyre, i en form med langvarig frigivelse og en HMG-CoA-reduktaseinhibitor i en form med öjeblikkelig frigivelse
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
EP1814541A4 (en) * 2004-11-22 2009-10-28 Dexcel Pharma Technologies Ltd STABLE ATORVASTATIN FORMULATIONS
US20090186834A1 (en) * 2005-03-24 2009-07-23 Microbia, Inc. Diphenylheterocycle cholesterol absorption inhibitors
WO2007030375A2 (en) * 2005-09-08 2007-03-15 Children's Hospital Medical Center Lysosomal acid lipase therapy for nafld and related diseases
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
CA2648280C (en) * 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
KR101403887B1 (ko) 2006-08-03 2014-06-20 트러스티즈 오브 터프츠 칼리지 홍조화를 유발하지 않는 니아신 유사체, 및 이의 사용 방법
WO2008023869A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
FI20080353A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi erittäin korkean lääkepitoisuuden tabletin valmistamiseksi
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US20100144864A1 (en) * 2007-04-05 2010-06-10 Ironwood Pharmaceuticals, Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
US8969514B2 (en) * 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US9307371B2 (en) 2008-01-18 2016-04-05 Verizon Patent And Licensing Inc. Method and system for SMS/MMS messaging to a connected device
BRPI0912842A8 (pt) * 2008-05-20 2019-01-29 Cerenis Therapeutics Holding composição farmacêutica, métodos para prevenir ou tratar o rubor induzido por niacina em um indivíduo, para reduzir pelo menos um sintoma de rubor relacionado com a terapia com niacina em um indivíduo, para diminuir os efeitos colaterais relacionados com a protaglandina em um indivíduo, para diminuir uma taxa de descontinuação do tratamento com niacina por um indivíduo, para aumentar a submissão do paciente ao tratamento com niacina, para tratar aterosclerose em um paciente, para tratar uma doença relacionada com um perfil de hdl baixo em um paciente, formulação do ácido nicotínico de dispensação modificada, uso da composição farmacêutica, e, microcápsula de aspirina
EP2488180A4 (en) 2009-10-12 2013-03-27 Ipca Lab Ltd PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT / PROPHYLAXIS OF NON-ALCOHOLIC FAT TREATMENTS
WO2011163612A1 (en) * 2010-06-24 2011-12-29 Trustees Of Tufts College Niacin mimetics, and methods of use thereof
TR201005325A2 (tr) * 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Atorvastatin ve aspirin içeren farmasötik formülasyonlar
EP2604256B1 (en) * 2011-12-14 2016-04-13 Hexal AG Multi layer coatings
CN102525942A (zh) * 2012-01-05 2012-07-04 金陵药业股份有限公司 一种阿托伐他汀钙肠溶微丸及其制备方法
WO2015143276A1 (en) * 2014-03-20 2015-09-24 Esperion Therapeutics, Inc. Carboxy-cyclopropyl undecanol compounds for treatment of liver disease and other medical disorders
CN104127391B (zh) * 2014-08-05 2016-08-24 李宝齐 一种含有阿托伐他汀钙的固体药物组合物
AU2016348638A1 (en) * 2015-11-06 2018-06-07 Gemphire Therapeutics Inc. Gemcabene combinations for the treatment of cardiovascular disease
CN105434391A (zh) * 2016-01-18 2016-03-30 上海蓝心医药科技有限公司 阿托伐他汀钙肠溶片及其制备方法和应用

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508320A (ja) * 1997-12-12 2002-03-19 ワーナー−ランバート・カンパニー スタチン−カルボキシアルキルエーテル配合物
JP2005527553A (ja) * 2002-03-29 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 自己免疫疾患の治療におけるスタチン類および他の自己免疫調節剤の利用
JP2005538104A (ja) * 2002-07-26 2005-12-15 メルク　シャープ　エンド　ドーム　リミテッド コレステロール吸収阻害剤、ＨＭＧ−ＣｏＡレダクターゼ阻害剤および安定化剤を含有する組成物
JP2006508973A (ja) * 2002-11-15 2006-03-16 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー Ｃｒｐを低下させ、かつ全身性炎症を軽減する方法
JP2006131559A (ja) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
JP2008533029A (ja) * 2005-03-08 2008-08-21 レリアント ファーマスーティカルズ インコーポレイテッド スタチン及びω−３脂肪酸による治療方法、並びにそれらの複合生成物
JP2009521452A (ja) * 2005-12-21 2009-06-04 シェーリング コーポレイション コレステロール降下剤およびｈ３受容体アンタゴニスト／逆アゴニストを使用する非アルコール性脂肪性肝疾患の処置
JPWO2009151116A1 (ja) * 2008-06-13 2011-11-17 持田製薬株式会社 非アルコール性脂肪肝炎の予防／改善・治療薬
JP2013516489A (ja) * 2010-01-08 2013-05-13 アイシス ファーマシューティカルズ， インコーポレーテッド アンジオポエチン様３発現の調節
JP2014509305A (ja) * 2010-12-27 2014-04-17 ミシガン ライフ セラピューティクス リミティッド ライアビリティ カンパニー 膵炎を治療するためのゲムカベンおよび誘導体
JP2015503588A (ja) * 2012-01-06 2015-02-02 ミシガン ライフ セラピューティクス リミティッド ライアビリティ カンパニーＭｉｃｈｉｇａｎ Ｌｉｆｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｌｃ 心血管疾患のリスクを低減する方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLINICALTRIALS.GOV, JPN6020037925, 28 October 2015 (2015-10-28), ISSN: 0004496550 *
MANDEMA, JAAP W. ET AL., THE AAPS JOURNAL, vol. 7, no. 3, JPN6020037929, 7 October 2005 (2005-10-07), pages 513 - 522, ISSN: 0004496551 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019043880A (ja) * 2017-09-01 2019-03-22 興和株式会社 医薬組成物

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